DK178782A - N-SUBSTITUTED 2,4-DIALCOXYBENZENESULPHONAMIDES - Google Patents
N-SUBSTITUTED 2,4-DIALCOXYBENZENESULPHONAMIDES Download PDFInfo
- Publication number
- DK178782A DK178782A DK178782A DK178782A DK178782A DK 178782 A DK178782 A DK 178782A DK 178782 A DK178782 A DK 178782A DK 178782 A DK178782 A DK 178782A DK 178782 A DK178782 A DK 178782A
- Authority
- DK
- Denmark
- Prior art keywords
- carbon atoms
- independently
- radical
- represent
- linear
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
Abstract
1. Claims for the Contracting States : BE, CH, DE, GB, IT, LI, LU, NL, SE Compounds corresponding to the general formula (I) : see diagramm : EP0064445,P19,F2 in which : n and m, independently from each other, have values from 0 to 4 ; R3 and R4 each represent, independently from each other, a lower alkyl radical having from 1 to 4 carbon atoms ; R1 and R2 represent, independently from each other, hydrogen atoms, linear or branched alkyl groups having from 1 to 4 carbon atoms, or forming conjointly with the nitrogen atom a nitrogenous heterocyclic group with 5 or 6 links, particularly a pyrrolidino, morpholino, piperazinyl, pyrrole or piperidino group, substituted or not by linear or branched alkyl radicals having from 1 to 4 carbon atoms ; R5 represents a hydrogen atom, a halogen, the group NO2 , NH2 or CF3 , an alkoxy radical having from 1 to 4 carbon atoms, or an alkyl sulfonyl radical having from 1 to 4 carbon atoms, and R6 and R7 represent, independently from each other, a hydrogen atom, an alkyl radical with 1 to 6 carbon atoms or a cycloalkyl radical with 3 to 6 carbon atoms, as well as their salts obtained with physiologically acceptable organic or inorganic acids. 1. Claims for the Contracting State : AT Process for preparing the hydrochlorides of the compounds of general formula (I) : see diagramm : EP0064445,P21,F3 in which : n and m, independently from each other, have the values from 0 to 4 ; R3 and R4 each represents, independently from each other, an alkyl radical having from 1 to 4 carbon atoms ; R1 and R2 represent, independently from each other, hydrogen atoms, linear or branched alkyl groups having from 1 to 4 carbon atoms, or forming conjointly with the nitrogen atom a nirogenous heterocyclic group with 5 or 6 links, particularly a pyrrolidino, morpholino, piperazinyl, pyrrole or piperidino group, substituted or not by linear or branched alkyl radicals having from 1 to 4 carbon atoms ; R5 represents a hydrogen atom, a halogen, the NO2 , NH2 or CF3 group, an alkoxy radical having from 1 to 4 carbon atoms or an alkylsulfonyl radical having from 1 to 4 carbon atoms, and R6 and R7 represent, independently from each other, a hydrogen atom, an alkyl radical having from 1 to 6 carbon atoms or a cycloalkyl radical having from 3 to 6 carbon atoms, as well as their salts obtained with physiologically acceptable organic or inorganic acids, comprising reacting an amine of formula (XI) : see diagramm : EP0064445,P21,F1 in which : n and m, independently from each other, have values from 1 to 4 ; R1 and R2 represent, independently form each other, hydrogen atoms, linear or branched alkyl groups having from 1 to 4 carbon atoms, or forming conjointly with the nitrogen atom a nitrogenous heterocyclic group with 5 or 6 links, particularly a pyrrolidino, morpholino, piperazinyl, pyrrole or piperidino group, substituted or not by linear or branched alkyl radicals having from 1 to 4 carbon atoms, and R6 and R7 represent, independently from each other, a hydrogen atom, an alkyl radical having from 1 to 6 carbon atoms or a cycloalkyl radical having from 3 to 6 carbon atoms, with a sulfochloride of formula (V) : see diagramm : EP0064445,P21,F2 in which : R3 and R4 each represents, independently from each other, a lower alkyl radical having from 1 to 4 carbon atoms, and A has the same meaning as R5 , with the exception of NH2 , followed, if necessary, by a reduction when A represents the NO2 group.
Description
især er et hydrogenatom, et alkylradikal med 1-6 kulstofatomer.especially is a hydrogen atom, an alkyl radical of 1-6 carbon atoms.
