DK164082B

DK164082B - DISPENSER

Info

Publication number: DK164082B
Application number: DK17486A
Authority: DK
Inventors: Robert Edward Newell; Paul Kenneth Rand; Carole Ann Osterweil
Original assignee: Glaxo Group Ltd
Priority date: 1986-01-14
Filing date: 1986-01-14
Publication date: 1992-05-11
Also published as: DK17486A; DK17486D0; DK164082C

Description

DK 164082 BDK 164082 B

Denne opfindelse vedrører en indretning til afgivelse af en blanding af et drivmiddel og et produkt fra en trykaerosol-beholder med en udløbsventil, hvilken indretning har et hus, der optager eller er indrettet til at optage en tryk-5 aerosolbeholder, og har en udløbstud tæt ved den ene ende af huset, et låg med en drejelig forbind- i.se til huset tæt ved husets anden ende, hvilket låg n b 'æges fra en lukket stilling, i hvilken det indeslv er »løbstuden, til en åben stilling, i hvilken udløbst en blotlagt. Ved 10 en foretrukken anvendelse er produk t e medikament.This invention relates to a device for dispensing a mixture of a propellant and a product from a pressure aerosol container with an outlet valve, which device has a housing which receives or is arranged to receive a pressure aerosol container and has an outlet spout tightly at one end of the housing, a lid with a rotatable connection to the housing close to the other end of the housing, which lid nb 'is driven from a closed position in which it is inside the' running spout 'to an open position in which expired a exposed. In a preferred use, the product is a drug.

Aerosoler, der indeholder en blandi \ af nedikamentet og et drivmiddel, er almindeligt benytted fx ad behandling af lidelser i det øverste og nederste aspi utionssystem. Til behandling af sådanne lidelser afgi as d r medikamenter i 15 sprayform til en patient ved hjælp af er oral eller nasal inhaleringsindretning omfattende et hus lier et hylster, i hvilket der er placeret en trykae>asol eholder, og et mundstykke eller en dyse, som fører ud f a det rørformede hus. Under brug anbringes aerosolbeholde an i huset, som 20 derefter af patienten holdes i en mere ε ler mindre lodret stilling, og inhalationsindretningens bu istykke eller dyse anbringes i patientens mund eller næsebc . Patienten inhalerer, medens aerosolbeholderen betjener til åbning af beholderens afgivelsesventil til afgive] e af medikament 25 fra beholderen via mundstykket eller dysan ind i patientens mund eller næsebor. En sådan indretning tendes fra fx DK B 146.675.Aerosols containing a mixture of the down-drug and a propellant are commonly used, for example, in the treatment of disorders of the upper and lower aspiration systems. For the treatment of such disorders, the medicament is delivered in spray form to a patient by means of an oral or nasal inhalation device comprising a housing and a sheath in which a trykae> asol holder is placed, and a mouthpiece or nozzle which carries out fa the tubular housing. During use, aerosol dispensers are placed in the housing, which are then held by the patient in a more or less vertical position, and the inhaler or nozzle of the inhaler is placed in the patient's mouth or nose. The patient inhales while the aerosol container operates to open the container delivery valve for dispensing drug 25 from the container via the mouthpiece or nozzle into the patient's mouth or nostrils. Such a device is lit from eg DK B 146,675.

I forbindelse med alle sådanne indretnii er frembringer patienten afgivelse af medikamentet ved it presse på en del 30 af aerosolbeholderen, hvilken del rager rem fra huset. Når et sådant tryk udøves, forskydes aeroso ueholderen i forhold til huset, hvorved aerosolbeholder' is afgivelsesventil åbnes. Nogle patienter, fx børn, ældre rsoner, personer, der lider af ledegigt, og svagelige har anskeligt ved at 35 holde inhalationsindretningen mod munde; eller næseboret, medens aerosolbeholderen presses ned i iorhold til huset 2In connection with all such devices, the patient produces the drug by pressing on a part 30 of the aerosol container, which part protrudes from the housing. When such pressure is applied, the aerosol container is displaced relative to the housing, thereby opening the aerosol container's dispensing valve. Some patients, such as children, the elderly, people suffering from rheumatoid arthritis, and the infirm, have difficulty holding the inhaler to their mouths; or the nostril, while the aerosol canister is pressed down in relation to the housing 2

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for at åbne afgivelsesventilen. Andre har vanskeligt ved at koordinere deres håndbevægelser med inhaleringen og kan som følge heraf gå glip af indtagelse af den ønskede medikamentdosis .to open the delivery valve. Others have difficulty coordinating their hand movements with the inhalation and may consequently miss taking the desired dose of medication.

