DK178382A - Fremgangsmaade til fremstilling af pyrazolopyridinderivater - Google Patents

Fremgangsmaade til fremstilling af pyrazolopyridinderivater Download PDF

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Publication number
DK178382A
DK178382A DK178382A DK178382A DK178382A DK 178382 A DK178382 A DK 178382A DK 178382 A DK178382 A DK 178382A DK 178382 A DK178382 A DK 178382A DK 178382 A DK178382 A DK 178382A
Authority
DK
Denmark
Prior art keywords
preparing
procedure
pyrazolopyridine derivatives
pyrazolopyridine
derivatives
Prior art date
Application number
DK178382A
Other languages
English (en)
Inventor
G Y Lesher
M D Gruett
Original Assignee
Sterling Drug Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc
Publication of DK178382A publication Critical patent/DK178382A/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)

Description

1) en lavere-alkansyre og et reducerende middel til fremstilling af I, hvori NB er NHR^ eller NR^R2, 2) med en blanding af myresyre og formaldehyd til fremstilling af I, hvor NB er N(CH3)2 eller 3) med et acylerende middel til fremstilling af I, hvori NB er NHAc, hvorefter 3-(NHAc)-forbindelsen eventuelt omsættes med et reducerende middel til fremstilling af den tilsvarende 3-NH-R^-forbindelse.
Forbindelserne er lægemidler med cardiotonisk virkning.
DK178382A 1981-04-28 1982-04-22 Fremgangsmaade til fremstilling af pyrazolopyridinderivater DK178382A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/258,363 US4361568A (en) 1981-04-28 1981-04-28 5-(Pyridinyl)-1H-pyrazolo[3,4-b]pyridin-3-amines and their cardiotonic use
US25836381 1981-04-28

Publications (1)

Publication Number Publication Date
DK178382A true DK178382A (da) 1982-10-29

Family

ID=22980254

Family Applications (1)

Application Number Title Priority Date Filing Date
DK178382A DK178382A (da) 1981-04-28 1982-04-22 Fremgangsmaade til fremstilling af pyrazolopyridinderivater

Country Status (13)

Country Link
US (1) US4361568A (da)
EP (1) EP0063754A1 (da)
JP (1) JPS57181088A (da)
KR (1) KR830010111A (da)
AU (1) AU8283782A (da)
CA (1) CA1175429A (da)
DK (1) DK178382A (da)
FI (1) FI821332L (da)
GR (1) GR76131B (da)
IL (1) IL65555A (da)
NO (1) NO821314L (da)
PT (1) PT74783B (da)
ZA (1) ZA822458B (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4666913A (en) * 1985-11-22 1987-05-19 William H. Rorer, Inc. Hydroxy and aminothiazolyl-benzodiazinone compounds, cardiotonic compositions including the same, and their uses
JP2004509891A (ja) 2000-09-22 2004-04-02 スミスクライン　ビーチャム　パブリック　リミテッド　カンパニー 抗糖尿病薬としてのピラゾロピリジンおよびピラゾロピリダジン
TWI325865B (en) 2003-02-27 2010-06-11 Palau Pharma Sa Pyrazolopyridine derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2232038A1 (de) * 1972-06-30 1974-01-10 Hoechst Ag 3-amino-1h-pyrazolo eckige klammer auf 3,4-b eckige klammer zu pyridine, ihre herstellung und verwendung
US4264603A (en) * 1980-03-17 1981-04-28 Sterling Drug Inc. 5-(Pyridinyl)-1H-pyrazolo[3,4-b]pyridine-3-amines, their use as cardiotonics and their preparation
US4265895A (en) * 1980-03-17 1981-05-05 Sterling Drug Inc. 1,2-Dihydro-5-pyridinyl-3H-pyrazolo[3,4-b]pyridin-3-ones and their use as cardiotonics

Also Published As

Publication number Publication date
IL65555A0 (en) 1982-07-30
US4361568A (en) 1982-11-30
PT74783A (en) 1982-05-01
NO821314L (no) 1982-10-29
ZA822458B (en) 1983-03-30
EP0063754A1 (en) 1982-11-03
CA1175429A (en) 1984-10-02
JPS57181088A (en) 1982-11-08
FI821332L (fi) 1982-10-29
FI821332A0 (fi) 1982-04-16
PT74783B (en) 1983-11-07
AU8283782A (en) 1982-11-04
GR76131B (da) 1984-08-03
IL65555A (en) 1985-02-28
KR830010111A (ko) 1983-12-26

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Legal Events

Date Code Title Description
AHB Application shelved due to non-payment