DK159812B - QUICK-DRY, STABLE, SLIM POWDER SUSPENSION, ITS APPLICATION AND PROCEDURE FOR ITS PREPARATION - Google Patents

Description

in

DK 159812 B

The present invention relates to a quick-drying, stable, powerful suspension of finely divided solid particles, the use of the suspension, and a method of preparing the suspension uniformly suspended in a carrier comprising a high alcohol content of a lower aliphatic monovalent alcohol. and a low water content, and hydroxyethyl cellulose as a suspending agent, and having particular utility in medical lotions and personal hygiene products such as rollons, dance shoes, lotions and on various substrates such as 10 deodorant pads.

Alcohol-based products are generally preferred because of their quick-drying and excellent solubilizing properties. However, inorganic salts are generally insoluble in alcohol, so preparations thereof require higher water-alcohol ratios, resulting in wetter products which dry more slowly. Salt concentrations are also limited by their solubility in such systems. On the other hand, the solubility of organic compounds (e.g., perfumes) depends on a high alcohol content, unless they are emulsified, and therefore compromises are usually required. Certain salts, such as sodium bicarbonate, decompose in water or water / alcohol solutions and are converted to sodium carbonate and therefore a powder suspension must be used.

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The present novel aqueous alcoholic suspensions containing hydroxyethyl cellulose as the major suspending agent make it possible to use alcohol soluble and insoluble ingredients in fast drying products containing a high alcohol content.

The prior art is full of compositions containing hydroxyethyl cellulose, as a thickener as such or in combination with other thickeners, as disclosed in U.S. Patent No. 4,002,881, which relates to a dentifrice, and in U.S. Patent No. 4,145. 413, which relates to a means of darkening the skin. The hydroxyethyl cellulose forms an aqueous gel in said compositions, thereby causing a thickening.

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Another group of compositions utilizing hydroxyethyl cellulose as a means of regulating drug release of a drug tablet are sustained release therapeutic compositions, as described in U.S. Patents No. 3,136.

5,695, 4,235,870 and 4,167,558.

Hydroxyethyl cellulose has also been used as a stabilizer for a composition containing the prostaglandin E group, as shown in U.S. Patent No. 4,036,954, and as a film-forming carrier for a drug, as disclosed in U.S. Patent No. 4,136,162.

Stable aqueous dispersions or suspensions of solids or water-insoluble compounds containing hydroxyethyl cellulose as one of a stabilizing or suspending combination are described in U.S. Patent No. 3,258,326, which relates to a solid pesticidal agent in aqueous media, and in U.S. Pat. No. 3,927,205, which discloses an aqueous suspension of a water-insoluble or sparingly soluble pharmaceutical. U.S. Patent No. 3,387,222 discloses an aqueous solution or suspension of a therapeutic agent containing hydroxyethyl cellulose as a thickening agent and useful as an impregnating agent for a synthetic medical compound.

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U.S. Patent No. 3,290,218 further discloses that an aqueous or non-aqueous suspension of water-insoluble ethyl cellulose provides a stable suspension of a pharmaceutical or cosmetically active solid. It is essential that the ethyl cellulose-3Q solution be substantially insoluble in the aqueous or non-aqueous carrier liquids.

Aqueous ethanol solutions of sodium or potassium bicarbonate as deodorant products are described in British patent no.

35, 1,553,739. Although these bicarbonate solutions are effective deodorants, armpit irritation has been observed at an amount of potassium bicarbonate of approx. 10%. It has also been found to be watery

DK 159812 B

3 or aqueous / alcoholic sodium bicarbonate solutions are pH stable.

Aging studies have shown that the bicarbonate in solution 5 decomposes and releases CO 2 and gradually converts to sodium carbonate (a known skin irritant). Bicarbonate solutions also have dissolution constraints. Relatively large amounts of water are required for higher amounts of bicarbonate. As a result, less alcohol is allowed, resulting in wetter and longer-summer drying products. Furthermore, preparation of sodium bicarbonate solutions above 6.9% is impossible due to its limited water solubility.

The prior art also discloses aerosol suspension in ones dispensed via a pressurized container containing sodium bicarbonate suspended with propellants in a 50:50 mixture of U.S. Patent No. 2,959,225, and alkali metal bicarbonate in a 0. 3 to 15% propellant soluble carrier such as ethanol with approx.

