DK151422B - Radioisotope GENERATOR - Google Patents
Radioisotope GENERATOR Download PDFInfo
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- DK151422B DK151422B DK501680AA DK501680A DK151422B DK 151422 B DK151422 B DK 151422B DK 501680A A DK501680A A DK 501680AA DK 501680 A DK501680 A DK 501680A DK 151422 B DK151422 B DK 151422B
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- DK
- Denmark
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- elution
- bottle
- radioisotope generator
- eluate
- generator according
- Prior art date
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Classifications
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- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/04—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes outside nuclear reactors or particle accelerators
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- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/0005—Isotope delivery systems
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S141/00—Fluent material handling, with receiver or receiver coacting means
- Y10S141/02—Fluidic flow control valves
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- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- High Energy & Nuclear Physics (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
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Opfindelsen angår en radioisotop-generator som angivet i krav 1's indledning.The invention relates to a radioisotope generator as set forth in the preamble of claim 1.
Sådanne generatorer benyttes til at opnå en opløsning af en radioaktiv datterisotop, såsom techne-5 tium-99m, ud fra en adsorberet radioaktiv moderisotop, såsom molybden-99, der frembringer datterisotopen ved radioaktivt henfald. Opløsningen af den radioaktive datterisotop kan benyttes i medicinen til diagnosticeringsformål. Ved brugen sluttes en beholder, som inde-10 holder et kvantum eluent, til kolonnens tilgangsåbning, og en udpumpet elutionsflaske sluttes til kolonnens afgangsåbning. Undertrykket i den udpumpede flaske suger eluenten fra beholderen gennem kolonnen og ind i flasken, hvorved den radioaktive datterisotop 15 elueres fra kolonnen.Such generators are used to obtain a solution of a radioactive daughter isotope, such as technology-99m, from an adsorbed radioactive parent isotope, such as molybdenum-99, which produces the daughter isotope by radioactive decay. The solution of the radioactive daughter isotope can be used in the medicine for diagnostic purposes. In use, a container containing a quantity of eluent is connected to the column inlet opening, and a pumped elution bottle is connected to the outlet port of the column. The vacuum in the pumped-out bottle sucks the eluent from the container through the column and into the bottle, thereby eluting the radioactive daughter isotope 15 from the column.
En fra U.S.A. patentskrift nr. 3 774 035 kendt generator af denne art er bestemt til at benyttes sammen med en eluentbeholder indeholdende et afmålt kvantum eluent, som er mindre end det kvantum eluat, der 20 kan rummes i elutionsflasken. Når eluentbeholderen er tømt og elutionsprocessen dermed afsluttet, er der i elutionsflasken stadig volumenkapacitet og undertryk til indsugning af en portion atmosfærisk luft, som strømmer ind i eluentbeholderen gennem et sterilfil-25 ter og videre gennem kolonnen og eluatledningen til elutionsflasken. I denne kendte generator er det kvantum eluat, som opsamles i flasken, altid fastlagt ved mængden af eluent i den benyttede eluentbeholder, og for at kunne levere flasker med forskelligt indhold af 30 eluat og dermed af radioaktiv datterisotop må man disponere over eluentbeholdere med lige så mange forskellige volumener. En anden ulempe ved den kendte generator er det permanent indbyggede sterilfilter i elu-entbeholderens luftindtag, som giver anledning til et 35 tilsvarende tryktab under hele elutionsprocessen.One from U.S.A. U.S. Patent No. 3,774,035, known generator of this kind is intended to be used in conjunction with an eluent container containing a metered quantity of eluent less than the quantity of eluatable 20 contained in the elution bottle. When the eluent vessel is emptied and the elution process is completed, there is still volume capacity and vacuum in the elution bottle to suck in a portion of atmospheric air which flows into the eluent vessel through a sterile filter and further through the column and elution tube to the elution bottle. In this known generator, the quantity of eluate collected in the bottle is always determined by the amount of eluent in the used eluent container, and in order to be able to supply bottles with different contents of 30 eluate and thus of radioactive daughter isotope one has to dispose of eluent containers with equal many different volumes. Another disadvantage of the known generator is the permanently built-in sterile filter in the air intake of the eluent container, which gives rise to a corresponding pressure loss during the entire elution process.
