DK180231B1 - Method of establishing a brain status indication parameter and system therefor - Google Patents

Method of establishing a brain status indication parameter and system therefor Download PDF

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Publication number
DK180231B1
DK180231B1 DKPA201870707A DKPA201870707A DK180231B1 DK 180231 B1 DK180231 B1 DK 180231B1 DK PA201870707 A DKPA201870707 A DK PA201870707A DK PA201870707 A DKPA201870707 A DK PA201870707A DK 180231 B1 DK180231 B1 DK 180231B1
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DK
Denmark
Prior art keywords
brain
energy metabolism
metabolism indicator
skull
indicator
Prior art date
Application number
DKPA201870707A
Other languages
English (en)
Inventor
Antonsen Segtnan Eivind
Original Assignee
Synaptic Aps
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synaptic Aps filed Critical Synaptic Aps
Priority to DKPA201870707A priority Critical patent/DK180231B1/en
Priority to CA3118046A priority patent/CA3118046A1/en
Priority to US17/289,610 priority patent/US11969240B2/en
Priority to PCT/DK2019/050327 priority patent/WO2020088730A1/en
Priority to JP2021547641A priority patent/JP7430730B2/ja
Priority to EP19797560.0A priority patent/EP3873339B1/en
Priority to CN201980081179.9A priority patent/CN113226168A/zh
Publication of DK201870707A1 publication Critical patent/DK201870707A1/da
Application granted granted Critical
Publication of DK180231B1 publication Critical patent/DK180231B1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A61B6/02—Devices for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
    • A61B6/03—Computerised tomographs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/40—Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4076—Diagnosing or monitoring particular conditions of the nervous system
    • A61B5/4088—Diagnosing of monitoring cognitive diseases, e.g. Alzheimer, prion diseases or dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4866—Evaluating metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A61B6/02—Devices for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
    • A61B6/03—Computerised tomographs
    • A61B6/037—Emission tomography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A61B6/50—Clinical applications
    • A61B6/501—Clinical applications involving diagnosis of head, e.g. neuroimaging, craniography
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V10/00—Arrangements for image or video recognition or understanding
    • G06V10/20—Image preprocessing
    • G06V10/26—Segmentation of patterns in the image field; Cutting or merging of image elements to establish the pattern region, e.g. clustering-based techniques; Detection of occlusion
    • G06V10/267—Segmentation of patterns in the image field; Cutting or merging of image elements to establish the pattern region, e.g. clustering-based techniques; Detection of occlusion by performing operations on regions, e.g. growing, shrinking or watersheds
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V2201/00—Indexing scheme relating to image or video recognition or understanding
    • G06V2201/03—Recognition of patterns in medical or anatomical images

Claims (8)

DK 180231 B1 34 PATENTKRAV
1. Fremgangsmåde til fastlæggelse af en hjernestatusindikationsparameter, der indikerer en hjernelidelse, hvilken fremgangsmåde omfatter følgende trin: - bestemmelse af en hjerneenergimetabolismeindikator for i det mindste en del af en patients hjerne, - bestemmelse af en kranieenergimetabolismeindikator for i det mindste en del af — nævnte patients kranium, - fastlæggelse af hjernestatusindikationsparameteren ved i det mindste at relatere nævnte hjerneenergimetabolismeindikator til nævnte kranieenergimetabolisme- indikator.
2. Fremgangsmåde ifølge krav 1, hvor nævnte relatering indebærer beregning af et forhold mellem hjerneenergimetabolismeindikatoren og kranieenergimetabolisme- indikatoren eller vice versa.
3. Fremgangsmåde ifølge et hvilket som helst af kravene 1-2, hvor nævnte del af hjernen omfatter i det mindste venstre halvdel af cerebellum, højre halvdel af cerebellum, venstre halvdel af cerebrum, højre halvdel af cerebrum eller en hvilken som helst kombination deraf.
4. Fremgangsmåde ifølge et hvilket som helst af kravene 1-3, hvilken fremgangsmåde omfatter fastlæggelse af en grad af symmetri mellem i det mindste en del af højre hjernehalvdel og en tilsvarende del af venstre hjernehalvdel, hvor graden af symmetri omfatter et forhold mellem i det mindste en del af højre hjernehalvdel og en tilsvarende del af venstre hjernehalvdel, et forhold mellem højre — halvdel af cerebrum og venstre halvdel af cerebrum, et forhold mellem højre halvdel
DK 180231 B1 35 af cerebellum og venstre halvdel af cerebellum eller en hvilken som helst kombination deraf.
5. Fremgangsmåde ifølge et hvilket som helst af kravene 1-4, hvor nævnte hjerne- — energimetabolismeindikator bestemmes ud fra en hjerneenergimetabolismeindikator- fordeling, og hvor nævnte kranieenergimetabolismeindikator bestemmes ud fra en kranieenergimetabolismeindikatorfordeling.
6. Fremgangsmåde ifølge et hvilket som helst af kravene 1-5, hvor energimetabolisme- indikatoren bestemmes ved hjælp af en neurobilleddannelsesteknik, såsom en teknik baseret på funktionel magnetisk resonansbilleddannelse (fMRI), en teknik baseret pa computertomografi (CT)-scanning, en teknik baseret på positronemissions- tomografi (PET), en teknik baseret på magnetencefalografi (MEG) eller elektro- encefalografi (EEG), en teknik baseret på enkeltfotonemissionscomputer- — tomografi (SPECT) eller en ultralydsbaseret teknik.
7. Fremgangsmåde ifølge et hvilket som helst af kravene 1-6, hvor hjernestatus- indikationsparameteren omfatter en ekspression af hjernefunktion.
8. Hjernestatusfastleggelsessystem (BSS) til fastlæggelse af en hjernestatus- indikationsparameter (BSI), der indikerer en hjernelidelse, hvilket system (BSS) omfatter: - en hjernescanningsindretning (BSD), der er konfigureret til at - bestemmelse af en hjerneenergimetabolismeindikator (BEM) for i det mindste en del af en patients (SUB) hjerne (BR), - bestemmelse af en kranietenergimetabolismeindikator (SEM) for i det mindste en del af nævnte patients (SUB) kranium (SK),
DK 180231 B1 36 - en computerindretning (CD), der er konfigureret til at fastlægge hjernestatus- indikationsparameteren (BSI) ved i det mindste at relatere nævnte hjerneenergi- metabolismeindikator (BEM) til nævnte kranieenergimetabolismeindikator (SEM).
DKPA201870707A 2018-10-31 2018-10-31 Method of establishing a brain status indication parameter and system therefor DK180231B1 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
DKPA201870707A DK180231B1 (en) 2018-10-31 2018-10-31 Method of establishing a brain status indication parameter and system therefor
CA3118046A CA3118046A1 (en) 2018-10-31 2019-10-30 Method of establishing a brain status indication parameter and system therefor
US17/289,610 US11969240B2 (en) 2018-10-31 2019-10-30 Method of establishing a brain status indication parameter and system therefor
PCT/DK2019/050327 WO2020088730A1 (en) 2018-10-31 2019-10-30 Method of establishing a brain status indication parameter and system therefor
JP2021547641A JP7430730B2 (ja) 2018-10-31 2019-10-30 脳状態指示パラメータを確立する方法および脳状態指示パラメータを確立するためのシステム
EP19797560.0A EP3873339B1 (en) 2018-10-31 2019-10-30 Method of establishing a brain status indication parameter and system therefor
CN201980081179.9A CN113226168A (zh) 2018-10-31 2019-10-30 建立脑部状态指标的方法及其系统

