DK1692097T3 - Tricykliske hydroxamat- og benzamidderivater, sammensætninger og fremgangsmåder - Google Patents
Tricykliske hydroxamat- og benzamidderivater, sammensætninger og fremgangsmåderInfo
- Publication number
- DK1692097T3 DK1692097T3 DK04806498T DK04806498T DK1692097T3 DK 1692097 T3 DK1692097 T3 DK 1692097T3 DK 04806498 T DK04806498 T DK 04806498T DK 04806498 T DK04806498 T DK 04806498T DK 1692097 T3 DK1692097 T3 DK 1692097T3
- Authority
- DK
- Denmark
- Prior art keywords
- compounds
- compositions
- methods
- hydroxamate
- tricyclic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/10—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/80—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03293143A EP1541549A1 (en) | 2003-12-12 | 2003-12-12 | Tricyclic hydroxamate and benzaminde derivatives, compositions and methods |
PCT/IB2004/004334 WO2005058803A1 (en) | 2003-12-12 | 2004-12-10 | Tricyclic hydroxamate and benzamide derivatives, compositions and methods |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1692097T3 true DK1692097T3 (da) | 2009-12-07 |
Family
ID=34486463
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK04806498T DK1692097T3 (da) | 2003-12-12 | 2004-12-10 | Tricykliske hydroxamat- og benzamidderivater, sammensætninger og fremgangsmåder |
Country Status (8)
Country | Link |
---|---|
US (1) | US7923579B2 (da) |
EP (2) | EP1541549A1 (da) |
AT (1) | ATE441628T1 (da) |
DE (1) | DE602004022974D1 (da) |
DK (1) | DK1692097T3 (da) |
ES (1) | ES2330749T3 (da) |
PT (1) | PT1692097E (da) |
WO (1) | WO2005058803A1 (da) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030129724A1 (en) | 2000-03-03 | 2003-07-10 | Grozinger Christina M. | Class II human histone deacetylases, and uses related thereto |
AU2005271841A1 (en) * | 2004-07-12 | 2006-02-16 | Merck & Co., Inc. | Inhibitors of histone deacetylase |
WO2006102557A2 (en) | 2005-03-22 | 2006-09-28 | The President And Fellows Of Harvard College | Treatment of protein degradation disorders |
CA2615105A1 (en) | 2005-07-14 | 2007-01-25 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
EP2573069A3 (en) * | 2006-12-19 | 2013-05-22 | MethylGene Inc. | Inhibitors of histone deacetylase and prodrugs thereof |
US8796330B2 (en) | 2006-12-19 | 2014-08-05 | Methylgene Inc. | Inhibitors of histone deacetylase and prodrugs thereof |
WO2009018344A1 (en) * | 2007-07-30 | 2009-02-05 | Regents Of The University Of Minnesota | Anticancer agents |
NZ586955A (en) | 2008-02-07 | 2012-06-29 | Generics Uk Ltd | Novel process for the preparation of vorinostat |
WO2009117808A1 (en) * | 2008-03-25 | 2009-10-01 | Methylgene Inc. | Inhibitors of histone deacetylase |
JP5665740B2 (ja) | 2008-07-23 | 2015-02-04 | プレジデント アンド フェローズ オブ ハーバード カレッジ | デアセチラーゼ阻害剤およびその使用 |
AU2009289649B2 (en) | 2008-09-03 | 2016-05-05 | Biomarin Pharmaceutical Inc. | Compositions including 6-aminohexanoic acid derivatives as HDAC inhibitors |
US8883851B2 (en) | 2008-10-15 | 2014-11-11 | Generics [Uk] Limited | Process for the preparation of vorinostat |
US8754129B2 (en) | 2008-11-26 | 2014-06-17 | Generics [Uk] Limited | Crystalline vorinostat form VI |
US8716344B2 (en) | 2009-08-11 | 2014-05-06 | President And Fellows Of Harvard College | Class- and isoform-specific HDAC inhibitors and uses thereof |
EP2638009A4 (en) * | 2010-01-08 | 2014-06-11 | Harvard College | FLUORINATED HDAC HEMMER AND USES THEREOF |
WO2012019772A1 (en) * | 2010-08-12 | 2012-02-16 | Institut De Recherche Pour Le Developpement (I.R.D) | Method for treating protozoan parasitic diseases |
EP2486923B1 (en) * | 2011-02-11 | 2015-09-09 | Dr. Felix Jäger und Dr. Stefan Drinkuth Laborgemeinschaft OHG | Histone deacetylase (HDAC) inhibiting compounds and method of making same |
US8957066B2 (en) | 2011-02-28 | 2015-02-17 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
US10059723B2 (en) | 2011-02-28 | 2018-08-28 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
