DK157892C - Fremgangsmaade til fremstilling af 3beta,7beta-dihydroxy-delta5-steroider - Google Patents

Fremgangsmaade til fremstilling af 3beta,7beta-dihydroxy-delta5-steroider

Info

Publication number
DK157892C
DK157892C DK484781A DK484781A DK157892C DK 157892 C DK157892 C DK 157892C DK 484781 A DK484781 A DK 484781A DK 484781 A DK484781 A DK 484781A DK 157892 C DK157892 C DK 157892C
Authority
DK
Denmark
Prior art keywords
dihydroxy
beta
preparing
delta5
7beta
Prior art date
Application number
DK484781A
Other languages
Danish (da)
English (en)
Other versions
DK484781A (da
DK157892B (da
Inventor
Karl Petzoldt
Rudolf Wiechert
Henry Laurent
Klaus Nickisch
Dieter Bittler
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of DK484781A publication Critical patent/DK484781A/da
Publication of DK157892B publication Critical patent/DK157892B/da
Application granted granted Critical
Publication of DK157892C publication Critical patent/DK157892C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/06—Hydroxylating
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C07J53/008—3 membered carbocyclic rings in position 15/16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK484781A 1980-11-03 1981-11-03 Fremgangsmaade til fremstilling af 3beta,7beta-dihydroxy-delta5-steroider DK157892C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19803042136 DE3042136A1 (de) 1980-11-03 1980-11-03 Verfahren zur herstellung von 3 (beta), 7 (beta) -dihydroxy- (delta) (pfeil hoch)5(pfeil hoch) -steroiden
DE3042136 1980-11-03

Publications (3)

Publication Number Publication Date
DK484781A DK484781A (da) 1982-05-04
DK157892B DK157892B (da) 1990-02-26
DK157892C true DK157892C (da) 1990-08-06

Family

ID=6116255

Family Applications (1)

Application Number Title Priority Date Filing Date
DK484781A DK157892C (da) 1980-11-03 1981-11-03 Fremgangsmaade til fremstilling af 3beta,7beta-dihydroxy-delta5-steroider

Country Status (6)