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA201870707A DK180231B1 (en) 2018-10-31 2018-10-31 Method of establishing a brain status indication parameter and system therefor

Publications (2)

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DK201870707A1 DK201870707A1 (da) 2020-06-08
DK180231B1 true DK180231B1 (en) 2020-08-28

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US (1) US11969240B2 (da)
EP (1) EP3873339B1 (da)
JP (1) JP7430730B2 (da)
CN (1) CN113226168A (da)
CA (1) CA3118046A1 (da)
DK (1) DK180231B1 (da)
WO (1) WO2020088730A1 (da)

Family Cites Families (13)

* Cited by examiner, † Cited by third party
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US20040049134A1 (en) * 2002-07-02 2004-03-11 Tosaya Carol A. System and methods for treatment of alzheimer's and other deposition-related disorders of the brain
US20050215889A1 (en) 2004-03-29 2005-09-29 The Board of Supervisory of Louisiana State University Methods for using pet measured metabolism to determine cognitive impairment
US7738683B2 (en) 2005-07-22 2010-06-15 Carestream Health, Inc. Abnormality detection in medical images
US8379957B2 (en) * 2006-01-12 2013-02-19 Siemens Corporation System and method for segmentation of anatomical structures in MRI volumes using graph cuts
CA2675228A1 (en) * 2007-01-30 2008-07-07 Ge Healthcare Limited Tools for aiding in the diagnosis of neurodegenerative diseases
US8488857B2 (en) 2007-03-06 2013-07-16 Koninklijke Philips Electronics N.V. Automated diagnosis and alignment supplemented with positron emission tomography (PET) and magnetic resonance (MR) flow estimation
JP5243865B2 (ja) 2008-07-07 2013-07-24 浜松ホトニクス株式会社 脳疾患診断システム
US8588486B2 (en) 2009-06-18 2013-11-19 General Electric Company Apparatus and method for isolating a region in an image
US9668710B2 (en) * 2011-03-18 2017-06-06 Koninklijke Philips N.V. Tracking brain deformation during neurosurgery
US11020006B2 (en) * 2012-10-18 2021-06-01 California Institute Of Technology Transcranial photoacoustic/thermoacoustic tomography brain imaging informed by adjunct image data
CN104548390B (zh) * 2014-12-26 2018-03-23 中国科学院深圳先进技术研究院 一种获得用于发射穿颅聚焦超声的超声发射序列的方法及系统
WO2017106645A1 (en) * 2015-12-18 2017-06-22 The Regents Of The University Of California Interpretation and quantification of emergency features on head computed tomography
US11518754B2 (en) 2017-02-17 2022-12-06 Yale University Radiolabeled pharmaceuticals and methods of making and using same

Also Published As

Publication number Publication date
EP3873339A1 (en) 2021-09-08
US11969240B2 (en) 2024-04-30
WO2020088730A1 (en) 2020-05-07
EP3873339B1 (en) 2024-05-15
CN113226168A (zh) 2021-08-06
US20210393224A1 (en) 2021-12-23
CA3118046A1 (en) 2020-05-07
DK201870707A1 (da) 2020-06-08
JP2022509347A (ja) 2022-01-20
JP7430730B2 (ja) 2024-02-13

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Effective date: 20200828