DK1578969T3 - Fremgangsmåde til optimering af genekspression ved anvendelse af synonym codonoptimering - Google Patents
Fremgangsmåde til optimering af genekspression ved anvendelse af synonym codonoptimeringInfo
- Publication number
- DK1578969T3 DK1578969T3 DK03810343.8T DK03810343T DK1578969T3 DK 1578969 T3 DK1578969 T3 DK 1578969T3 DK 03810343 T DK03810343 T DK 03810343T DK 1578969 T3 DK1578969 T3 DK 1578969T3
- Authority
- DK
- Denmark
- Prior art keywords
- gene expression
- codon optimization
- synonymous codon
- codon
- organism
- Prior art date
Links
- 108020004705 Codon Proteins 0.000 title abstract 4
- 230000014509 gene expression Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000005457 optimization Methods 0.000 title 1
- 108091033319 polynucleotide Proteins 0.000 abstract 3
- 102000040430 polynucleotide Human genes 0.000 abstract 3
- 239000002157 polynucleotide Substances 0.000 abstract 3
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
- C12N15/8274—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for herbicide resistance
- C12N15/8277—Phosphinotricin
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Cell Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US42516302P | 2002-11-08 | 2002-11-08 | |
PCT/AU2003/001487 WO2004042059A1 (en) | 2002-11-08 | 2003-11-10 | A method for optimising gene expression using synonymous codon optimisation |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1578969T3 true DK1578969T3 (da) | 2010-08-02 |
Family
ID=32312937
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK03810343.8T DK1578969T3 (da) | 2002-11-08 | 2003-11-10 | Fremgangsmåde til optimering af genekspression ved anvendelse af synonym codonoptimering |
Country Status (10)
Country | Link |
---|---|
US (2) | US20060292566A1 (da) |
EP (1) | EP1578969B1 (da) |
JP (1) | JP2006506986A (da) |
AT (1) | ATE463570T1 (da) |
AU (1) | AU2003275776B2 (da) |
DE (1) | DE60332041D1 (da) |
DK (1) | DK1578969T3 (da) |
ES (1) | ES2346525T3 (da) |
NZ (1) | NZ539893A (da) |
WO (1) | WO2004042059A1 (da) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE456666T1 (de) * | 2004-05-26 | 2010-02-15 | Anima Cell Metrology | Verfahren zur auswertung von ribonukleotidsequenzen |
US20080044853A1 (en) * | 2004-06-21 | 2008-02-21 | Novozymes A/S | Stably Maintained Multiple Copies of at Least Two Orf in the Same Orientation |
EP1766397B1 (en) * | 2004-06-30 | 2016-03-09 | DiscoveRx Corporation | Analysis of intracellular modifications |
HUE025440T2 (en) | 2006-10-24 | 2016-04-28 | Basf Se | A method for reducing gene expression using modified codon usage |
US9012152B2 (en) | 2007-01-09 | 2015-04-21 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Anti-bacterial peptides and methods of treating diseases using same |
WO2008144012A2 (en) * | 2007-05-14 | 2008-11-27 | The Regents Of The University Of California | Xylose- and arabinose- metabolizing enzyme -encoding nucleotide sequences with refined translational kinetics and methods of making same |
AU2008314485B9 (en) * | 2007-10-15 | 2015-02-26 | Jingang Medicine (Australia) Pty Ltd | Expression system for modulating an immune response |
JP5396071B2 (ja) | 2008-12-05 | 2014-01-22 | 独立行政法人海洋研究開発機構 | 細胞の増殖を抑制する方法 |
WO2011036666A2 (en) * | 2009-09-24 | 2011-03-31 | Anima Cell Metrology, Inc. | Systems and methods for measuring translation of target proteins in cells |
US9795658B2 (en) | 2010-04-20 | 2017-10-24 | Admedus Vaccines Pty Ltd | Expression system for modulating an immune response |
EP2394667A1 (en) * | 2010-06-10 | 2011-12-14 | Laboratorios Del Dr. Esteve, S.A. | Vectors and sequences for the treatment of diseases |
KR101263806B1 (ko) | 2011-09-29 | 2013-05-13 | 한국과학기술정보연구원 | 유전체 시퀀스 내 코돈 상관 관계 패턴 계산 방법 및 장치 |
WO2016102569A1 (en) | 2014-12-22 | 2016-06-30 | Veterinærinstituttet | Salmon gill poxvirus |
US10724040B2 (en) | 2015-07-15 | 2020-07-28 | The Penn State Research Foundation | mRNA sequences to control co-translational folding of proteins |
US10806749B2 (en) * | 2015-12-25 | 2020-10-20 | Sbi Biotech Co., Ltd. | TLR inhibitory oligonucleotides and their use |
US11492636B2 (en) | 2016-10-17 | 2022-11-08 | Whitehead Institute For Biomedical Research | Modified bialaphos resistance acetyltransferase compositions and uses thereof |
WO2023026292A1 (en) * | 2021-08-25 | 2023-03-02 | Ramot At Tel-Aviv University Ltd. | Optimized expression in target organisms |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5689052A (en) * | 1993-12-22 | 1997-11-18 | Monsanto Company | Synthetic DNA sequences having enhanced expression in monocotyledonous plants and method for preparation thereof |
