DK164163C - ANALOGIFREMGANGSMAADE for preparing 4-oxo-4H-OE1AA-benzopyran-8-yl-alkanoic acids or esters or DIALKYLAMINOALKYLAMIDER thereof or alkali metal salts thereof, and 4-oxo-4H-OE1AA-benzopyran-8-yl-alkanenitriles FOR USE AS INTERMEDIATES - Google Patents

ANALOGIFREMGANGSMAADE for preparing 4-oxo-4H-OE1AA-benzopyran-8-yl-alkanoic acids or esters or DIALKYLAMINOALKYLAMIDER thereof or alkali metal salts thereof, and 4-oxo-4H-OE1AA-benzopyran-8-yl-alkanenitriles FOR USE AS INTERMEDIATES

Info

Publication number
DK164163C
DK164163C DK523082A DK523082A DK164163C DK 164163 C DK164163 C DK 164163C DK 523082 A DK523082 A DK 523082A DK 523082 A DK523082 A DK 523082A DK 164163 C DK164163 C DK 164163C
Authority
DK
Denmark
Prior art keywords
benzopyran
oxo
oe1aa
esters
dialkylaminoalkylamider
Prior art date
Application number
DK523082A
Other languages
Danish (da)
Other versions
DK523082A (en
DK164163B (en
Inventor
Philippe Briet
Jean-Jacques Berthelon
Francois Collonges
Original Assignee
Lipha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lipha filed Critical Lipha
Publication of DK523082A publication Critical patent/DK523082A/en
Publication of DK164163B publication Critical patent/DK164163B/en
Application granted granted Critical
Publication of DK164163C publication Critical patent/DK164163C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/34—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only
    • C07D311/36—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only not hydrogenated in the hetero ring, e.g. isoflavones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Control Of Motors That Do Not Use Commutators (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The invention concerns [oxo-4-4H-[1]-benzopyran-8-yl]-alcanoic acids and their derivatives, their manufacture, represented by the formula. <IMAGE> where AR is hydrogen, a phenyl radical which may or may not be substituted thenyl, furyl, naphthyl, a lower alkyl, cycloalkyl, aralkyl radical; B is a linear or branched lower alkyl radical, either saturated or ethylinically unsaturated; R1 is hydrogen or a phenyl radical; X is hydrogen or a lower alkyl or alkoxy radical and n=1, as well as salts, esters, aminoesters and amides. Compounds and their derivatives may be used as medicines, in particular in the control of tumors.
DK523082A 1981-11-25 1982-11-24 ANALOGIFREMGANGSMAADE for preparing 4-oxo-4H-OE1AA-benzopyran-8-yl-alkanoic acids or esters or DIALKYLAMINOALKYLAMIDER thereof or alkali metal salts thereof, and 4-oxo-4H-OE1AA-benzopyran-8-yl-alkanenitriles FOR USE AS INTERMEDIATES DK164163C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8122020 1981-11-25
FR8122020A FR2516922A1 (en) 1981-11-25 1981-11-25 ACIDS (OXO-4-4H- (1) -BENZOPYRAN-8-YL) ALKANOIC, SALTS AND DERIVATIVES, PREPARATION AND DRUG CONTAINING THEM

Publications (3)

Publication Number Publication Date
DK523082A DK523082A (en) 1983-05-26
DK164163B DK164163B (en) 1992-05-18
DK164163C true DK164163C (en) 1992-10-19

Family

ID=9264332

Family Applications (1)

Application Number Title Priority Date Filing Date
DK523082A DK164163C (en) 1981-11-25 1982-11-24 ANALOGIFREMGANGSMAADE for preparing 4-oxo-4H-OE1AA-benzopyran-8-yl-alkanoic acids or esters or DIALKYLAMINOALKYLAMIDER thereof or alkali metal salts thereof, and 4-oxo-4H-OE1AA-benzopyran-8-yl-alkanenitriles FOR USE AS INTERMEDIATES

Country Status (24)