90% propellant in British Patent No. 1,476,117. The difficulties and disadvantages of sodium or potassium bicarbonate aerosol suspensions discussed in the aforementioned patents include precipitation and / or agglomeration of the dry particles, clogging of the dispensing nozzle, non-uniform spraying of deodorant material, lack of deodorant material, -25 night deodorant on the sprayed area, due to the return of the dry powder and / or too wet spray liquid resulting in too long a drying time, besides being detrimental to the environment.

30 However, there is no description of a stable suspension of finely divided solids in an aqueous alcoholic medium, such as ethanol, containing a high alcohol content and a minimal water content, using hydroxethyl cellulose as the major suspending agent.

The object of the present invention is to provide a stable, fast-drying mucous powder suspension in an alcoholic

DK 159812 B

medium containing a minimal amount of water, and a critical amount of hydroxyethyl cellulose as suspending agent in amounts above its normal solution! in the alcoholic medium, which suspension requires no or little shaking before use, especially a suspension in which the powder is alkali metal bicarbonate.

The powder suspension according to the invention is characterized in that the amount of hydroxyethyl cellulose exceeds the solubility of the water-soluble hydroxyethyl cellulose in the alcohol, and the water content is sufficient to prevent precipitation of the suspending agent and at least 5% by weight.

More particularly, the present invention relates to a suspension in which the suspended powder consists of alkali metal bicarbonate particles and is 1-20 w / w%. The alcoholic medium may be a lower monovalent alcohol selected from the group consisting of methanol, ethanol, isopropanol and mixtures thereof. The use of polyhydric alcohols, such as propylene glycol, butylene glycol and polyols thereof, and glycerine reduce the critical amount of water required in the hydroxyethyl cellulose-containing alcoholic medium. Addition of alcohol-soluble compounds such as oils, perfumes, etc. has no detrimental effect on the properties of the present aqueous alcoholic powder suspensions. Also, the presence of co-suspending agents such as silica, bentonite and the like has no detrimental effect on the aqueous alcoholic pulse versus suspensions of the invention.

30 Surprisingly, it has been found that powders can be suspended in alcoholic / aqueous media containing a high alcohol content and a low water content by using the water-soluble hydroxyethyl cellulose in amounts above its alcohol solubility which can be increased by special polyhydric alcohols. This polymer 35 is unique in its ability to form stable suspensions.

Although hydroxyethyl cellulose is usually considered a thickener for aqueous type systems, it has shown

DK 159812B

5 having unusual suspending properties in high alcoholic aqueous alcoholic systems. Such suspensions are cool and slimy and provide excellent suspending properties. This suspending agent provides exceptionally stable mucus-like suspensions without any powder excretion after 13 weeks at -18 ° C, 4 ° C, ambient temperature, 35 ° C, 43 ° C and 49 ° C, and requires no shaking prior to use. This unexpected property of forming a stable mucosal powder suspension in a high alcohol and low water content medium is not borne by other cellulose derivatives such as hydroxypropyl cellulose, sodium carboxymethyl cellulose, hydroxypropyl methyl cellulose (methocel) and other water-soluble polymers. Using 10% micropulvered sodium bicarbonate as the particulate material to be suspended in an alcoholic / aqueous medium containing 25% water, the suspending properties of other water-soluble cellulose-like gums were tested by the addition of 0.4% hydroxypropylmethylcellulose, , 4% hydroxypropyl cellulose, or 0.8% sodium carboxymethyl cellulose. It was found that all of the above samples separated a clear 20 water layer from above, the separation occurring within minutes. The physical appearance of the desired suspension is the formation of a slimy liquid that appears cool when poured. The present novel alcoholic / aqueous hydroxyethyl cellulose-containing media provide excellent suspending properties for 25 powders of excellent stability over a wide temperature range.

The products are delivered well from roll-on and pump dispensers. The toughness of the hydroxyethyl suspension system is believed to be due to its better suspending properties.

In addition to the hydroxyethyl cellulose, which is the major suspending agent, it is optional to use co-suspending agents such as finely divided silica (Cab-O-sil) or concreteite in combination with hydroxyethyl cellulose. The hydroxyethyl cellulose as such constitutes approx. 0.1 to 1%, and the finely divided silica or bentonite constitutes approx. 0.1 to 1%, and the total amount is preferably about 0.9 to 2% by weight of the total composition.