Country Link
US (2) US4416985A (cs)
EP (1) EP0051143B1 (cs)
JP (1) JPS57122798A (cs)
AT (1) ATE8274T1 (cs)
DE (2) DE3042136A1 (cs)
DK (1) DK157892C (cs)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE15206T1 (de) * 1981-09-21 1985-09-15 Schering Ag 3-beta,7-beta,15-alpha-trihydroxy-5-androsten-1 - one, ihre 3,15-trimethylessigsaeure-ester und ihre herstellung.
KR0147376B1 (ko) * 1988-07-07 1998-08-17 오노 알버어스 개질된 폴리페닐렌 에테르의 제조 방법 및 비닐 치환 방향족의 개질된 고온 경질 중합체 내에서의 이의 사용 방법
US5219951A (en) * 1988-07-07 1993-06-15 Shell Internationale Research Maatschappij B.V. Process for preparation of modified polyphenylene ether or related polymers and the use thereof in modified high temperature rigid polymer of vinyl substituted aromatics
US5215894A (en) * 1992-02-25 1993-06-01 Merck & Co., Inc. Biological process for producing 17β-N-monosubstituted carbamoyl-11-oxo-4-aza-5-α-androst-3-one testosterone-5-α reductase inhibitors
DE19633685C1 (de) 1996-08-12 1997-10-09 Schering Ag Verfahren zur Herstellung von Drospirenon (6beta,7beta;15 beta,16beta-Dimethyl-en-3-oxo-17alpha-pregn-4-en-21,17-carbolacton, DRSP) sowie 7alpha-(3-Hydroxy-1-propyl)-6beta,7beta;15beta, 16beta-dimethylen-5beta-androstan-3beta,5,17beta-triol (ZK 92836) und 6beta,7beta;15beta,16beta-dimethylen-5beta-hydroxy-3-oxo-17alpha-androstan-21,17-carbolacton (90965) als Zwischenprodukte des Verfahrens
CA2495412A1 (en) * 2002-08-16 2004-02-26 Pharmacia & Upjohn Company 5 androsten-3.beta.-ol steroid intermediates and processes for their preparation
US20070066579A1 (en) * 2002-08-16 2007-03-22 White Michael J 5-androsten-3beta-ol steroid intermediates and processs for their preparation
HUP0402465A2 (en) * 2004-11-30 2006-07-28 Richter Gedeon Vegyeszet Industrial process for preparing 17-hydroxy-6-betha, 7-betha, 15-betha, 16-betha-bis-methylene-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid gamma lacton and the main intermediates of the process
HUP0402466A2 (en) * 2004-11-30 2006-07-28 Richter Gedeon Vegyeszet Industrial process for preparing 17-hydroxy-6-betha, 7-betha, 15-betha, 16-betha-bis-methylene-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid gamma lacton and the main, intermediates of the process
ITMI20042338A1 (it) * 2004-12-06 2005-03-06 Ind Chimica Srl Processo per la preparazione di drospirenone
ATE403668T1 (de) 2005-07-21 2008-08-15 Bayer Schering Pharma Ag Verfahren zur herstellung von 3-oxo-pregn-4-en-21,17-carbolactonen durch die metallfreie oxidation von 17-(3-hydroxypropyl)-3,17- dihydroxyandrostanen
WO2007009821A1 (en) 2005-07-21 2007-01-25 Bayer Schering Pharma Aktiengesellschaft Process for the production of 3-oxo-pregn-4-ene-21,17-carbolactones by the metal-free oxidation of 17-(3-hydroxypropyl)-3,17-dihydroxyandrostanes
WO2008137050A2 (en) * 2007-05-01 2008-11-13 Sicor Inc. A process for preparing drospirenone and intermediate thereof
DE102007030596B3 (de) * 2007-06-28 2009-03-12 Bayer Schering Pharma Aktiengesellschaft Verfahren zur Herstellung von 17-(3-Hydroxypropyl)-17-hydroxysteroiden
ES2355586T3 (es) 2007-07-26 2011-03-29 Newchem S.P.A. Procedimiento de preparación de drospirenona.
CN101570775B (zh) * 2008-05-04 2012-03-21 上海医药工业研究院 微生物转化法制备3β,7β-二羟基-15β,16β-亚甲基-5-雄烯-17-酮的方法
ES2432063T3 (es) * 2009-06-16 2013-11-29 Crystal Pharma, S.A.U. Procedimiento para la obtención de 17-espirolactonas en esteroides
ES2419663T3 (es) 2010-08-03 2013-08-21 Newchem S.P.A. Métodos para la preparación de Drospirenona y productos intermedios de la misma
WO2012107513A1 (en) 2011-02-10 2012-08-16 Crystal Pharma, S.A.U. Process for obtaining drospirenone
CN105164144B (zh) 2013-04-12 2017-03-08 工业化学有限公司 用于制备屈螺酮的工艺
WO2014174338A1 (en) 2013-04-22 2014-10-30 Industriale Chimica S.R.L. Process for preparing an intermediate useful in the production of drospirenone
CN109824751B (zh) * 2019-04-08 2021-11-26 郑州大学 一种15β，16β-环丙烷化制备屈螺酮关键中间体的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3429778A (en) * 1967-08-24 1969-02-25 Squibb & Sons Inc Synthesis of steroids
NL7701384A (nl) * 1977-02-10 1978-08-14 Akzo Nv Werkwijze voor het bereiden van nieuwe steroiden van de oestraanreeks.
US4267117A (en) * 1978-06-19 1981-05-12 The Upjohn Company Compounds and process
US4336332A (en) 1979-02-20 1982-06-22 Hoffmann-La Roche, Inc. Process for the manufacture of hydroxylated steroids
ATE15206T1 (de) * 1981-09-21 1985-09-15 Schering Ag 3-beta,7-beta,15-alpha-trihydroxy-5-androsten-1 - one, ihre 3,15-trimethylessigsaeure-ester und ihre herstellung.
US4470981A (en) * 1982-12-20 1984-09-11 Hesse Robert H Chemical compounds

Also Published As

Publication number Publication date
JPH0121759B2 (cs) 1989-04-24
JPS57122798A (en) 1982-07-30
US4614616A (en) 1986-09-30
US4416985A (en) 1983-11-22
DE3164576D1 (en) 1984-08-09
EP0051143B1 (de) 1984-07-04
DK484781A (da) 1982-05-04
DE3042136A1 (de) 1982-06-09
EP0051143A1 (de) 1982-05-12
ATE8274T1 (de) 1984-07-15
DK157892B (da) 1990-02-26

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