Country Link
US (2) US4602034A (en)
EP (1) EP0080934B1 (en)
JP (1) JPS5896082A (en)
AT (1) ATE31927T1 (en)
AU (1) AU563190B2 (en)
CA (1) CA1213595A (en)
CS (1) CS248035B2 (en)
DD (1) DD204919A5 (en)
DE (1) DE3277970D1 (en)
DK (1) DK164163C (en)
ES (1) ES517637A0 (en)
FR (1) FR2516922A1 (en)
HU (1) HU192112B (en)
IE (1) IE54130B1 (en)
IL (1) IL67291A0 (en)
IN (1) IN158843B (en)
MA (1) MA19650A1 (en)
MX (1) MX173498B (en)
NO (1) NO159169C (en)
NZ (1) NZ202596A (en)
OA (1) OA07257A (en)
SU (1) SU1250171A3 (en)
YU (2) YU43726B (en)
ZA (1) ZA828436B (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2536397A2 (en) * 1981-11-25 1984-05-25 Lipha [4-oxo-4H-1-Benzopyran-8-yl]alkanoic acids, their salts and derivatives, their preparation and medicinal products containing them
DE3311004A1 (en) * 1983-03-25 1984-09-27 Bayer Ag, 5090 Leverkusen CHROMON AND THIOCHROMON-8 ALDEHYDE AND A METHOD FOR THE PRODUCTION THEREOF
JPS62215581A (en) * 1986-03-18 1987-09-22 Koichi Shiyudo Flavone carboxylic acid derivative
IL85554A0 (en) * 1987-03-02 1988-08-31 Takeda Chemical Industries Ltd Chromone derivatives
MA21528A1 (en) * 1988-04-06 1989-12-31 Lipha SUBSTITUTE COMPONENTS OF FLAVONOIDE, THEIR SALTS, THEIR MANUFACTURES AND PRODUCTS CONTAINING THESE MATERIALS.
USH1427H (en) * 1988-04-06 1995-04-04 Briet; Phillipe Substituted flavonoid compounds, their salts, their manufacture and their use in combination with interleukin-2
US5116954A (en) * 1988-04-06 1992-05-26 Lipha, Lyonnaise Industrielle Pharmaceutique Pharmaceutically useful flavonoic compounds containing at least one substituent on the benzopyranone ring moiety
US5126129A (en) * 1988-05-23 1992-06-30 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services Cancer therapy using interleukin-2 and flavone compounds
DE68913997T2 (en) * 1989-01-19 1994-07-28 Upjohn Co FLUORINE FLAVON ACETIC ACID.
US5238954A (en) * 1989-01-19 1993-08-24 The Upjohn Company Fluorinated flavone acetic acid
US5703130A (en) * 1995-06-07 1997-12-30 Institute Of Materia Medica, An Institute Of The Chinese Academy Of Medical Sciences Chalcone retinoids and methods of use of same
US5716982A (en) * 1995-06-07 1998-02-10 Institute Of Materia Medica, An Institute Of The Chinese Academy Of Medical Sciences Retinoids and methods of use of same
US5968940A (en) * 1995-06-08 1999-10-19 Institute Of Materia Medica Retinoids and methods of use of same
JP4638098B2 (en) * 1999-06-14 2011-02-23 キャンサー・リサーチ・テクノロジー・リミテッド Cancer treatment
EP1218002A4 (en) 2000-01-24 2004-09-22 Jozef S Mruk Use of flavone 8-acetic acid in vascular and cardiovascular interventions and acute coronary syndromes
WO2002009700A1 (en) * 2000-07-28 2002-02-07 Cancer Research Technology Limited Cancer treatment by combination therapy
GB0121285D0 (en) * 2001-09-03 2001-10-24 Cancer Res Ventures Ltd Anti-cancer combinations
GB2386836B (en) * 2002-03-22 2006-07-26 Cancer Res Ventures Ltd Anti-cancer combinations
GB2394658A (en) * 2002-11-01 2004-05-05 Cancer Rec Tech Ltd Oral anti-cancer composition
GB0321999D0 (en) * 2003-09-19 2003-10-22 Cancer Rec Tech Ltd Anti-cancer combinations
US20100297112A1 (en) * 2005-08-26 2010-11-25 Antisoma Research Limited Combinations comprising dmxaa for the treatment of cancer
WO2011023287A1 (en) 2009-08-27 2011-03-03 Merck Patent Gmbh Use of faa and its derivatives in cosmetics and dermatology
KR102012398B1 (en) 2009-11-05 2019-08-20 리젠 파마슈티컬스 소시에떼 아노님 Novel benzopyran kinase modulators
CN103304531A (en) * 2013-06-25 2013-09-18 南方医科大学 3-aryl flavone acetic acid
EP3426242A4 (en) * 2016-03-11 2020-03-18 H. Lee Moffitt Cancer Center And Research Institute, Inc. Icariin and icaritin derivatives

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2921070A (en) * 1957-11-05 1960-01-12 Recordati Lab Farmacologico S Basic esters of 3-methylflavone-8-carboxylic acid
US3350411A (en) * 1963-10-10 1967-10-31 Pharma Seceph S A Soc D Expl C Process for preparing 3-methylflavone-8-carboxylic acid
BE757821A (en) * 1970-08-01 1971-04-01 Recordati Chem Pharm PROCESS FOR THE PREPARATION OF 3-PROPIONYL-SALICYLIC ACID AND DERIVATIVES OF THIS ACID
US4148900A (en) * 1973-12-27 1979-04-10 Carlo Erba S.P.A. 5:6-Benzo-γ-pyrone derivatives and process for their preparation
GB1479518A (en) * 1973-12-27 1977-07-13 Erba Carlo Spa 5,6-benzo-ypsilon-pyrone derivatives
FR2281112A1 (en) * 1974-08-05 1976-03-05 Lipha NEW CHOLERETIC AND ANTI-INFLAMMATORY DRUG
GB1469823A (en) * 1974-08-13 1977-04-06 Farma Lepori Flavone derivatives
DE2549745A1 (en) * 1974-11-20 1976-05-26 Lipha PROPIONIC ACIDS SUBSTITUTED BY A CHROMONYL RESIDUE AND THEIR DERIVATIVES AND USES

