DK1761524T3 - Oxygenholdige annelerede phenylpiperazin- og phenyldiazepancarboxamider som dopamin-D3-antagonister - Google Patents
Oxygenholdige annelerede phenylpiperazin- og phenyldiazepancarboxamider som dopamin-D3-antagonisterInfo
- Publication number
- DK1761524T3 DK1761524T3 DK05823871T DK05823871T DK1761524T3 DK 1761524 T3 DK1761524 T3 DK 1761524T3 DK 05823871 T DK05823871 T DK 05823871T DK 05823871 T DK05823871 T DK 05823871T DK 1761524 T3 DK1761524 T3 DK 1761524T3
- Authority
- DK
- Denmark
- Prior art keywords
- phenyldiazepanecarboxamides
- phenylpiperazine
- dopamine
- antagonists
- oxygen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Otolaryngology (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Polyesters Or Polycarbonates (AREA)
- External Artificial Organs (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004063797A DE102004063797A1 (de) | 2004-12-30 | 2004-12-30 | Sauerstoffhaltige annelierte Phenylpiperazin- und Phenyldiazepancarboxamide |
| PCT/EP2005/014047 WO2006072430A1 (de) | 2004-12-30 | 2005-12-27 | Sauerstoffhaltige annelierte phenylpiperazin- und phenyldiazepancarboxamide als dopamin d3 antagonisten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1761524T3 true DK1761524T3 (da) | 2008-04-07 |
Family
ID=36102609
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK05823871T DK1761524T3 (da) | 2004-12-30 | 2005-12-27 | Oxygenholdige annelerede phenylpiperazin- og phenyldiazepancarboxamider som dopamin-D3-antagonister |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US20080194539A1 (da) |
| EP (1) | EP1761524B1 (da) |
| JP (1) | JP2008526700A (da) |
| KR (1) | KR20070102673A (da) |
| CN (1) | CN101027294A (da) |
| AU (1) | AU2005324107A1 (da) |
| BR (1) | BRPI0519485A2 (da) |
| CA (1) | CA2576332A1 (da) |
| DE (2) | DE102004063797A1 (da) |
| DK (1) | DK1761524T3 (da) |
| EA (1) | EA200701366A1 (da) |
| ES (1) | ES2297767T3 (da) |
| HK (1) | HK1100845A1 (da) |
| HR (1) | HRP20080075T3 (da) |
| IL (1) | IL180763A0 (da) |
| MX (1) | MX2007006369A (da) |
| NO (1) | NO20072587L (da) |
| PL (1) | PL1761524T3 (da) |
| PT (1) | PT1761524E (da) |
| SI (1) | SI1761524T1 (da) |
| WO (1) | WO2006072430A1 (da) |
| ZA (1) | ZA200701972B (da) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010040274A1 (zh) * | 2008-10-10 | 2010-04-15 | 中国人民解放军军事医学科学院毒物药物研究所 | 新型多巴胺d3受体配体，其制备方法及其医药用途 |
| US9227944B2 (en) | 2008-10-10 | 2016-01-05 | Institute Of Pharmacology And Toxicology Academy Of Military Science P.L.A. China | Dopamine D3 receptor ligands and preparation and medical uses of the same |
| WO2010104194A1 (en) * | 2009-03-10 | 2010-09-16 | Takeda Pharmaceutical Company Limited | Benzofuran derivatives |
| CN103282369A (zh) * | 2011-04-08 | 2013-09-04 | 劳乐斯实验室私营有限公司 | 抗逆转录病毒化合物与抗氧化酸的固体形式、其制备方法以及其药物组合物 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1340113C (en) * | 1988-05-24 | 1998-11-03 | Magid A. Abou-Gharbia | Aryl-and heteroaryl piperazinyl carboxamides having central nervous system activity |
| IL92544A0 (en) * | 1988-12-08 | 1990-08-31 | Duphar Int Res | Piperazine derivatives,their preparation and pharmaceutical compositions containing them |
| DE4127849A1 (de) * | 1991-08-22 | 1993-02-25 | Merck Patent Gmbh | Benzodioxanderivate |
| DE4333254A1 (de) * | 1993-09-30 | 1995-04-06 | Merck Patent Gmbh | Piperidine und Piperazine |
| DE69819173T2 (de) * | 1997-07-25 | 2004-04-15 | H. Lundbeck A/S | Indole und 2,3-dihydroindolderivate, ihre herstellung und verwendung |
| FR2781671A1 (fr) * | 1998-07-28 | 2000-02-04 | Synthelabo | Compositions pharmaceutiques contenant un inhibiteur de la recapture de la serotonine et leur application en therapeutique |
| AR022303A1 (es) * | 1999-01-22 | 2002-09-04 | Lundbeck & Co As H | Derivados de piperidina, tetrahidropiridina y piperazina, su preparacion y utilizacion |
