DK1718200T3 - Apparat til måling af blodglucose under anvendelse af impedansmålinger af subdermalt kropsvæv - Google Patents

Apparat til måling af blodglucose under anvendelse af impedansmålinger af subdermalt kropsvæv Download PDF

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Publication number
DK1718200T3
DK1718200T3 DK05706464.4T DK05706464T DK1718200T3 DK 1718200 T3 DK1718200 T3 DK 1718200T3 DK 05706464 T DK05706464 T DK 05706464T DK 1718200 T3 DK1718200 T3 DK 1718200T3
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DK
Denmark
Prior art keywords
impedance
body tissue
electrodes
subdermal
measuring
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DK05706464.4T
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English (en)
Inventor
Stig Ollmar
Ulrik Birgersson
Fredrik Neiderud
Peter Aberg
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Dermal Devices Inc
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Publication of DK1718200T3 publication Critical patent/DK1718200T3/da

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/053—Measuring electrical impedance or conductance of a portion of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/053—Measuring electrical impedance or conductance of a portion of the body
    • A61B5/0538—Measuring electrical impedance or conductance of a portion of the body invasively, e.g. using a catheter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7271—Specific aspects of physiological measurement analysis
    • A61B5/7278—Artificial waveform generation or derivation, e.g. synthesising signals from measured signals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
    • A61M5/1723—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic using feedback of body parameters, e.g. blood-sugar, pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/318—Heart-related electrical modalities, e.g. electrocardiography [ECG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/20—Blood composition characteristics
    • A61M2230/201—Glucose concentration

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Pathology (AREA)
  • Medical Informatics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Optics & Photonics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Artificial Intelligence (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Physiology (AREA)
  • Psychiatry (AREA)
  • Signal Processing (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • External Artificial Organs (AREA)

Claims (11)

1
1. Apparat til måling eller overvågning af blodglucoseniveau hos et individ ved hjælp af måling af impedans i et subdermalt kropsvæv hos individet som følge af en elektrisk strøm, der strømmer gennem nævnte kropsvæv, og bestemmelse af et blodglucoseniveau hos nævnte individ baseret på den målte impedans, hvor nævnte apparat er et firpunktsudstyr, som er konfigureret til at udføre en firpunktsimpedansanalyse, hvilket apparat omfatter: - et par injektionselektroder, der er indrettet til injektion af elektrisk strøm ind i kropsvævet, hvor den elektriske strøm ledes gennem subdermalt eller subkutant væv hos nævnte individ, - et par måleelektroder, der er indrettet til detektion af den spænding, som forårsages af nævnte strøm, der injiceres af injektionselektrodeme, efter den er strømmet gennem kropsvævet, - et middel til måling af impedans i det subdermale kropsvæv mellem nævnte injektionselektroder og nævnte måleelektroder, - en mikroprocessor, der er operativt forbundet med midlet til måling af impedans, og som er programmeret til at bestemme et glucoseniveau i blodet hos individet baseret på en sammenligning af den målte impedans med et forudbestemt forhold mellem impedans i det subdermale kropsvæv og glucoseniveau.
2. Apparat ifølge krav 1, hvor det subdermale væv er muskel, fedt eller blodkar.
3. Apparat ifølge et hvilket som helst af de foregående krav, der yderligere omfatter et amperemeter, et voltmeter og en elektrisk strømkilde til måling af impedansen i det subdermale kropsvæv mellem nævnte injektionselektroder og nævnte 2 måleelektroder, hvor amperemeteret og den elektriske strømkilde er i operativ forbindelse med injektionselektrodeme, og voltmeteret er i operativ forbindelse med måleelektroderne.
4. Apparat ifølge krav 3, hvor nævnte elektriske strømkilde er konfigureret til at tilvejebringe elektrisk strøm ved en flerhed af frekvenser i et område på 1 Hz til 10 MHz.
5. Apparat ifølge et hvilket som helst af de foregående krav, hvor mikroprocessoren er operativt forbundet med en insulinpumpe og indbefatter midler til justering af mængden af insulinstrøm via pumpen til individet baseret på det bestemte blodglucoseniveau.
6. Apparat ifølge et hvilket som helst af de foregående krav, der yderligere omfatter midler til kalibrering af apparatet i forhold til et direkte målt glucoseniveau hos nævnte individ.
7. Apparat ifølge et hvilket som helst af de foregående krav, hvor mikroprocessoren er programmeret til at bestemme glucoseniveauet hos et individ baseret på en hovedkomponentanalyse og en delvis mindste kvadraters-regressionsanalyse.
8. Apparat ifølge et hvilket som helst af de foregående krav, der yderligere omfatter en indikator, som er operativt forbundet med mikroprocessoren, til indikation af den bestemte mængde glucose.
9. Apparat ifølge krav 8, hvor indikatoren omfatter et visuelt display.
10. Apparat ifølge et hvilket som helst af de foregående krav, hvor måleelektroderne er indrettet til indføring i subdermalt eller subkutant kropsvæv. 3
11. Apparat ifølge et hvilket som helst af de foregående krav, hvor mindst én af parret af injektionselektroder eller parret af måleelektroder er indrettet til indføring i subdermalt eller subkutant kropsvæv.
DK05706464.4T 2004-02-05 2005-02-04 Apparat til måling af blodglucose under anvendelse af impedansmålinger af subdermalt kropsvæv DK1718200T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54174804P 2004-02-05 2004-02-05
PCT/CA2005/000148 WO2005074796A1 (en) 2004-02-05 2005-02-04 Method and apparatus for measuring glucose in body fluids using sub-dermal body tissue impedance measurements

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DK1718200T3 true DK1718200T3 (da) 2016-07-25

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US (2) US9022932B2 (da)
EP (1) EP1718200B1 (da)
CA (2) CA2568032C (da)
DK (1) DK1718200T3 (da)
ES (1) ES2582185T3 (da)
PL (1) PL1718200T3 (da)
WO (1) WO2005074796A1 (da)

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Also Published As

Publication number Publication date
CA2917663A1 (en) 2005-08-18
US9022932B2 (en) 2015-05-05
EP1718200A1 (en) 2006-11-08
WO2005074796A1 (en) 2005-08-18
CA2917663C (en) 2018-11-13
PL1718200T3 (pl) 2017-01-31
US20070161881A1 (en) 2007-07-12
CA2568032A1 (en) 2005-08-18
EP1718200A4 (en) 2009-07-15
CA2568032C (en) 2016-04-12
US20160007891A1 (en) 2016-01-14
US9833178B2 (en) 2017-12-05
EP1718200B1 (en) 2016-04-13
ES2582185T3 (es) 2016-09-09

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