DK1539976T3 - Fremgangsmåde til fremstilling af biologisk nedbrydelige, funktionaliserede polymerpartikler og deres anvendelse som lægemiddelbærere - Google Patents

Fremgangsmåde til fremstilling af biologisk nedbrydelige, funktionaliserede polymerpartikler og deres anvendelse som lægemiddelbærere

Info

Publication number
DK1539976T3
DK1539976T3 DK03747816.1T DK03747816T DK1539976T3 DK 1539976 T3 DK1539976 T3 DK 1539976T3 DK 03747816 T DK03747816 T DK 03747816T DK 1539976 T3 DK1539976 T3 DK 1539976T3
Authority
DK
Denmark
Prior art keywords
biodegradable
preparation
polymer particles
functionalized polymer
drug carriers
Prior art date
Application number
DK03747816.1T
Other languages
English (en)
Inventor
Bernd Helmut Adam Rehm
Original Assignee
Univ Massey
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Massey filed Critical Univ Massey
Application granted granted Critical
Publication of DK1539976T3 publication Critical patent/DK1539976T3/da

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6927Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
    • A61K47/6929Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
    • A61K47/6931Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/62Carboxylic acid esters
    • C12P7/625Polyesters of hydroxy carboxylic acids
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/29Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nanotechnology (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • Medical Informatics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK03747816.1T 2002-08-30 2003-08-22 Fremgangsmåde til fremstilling af biologisk nedbrydelige, funktionaliserede polymerpartikler og deres anvendelse som lægemiddelbærere DK1539976T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10240035A DE10240035A1 (de) 2002-08-30 2002-08-30 Biogene Polyester-Partikel definierter Größe mit funktionalisierten Oberflächen:Herstellungsverfahren und pharmazeutische Zubereitungen, in denen diese enthalten sind
PCT/DE2003/002799 WO2004020623A2 (de) 2002-08-30 2003-08-22 Verfahren zur herstellung von biologisch abbaubaren, funktionalisierten polymerpartikeln und deren verwendung als arzneimittelträger

Publications (1)

Publication Number Publication Date
DK1539976T3 true DK1539976T3 (da) 2011-05-23

Family

ID=31502153

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03747816.1T DK1539976T3 (da) 2002-08-30 2003-08-22 Fremgangsmåde til fremstilling af biologisk nedbrydelige, funktionaliserede polymerpartikler og deres anvendelse som lægemiddelbærere

Country Status (14)

Country Link
US (3) US7622277B2 (da)
EP (2) EP1539976B1 (da)
JP (2) JP5160729B2 (da)
AT (1) ATE497543T1 (da)
AU (2) AU2003266922B2 (da)
CA (1) CA2497255C (da)
CY (1) CY1113685T1 (da)
DE (2) DE10240035A1 (da)
DK (1) DK1539976T3 (da)
ES (1) ES2360617T3 (da)
PT (1) PT1539976E (da)
SG (1) SG153663A1 (da)
SI (1) SI1539976T1 (da)
WO (1) WO2004020623A2 (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10240035A1 (de) * 2002-08-30 2004-03-11 Rehm, Bernd H.A., PD Dr.rer.nat. Biogene Polyester-Partikel definierter Größe mit funktionalisierten Oberflächen:Herstellungsverfahren und pharmazeutische Zubereitungen, in denen diese enthalten sind
DK1929010T3 (da) * 2005-09-27 2014-03-10 Polybatics Ltd Anvendelse af polymer partikler
SG178144A1 (en) * 2009-07-29 2012-03-29 Bernd Helmut Adam Rehm Polymer particles and uses thereof
EP3626739A1 (en) * 2011-06-24 2020-03-25 Stephen D. Gillies Light chain immunoglobulin fusion proteins and methods of use thereof
WO2013190453A2 (en) * 2012-06-18 2013-12-27 Tracy Thompson Compositions for separation methods
WO2015006758A1 (en) * 2013-07-12 2015-01-15 University Of Central Florida Research Foundation, Inc. Functionalized polymer particles for biosensing
US11198831B2 (en) 2019-01-31 2021-12-14 Kvi Llc Lubricant for a device

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5480794A (en) * 1987-06-29 1996-01-02 Massachusetts Institute Of Technology And Metabolix, Inc. Overproduction and purification of soluble PHA synthase
SE466521B (sv) 1988-10-03 1992-02-24 Kurt G I Nilsson Reagens vid analys bestaaende av ett enzym och en annan ligand, vilka aer kovalent bundna till en vattenoloeslig partikel med en diameter paa mindre aen 500 aa
US5610041A (en) 1991-07-19 1997-03-11 Board Of Trustees Operating Michigan State University Processes for producing polyhydroxybutyrate and related polyhydroxyalkanoates in the plastids of higher plants
GB9414506D0 (en) * 1994-07-18 1994-09-07 Zeneca Ltd Improved production of polyhydroxyalkanoate
US6600029B1 (en) 1995-12-19 2003-07-29 Regents Of The University Of Minnesota Metabolic engineering of polyhydroxyalkanoate monomer synthases
DE19745950A1 (de) 1997-10-17 1999-04-22 Dds Drug Delivery Service Ges Arzneistoffträgerpartikel für die gewebespezifische Arzneistoffapplikation
EP1044278A1 (en) 1998-01-05 2000-10-18 Monsanto Company Biosynthesis of medium chain length polyhydroxyalkanoates
US6103956A (en) 1998-03-31 2000-08-15 Regents Of The University Of Minnesota Polyhydroxyalkanoate synthesis in plants
EP1100928B1 (en) 1998-07-30 2006-02-01 Metabolix, Inc. Bifunctional enzymes for biopolymer production
US6146665A (en) * 1998-09-09 2000-11-14 Mcgill University Entrapment or microencapsulation of drugs in a polyhydroxyalkanoate formed by enzyme synthesis
US6835820B2 (en) 1999-01-07 2004-12-28 The University Of Massachusetts Polyhydroxyalkanoate biosynthesis associated proteins and coding region in bacillus megaterium
JP2003503033A (ja) 1999-06-24 2003-01-28 メタボリックス,インコーポレイテッド 植物多重遺伝子発現構築物
DE10037270B4 (de) 2000-07-28 2007-09-13 Müller, Werner E. G., Prof. Dr. Silicatein-vermittelte Synthese von amorphen Silikaten und Siloxanen und ihre Verwendung
JP4024676B2 (ja) 2000-11-17 2007-12-19 メタボリックス,インコーポレイテッド 脂肪酸生合成経路からの中間鎖長のポリヒドロキシアルカノエートの産生
DE10240035A1 (de) * 2002-08-30 2004-03-11 Rehm, Bernd H.A., PD Dr.rer.nat. Biogene Polyester-Partikel definierter Größe mit funktionalisierten Oberflächen:Herstellungsverfahren und pharmazeutische Zubereitungen, in denen diese enthalten sind

