DK1719520T3 - Antigenepitoper af reguleringsprotein af virulensfaktor i staphylococcus aureus og mimotoper deraf og anvendelse - Google Patents

Antigenepitoper af reguleringsprotein af virulensfaktor i staphylococcus aureus og mimotoper deraf og anvendelse Download PDF

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Publication number
DK1719520T3
DK1719520T3 DK03756419.2T DK03756419T DK1719520T3 DK 1719520 T3 DK1719520 T3 DK 1719520T3 DK 03756419 T DK03756419 T DK 03756419T DK 1719520 T3 DK1719520 T3 DK 1719520T3
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Prior art keywords
residue
amino acid
trap
staphylococcus aureus
replacement
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DK03756419.2T
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English (en)
Inventor
Ningsheng Shao
Guang Yang
Chuan Liu
Yaping Gao
Jie Dong
Hongmei Ding
Beifen Shen
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Applied Nanosystems Bv
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Claims (7)

1
1. Antigenepitop af TRAP (Target of RNA III activating protein), et reguleringsprotein af virulensfaktoren i staphylococcus aureus, der omfatter en aminosyresekvens som vist i SEQ ID NO: 1 i sekvenslisten.
2. Antigenepitop af TRAP (Target of RNA III activating protein), et reguleringsprotein af virulensfaktoren i staphylococcus aureus, der omfatter en aminosyresekvens som vist i SEQ ID NO: 2.
3. Mimotop af TRAP, kendetegnet ved, at den har en aminosyresekvens med følgende formel: XPXHHQHXTGFT, hvor X repræsenterer en hvilken som helst aminosyre udvalgt fra 21 kendte, naturligt forekommende L-type-aminosyrerester eller D-isomerer deraf.
4. Mimotop af TRAP, kendetegnet ved, at den har en aminosyresekvens med følgende formel: SWFDXXLYPXXX, hvor X repræsenterer en hvilken som helst aminosyre udvalgt fra 21 kendte, naturligt forekommende L-type-aminosyrerester eller D-isomerer deraf.
5. Mimotop af TRAP, kendetegnet ved, at den omfatter en aminosyresekvens, der er resultatet af udskiftningen af en aminosyre i sekvensen ifølge krav 1 eller 2 på baggrund af ligheden mellem aminosyrer, hvilken udskiftning omfatter én eller flere af: a) udskiftning af glutaminrest (Q), glutamatrest (E), aspartatrest (D) og asparaginrest (E) med hinanden; b) udskiftning af tryptophanrest (W), tyrosinrest (Y) og phenylalaninrest (F) med hinanden: c) udskiftning af lysinrest (K) og argininrest (R) med hinanden; d) udskiftning af serinrest (S) og threoninrest (T) med hinanden; e) udskiftning af alaninrest (A) og glycinrest (G) med hinanden; f) udskiftning af leucinrest (L) og methioninrest (M) med hinanden.
6. Mimotop af TRAP, kendetegnet ved, at den omfatter en aminosyresekvens, der er resultatet af udskiftningen af en aminosyre i sekvensen ifølge krav 3 eller 4 på baggrund af ligheden mellem aminosyre, hvilken udskiftning omfatter én eller flere af: 2 a) udskiftning af glutaminrest (Q), glutamatrest (E), aspartaterest (D) og asparaginrest (E) med hinanden; b) udskiftning af trvptophanrest (W), tyrosinrest (Y) og phenylalaninrest (F) med hinanden; c) udskiftning af lysinrest (K) og argininrest (R) med hinanden; d) udskiftning af serinrest (S) og threoninrest (T) med hinanden; e) udskiftning af alaninrest (A) og glycinrest (G) med hinanden; f) udskiftning af leucinrest (L) og methioninrest (M) med hinanden.
7. Anvendelse af et polypeptid omfattende en hvilken som helst af sekvenserne ifølge krav 1 til 6 i en hvilken som helst form til fremstilling af et medikament eller en vaccine mod staphylococcus ai/reus-infektioner.
DK03756419.2T 2003-07-21 2003-09-27 Antigenepitoper af reguleringsprotein af virulensfaktor i staphylococcus aureus og mimotoper deraf og anvendelse DK1719520T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CNA031502032A CN1569893A (zh) 2003-07-21 2003-07-21 金葡菌毒力因子调控蛋白的抗原表位及其模拟表位和用途
PCT/CN2003/000827 WO2005007683A1 (en) 2003-07-21 2003-09-27 Antigen epitopes of the regulatory protein of virulence factor in staphylococcus aureus and their mimotopes and use

Publications (1)

Publication Number Publication Date
DK1719520T3 true DK1719520T3 (da) 2015-05-11

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ID=34069991

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Application Number Title Priority Date Filing Date
DK03756419.2T DK1719520T3 (da) 2003-07-21 2003-09-27 Antigenepitoper af reguleringsprotein af virulensfaktor i staphylococcus aureus og mimotoper deraf og anvendelse

Country Status (6)

Country Link
EP (1) EP1719520B1 (da)
CN (1) CN1569893A (da)
AU (1) AU2003304343A1 (da)
DK (1) DK1719520T3 (da)
ES (1) ES2535777T3 (da)
WO (1) WO2005007683A1 (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100540047C (zh) * 2006-04-17 2009-09-16 中国人民解放军军事医学科学院基础医学研究所 Trap蛋白在制备治疗金黄色葡萄球菌感染的药品中的应用
CN101066463B (zh) * 2007-05-24 2010-09-15 上海大学 金黄色葡萄球菌DNA疫苗pcDNA3.1(+)-Minigene及其制备方法
WO2011113160A1 (en) 2010-03-17 2011-09-22 Socpra - Sciences Et Génie, S.E.C. Bacterial vaccine components from staphylococcus aureus and uses thereof
CN105254719B (zh) * 2015-10-21 2018-07-13 黑龙江八一农垦大学 金黄色葡萄球菌trap蛋白的cd4+t细胞表位鉴定及其重组表位疫苗
WO2018072031A1 (en) 2016-10-21 2018-04-26 Socpra Sciences Et Génies S.E.C. Vaccine constructs and uses thereof against staphylococcus infections
CN110156887B (zh) * 2018-02-12 2023-01-13 中国人民解放军军事科学院军事医学研究院 人vasn蛋白抗原表位、抗原模拟表位及其用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6747129B1 (en) * 1998-09-15 2004-06-08 The Regents Of The University Of California Target of RNAIII activating protein(TRAP)

Also Published As

Publication number Publication date
WO2005007683A8 (fr) 2006-06-15
AU2003304343A8 (en) 2005-02-04
EP1719520B1 (en) 2015-04-15
EP1719520A1 (en) 2006-11-08
CN1569893A (zh) 2005-01-26
ES2535777T3 (es) 2015-05-14
AU2003304343A1 (en) 2005-02-04
WO2005007683A1 (en) 2005-01-27
EP1719520A4 (en) 2009-06-24

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