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Med henblik på bl.a. at afhjælpe de nævnte ulemper er en radioisotop-generator ifølge opfindelsen ejendommelig ved, at den har midler til at åbne for indsugning af steril luft i eluatledningen, hvorved 5 strømningen af eluat gennem denne ledning kan afbrydes på et vilkårligt tidspunkt af en igangværende elu-tionsproces samtidig med, at steril luft strømmer både i retning af generatorens kolonne og i retning af elu-tionsflasken.For the purpose of: alleviating said drawbacks, a radioisotope generator according to the invention is characterized in that it has means for opening sterile air in the eluate conduit, whereby the flow of eluate through this conduit can be interrupted at any time by an ongoing elution process. while sterile air flows both in the direction of the generator column and in the direction of the elution bottle.
10 Med en generator ifølge opfindelsen er brugeren helt fritstillet med hensyn til valg af det volumen af eluat, som ønskes opsamlet i en tilsluttet elutions-flaske, idet elutionsprocessen automatisk afbrydes, når der åbnes for den sterile lufts indstrømning i 15 eluatledningen, uanset hvor meget eluent der endnu måtte være tilbage i eluentbeholderen. Det er således specielt muligt, ved successiv fyldning af flere elu-tionsflasker hver med væsentlig lavere volumen end den benyttede eluentbeholder, at gennemføre en frak-20 tioneret elution og derved opnå en højere koncentration af den radioaktive datterisotop i eluatet. En sådan høj koncentration af radioisotopen er f.eks. påkrævet til bolusinjektioner. En yderligere fordel ved opfindelsen er, at der kun benyttes steril luft til 25 gennemskylning af den til elutionsflasken hørende del af eluatledningen og til udfyldning af flaskens restvolumen efter afbrydelse af elutionsprocessen. Denne kan således gennemføres med fuld udnyttelse af undertrykket i elutionsflasken.With a generator according to the invention, the user is completely exempted in choosing the volume of eluate desired to be collected in a connected elution bottle, the elution process being automatically interrupted when opening to the sterile air inflow into the eluate line, no matter how much eluent remaining in the eluent vessel. Thus, it is especially possible, by successively filling several elution bottles each with substantially lower volume than the used eluent container, to carry out a fractionated elution, thereby achieving a higher concentration of the radioactive daughter isotope in the eluate. Such a high concentration of the radioisotope is e.g. required for bolus injections. A further advantage of the invention is that only sterile air is used for flushing the part of the eluate bottle belonging to the elution bottle and for filling the residual volume of the bottle after interruption of the elution process. This can thus be accomplished with full utilization of the vacuum in the elution bottle.
30 De nævnte midler udgøres i en foretrukket ud førelsesform af en fra eluatledningen afgrenet luftindstrømningsledning med et manuelt aktiveret ventilorgan til valgfri åbning og lukning af indstrømningsledningen. I denne udførelsesform er ventilorganet i 35 sin helhed fortrinsvis placeret indvendig i generato- 3 151422 rens hus. Herved kan hermetisk tæthed af generatorhuset, som er nødvendig af hensyn til generatorens forsendelse, let opretholdes. Med henblik på enkel betjening af generatoren foretrækkes det især, at et akti-5 veringsorgan for ventilorganet har en fra generatorens hus udragende del placeret til at påvirkes ved en bevægelse af elutionsflasken. Elutionsprocessen kan da afbrydes blot ved udøvelse af et nedadgående tryk på den udpumpede elutionsflaske.Said means are in a preferred embodiment of an air inflow line branched from the eluate conduit with a manually actuated valve means for optional opening and closing of the inflow line. In this embodiment, the valve member as a whole is preferably located internally in the housing of the generator. In this way, the hermetic tightness of the generator housing, which is necessary for the generator's shipment, can be easily maintained. For ease of operation of the generator, it is particularly preferred that an actuator for the valve member has a portion projecting from the generator housing positioned to be affected by movement of the elution bottle. The elution process can then be interrupted simply by applying a downward pressure on the pumped elution bottle.