Forbindelserne anvendes til fremstilling af beroligende og anxiolytiske lægemidler.The compounds are used for the preparation of sedative and anxiolytic drugs.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8108125A FR2504528A1 (en) | 1981-04-23 | 1981-04-23 | DIALCOXY (2,4) N-SUBSTITUTED BENZENESULFONAMIDES |
FR8108125 | 1981-04-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK178782A true DK178782A (en) | 1982-10-24 |
Family
ID=9257710
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK178782A DK178782A (en) | 1981-04-23 | 1982-04-22 | N-SUBSTITUTED 2,4-DIALCOXYBENZENESULPHONAMIDES |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0064445B1 (en) |
JP (1) | JPS57181053A (en) |
AT (1) | ATE9996T1 (en) |
CA (1) | CA1196919A (en) |
DE (1) | DE3261038D1 (en) |
DK (1) | DK178782A (en) |
ES (1) | ES511609A0 (en) |
FR (1) | FR2504528A1 (en) |
IE (1) | IE52855B1 (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3363289D1 (en) * | 1982-09-28 | 1986-06-05 | Beecham Wuelfing Gmbh & Co Kg | SULFON AMIDES |
JPS5976051A (en) * | 1982-10-21 | 1984-04-28 | Tanabe Seiyaku Co Ltd | Naphthalene derivative, its preparation and method for determining optical purity using said derivative |
FR2553409B1 (en) * | 1983-10-18 | 1986-04-18 | Choay Sa | NOVEL BENZENESULFONYL-LACTAMES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ACTIVE SUBSTANCE OF PHARMACEUTICAL COMPOSITIONS |
FR2598412B1 (en) * | 1986-03-12 | 1988-10-21 | Sanofi Sa | NOVEL DIARYLCETON DERIVATIVES AND PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
KR100262419B1 (en) * | 1993-06-23 | 2000-09-01 | 나가야마 오사무 | Benzene derivative useful for ischemic diseases |
EP0883613A1 (en) * | 1996-02-09 | 1998-12-16 | Smithkline Beecham Plc | Sulfonamide derivatives as 5ht7 receptor antagonists |
WO1997049695A1 (en) * | 1996-06-25 | 1997-12-31 | Smithkline Beecham P.L.C. | Sulfonamide derivatives as 5ht7 receptor antagonists |
ES2161594B1 (en) * | 1998-12-17 | 2003-04-01 | Servier Lab | NEW DERIVATIVES OF HYDRAZIDE, ITS PREPARATION PROCEDURE AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
SK542007A3 (en) * | 2007-04-20 | 2008-11-06 | Unimed Pharma, Spol. S R. O. | Substituted sulfonamides, process for preparing them, medicament containing them and their use |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB667772A (en) * | 1947-11-28 | 1952-03-05 | Gen Aniline & Film Corp | Monosulfonamide derivatives of resorcinol |
DE2128011A1 (en) * | 1971-06-05 | 1972-12-14 | Cassella Farbwerke Mainkur AG, 6000 Frankfurt-Fechenheim | New sulfonyl compounds and processes for their production |
FR2313918A1 (en) * | 1975-06-09 | 1977-01-07 | Choay Sa | 2-METHOXY BENZENESULFONAMIDES N-SUBSTITUTE, PROCESS FOR THE PREPARATION AND MEDICINAL PRODUCTS CONTAINING THEM |
-
1981
- 1981-04-23 FR FR8108125A patent/FR2504528A1/en active Granted
-
1982
- 1982-04-20 IE IE925/82A patent/IE52855B1/en unknown
- 1982-04-21 AT AT82400717T patent/ATE9996T1/en active
- 1982-04-21 CA CA000401378A patent/CA1196919A/en not_active Expired
- 1982-04-21 EP EP82400717A patent/EP0064445B1/en not_active Expired
- 1982-04-21 DE DE8282400717T patent/DE3261038D1/en not_active Expired
- 1982-04-22 ES ES511609A patent/ES511609A0/en active Granted
- 1982-04-22 DK DK178782A patent/DK178782A/en not_active Application Discontinuation
- 1982-04-23 JP JP57068566A patent/JPS57181053A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
EP0064445A1 (en) | 1982-11-10 |
IE52855B1 (en) | 1988-03-30 |
FR2504528B1 (en) | 1984-05-11 |
FR2504528A1 (en) | 1982-10-29 |
ES8306107A1 (en) | 1983-06-01 |
CA1196919A (en) | 1985-11-19 |
JPH0153669B2 (en) | 1989-11-15 |
DE3261038D1 (en) | 1984-11-29 |
JPS57181053A (en) | 1982-11-08 |
ATE9996T1 (en) | 1984-11-15 |
EP0064445B1 (en) | 1984-10-24 |
IE820925L (en) | 1982-10-23 |
ES511609A0 (en) | 1983-06-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
AHB | Application shelved due to non-payment |