5 Formålet med den foreliggende opfindelse er at tilvejebringe en måde til at gøre det lettere for sådanne patienter at afgive medikament fra en aerosolbeholder og ligeledes at tilvejebringe en måde til i alt væsentligt at indeslutte aerosolbeholderen, aerosolhuset og mundstykket 10 eller dysen, når indretningen ikke er i brug.The object of the present invention is to provide a way of making it easier for such patients to dispense medicament from an aerosol container and also to provide a way of substantially enclosing the aerosol container, the aerosol housing and the nozzle 10 or the nozzle when the device is not in use.

Dette formål opnås ved, at den indledningsvis nævnte indretning er ejendommelig ved, at en drivarm er indrettet til drejningsbevægelse i forhold til huset, så at den kan lukkes mod en del af huset, som ikke er dækket af låget, og 15 har en del, som, når og kun når låget er i sin åbne stilling, og armen er lukket mod huset, udøver en kraft på beholderen til at forskyde beholderen i forhold til huset og derved åbne beholderens udløbsventil til afgivelse af blandingen fra beholderen via udløbstuden.This object is achieved in that the device mentioned in the introduction is characterized in that a drive arm is arranged for rotational movement relative to the housing, so that it can be closed against a part of the housing which is not covered by the lid, and has a part, which, when and only when the lid is in its open position and the arm is closed against the housing, exerts a force on the container to displace the container relative to the housing and thereby open the outlet valve of the container to dispense the mixture from the container via the outlet spout.

20 Udløbstuden kan være konstrueret som et mundstykke, der kan anbringes i munden på en patient, eller den kan være konstrueret som en dyse til indsætning i en patients næsebor.The spout may be designed as a mouthpiece that can be placed in a patient's mouth, or it may be designed as a nozzle for insertion into a patient's nostril.

I den foretrukne udførelsesform er låget hængslet til legemet eller huset, og aktiveringsarmen er hængslet til låget.In the preferred embodiment, the lid is hinged to the body or housing and the actuating arm is hinged to the lid.

μη.μη.

25 Opfindelsen Vil i dét følgende blive nærmere forklaret under henvisning til tegningen, der viser to udførelsesformer for en dispenser ifølge opfindelsen, og på hvilken fig. 1 viser en første udførelsesform for en inhalationsindretning ifølge opfindelsen og med et låg i en åben 30 stilling og med indretningen i en klargjort stilling,The invention will be explained in more detail below with reference to the drawing, which shows two embodiments of a dispenser according to the invention, and in which fig. 1 shows a first embodiment of an inhalation device according to the invention and with a lid in an open position and with the device in a prepared position,

J IJ I

fig. 2 viser den i fig. 1 viste indretning, adskilt og set i perspektiv, 3fig. 2 shows the device shown in FIG. 1, separated and seen in perspective, 3

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fig. 3 svarer til fig, i, men viser en anden udførelses-form, og fig. 4 viser den i fig. 3 viste indretning, adskilt og set i perspektiv.fig. Fig. 3 corresponds to Fig. 1 but shows another embodiment, and 4 shows the device shown in FIG. 3, separated and seen in perspective.

5 Den i fig. 1 og 2 viste udførelsesform e en inhalationsindretning til medikamenter, der er inde oldt i en aerosoldåse, et hult legeme 1, der er åbent i d n ene ende, som herefter for at lette forklaringen l enæv es legemets øverste ende. Når indretningen er i brutj, hc les legemet nor-10 malt i denne stilling af en patient Leg met har en udløbstud 2, der rager lateralt frem fra i egem t tæt ved den anden, dvs. legemets nederste ende. 3 legf et 1 kan der anbringes en trykaerosoldåse 3 venden ie p< hovedet, således som det fremgår af fig. 1. En udløbsvent Idel 4 af dåsen 3 15 indgriber med et tapformet legeme 5 i bi iden af legemet 1.The device shown in FIG. 1 and 2, an inhalation device for medicaments contained in an aerosol can, a hollow body 1 open at one end, which is then used to facilitate the explanation of the upper end of the body. When the device is in the broth, the body is normally read in this position by a patient. The body has an outlet spout 2 projecting laterally from the body close to the other, i.e. the lower end of the body. 3, a pressure aerosol can 3 can be placed upside down, as shown in FIG. An outlet vent Part 4 of the can 3 15 engages with a pin-shaped body 5 in the side of the body 1.

Det tapformede legeme 5 har en udløbspar age 6 (se fig. 1).The pin-shaped body 5 has an outlet pair 6 (see Fig. 1).