Also Published As

Publication number Publication date
US20060160194A1 (en) 2006-07-20
DE10240035A1 (de) 2004-03-11
EP2302064A1 (de) 2011-03-30
US20140206759A1 (en) 2014-07-24
WO2004020623A2 (de) 2004-03-11
AU2003266922B2 (en) 2009-09-24
SI1539976T1 (sl) 2011-07-29
CY1113685T1 (el) 2016-06-22
CA2497255A1 (en) 2004-03-11
AU2009210395A1 (en) 2009-09-10
US7622277B2 (en) 2009-11-24
US20100086972A1 (en) 2010-04-08
JP2012249634A (ja) 2012-12-20
EP1539976B1 (de) 2011-02-02
DE50313457D1 (de) 2011-03-17
EP1539976A2 (de) 2005-06-15
ES2360617T3 (es) 2011-06-07
AU2003266922A1 (en) 2004-03-19
JP5160729B2 (ja) 2013-03-13
PT1539976E (pt) 2011-05-05
JP2005536222A (ja) 2005-12-02
WO2004020623B1 (de) 2004-10-07
CA2497255C (en) 2013-04-23
SG153663A1 (en) 2009-07-29
WO2004020623A3 (de) 2004-08-12
ATE497543T1 (de) 2011-02-15

Similar Documents

Publication Publication Date Title
WO2007123763A3 (en) Articles having localized molecules disposed thereon and methods of producing same
Numata et al. Synthesis of adhesive peptides similar to those found in blue mussel (Mytilus edulis) using papain and tyrosinase
Degen et al. Impact of molecular architecture and adsorption density on adhesion of mussel-inspired surface primers with catechol-cation synergy
SE0100875D0 (sv) Method of preparing supported lipid film membranes and use thereof
WO2002085519A3 (en) High capacity methods for separation, purification, concentration, immobilization and synthesis of compounds and applications based thereupon
CY1113685T1 (el) Μεθοδος παραγωγης βιολογικα αποικοδομησιμων, λειτουργικοποιημενων πολυμερικων σωματιδιων και χρηση αυτων ως φορεων φαρμακων
ATE473438T1 (de) Zuführung von molekülen an eine lipiddoppelschicht
BR0014703A (pt) Dispersão polimérica aquosa, processo para preparação da mesma, substrato ligado, e, uso de uma dispersão polimérica aquosa
DE50015917D1 (de) Filmförmige Zubereitung zur biphasigen Freisetzung pharmakologisch wirksamer oder anderer Substanzen
BRPI0413790A (pt) sistema sem fio, método sem fio, dispositivo de sistema sem fio, dispositivo de usuário sem fio e métodos de operar um dispositivo de sistema sem fio e um dispositivo de usuário sem fio
AR050621A1 (es) Sistema terapeutico transdermal con una capa adherente procedimiento para el siliconado de una capa de respaldo y empleo de la capa de respaldo
BR0012609A (pt) Filtro de microorganismo e método para remoção de microorganismo da água
BR0313757A (pt) Agente de absorção de água, e, processo para a produção do mesmo
NO20051370L (no) Multilaminat baksidekonstruksjon som kan preges og paskrives
SE9803838D0 (sv) A chromatography method and a column material useful in said method
ATE520327T1 (de) Strukturierte oberfläche mit schaltbarer haftfähigkeit
WO2004024303A3 (de) Faserkassette und modular aufgebautes kassettensystem
WO2002020685A3 (en) Use of a pressure-sensitive adhesive tape for increasing the stability of a stack of goods
ATE452751T1 (de) Ausbildung von dünnfilmen auf substraten unter verwendung eines porösen trägers
ATE365756T1 (de) Feuchtigkeitshärtende schmelzklebstoffe, verfahren zu deren herstellung und deren verwendung
WO2003026712A1 (fr) Procede de formation de membrane basale, procede d'elaboration d'echantillon de membrane basale, tissu artificiel reconstitue utilisant cet echantillon, et procede d'elaboration de ce tissu
DK1699614T3 (da) Fleksibelt, flerlaget, mikrostruktureret substrat
BRPI0618454A2 (pt) embalagem para artigos adesivos para dentaduras
Raman et al. Adhesive barnacle peptides exhibit a steric-driven design rule to enhance adhesion between asymmetric surfaces
BRPI0515217A (pt) pelìcula polimérica, artigo composto, processo para preparar uma pelìcula e uso de uma pelìcula