DK2680694T3 (da) | 2011-02-28 | 2019-03-25 | Biomarin Pharm Inc | Histondeacetylasehæmmere |
CN102329246B (zh) * | 2011-07-04 | 2013-11-20 | 潍坊博创国际生物医药研究院 | 多靶点型他米巴罗汀衍生物、其制备方法和用途 |
CA2848540A1 (en) | 2011-09-15 | 2013-03-21 | Arizona Board Of Regents, A Body Corporate Of The State Of Arizona Acting For And On Behalf Of Arizona State University | Therapeutic compounds |
CN103664680A (zh) * | 2012-09-26 | 2014-03-26 | 山东鲁北药业有限公司 | 一种他米巴罗汀合成的新工艺 |
US10029988B2 (en) | 2013-03-15 | 2018-07-24 | Biomarin Pharmaceutical Inc. | HDAC inhibitors |
US10328040B2 (en) | 2014-01-17 | 2019-06-25 | Arizona Board Of Regents On Behalf Of Arizona State University | Therapeutic methods |
US20170114019A1 (en) | 2014-06-04 | 2017-04-27 | Haro Pharmaceutical Inc. | 18-20 member bi-polycyclic compounds |
CN107304172B (zh) * | 2016-04-20 | 2020-04-03 | 沈阳药科大学 | 八氢蒽类化合物及其制备方法和用途 |
CN106187818B (zh) * | 2016-06-27 | 2017-12-08 | 刘美新 | 一种制备抗癌药物伏立诺他的方法 |
US10238655B2 (en) | 2017-01-23 | 2019-03-26 | Arizona Board Of Regents On Behalf Of Arizona State University | Dihydroindene and tetrahydronaphthalene compounds |
US10231947B2 (en) | 2017-01-23 | 2019-03-19 | Arizona Board Of Regents On Behalf Of Arizona State University | Isochroman compounds and methods of use thereof |
US10238626B2 (en) | 2017-01-23 | 2019-03-26 | Arizona Board Of Regents On Behalf Of Arizona State University | Therapeutic compounds |
US20230096380A1 (en) * | 2020-02-06 | 2023-03-30 | Children's Hospital Medical Center | Compounds, compositions, methods for treating diseases and nerve damage, and methods for preparing compounds |
CN112479918B (zh) * | 2020-12-11 | 2023-07-14 | 成都大学 | 一种维甲酸类衍生物Am580的合成方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
LU86351A1 (fr) * | 1986-03-12 | 1987-11-11 | Oreal | Composes benzopyrannyl et benzothiopyrannyl benzoiques,leur procede de preparation et leur utilisation en cosmetique et en medecine humaine et veterinaire |
DE3903990A1 (de) * | 1989-02-10 | 1990-08-30 | Basf Ag | Phenylhydrazone, ihre herstellung und daraus hergestellte arzneimittel und kosmetika |
LU87821A1 (fr) * | 1990-10-12 | 1992-05-25 | Cird Galderma | Composes bi-aromatiques,et leur utilisation en medecine humaine et veterinaire et en cosmetique |
FR2746098B1 (fr) * | 1996-03-14 | 1998-04-30 | Composes propynyl biaromatiques | |
CA2391952C (en) * | 1999-11-23 | 2012-01-31 | Methylgene Inc. | Inhibitors of histone deacetylase |
US6376548B1 (en) * | 2000-01-28 | 2002-04-23 | Rohm And Haas Company | Enhanced propertied pesticides |
PE20020354A1 (es) * | 2000-09-01 | 2002-06-12 | Novartis Ag | Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda) |
BR0210191A (pt) * | 2001-06-06 | 2004-04-06 | Agouron Pharma | Agentes não peptìdicos da gnrh, composições farmacêuticas e métodos para o seu uso, e processos para os preparar e aos seus intermediários |
-
2003
- 2003-12-12 EP EP03293143A patent/EP1541549A1/en not_active Withdrawn
-
2004
- 2004-12-10 DE DE602004022974T patent/DE602004022974D1/de active Active
- 2004-12-10 WO PCT/IB2004/004334 patent/WO2005058803A1/en active Application Filing
- 2004-12-10 ES ES04806498T patent/ES2330749T3/es active Active
- 2004-12-10 DK DK04806498T patent/DK1692097T3/da active
- 2004-12-10 PT PT04806498T patent/PT1692097E/pt unknown
- 2004-12-10 US US10/581,947 patent/US7923579B2/en not_active Expired - Fee Related
- 2004-12-10 EP EP04806498A patent/EP1692097B1/en not_active Not-in-force
- 2004-12-10 AT AT04806498T patent/ATE441628T1/de active
Also Published As
Publication number | Publication date |
---|---|
EP1692097B1 (en) | 2009-09-02 |
EP1541549A1 (en) | 2005-06-15 |
ATE441628T1 (de) | 2009-09-15 |
ES2330749T3 (es) | 2009-12-15 |
WO2005058803A1 (en) | 2005-06-30 |
DE602004022974D1 (de) | 2009-10-15 |
US20070129368A1 (en) | 2007-06-07 |
EP1692097A1 (en) | 2006-08-23 |
PT1692097E (pt) | 2009-10-30 |
US7923579B2 (en) | 2011-04-12 |
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