Når dåsen 3 trykkes ned i forhold til di tapformede legeme 5, vil ventildelen 4 naturligvis forbli- stationær, da den indgriber med det tapformede legeme, o# ien relative bevæ-20 gelse af aerosoldåsen og ventildelen åti ur ventildelen 4, så at der fra dåsen 3 afgives en dosis ; : blandingen af medikament og drivmiddel, hvilken bland i ig passerer gennem passagen 6 og føres ind i patientens mui I gennem udløbstuden 2.When the can 3 is pressed down relative to the pin-shaped body 5, the valve part 4 will of course remain stationary, as it engages with the pin-shaped body, relative to the relative movement of the aerosol can and the valve part eight clockwise of the valve part 4, so that from the can 3 is given a dose; : the mixture of drug and propellant, which mixture i ig passes through the passage 6 and is introduced into the patient's mui I through the outlet spout 2.

25 Tæt ved legemet l's åbne ende er der hængslet et låg 7. Til dette formål har låget 7 tæt ved sin øvrrste ende indre tappe 8, der indgriber i huller 13 i låuemet. Som følge af denne hængslede forbindelse kan låget 7 bevæges mellem en låst stilling, i hvilken lågets nederst- endedel lukker 30 udløbstuden 2, og en åben stilling, i h ilken udløbstuden er blotlagt. Under brug svinges låget c . 180° til den i fig. 1 viste stilling. Låget 7 har to y ire tappe 9, hvis centre er forskudt i forhold til tappen 8's centre. En drivarm 10 har tæt ved sin øverste ende huller 11, i hvilke 35 tappene 9 optages, så at armen er forbundet i en hængselforbindelse til legemet via låget. Denne arm 10 passer 4Close to the open end of the body 1, a lid 7 is hinged. For this purpose, the lid 7 has near its upper end inner pins 8 which engage in holes 13 in the lid. As a result of this hinged connection, the lid 7 can be moved between a locked position, in which the lower end part of the lid closes the outlet spout 2, and an open position in which the outlet spout is exposed. During use, swing the lid c. 180 ° to the one shown in fig. 1 shown position. The lid 7 has two y ire pins 9, the centers of which are offset relative to the centers of the pin 8. A drive arm 10 has near its upper end holes 11, in which the pins 9 are received, so that the arm is connected in a hinge connection to the body via the lid. This arm 10 fits 4

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omkring en del af legemet 1, som ikke er dækket af låget 7.around a part of the body 1 which is not covered by the lid 7.

I visse stillinger vil undersiden af armens øverste del 12 virke som en understøtning mod aerosolbeholderen 3. Det foretrækkes, at tappene 8 har en diameter, der er tilnær-5 melsesvis halvdelen af diameteren af de ydre tappe 9. Tappen 8 er indrettet·til at bevæge sig i en epicycloid bevægelse i forhold tiladen ydre tap 9, når låget hæves til klargøring af?indretningen, og når amen presses ned, til aktivering af1eindretningen. Tappen 8 kan i stedet (ikke 10 vist) være ia&M-ettet til at bevæge sig i en hypocycloid bevægelse i forhold til den ydre tap 9.In certain positions the underside of the upper part 12 of the arm will act as a support against the aerosol container 3. It is preferred that the pins 8 have a diameter which is approximately half the diameter of the outer pins 9. The pin 8 is arranged to move in an epicycloid motion relative to the outer pin 9 when the lid is raised to prepare the device and when the amen is pressed down to activate the device. The pin 8 may instead (not shown 10) be ia & M-one to move in a hypocycloid motion relative to the outer pin 9.

Til klargøring af indretningen åbner patienten låget 7, fortrinsvis til den i fig. 1 viste helt åbne stilling. Den relative bevægelse5 af tappene 8 og 9 flytter aerosolbehol-15 deren 3 og legemet! i i en lodret retning i forhold til amen 10 til* en stilling, hvor aerosolbeholderen er i kontakt med undersiden af araens øverste del 12, og fortsat bevægelse af flaget?? 7 får armen 10 til at dreje opefter og udefter til eft "klar stilling" (fig. 1).To prepare the device, the patient opens the lid 7, preferably to the one shown in fig. 1 showed completely open position. The relative movement5 of the pins 8 and 9 moves the aerosol container 15 and the body! i in a vertical direction relative to amen 10 to * a position where the aerosol container is in contact with the underside of the upper part 12 of the macaw, and continued movement of the flag ?? 7 causes the arm 10 to rotate upward and outward to the "ready position" (Fig. 1).