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The particulate material suspended in the alcoholic / aqueous carrier may be any inorganic or organic salt which is insoluble in alcohol, such as sodium or potassium bicarbonate, zinc decylene, pigments, certain aluminum or zirconium compounds and the like. In particular, the suspended powder which is insoluble in alcohol may be selected by the group consisting of an inorganic or organic metal salt, pigment, mineral, polymer or salt thereof, or powders derived from grains.

It has been found that high amounts of the salt or other powdered material can be suspended in the present alcoholic / aqueous media containing hydroxyethyl cellulose as the suspending agent. Hereby large quantities of particulate material can be incorporated into stable alcoholic / aqueous media.

It is preferred to use microp powdered powder, having a particle size of approx. 5 to 100 microns and preferably 10 to 25 microns. The smaller the particles, the easier it is to suspend them in the carrier, and the resulting product gives a non-grainy smooth feel when applied and dried on the skin.

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Although powder suspensions have essentially no concentration limits and can be used with any desired effective amount, amounts up to approx. 50% and as low as 1% are suspended.

The carrier in which the particulate material is suspended comprises an alcoholic aqueous medium, the alcohol being a monovalent alcohol which is a lower alkanol such as ethanol, isopropyl alcohol or methanol. Polyhydric alcohols may be used in part instead of the monovalent alcohol but do not exceed the content of monovalent alcohol. Suitable polyhydric alcohols include glycerine, propylene glycol, butylene glycol and polyglycols thereof. The content of hydroxyethyl cellulose must exceed the solubility of the water-soluble hydroxyethyl cellulose in the alcoholic medium. The solubility of this water-soluble polymer in ethanol is 70% by weight. Below this level is obtained a uniform viscous liquid that can be poured evenly.

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Although it has an aesthetically pleasing appearance, it cannot carry suspended powder and excretion will occur. At concentrations above the solubility, the hydroxyethyl cellulose forms the desired mucous liquid type. A 70:30 ratio of 5 ethanol to water is therefore optimal. However, it was found that this problem can be eliminated by sufficient addition of a polyhydric alcohol such as glycerine, propylene glycol, butylene glycol and polyglycols thereof. It has therefore been found that the monovalent alcohol constitutes approx. 55 to 85% and the water content 10 may be as low as 5% if at least 10% polyhydric alcohol is present in the suspension. The combined content of water and polyhydric alcohol is at least approx. 15% and can be up to approx. 30%, while the water content as such can be up to approx. 25%. Thus, it is clear that the amounts of monovalent alcohol, water and polyhydric alcohol are interdependent.

The mucous aqueous alcoholic suspensions of the invention may be used to prepare solid or semi-solid alcohol-based products such as sticks or creams. They have proven particularly useful in the manufacture of roll-on deodorants, deodorant sticks, medical lotions, medical rubbing preparations and other quick-drying cosmetic preparations.

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They have shown particular use in the preparation of fast-drying stable bicarbonate-containing deodorant products which require no or little shaking before use. These deodorant preparations using suspensions of sodium or potassium bicarbonate have been found to be less irritating to the skin than bicarbonate solutions.

The deodorant product may also be formulated as a deodorant pin by the addition of a fatty acid salt such as sodium stearate as a gelling agent. A sodium salt of a saturated higher fatty acid containing 14 to 22 carbon atoms, such as myristin, palmitin, stearin, etc. has been shown to be effective as a gelling agent in

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8 to form a solid pin, whereas the lower fatty acid salts and the unsaturated fatty acid salts do not act as gelling agents therein. The resultant pin is a solid mucous suspension of deodorant active ingredient in an alcoholic / aqueous medium.

5

This use as an intermediate of the mucous suspension prevents secretion after hot pouring into containers and allows a longer cooling period to solidify. This is particularly advantageous, because in the usual solidification of 10 heat suspension preparations, rapid cooling, which is usually approx. 1 to 5 minutes, necessary to avoid suspension of suspended particles. With the present slime-like suspensions, the suspended particles are not separated or precipitated and there is longer time for cooling, which is to be done when forming a solid pin.