Opfindelsen forklares mere detaljeret med Ί0 hensyn til nogle foretrukne udførelsesformer, som er vist på tegningen.The invention is explained in more detail with respect to some preferred embodiments shown in the drawing.
På tegningen er fig. 1 et tværsnit gennem en radioisotop-generator ifølge opfindelsen, som indeholder en ud-15 førelsesform for midler til afbrydelse af elutionsprocessen, fig. 2 et delsnit, som illustrerer påvirkningen af de i fig. 1 viste midler ved hjælp af en afskærmet elutionsflaske, og 20 fig. 3 et andet delsnit, som anskueliggør en anden udførelsesform af midler til afbrydelse af elutionsprocessen i en radioisotop-generator.In the drawing, FIG. 1 is a cross-section through a radioisotope generator according to the invention containing an embodiment of means for interrupting the elution process; FIG. 2 is a sectional view illustrating the effect of FIG. 1 by means of a shielded elution bottle, and FIG. 3 shows a second section which illustrates another embodiment of means for interrupting the elution process in a radioisotope generator.
Fig. 1 viser en radioisotop-generator 10 med et hus 12, som omslutter generatoren 10, og 25 en omgivende beholder 15 af bly. På den øverste del af en kolonne 14 er der en tilgangsåbning 16 for eluent, som fra et ikke vist eluentreservoir strømmer gennem en eluentledning 18. På den nedre del af kolonnen 14 er der en afgangsåbning 30 20, hvortil en eluatledning 22 er sluttet. Led ningen 22 forbinder kolonnen 14 med et tappeaggregat 24, der indeholder en injektionsnål 26 omgivet af en aftagelig nålehætte 28. Aggregatet 4 151422 24's injektionsnål 26 rager fra generatorhuset 12 ind i et tappested 29, som er indrettet til at optage en ikke vist udpumpet elutionsflaske. Med henblik på forsendelse af generatorens kolonne 14 er tappe-5 stedet 29 hermetisk lukket ved hjælp af et fastspændt eller påskruet låg 30, fortrinsvis et for-falskningssikkert låg.FIG. 1 shows a radioisotope generator 10 with a housing 12 enclosing the generator 10 and 25 a surrounding container 15 of lead. On the upper part of a column 14 there is an inlet port 16 for the eluent which flows from an eluent reservoir not shown through an eluent line 18. On the lower part of the column 14 there is an outlet opening 30 20 to which an eluate line 22 is connected. The conduit 22 connects column 14 with a tapping assembly 24 containing an injection needle 26 surrounded by a removable needle cap 28. The injection needle 26 of the assembly 4 projects from the generator housing 12 into a tapping point 29 which is adapted to receive an unexposed eluted bottle. . For dispatching of column 14 of the generator, the tapping site 29 is hermetically sealed by means of a clamped or screwed-on lid 30, preferably a forgery-proof lid.
I generatorhuset 12 er der midler 32 indrettet til at afbryde en elutionsproces, som foregår 10 i generatoren 10. I den viste udførelsesform omfatter midlerne 32 en stang 34 med en påvirkningsende 36, der rager ind i tappestedet 29 gennem en åbning 38 i huset 12. En skruefjeder 40 uden om stangen 34 ligger mod et stop 41 på stangen 15 og en bæreplade 42, således at fjederen forbelaster stangen i retning mod tappestedet 29. Stangen 34's endedel 44 modsat stangenden 36 rager ned gennem en åbning 46 i bærepladen 42 og er U-formet, således at den distale ende af stangen er ført bag-20 læns gennem en åbning 47 i bærepladen. En luftindstrømningsledning 48 med et sterilisationsfilter 50 ved sin ene ende går gennem stangen 34's U-formede endedel 44 og er ved sin anden ende sluttet til eluatledningen 22 ved hjælp af et gren-25 rør 52.In the generator housing 12, means 32 are arranged to interrupt an elution process which takes place 10 in the generator 10. In the illustrated embodiment, the means 32 comprise a rod 34 with an impact end 36 projecting into the tapping point 29 through an opening 38 in the housing 12. A coil spring 40 outside the rod 34 bears against a stop 41 on the rod 15 and a support plate 42 so that the spring preloads the rod in the direction of the tapping point 29. The end portion 44 of the rod 34 opposite the rod end 36 projects down through an opening 46 in the support plate 42 and is U shaped so that the distal end of the rod is guided backwards through an aperture 47 in the support plate. An air inflow line 48 with a sterilization filter 50 at one end passes through the U-shaped end portion 44 of the rod 34 and is connected at its other end to the eluate conduit 22 by a branch tube 52.