Also Published As

Publication number Publication date
DE3277970D1 (en) 1988-02-18
IL67291A0 (en) 1983-03-31
ATE31927T1 (en) 1988-01-15
AU563190B2 (en) 1987-07-02
YU163084A (en) 1985-03-20
ES8308323A1 (en) 1983-08-16
NO159169B (en) 1988-08-29
DK523082A (en) 1983-05-26
IN158843B (en) 1987-01-31
NO159169C (en) 1988-12-07
YU264982A (en) 1984-12-31
AU9073082A (en) 1983-06-02
IE54130B1 (en) 1989-06-21
CA1213595A (en) 1986-11-04
US4602034A (en) 1986-07-22
SU1250171A3 (en) 1986-08-07
JPH0214352B2 (en) 1990-04-06
HU192112B (en) 1987-05-28
FR2516922A1 (en) 1983-05-27
YU43675B (en) 1989-10-31
OA07257A (en) 1984-04-30
NZ202596A (en) 1986-02-21
ZA828436B (en) 1983-09-28
FR2516922B1 (en) 1984-02-10
IE822752L (en) 1983-05-25
MA19650A1 (en) 1983-07-01
DK164163B (en) 1992-05-18
DD204919A5 (en) 1983-12-14
US4783533A (en) 1988-11-08
ES517637A0 (en) 1983-08-16
EP0080934A1 (en) 1983-06-08
YU43726B (en) 1989-10-31
CS248035B2 (en) 1987-01-15
NO823940L (en) 1983-05-26
EP0080934B1 (en) 1988-01-13
JPS5896082A (en) 1983-06-07
MX173498B (en) 1994-03-10

Similar Documents

Publication Publication Date Title
DK164163C (en) ANALOGIFREMGANGSMAADE for preparing 4-oxo-4H-OE1AA-benzopyran-8-yl-alkanoic acids or esters or DIALKYLAMINOALKYLAMIDER thereof or alkali metal salts thereof, and 4-oxo-4H-OE1AA-benzopyran-8-yl-alkanenitriles FOR USE AS INTERMEDIATES
DK443482A (en) PROCEDURE FOR THE PREPARATION OF CARBOXYLIC ACID DERIVATIVES
DK150064C (en) METHOD OF ANALOGY FOR THE PREPARATION OF ALFA- (2-HYDROXYETHYL) -2-OXO-1-PYRROLIDINE ACETIC ACID AND AMIDER THEREOF
DE69033069T2 (en) Prostaglandin analogs
DK237483D0 (en) PROCEDURE FOR THE PREPARATION OF PROPIONIC ACID DERIVATIVES
DK439082A (en) 4-ACYLAMINO-1-AZA-ADAMANTAN COMPOUNDS AND PROCEDURES FOR PREPARING THEREOF
MX20482A (en) PROCEDURE FOR THE PREPARATION OF NEW DERIVATIVES OF 4-PHENYL METHYL-1H-INDOL.
SE8405275D0 (en) 1,2-DITHIOLAN DERIVATIVES, PROCESSES FOR THEIR PRODUCTION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE
DE3579894D1 (en) METHOD FOR PRODUCING AMINOTHIAZOLIC ACETIC DERIVATIVES.
ATE52765T1 (en) ALPHA AMINOOXY C4 ALKANOIC ACIDS AND ESTERS.
DK374281A (en) PROCEDURE FOR THE PREPARATION OF ACYLATED FURANYL AND THIENYLACRYLIC ACIDS
DK159272C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF ALFA-SUBSTITUTED UREIDOBENZYLPENICILLANIC ACID
ES8504782A1 (en) Substituted 4-piperidinomethyl-1,3-dioxolanes.
DK0397048T3 (en) Process for the preparation of 2-mercapto-4-methyl-1,3-thiazol-5-yl acetic acid and its esters
DK27081A (en) INDAN-4-YL-N-ALKYL-CARBAMIC ACID ESTERS, PROCEDURES FOR PREPARING THEM AND THEIR USE AS FUNGICIDES
SE8200679L (en) 1-BENZYL-4- (4- (2-PYRIMIDINYLAMINO) BENZYL 1-2,3-DIOXOPIPERAZINE DERIVATIVES, SALTS THEREOF, PROCEDURES FOR PREPARING THEREOF AND CARCINOSTATIC AGENTS OF THE INVENTION
JPS53149932A (en) 2-(3-alkylnitrosoureido)-hexapyranoside derivatives
ES402968A1 (en) Procedure for the preparation of mixed esters of 2,6 pyridindimethanol. (Machine-translation by Google Translate, not legally binding)
JPS53149931A (en) 2-(3-alkylureido)-hexapyranoside derivatives
ATE144257T1 (en) TETRAHYDRO-4-PHENYLIMINO-3-THIOPHENACETIC ACIDS
ES2083961T3 (en) ACIDOS 3-ANILINO-2-HIDROXICARBONIL-4-TIOFENOACETICOS.

Legal Events

Date Code Title Description
PBP Patent lapsed