| GB9905010D0 (en) * | 1999-03-04 | 1999-04-28 | Merck Sharp & Dohme | Therapeutic agents |
| ES2188344B1 (es) * | 2000-11-29 | 2004-09-16 | Laboratorios Vita, S.A. | Compuestos derivados de benzotiofeno, su procedimiento de obtencion y utilizacion de los mismos. |
| HUP0103987A3 (en) * | 2001-09-28 | 2004-11-29 | Richter Gedeon Vegyeszet | Phenylpiperazinylalkyl carboxylic acid amid derivatives, process for their preparation, pharmaceutical compositions containing them and their intermediates |
| CN1665503A (zh) * | 2002-07-04 | 2005-09-07 | 施瓦茨制药有限公司 | 杂芳烃甲酰胺作为多巴胺－d3配体用于治疗中枢神经系统疾病的用途 |
| WO2004024878A2 (en) * | 2002-09-14 | 2004-03-25 | Gov't Of The U.S.A. As Represented By The Secretary Of The Department Of Health And Human Services | Structurally rigid dopamine d3 receptor selective ligands and process for making them |
| DE10259244A1 (de) * | 2002-12-17 | 2004-07-01 | Merck Patent Gmbh | N-(Indolethyl-)cycloamin-Verbindungen |
| WO2004082686A2 (en) * | 2003-03-13 | 2004-09-30 | Dynogen Pharmaceuticals, Inc. | Use of compounds with combined 5-ht1a and ssri activities to treat sexual dysfunction |
-
2004
- 2004-12-30 DE DE102004063797A patent/DE102004063797A1/de not_active Ceased
-
2005
- 2005-12-27 PT PT05823871T patent/PT1761524E/pt unknown
- 2005-12-27 MX MX2007006369A patent/MX2007006369A/es not_active Application Discontinuation
- 2005-12-27 JP JP2007548748A patent/JP2008526700A/ja active Pending
- 2005-12-27 EP EP05823871A patent/EP1761524B1/de active Active
- 2005-12-27 PL PL05823871T patent/PL1761524T3/pl unknown
- 2005-12-27 BR BRPI0519485-7A patent/BRPI0519485A2/pt not_active Application Discontinuation
- 2005-12-27 CA CA002576332A patent/CA2576332A1/en not_active Abandoned
- 2005-12-27 DK DK05823871T patent/DK1761524T3/da active
- 2005-12-27 CN CNA2005800324230A patent/CN101027294A/zh active Pending
- 2005-12-27 US US11/794,386 patent/US20080194539A1/en not_active Abandoned
- 2005-12-27 ES ES05823871T patent/ES2297767T3/es active Active
- 2005-12-27 EA EA200701366A patent/EA200701366A1/ru unknown
- 2005-12-27 KR KR1020077014615A patent/KR20070102673A/ko not_active Application Discontinuation
- 2005-12-27 AU AU2005324107A patent/AU2005324107A1/en not_active Abandoned
- 2005-12-27 DE DE502005002058T patent/DE502005002058D1/de not_active Expired - Fee Related
- 2005-12-27 SI SI200530145T patent/SI1761524T1/sl unknown
- 2005-12-27 WO PCT/EP2005/014047 patent/WO2006072430A1/de active IP Right Grant
-
2007
- 2007-01-17 IL IL180763A patent/IL180763A0/en unknown
- 2007-01-18 ZA ZA200701972A patent/ZA200701972B/en unknown
- 2007-05-21 NO NO20072587A patent/NO20072587L/no not_active Application Discontinuation
- 2007-06-05 HK HK07105930A patent/HK1100845A1/xx not_active IP Right Cessation
-
2008
- 2008-02-19 HR HR20080075T patent/HRP20080075T3/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006072430A1 (de) | 2006-07-13 |
| HK1100845A1 (en) | 2007-09-28 |
| MX2007006369A (es) | 2007-07-11 |
| BRPI0519485A2 (pt) | 2009-02-03 |
| PT1761524E (pt) | 2008-02-21 |
| PL1761524T3 (pl) | 2008-04-30 |
| AU2005324107A1 (en) | 2006-07-13 |
| CA2576332A1 (en) | 2006-07-13 |
| HRP20080075T3 (en) | 2008-03-31 |
| US20080194539A1 (en) | 2008-08-14 |
| SI1761524T1 (sl) | 2008-04-30 |
| ES2297767T3 (es) | 2008-05-01 |
| DE102004063797A1 (de) | 2006-07-13 |
| KR20070102673A (ko) | 2007-10-19 |
| ZA200701972B (en) | 2008-04-30 |
| AU2005324107A2 (en) | 2006-07-13 |
| EP1761524B1 (de) | 2007-11-21 |
| EA200701366A1 (ru) | 2008-02-28 |
| IL180763A0 (en) | 2007-06-03 |
| NO20072587L (no) | 2007-05-21 |
| EP1761524A1 (de) | 2007-03-14 |
| DE502005002058D1 (de) | 2008-01-03 |
| JP2008526700A (ja) | 2008-07-24 |
| CN101027294A (zh) | 2007-08-29 |
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