Da stangen 34 kan glide i åbningerne 46 og 47 i bærepladen 42, og da luftindstrømningsledningen 48 er fremstillet af fleksibelt materiale, vil fjederen 40's påvirkning af stangen sammenklem-30 me eller lukke luftindstrømningsledningen ved at trykke ledningen sammen mellem stangens U-formede endedel 44 og bærepladen. En nedadgående bevægelse af stangen 34 mod fjederen 40's forbelastning · ophæver klemvirkningen og tillader en strøm af ste-35 ril luft gennem luftindstrømningsledningen 48.Since the rod 34 may slide in the openings 46 and 47 of the carrier plate 42, and since the air inflow line 48 is made of flexible material, the spring 40's impact on the rod will clamp or close the air inflow line by pressing the conduit between the U-shaped end portion 44 of the rod and the carrier plate. A downward movement of the rod 34 against the preload of spring 40 abolishes the clamping effect and allows a flow of sterile air through the air inflow line 48.
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Selv om stangen 34's ende 36, der fungerer som midlerne 32's påvirkningsdel, rager gennem åbningen 38 ind i huset 12's tappested 29, fremgår det af fig. 1, at midlerne 30 i deres hel-5 hed ligger indvendig i generatoren 101 s hermetisk lukkede hus, eftersom skruelåget 30 er et forfalsk-ningssikkert låg, der lukker generatorhusets tappested hermetisk, og at generatoren således opfylder gældende regulativer for forsendelse af radioisotop-10 generatorer.Although the end 36 of the rod 34, which acts as the actuating portion of the means 32, protrudes through the opening 38 into the tapping point 29 of the housing 12, it can be seen in FIG. 1, that the means 30 in their entirety lie inside the generator 101 s hermetically sealed housing, since the screw cap 30 is a counterfeit safe lid that hermetically closes the generator housing tapping point and that the generator thus complies with applicable regulations for dispatching radioisotope 10. generators.
Funktionen af generatoren 10 inklusive midlerne 32 ved en elutionsproces kan bedst forklares med henvisning til både fig. 1 og 2. Først fjernes skruelåget 30 fra huset 12, og derefter fjernes 15 hætten 28 fra nålen 26, umiddelbart før elutionen af generatorens kolonne 14. Hvis generatoren imidlertid har været benyttet tidligere til en elutionsproces, vil en ikke vist flaske, som indeholder et bakteriostatisk middel, normalt have erstattet 20 nålehætten 28, og det vil derfor være denne flaske og ikke hætten, som fjernes. En vakuumflaske 60 til opsamling af eluat og forsynet med et beskyttende blyskjold 62 forberedes til fyldning med eluat ved, at man bøjer en ikke vist flig tilbage fra 25 flaskens flangede låg 64, således at en gummiprop 66 blottes, hvorefter man anbringer flasken med bunden i vejret i generatorhuset 12's tappeområde 29, hvorved injektionsnålen 26 gennemborer flaskens gummiprop. Som vist i fig. 2 ligger elutionsflasken 30 60's skjold 62 an^mod stangen 34's påvirknings ende 36 under élutionsprocessen, men det trykker ikke stangen ned. Da luftindstrømningsledningen 48 er klemt sammen ved hjælp af stangen 34, suges eluat fra kolonnen 14 ind i flasken 60 på grund af 35 undertrykket i flasken. Det i elutionsflasken 60 op- 6 151422 samlede kvantum eluat kan fastlægges visuelt, hvis flaskens skjold 62 har et ikke vist vindue af blyglas. Elutionsprocessen kan afbrydes når som helst ved, at man blot trykker elutionsflasken 60 nedad 5 mod stangen 34's påvirkningsende 36. Da stangen 34 er glidende lejret i åbningerne 46 og 47, bliver stangen derved ført nedad mod fjederen 40's forbelastning, således at sammenklemningen eller lukningen af luftindstrømningsledningen 48 ophører, 10 hvorefter luften kan strømme gennem ledningen. Generatorens kolonne 14, eluatledningen 22 og elutions-flasken 60 er nu alle samtidig udsat for steril luft, som suges ind gennem filteret 50, ledningen 48 og grenrøret 52, hvorved