The suspension deodorant products may also contain non-volatile polar or non-polar constituents to effect deposition of a dry non-sticky invisible film on the skin upon evaporation and not a white bicarbonate residue. These non-volatile agents include polyhydric alcohols such as glycation, propylene glycol, butylene glycol and polyglycols thereof, and emollient oils such as wheat germ oil and any other alcohol soluble oils including isopropyl myristate, isopropyl palmitate, other fatty esters, fatty esters, fatty ethers such as stearyl ether, ethoxylated fatty alcohols and acids. The amount of plasticizer present is less approx. 1 to 5%. It has also been found that the presence of smaller amounts of lipophilic agents such as oils, silicone, lecithin and 30 waxes and / or water-insoluble resins and polymers in this deodorant suspension product will regulate bicarbonate release in the armpit. It has been observed that a bicarbonate roll-on deodorant suspension containing wheat germ oils and steryl aryl oils forms a water resistant film when dry, which may explain the gradual release of bicarbonate into the armpit and reduce the risk of skin irritation. Experimental results have shown that most of the bicarbonate is released in solution 9

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bet of 15 minutes with increasing volumes through periods of 1 hour and 6% hour, showing a timed release property of the dry film. Other deodorant agents may be used in place of the active bicarbonate component.

5

In addition to the essential components of the present agent, minor amounts of such components as perfumes, colorants, ultraviolet light absorbing agents, and the like may be included to enhance the aesthetic value and consumer acceptance of the product. Salts or pH buffers can be dissolved or suspended in the present alcoholic / aqueous suspension product if desired. Smaller amounts of other ingredients which have no detrimental effect on the beneficial properties of the present agents may also be included.

Known bacteriostats may also be added. However, a bicarbonate suspension is effective as a deodorant without the use of added bacteriostats.

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The suspensions of the invention have found utility in personal hygiene deodorant products such as roll-on, dance shoes, on substrates such as deodorant pads, foot lotions and body lotions.

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Another use of the present mucous aqueous alcoholic media is to prepare fast-drying stable drug lotions containing a particulate active ingredient such as zinc aundecylenate and other antifungal / antibacterial agent which can be dispensed via a pump or by simple spreading of the fingers. The same additives can be included in the drug lotions as in the deodorant products.

The process for preparing the stable mucous pulse counter-suspensions of the invention generally comprises combining a heated aqueous or aqueous / monovalent or polyhydric alcoholic mixture containing hydroxyethane.

DK 159812 B

10 yl cellulose as a suspending agent with a monovalent alcoholic dispersion of a particulate material such as an alkali-1-metal bicarbonate or, zinc -undecylenate or the like, which may contain another suspending agent, and mixing until a thick stable mucous, tough suspension is formed. Specifically, a clear portion 1 consisting of a viscous solution of hydroxyethyl cellulose is prepared by heating and mixing with water, or an aqueous mixture of monovalent or polyhydric alcohol to a temperature of ca. 54 to 60 ° C. Part 2, 10, preferably homogenized dispersion of part in curd shaped material in a monovalent alcohol with or without a suspending agent is added under mixing to part 1 to form a thick uniform mucosal tough suspension wherein the solid particles are uniformly suspended and remain in suspension. . The perfume, coloring agents, plasticizers and other optional ingredients may be added to the alcoholic particulate dispersion before being added to the aqueous / alcoholic viscous hydroxyethyl cellulose solution or afterwards. The final suspension is preferably homogenized to produce a homogeneously finely thick mucus suspension product. If a pin is desired, a suitable gelling agent, such as a sodium salt of a saturated C14-C22 fatty acid (e.g., myristic acid, palmitic acid, stearic acid, etc.), is dissolved in part 1 and the final mucous suspension is poured into pin containers and allowed to dry at room temperature. The final product is a solid, slimy suspension of powder in an alcoholic / aqueous medium containing hydroxyethyl cellulose.

Another method of preparing stable mucosal particulate suspensions consists in adding, in succession, the ingredients to a heated solution (about 60 ° C) of water and alcohol, with stirring and / or homogenization. More particularly, the hydroxyethyl cellulose is added to the hot aqueous / alcoholic solution, followed by the monovalent alcohol and followed by another suspending agent, if desired, and then the particulate material, followed by the perfume, the color or other optional ingredients.

