DK15388D0 - PROCEDURE FOR THE PREPARATION OF A DELAY PRODUCT CONTAINING DILTIAZEM WITH A SPECIAL DAILY DOSAGE - Google Patents

PROCEDURE FOR THE PREPARATION OF A DELAY PRODUCT CONTAINING DILTIAZEM WITH A SPECIAL DAILY DOSAGE

Info

Publication number
DK15388D0
DK15388D0 DK015388A DK15388A DK15388D0 DK 15388 D0 DK15388 D0 DK 15388D0 DK 015388 A DK015388 A DK 015388A DK 15388 A DK15388 A DK 15388A DK 15388 D0 DK15388 D0 DK 15388D0
Authority
DK
Denmark
Prior art keywords
preparation
procedure
product containing
daily dosage
delay product
Prior art date
Application number
DK015388A
Other languages
Danish (da)
Other versions
DK173505B1 (en
DK15388A (en
Inventor
Dieter Barth
Original Assignee
Varnel Chem Business Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Varnel Chem Business Sa filed Critical Varnel Chem Business Sa
Publication of DK15388D0 publication Critical patent/DK15388D0/en
Publication of DK15388A publication Critical patent/DK15388A/en
Application granted granted Critical
Publication of DK173505B1 publication Critical patent/DK173505B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

A process is described for the preparation of a solid dosage form for oral administration in hard gelatin capsules containing pellets based on diltiazem, with controlled liberation "in vitro" of the active substance, such that a slow release and a prolonged absorption "in vivo" are possible with blood levels which are active following administration of a single dose of 180 mg every 24 hours, preferably in combination with a proportionately variable quantity of immediate-release pellets in order to obtain good blood levels even in the initial phase of absorption. <IMAGE>
DK198800153A 1987-02-20 1988-01-13 Process for producing a slow release diltiazem pellet and using pellets thus prepared DK173505B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH63787 1987-02-20
CH63787 1987-02-20

Publications (3)

Publication Number Publication Date
DK15388D0 true DK15388D0 (en) 1988-01-13
DK15388A DK15388A (en) 1988-08-21
DK173505B1 DK173505B1 (en) 2001-01-15

Family

ID=4191649

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198800153A DK173505B1 (en) 1987-02-20 1988-01-13 Process for producing a slow release diltiazem pellet and using pellets thus prepared

Country Status (12)

Country Link
EP (1) EP0282698B1 (en)
JP (1) JP2863528B2 (en)
KR (1) KR960011232B1 (en)
AT (1) ATE172112T1 (en)
AU (1) AU1196988A (en)
BR (1) BR8800763A (en)
CA (1) CA1327006C (en)
DE (1) DE3856258T2 (en)
DK (1) DK173505B1 (en)
ES (1) ES2125215T3 (en)
MX (1) MX10490A (en)
ZA (1) ZA881181B (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3737741A1 (en) * 1987-11-06 1989-05-18 Goedecke Ag ORAL MEDICAL FORM FOR THE ONLY DAILY TREATMENT OF HYPERTENSION WITH DILTIAZEMHYDROCHLORIDE
DE3922167A1 (en) * 1988-04-16 1991-01-17 Sanol Arznei Schwarz Gmbh Oral diltiazem hydrochloride dosage forms - for admin. once a day, contg. fast- and delayed-release components
US5133974A (en) * 1989-05-05 1992-07-28 Kv Pharmaceutical Company Extended release pharmaceutical formulations
SE8902699D0 (en) * 1989-08-09 1989-08-09 Lejus Medical Ab DILTIAZEM CONTAINING PHARMACEUTICAL COMPOSITIOS
US5286497A (en) * 1991-05-20 1994-02-15 Carderm Capital L.P. Diltiazem formulation
ZA923474B (en) * 1991-05-20 1993-01-27 Marion Merrell Dow Inc Diltiazem formulation
JP3746315B2 (en) 1994-07-07 2006-02-15 ダイセル化学工業株式会社 Separating agent
US5834024A (en) * 1995-01-05 1998-11-10 Fh Faulding & Co. Limited Controlled absorption diltiazem pharmaceutical formulation
US5567441A (en) * 1995-03-24 1996-10-22 Andrx Pharmaceuticals Inc. Diltiazem controlled release formulation
FR2742660B1 (en) * 1995-12-22 1998-04-03 Ethypharm Lab Prod Ethiques NOVEL FORMS OF EXTENDED RELEASE MICROGRANULES CONTAINING DILTIAZEM AS ACTIVE INGREDIENT
KR100341829B1 (en) * 1996-03-08 2002-08-22 니코메드 덴마크 에이/에스 Modified release multiple-units dosage composition
US5830503A (en) * 1996-06-21 1998-11-03 Andrx Pharmaceuticals, Inc. Enteric coated diltiazem once-a-day formulation
FR2754710B1 (en) * 1996-10-22 1998-12-31 Prographarm Lab PROCESS FOR THE PREPARATION OF A MULTIPARTICULAR PHARMACEUTICAL FORM WITH CONTROLLED RELEASE PLURISEQUENTIELLE
EP1010457A4 (en) 1996-12-10 2006-03-22 Asahi Chemical Ind Porous polyvinylidene fluoride resin film and process for producing the same
US6162463A (en) * 1997-05-01 2000-12-19 Dov Pharmaceutical Inc Extended release formulation of diltiazem hydrochloride
US7108866B1 (en) * 1999-12-10 2006-09-19 Biovall Laboratories International Srl Chronotherapeutic diltiazem formulations and the administration thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4173626A (en) * 1978-12-11 1979-11-06 Merck & Co., Inc. Sustained release indomethacin
JPS5867616A (en) * 1981-10-15 1983-04-22 Tanabe Seiyaku Co Ltd Enteric microcapsule and its preparation
JPS604120A (en) * 1983-06-22 1985-01-10 Shionogi & Co Ltd Pharmaceutical preparation of pinacidil of long acting type
FR2554718B1 (en) * 1983-11-14 1986-04-04 Ethypharm Sa NEW ORAL SULPIRIDE FORMS FOR SULPIRIDE
IE56999B1 (en) * 1983-12-22 1992-03-11 Elan Corp Plc Pharmaceutical formulation
IT1178511B (en) * 1984-09-14 1987-09-09 Pharmatec Spa PROCEDURE FOR THE PREPARATION OF A SOLID FORM FOR ORAL USE BASED ON NIFEDIPINE WITH RELEASE

Also Published As

Publication number Publication date
KR960011232B1 (en) 1996-08-21
DE3856258D1 (en) 1998-11-19
ES2125215T3 (en) 1999-03-01
ZA881181B (en) 1988-08-16
ATE172112T1 (en) 1998-10-15
BR8800763A (en) 1988-10-04
AU1196988A (en) 1988-08-25
MX10490A (en) 1993-12-01
JP2863528B2 (en) 1999-03-03
JPH01216934A (en) 1989-08-30
DK173505B1 (en) 2001-01-15
EP0282698A1 (en) 1988-09-21
DE3856258T2 (en) 1999-04-29
DK15388A (en) 1988-08-21
CA1327006C (en) 1994-02-15
KR880009640A (en) 1988-10-04
EP0282698B1 (en) 1998-10-14

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed

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