DK160617C - PROCEDURE FOR THE REMOVAL OF OLIGOMERS AND SLOW MONOMERS FROM LEUKOCYT INTERFERON (IFN-ALFA) PREPARATIONS - Google Patents

PROCEDURE FOR THE REMOVAL OF OLIGOMERS AND SLOW MONOMERS FROM LEUKOCYT INTERFERON (IFN-ALFA) PREPARATIONS

Info

Publication number
DK160617C
DK160617C DK498183A DK498183A DK160617C DK 160617 C DK160617 C DK 160617C DK 498183 A DK498183 A DK 498183A DK 498183 A DK498183 A DK 498183A DK 160617 C DK160617 C DK 160617C
Authority
DK
Denmark
Prior art keywords
ifn
oligomers
interferon
leukocyt
alfa
Prior art date
Application number
DK498183A
Other languages
Danish (da)
Other versions
DK160617B (en
DK498183A (en
DK498183D0 (en
Inventor
Paul Douglas Johnston
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of DK498183D0 publication Critical patent/DK498183D0/en
Publication of DK498183A publication Critical patent/DK498183A/en
Publication of DK160617B publication Critical patent/DK160617B/en
Application granted granted Critical
Publication of DK160617C publication Critical patent/DK160617C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/829—Blood

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

A method of removing oligomers and slow monomer from leukocute interferon (IFN- alpha ) having high sequence homology with human leukocyte interferon which method comprises: a) incubating a buffer solution containing 1-20 mg/ml of IFN- alpha at a pH between 3 and approximately 4.8 for 30 minutes-24 hours at 28-40 DEG C to precipitate oligomers and slow monomer followed by; b) recovering native IFN- alpha .
DK498183A 1982-11-01 1983-10-31 PROCEDURE FOR THE REMOVAL OF OLIGOMERS AND SLOW MONOMERS FROM LEUKOCYT INTERFERON (IFN-ALFA) PREPARATIONS DK160617C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/438,129 US4534906A (en) 1982-11-01 1982-11-01 Removal of impurities from human leukocyte interferon preparations
US43812982 1982-11-01

Publications (4)

Publication Number Publication Date
DK498183D0 DK498183D0 (en) 1983-10-31
DK498183A DK498183A (en) 1984-05-02
DK160617B DK160617B (en) 1991-04-02
DK160617C true DK160617C (en) 1991-09-16

Family

ID=23739353

Family Applications (1)

Application Number Title Priority Date Filing Date
DK498183A DK160617C (en) 1982-11-01 1983-10-31 PROCEDURE FOR THE REMOVAL OF OLIGOMERS AND SLOW MONOMERS FROM LEUKOCYT INTERFERON (IFN-ALFA) PREPARATIONS

Country Status (10)

Country Link
US (1) US4534906A (en)
EP (1) EP0108585B1 (en)
JP (1) JPS5998096A (en)
AT (1) ATE43639T1 (en)
AU (1) AU575304B2 (en)
CA (1) CA1211711A (en)
DE (1) DE3379964D1 (en)
DK (1) DK160617C (en)
IE (1) IE56181B1 (en)
ZA (1) ZA838109B (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8401911A (en) * 1984-06-15 1986-01-02 Stichting Rega V Z W ANTI-VIRAL PROTEIN, METHOD FOR PRODUCING THE SAME, AND PHARMACEUTICAL PREPARATIONS CONTAINING THIS PROTEIN.
US5196323A (en) * 1985-04-27 1993-03-23 Boehringer Ingelheim International Gmbh Process for preparing and purifying alpha-interferon
DE3515336C2 (en) * 1985-04-27 1994-01-20 Boehringer Ingelheim Int Process for the preparation and purification of â-interferon
US4961969A (en) * 1987-05-11 1990-10-09 Cetus Corporation Process for recovering microbially produced interferon-β
WO1989003225A1 (en) * 1987-10-06 1989-04-20 Interferon Sciences, Inc. Purification of monomeric interferon
US4765903A (en) * 1987-10-06 1988-08-23 Interferon Sciences, Inc. Purification of monomeric interferon
US5182369A (en) * 1990-02-28 1993-01-26 Monsanto Company Method for purifying somatotropin monomers
WO1995032222A1 (en) * 1994-05-19 1995-11-30 Monsanto Company Method for purifying somatotropin monomers
US6281337B1 (en) 1998-11-12 2001-08-28 Schering Corporation Methods for conversion of protein isoforms
CN100536919C (en) * 2001-01-09 2009-09-09 贝勒研究院 Interferon antagon and usage of Flt3L antagon
ITBO20010426A1 (en) * 2001-07-06 2003-01-06 Alfa Wassermann Spa PHARMACOLOGICALLY ACTIVE PROTEIN PURIFICATION PROCESS BY CATIONIC EXCHANGE CHROMATOGRAPHY
KR100531670B1 (en) * 2003-12-03 2005-11-28 씨제이 주식회사 Processes for preparing interferon alpha
PL2195338T3 (en) 2007-10-01 2014-05-30 Pharmaessentia Corp N-terminal modified interferon-alpha
AU2009330278B2 (en) 2008-12-23 2013-01-31 Merck Sharp & Dohme Corp. Purification of recombinantly produced interferon
EP3088409B1 (en) 2013-12-25 2019-02-06 Jellyfish Research Laboratories, Inc. Continuous production method for decomposition product from water-insoluble macromolecular compound

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA796175B (en) * 1978-11-24 1980-11-26 Hoffmann La Roche Purified proteins and process therefor
IN150740B (en) * 1978-11-24 1982-12-04 Hoffmann La Roche
FI77877C (en) * 1979-04-20 1989-05-10 Technobiotic Ltd Process for the preparation and purification of human Le-shaped interferon protein.
AU8736282A (en) * 1981-08-13 1983-02-22 American National Red Cross, The Filtration method for cell produced antiviral substances

Also Published As

Publication number Publication date
EP0108585A3 (en) 1985-07-31
DK160617B (en) 1991-04-02
DE3379964D1 (en) 1989-07-06
EP0108585A2 (en) 1984-05-16
JPH0434560B2 (en) 1992-06-08
IE832542L (en) 1984-05-01
US4534906A (en) 1985-08-13
ATE43639T1 (en) 1989-06-15
DK498183A (en) 1984-05-02
CA1211711A (en) 1986-09-23
AU2085583A (en) 1984-05-10
ZA838109B (en) 1984-09-26
JPS5998096A (en) 1984-06-06
AU575304B2 (en) 1988-07-28
IE56181B1 (en) 1991-05-08
EP0108585B1 (en) 1989-05-31
DK498183D0 (en) 1983-10-31

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