ij, i : 20 Til brug af indretningen indsætter patienten udløbstuden 2 i sin mund og? frembringer afgivelse af aerosolen ved sammentrykning af legemet 1 og armen 10. Under sammentrykningen udøver undersiden af amens øverste del 12 tryk mod aerosolbeholdéren 3, hvilket får ventildelen 4 til at af-25 give en dosiå*- genriSm udløbspassagen 6 og gennem udløbstuden 2 ind i patientens mund.ij, i: 20 To use the device, the patient inserts the spout 2 into his mouth and? produces release of the aerosol by compressing the body 1 and the arm 10. During the compression, the underside of the upper part 12 of the amene exerts pressure against the aerosol container 3, which causes the valve part 4 to dispense a dose * - genriSm outlet passage 6 and through the outlet spout 2 into the patient's mouth.

Patienten kameventuelt tage yderligere doser ved gentagne gange at presse l'dgemet og armen sammen, eller patienten kan lukke irtdtetnihgen ved at sænke låget 7 ned over ud-30 løbstuden 2.ΛΘ V'HThe patient may, if necessary, take additional doses by repeatedly squeezing the l'dgemet and the arm together, or the patient may close the irtdtetnihgen by lowering the lid 7 down over the outlet nozzle 2.ΛΘ V'H

13 P-13 P-

I fig. 3 og 4 er tfi'st en anden udførelsesf om, der i alt væsentligt, kfonstruktionsmæssigt og funktionsmæssigt, svarer til den i* fig. 1 og 2 viste udførelsesfora, hvorfor denne udførelsesform ikke vil blive beskrevet detaljeret. IIn FIG. 3 and 4 are in fact a second embodiment which, essentially, structurally and functionally, corresponds to that shown in FIG. 1 and 2, so that this embodiment will not be described in detail. IN

Claims

25 PATENT REQUIREMENTS

Device for dispensing a mixture of a propellant and a product from a pressure aerosol container *. · (3) with an outlet valve (4), which device has a; ice (1), which receives or is arranged to receive a wooden aerosol container (3) 30 and has an outlet spout (2) close to the end of the housing (1), a lid (7) with a rotatable connection '. il the housing (1) close to the other end of the housing, which lid (7) is moved from a closed position in which it encloses the outlet spout (2), DK 164082B 6 to an open position in which the outlet spout (2) is exposed, 31 characterized in that a drive arm (10) is arranged for rotational movement relative to the housing (1), so that the arm 5 (10) can close @ S against a part of the housing (1) which is not covered by the lid (7). ), ipog has a part which, when and only when the lid (7) is in its open position and the arm (10) is closed against the housing (1), exerts electric force on the container (3) to displace the container (3] P in relation to the housing (1) and thereby opens the outlet valve (4) of the container (3) for dispensing the mixture from containers ^ (3) through the outlet spout (2).

Decor! according to claim 1, characterized in that the drive arm (10) is rotatably connected to the cover (7) for rotational movement about an axis which is located close to but offset relative to the axis of rotation! for the rotation connection between the cover (7) and the housing (1) .1 'at. :

Device according to claim 2, characterized in that the lid (7) has two pairs of pivots (8} ε9), a smaller pair (8) received in a corresponding opening of openings (13) in the housing (1) for delimiting an axis for rotational movement between the lid (7) and the housing (1), and a support pair (9) received in a corresponding pair of openings 1 (11)! The drive arm (10) for delimiting the axis 25 for rotational movement between the lid (7) and the drive arm (10). 1-31- {

Device: according to claim 2, k e n d e t é »Tg n 'é? t in that the lid (7) has a first pair of revolving pins (9f) received in a corresponding pair of openings (11) in the drive arm (10) and that the housing (1) carries a second pair of rotating pins (8) ), which is smaller than the first pair (9) and which is accommodated in a corresponding pair of openings (13) formed in the lid (7) in the vicinity of the first pair of pivot pins (9). 7 DK 164082 B

Device according to claim 3 or 4, characterized in that the smaller pair of pivots (8) have a diameter which is approximately half the diameter of the larger pair (9).

Device according to any one of the preceding claims, characterized in that a pin-shaped body (5) is provided in the housing (1) for removably receiving the outlet valve (4) of the container (3) in the body (5).

Device according to any one of the preceding claims, characterized in that the device is designed in such a way that rotation of the lid (7) from the closed position to the open position moves the container (3) and the housing (1 ) relative to the drive arm (10) to a position where the container (3) comes into contact with the underside of the top part (12) of the arm and causes the drive arm (10) to rotate away from the housing (1).