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This method gives a thinner suspension than when using the aforementioned two-part method. However, both methods first require the preparation of a viscous aqueous hydroxyethyl cellulose solution before adding final amounts of monovalent alcohol. The order of addition and preparation methods are therefore important to obtain the desired mucous suspension.

The following concrete examples further illustrate the invention. All amounts of various components are by weight, unless otherwise stated.

EXAMPLES 1-4

Part 1 12 2 å

Deionized water 15.00 15.00 5.00 15.00

Propylene Glycol - 10.00 10.00 SD 40 Ethanol 10.00 - 15.00 Natrosol 250 HR (1) 0.40 0.40 0.40 0.40

Part 2 12 3 4 SD 40 Ethanol 63.15 60.65 70.65 56.10

Cab-O-Sil (2) 0.50 0.50 0.50 0.50 Sodium Ribicarbonate 10.00 10.00 10.00 5.00 (Micropulverized)

Zinc rincinoleate ~ "5.00

Part 3 1 2 2 2 30 "Λ

Perfume 0.50 0.50 0.50 0.50 FD&C Green No. 0.30 0.30 (0.1%) 35

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12

Part 3 (continued) .1 2 ^ 3 4 D&C Green No. 0.15 0.15 (2.75%)

Arlamol E1 - 1.50 1.50 1.50 (4)

Wickenol 535v - 1.00 1.00 1.00 100.00 100.00 100.00 5 pH 1% aqueous solution 8.45 -

Appearance Thick, Thick, Thick, Lotion viscous viscous viscous consistency • slimy slimy slimy slimy suspension suspension suspension suspension

Example 1 quickly dries to an even dry non-sticky white powder on the skin.

Examples 2, 3 and 4 dry to an even dry non-sticky 10 invisible film on the skin.

No examples show any excretion of bicarbonate or liquid upon standing, and no one requires shaking before use and none is irritating to the skin.

Aging experiments over a period of 2 weeks at room temperature, 15 4 ° C and 43 ° C show no excretion of bicarbonate.

Preparation of Examples.

Step 1.

Part 1 (all examples): disperses natrosol in either ethanol or propylene glycol. Add water under constant mixture 20 and heat to 54-60 ° C until a uniform clear viscous solution is formed.

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Step 2.

Part 2 (Examples 1-3): Disperse Cab-O-Sil in alcohol and gradually add sodium bicarbonate with rapid mixing.

Homogenize to uniformity.

5 (Example 4) dissolve zinc castinoleate in hot ethanol. Add sodium bicarbonate and Cab-O-Sil and mix. Homogenize to uniformity.

•

Step 3.

Add part 2 to part 1 while mixing (forming a thick 10 slimy 'tough suspension').

Step 4.

Part 3 · Mix all ingredients with Parts 1 and 2. Homogenize the mixture to a thick uniform mucous suspension.

^ Natrosol 250 HR: Hercules Inc., Hydroxyethyl Cellulose.

(2) Cab-O-Sil: Cabot Corporation, finely divided silica.

(3)

Arlamol E: I.C.I. American Inc., Polyoxypropylene Stearyl = Ether.

(4)

Wickenol 535: Wickhen Products Inc., Wheat germ glycerides. EXAMPLE 5 Component%

Propylene glycol 10.0

Bentone LT (1) 0.5

Deionized water 15.0

Sodium bicarbonate Microp powder 10.0 25 SD 40 Ethanol 64.5 100.0 14

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This example also forms a good uniform mucus suspension, with bentone LT being a combination of hydroxyethyl cellulose and bentonite clays. This example shows the specificity of this particular suspending agent to form a stable mucous viscous suspension in accordance with the present invention.

Preparation of Example 5 1. Disperses bentone LT in propylene glycol.

2. Add water and heat to 54-60 ° C until mixture 10 is uniformly viscous.

3. Add sodium bicarbonate and mix continuously.

4. Add alcohol, mix completely until uniform and homogenize.

^ Bentone LT: NL Industries Gellant is an organols material designed for low molecular weight systems of polar solvent / water, and 100% water systems. It is a combination of hydroxyethyl cellulose and bentonite clay.

