DK173134B1 - Isolated nucleic acid encoding a polypeptide of the CEA gene family replicable recombinant cloning vehicle with - Google Patents

Isolated nucleic acid encoding a polypeptide of the CEA gene family replicable recombinant cloning vehicle with Download PDF

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Publication number
DK173134B1
DK173134B1 DK198704204A DK420487A DK173134B1 DK 173134 B1 DK173134 B1 DK 173134B1 DK 198704204 A DK198704204 A DK 198704204A DK 420487 A DK420487 A DK 420487A DK 173134 B1 DK173134 B1 DK 173134B1
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DK
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Prior art keywords
nucleic acid
polypeptide
cea
acid encoding
isolated nucleic
Prior art date
Application number
DK198704204A
Other languages
Danish (da)
Other versions
DK420487D0 (en
DK420487A (en
Inventor
Thomas R Barnett
James J Elting
Michael E Kamarck
Original Assignee
Bayer Ag
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Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of DK420487D0 publication Critical patent/DK420487D0/en
Publication of DK420487A publication Critical patent/DK420487A/en
Application granted granted Critical
Publication of DK173134B1 publication Critical patent/DK173134B1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3007—Carcino-embryonic Antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)

Abstract

A nucleic acid comprising a base sequence which codes for a CEA peptide sequence or nucleic acids having a base sequence hybridizable therewith, replicable recombinant cloning vehicles having an insert comprising such nucleic acid, cells transfected, infected or injected with such cloning vehicles, polypeptides expressed by such cells, antibody preparations specific for such polypeptides, immunoassays for detecting CEA using such antibody preparations and nucleic acid hybridization methods for detecting a CEA nucleic acid sequence using a nucleic acid probe comprising the above described nucleic acid.
DK198704204A 1986-08-13 1987-08-12 Isolated nucleic acid encoding a polypeptide of the CEA gene family replicable recombinant cloning vehicle with DK173134B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US89636186A 1986-08-13 1986-08-13
US1668387A 1987-02-19 1987-02-19
US6003187A 1987-06-19 1987-06-19

Publications (3)

Publication Number Publication Date
DK420487D0 DK420487D0 (en) 1987-08-12
DK420487A DK420487A (en) 1988-02-14
DK173134B1 true DK173134B1 (en) 2000-01-31

Family

ID=27360631

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198704204A DK173134B1 (en) 1986-08-13 1987-08-12 Isolated nucleic acid encoding a polypeptide of the CEA gene family replicable recombinant cloning vehicle with

Country Status (12)

Country Link
EP (1) EP0263933B1 (en)
JP (2) JP3253609B2 (en)
AT (1) ATE96168T1 (en)
AU (1) AU598573B2 (en)
DE (1) DE3787864T2 (en)
DK (1) DK173134B1 (en)
ES (1) ES2059330T3 (en)
FI (1) FI873478A (en)
IE (1) IE60279B1 (en)
IL (1) IL83484A (en)
NZ (1) NZ221385A (en)
ZA (1) ZA875951B (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5122599A (en) * 1986-08-13 1992-06-16 Molecular Diagnostics, Inc. CDNAS coding for members of the carcinoembryonic antigen family
JP2607492B2 (en) * 1987-01-14 1997-05-07 サントリー株式会社 Human carcinoembryonic antigen
US4908417A (en) * 1988-05-17 1990-03-13 Sumitomo Chemical Company, Limited Thermosetting resin composition
JPH02107189A (en) * 1988-05-25 1990-04-19 City Of Hope Cancer embryo antigen fregment
EP0346702A3 (en) * 1988-06-16 1991-08-28 Miles Inc. Transfectant cell lines which express isolated genes of the carcinoembryonic antigen family
US5200316A (en) * 1990-02-15 1993-04-06 Miles Inc. Immunoassay methods using noncross reactive cea gene family members antibodies
ATE248924T1 (en) * 1991-05-06 2003-09-15 Us Gov Health & Human Serv CARCINOEMBRYONAL ANTIGEN-EXPRESSING RECOMBINANT VIRUSES AND METHODS OF THEIR APPLICATION
CA2116640A1 (en) * 1993-03-25 1994-09-26 Alexey Terskikh Carcinoembryonic antigen derivatives
US6001349A (en) * 1995-02-22 1999-12-14 Therion Biologics Corporation Generation of human cytotoxic T-cells specific for carcinoma self-associated antigens and uses thereof
CN100523216C (en) * 2001-03-02 2009-08-05 匹兹堡大学 PCR method
US8119352B2 (en) 2006-06-20 2012-02-21 Cepheld Multi-stage amplification reactions by control of sequence replication times
WO2009114207A2 (en) 2008-03-14 2009-09-17 Sanofi Pasteur Biologics Co. Replication-defective flavivirus vaccines and vaccine vectors
CN105175542B (en) 2010-12-16 2018-12-18 弗·哈夫曼-拉罗切有限公司 Diagnosing and treating relevant to TH2 inhibition
WO2014140938A2 (en) 2013-03-14 2014-09-18 Centre Hospitalier Universitaire Vaudois Immunological methods

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4180499A (en) * 1971-01-27 1979-12-25 Hoffmann-La Roche Inc. Carcinoembryonic antigens
US4228236A (en) * 1978-05-15 1980-10-14 Northwestern University Process of producing carcinoembryonic antigen
JP2507982B2 (en) * 1984-04-10 1996-06-19 武田薬品工業株式会社 Method for producing human carcinoembryonic antigen-reactive monoclonal antibody

Also Published As

Publication number Publication date
IE60279B1 (en) 1994-06-29
FI873478A0 (en) 1987-08-11
DK420487D0 (en) 1987-08-12
NZ221385A (en) 1991-06-25
DE3787864D1 (en) 1993-11-25
ZA875951B (en) 1988-02-19
EP0263933A1 (en) 1988-04-20
JP3253609B2 (en) 2002-02-04
ATE96168T1 (en) 1993-11-15
AU7686887A (en) 1988-03-24
JPH09136900A (en) 1997-05-27
IL83484A0 (en) 1988-01-31
IL83484A (en) 1993-01-31
EP0263933B1 (en) 1993-10-20
ES2059330T3 (en) 1994-11-16
DK420487A (en) 1988-02-14
AU598573B2 (en) 1990-06-28
DE3787864T2 (en) 1994-02-10
FI873478A (en) 1988-02-14
IE872161L (en) 1988-02-13
JPS63119681A (en) 1988-05-24

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PUP Patent expired