US5795737A (en) * | 1994-09-19 | 1998-08-18 | The General Hospital Corporation | High level expression of proteins |
US6114148C1 (en) * | 1996-09-20 | 2012-05-01 | Gen Hospital Corp | High level expression of proteins |
WO1999002694A1 (en) * | 1997-07-09 | 1999-01-21 | The University Of Queensland | Nucleic acid sequence and method for selectively expressing a protein in a target cell or tissue |
AUPP807899A0 (en) * | 1999-01-08 | 1999-02-04 | University Of Queensland, The | Codon utilization |
AUPP807799A0 (en) * | 1999-01-08 | 1999-02-04 | University Of Queensland, The | Polynucleotide and method |
AU2001238163A1 (en) * | 2000-03-07 | 2001-09-17 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Cdna encoding a trag gene (tgf- beta resistance associated gene) and its protein product |
-
2003
- 2003-11-10 WO PCT/AU2003/001487 patent/WO2004042059A1/en active Application Filing
- 2003-11-10 US US10/534,130 patent/US20060292566A1/en not_active Abandoned
- 2003-11-10 ES ES03810343T patent/ES2346525T3/es not_active Expired - Lifetime
- 2003-11-10 DE DE60332041T patent/DE60332041D1/de not_active Expired - Lifetime
- 2003-11-10 EP EP03810343A patent/EP1578969B1/en not_active Expired - Lifetime
- 2003-11-10 JP JP2004548944A patent/JP2006506986A/ja active Pending
- 2003-11-10 DK DK03810343.8T patent/DK1578969T3/da active
- 2003-11-10 AT AT03810343T patent/ATE463570T1/de active
- 2003-11-10 AU AU2003275776A patent/AU2003275776B2/en not_active Ceased
- 2003-11-10 NZ NZ539893A patent/NZ539893A/en not_active IP Right Cessation
-
2012
- 2012-09-14 US US13/619,345 patent/US20130074218A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU2003275776B2 (en) | 2009-06-18 |
JP2006506986A (ja) | 2006-03-02 |
AU2003275776A1 (en) | 2004-06-07 |
EP1578969A1 (en) | 2005-09-28 |
WO2004042059A1 (en) | 2004-05-21 |
US20130074218A1 (en) | 2013-03-21 |
NZ539893A (en) | 2008-06-30 |
ES2346525T3 (es) | 2010-10-18 |
ATE463570T1 (de) | 2010-04-15 |
EP1578969B1 (en) | 2010-04-07 |
US20060292566A1 (en) | 2006-12-28 |
DE60332041D1 (de) | 2010-05-20 |
EP1578969A4 (en) | 2007-01-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK1578969T3 (da) | Fremgangsmåde til optimering af genekspression ved anvendelse af synonym codonoptimering | |
CR10933A (es) | Mezclas fungicidas que comprenden 1-metilpirazol-4-ilcarboxanilidas sustituidas | |
ATE550729T1 (de) | Verfahren und vorrichtung zur codeverschleierung | |
MX2007004884A (es) | Generacion de plantas con contenido alterado de aceite. | |
TW200627740A (en) | Earthquake-safe server-rack | |
DK1402075T3 (da) | Udvikling af egnede mutationer til svækkelse af dengue-vira samt kimære dengue-vira | |
TW200504893A (en) | Heat pipe with temperature control | |
MY137984A (en) | Progressive addition lenses with adjusted image magnification. | |
DE602005020027D1 (de) | Verfahren und computerprogramm zum anpassen der farbe einer benutzeroberfläche eines mobilkommunikationsgeräts und entsprechendes mobilkommunikationsgerät | |
DK1667513T3 (da) | Fremgangsmåde til beskyttelse af græs ved anvendelse af en endofyt. | |
ATE535901T1 (de) | Vorrichtung und verfahren zur ansteuerung einer bildanzeigevorrichtung | |
TW200710563A (en) | An optical pellicle with a filter and a vent | |
TW200721809A (en) | Method for exposure compensation using a flashlight of a camera | |
FR2889319B1 (fr) | Procede de detourage d'une lentille ophtalmique avec reacquisition d'un referentiel de centrage initial | |
DE602004005457D1 (de) | Rückbeleuchtungs-lichtleiter für das tastenfeld der fernbedienung eines elektronischen geräts | |
WO2008079545A3 (en) | Generation of plants with altered protein, fiber, or oil content | |
WO2003079766A3 (en) | Generation of plants with altered oil content | |
WO2008061153A3 (en) | Generation of plants with altered protein, fiber, or oil content | |
TW200738870A (en) | Bleaching activator granule | |
Giordano | Luigi Crocetti's Libraries | |
MX2009006462A (es) | Generacion de plantas con contenido de aceite, proteina o fibra alterado. | |
ITPS20030017A1 (it) | Corona perfezionata per bruciatori di fornelli a gas. | |
WO2008076980A3 (en) | Generation of plants with altered oil, protein, or fiber content | |
MXPA05006758A (es) | Generacion de plantas con contenido alterado de aceite. | |
CR9529A (es) | Anilidas de acido tiazolcarboxilico |