EXAMPLE 6

Example 2 is repeated except that the stearyl ether and wheat germ glycerides are omitted and the ethanol content is increased to 63.15%. This product provides a stable uniform mucus suspension with high viscosity, of which the bicarbonate particles do not secrete upon standing but remain in suspension. When used in a 2.5 cm roll-on container, this product provides good dispensing and quick drying to form an invisible film on the skin.

DK 159812B

EXAMPLES 7 and 8.

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Roll-on deodorant Medical rub ± ngs ~ - preparation

Part 1 --

Water 15.00 17.0 5 Propylene Glycol 10.00 10.0

Natrosol 250 HR (1) 0.40 0.4

Part 2 SD 40 Ethanol 60.40 64.3

Cab-O-Sil (2) 0.50 0.5 3_0 Sodium Bicarbonate 10.00 (Microp Powdered)

Zincundecylenate - 5.0

Part 3

Wheat germ glycerides 1.00 1.0 15 Arlamol E (3) 1.50 1.5

Perfume 0.50 0.3

Color solution 0.65

Uvinul D-50 (5) 0.05 100.00 100.00 (5)

Absorbent for ultraviolet light, 2,4-dehydroxybenzo = phenone: GAF Corporation.

Course of action.

Part 1

Combine water and propylene glycol and gradually add natrosol while mixing. Heat to 60 ° C to form a uniformly wiped mixture.

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Part 2

Homogenize Cab-O-Sil and then bicarbonate or zinc = undecylenate in ethanol. Gradually add part 2 to dell while mixing.

5 Part 3

While mixing, add part 3 ingredients to parts 1 and 2, then homogenize the entire mixture.

Results.

Both products form a cool slimy white opaque 10 liquid with excellent suspending properties. No appreciable excretion of sodium bicarbonate in Example 7 is observed after 13 weeks of storage within a wide temperature range.

EXAMPLE_7 Stability at various temperatures (unshaken)

Temperature conditions -18 ° C 4 ° C Room temperature. 35 ° C 43 ° C 49 ° C

% NaHCO3 10.6 10.5 10.6 10.6 10.3 10.1

Analyzed (upper 0.6 cm of the sink) 20 Shaken control at room temperature = 10.7.

The following examples illustrate the effect of the amounts of water on the formation and stability of the desired suspensions and the advantage of adding a polyhydric alcohol to low moisture preparations.

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EXAMPLES 9-14

Example 9 1 £ 11 12 13 14

Part 1. % % % % % %

Water 37.7 25.0 15.0 15.0 5.0 15.0

Propylene glycol 10.0 - - 10.0 20.0

Glycerin - - - - - 10.0

Natrosol 0.4 0.4 0.4 0.4 0.4 0.4 0.4

Part 2.

SD 40 Ethanol 37.7 64.4 74.6 64.6 60.4 64.6

Cab-O-Sil 0.5- - - 0.5

Sodium bicarbonate 10.0 10.0 10.0 10.0 10.0 10.0 (Microp Powdered)

Part 3.

Consists of oils, perfume 3.7- - - 3.7-

Color, UV

absorbent 0.2 agent _ _ _ _ _ _ 100.0 100.0 100.0 100.0 100.0 100.0

Example i) 1 £ 1]. 12_ 1_3 14

Appearance: single-non-slimy-slimy-slimy-like gay-like

Stability: sepa- stable sepa- stable stable stabilized ration at standstill

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1.8 'i 10 U 12 13 14

Notes: over-water-unsatisfied Satisfied satisfaction of high-stressed-posing pos- sible still water approxi- mately propylene-propylene- propylene-rich water glyoolcamoglycolccm-glycolcom- to a little retirement pension retirement.

surplus

Course of action:

Similar procedures, as used in Examples 7 and 8, except for composition 13. Half of the amount of propylene glycol is combined with water added to natrosol, and the mixture is heated to 60 ° C and mixed until uniformly thick. The rest of the propylene glycol is added and mixed before adding part 2.

Stability after 5 weeks (room temperature, unshaken).

Example 10 12 13 14% NaHCO 3 10.3 10.6 10.5 10.1

Analyzed (upper 0.6 cm of fluid) Example 15 15 Medical lotion for rubbing.

Part 1 %

Deionized water 24.0

Hydroxyethyl cellulose 0.4

Isopropanol 15.0 Part 2

Isopropanol 53.1

Cab-O-Sil 0.5 19

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Part 2 (continued) Z incundecylenate 5.0

Perfume 0.5

Zinc stearate 1.5

Course of action; Part I Dispersate the hydroxyethyl cellulose in alcohol, add water and heat the mixture with stirring to 60 ° C.

Part 2: Add Cab-O-Sil to alcohol and mix well. Add zinc cecylenate and mix the dispersion well. Add zinc stearate and perfume and mix. Mix parts 1 and 2.

10 A thick, slimy gel of cream texture is formed.

After application to the skin, it has a very smooth feel and is reasonably water-resistant under water.

EXAMPLE 16

Example 8 is repeated except that the water content is reduced to 14% and the ethanol content is increased to 67.3%.

The resulting product is a good suspension with a cool consistency.

EXAMPLE 17

Deodorant diocese.

20 — L ·. in

Deionized water 5.0

Propylene Glycol (Part 1) 10.0

Hydroxyethyl cellulose 0.4

Propylene Glycol (Part 2) 15.0 Sodium Stearate 6.0 20

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Part 2. %

Anhydrous ethanol 53.1

Cab-O-Sil 0.5

Micropulverized NaHCO® 10.0 5 Part 1: Mix the water and part 1 propylene glycol and add hydroxyethyl cellulose. Heat the mixture to 60-66 ° C until a viscous gel is formed. Part 2 propylene glycol is added and mixed well to form a homogeneous thick gel solution. Sodium 10 stearate is added and the mixture is heated to 66-71 ° C until the sodium stearate is completely dissolved.

Part 2: Cab-O-Sil is dispersed in ethanol and sodium bicarbonate is added and mixed until uniformly dispersed and suspended. The mixture is heated to 15 to approx. 57 ° C.

Part 2 is added to part 1 under mixing to form a viscous mucous suspension which is poured into pin containers and allowed to cool to room temperature. There is no visible separation. An excellent suspension in pin 2q is obtained which is smooth on application and non-sticky.

Other polyhydric alcohols may be used in place of propylene glycol or glycerine in whole or in part in the above examples, such as butylene glycol, polypropylene glycol, etc.

Similarly, ethanol and isopropanol can be replaced with methanol. Likewise, other particulate material may be used in place of sodium bicarbonate and zinc ounceylate, such as potassium bicarbonate, inorganic or organic salts or other alcohol-insoluble powders.

Claims (9)

A rapidly drying, stable mucous powder suspension of finely divided solid particles uniformly suspended in a carrier comprising a high alcohol content of a lower aliphatic monovalent alcohol and a low water content, and hydroxyethyl cellulose as the suspending agent, characterized in that the amount of hydroxyethyl cellulose exceeds the solubility of the water-soluble hydroxyethyl cellulose in the alcohol and the water content is sufficient to prevent precipitation of the suspending agent and at least 5% by weight Suspension according to claim 1, characterized in that the suspended powder consists of alkali metal bicarbonate particles and is 0.1-20 w / w%. Suspension according to claim 1, characterized in that 2q of the suspended powder consists of zinundecylate. Suspension according to claim 1, characterized in that it contains a polyhydric alcohol in an amount which does not exceed the content of monovalent alcohol and is sufficient to prevent precipitation of the suspending agent. Use of the suspension according to claim 1 for the preparation of a solid suspension. DK 159812B Use according to claim 5, characterized in that a sodium salt of a saturated C14-C22 fatty acid as a gelling agent is dissolved in the heated hydroxyethyl cellulose solution before mixing with the alcoholic dispersion of the powdered material and the slime-like suspension is poured into pin containers and allowed to cool to room temperature. Use of the suspension according to claim 1 for the preparation of a viscous lotion. Process for preparing the suspension according to claim 1, characterized in that a viscous aqueous hydroxyethyl cellulose solution is first prepared before the addition of the monovalent alcohol and the powdered material. Process for the preparation of the mucous suspension according to claim 1, characterized in that a clear viscous aqueous or aqueous alcoholic solution of hydroxyethyl cellulose heated to a temperature of approx. 54-60 ° C, and this heated viscous solution is mixed with a monovalent alcohol dispersion of the powdered material until a viscous mucous suspension is formed with the powdered particles uniformly suspended therein. 25 30 35