elutionsprocessen 15 standser.The operation of the generator 10 including the means 32 in an elution process can best be explained with reference to both FIGS. 1 and 2. First, the screw cap 30 is removed from the housing 12, and then the cap 28 is removed from the needle 26, immediately before the elution of the column 14. If, however, the generator has been used previously for an elution process, a bottle which does not show a bacteriostatic agent, usually have replaced the needle cap 28, and it will therefore be this bottle and not the cap that is removed. A vacuum bottle 60 for collecting eluate and provided with a protective lead shield 62 is prepared for filling with eluate by bending a tab not shown from the flanged lid 64 of the bottle so as to expose a rubber stopper 66 and then affixing the bottle to the bottom. the weather in the tapping area 29 of the generator housing 12, whereby the injection needle 26 pierces the rubber stopper of the bottle. As shown in FIG. 2, the shield 62 of the elution bottle 30 60 abuts the end 36 of the rod 34 during the elution process, but it does not depress the rod. Since the air inflow line 48 is squeezed by the rod 34, eluate from column 14 is sucked into the bottle 60 due to the 35 suppressed in the bottle. The total amount of eluate in the elution bottle 60 can be determined visually if the shield 62 of the bottle has a lead glass window not shown. The elution process can be interrupted at any time by simply pushing the elution bottle 60 downwardly 5 toward the impact end 36 of the rod 34, since the rod 34 is slidably mounted in the openings 46 and 47, the rod thereby being guided downwardly against the preload of the spring 40 so the air inlet conduit 48 ceases, after which air can flow through the conduit. Generator column 14, eluate conduit 22, and elution bottle 60 are all simultaneously subjected to sterile air which is sucked in through filter 50, conduit 48, and manifold 52, thereby stopping elution process 15.
En anden udførelsesform for midler til afbrydelse af elutionsprocessen i en radioisotop-generator er vist i fig. 3, som er et delsnit gennem en radioisotop-generator med en eluatledning 22, et 20 nåleaggregat 24, en bæreplade 42 og en luftindstrømningsledning 48 svarende til generatoren ifølge fig. 1. I denne udførelsesform omfatter midler 70 til afbrydelse af en elutionsproces en stang 72 af fjedrende materiale, hvis nedre endedel 74 25 er bøjet i form af en fjeder, som forbelaster stangen opefter. Den distale ende af stangen 72's nedre endedel 74 er fastgjort i et bæreorgan 76, som er monteret på bærepladen 42. Stangen 72 går gennem en åbning 78 i bærepladen 42 og bæreorganet 76, 30 og stangens ikke viste øvre ende rager ind i et ikke vist tappeområde i lighed med det i fig. 1 viste. Luftindstrømningsledningen 48 sammenklemmes eller lukkes mellem et bukket mellemstykke 79 af stangen 72 og en fordybning 80 i bæreorganet 76, 35 som dannes af nedadragende ører 82, der styrer 7 151422 stangen og ledningen. Når stangen 72, som er glidende lejret i det ikke viste generatorhus og i bæreorganet 76's åbning 78, trykkes nedad mod sin egen fjederbelastning ved hjælp af en ikke vist 5 afskærmet elutionsflaske på samme måde som beskrevet ovenfor, afbrydes sammenklemningen eller lukningen af ledningen 48, således at generatoren og elutions-flasken udsættes for steril luft, som suges gennem et ikke vist sterilisationsfilter og luftindstrømnings-10 ledningen 48.Another embodiment of means for interrupting the elution process in a radioisotope generator is shown in FIG. 3, which is a partial section through a radioisotope generator with an eluate conduit 22, a needle assembly 24, a support plate 42 and an air inflow conduit 48 corresponding to the generator of FIG. 1. In this embodiment, means 70 for interrupting an elution process comprise a rod 72 of resilient material, the lower end portion 74 of which is bent in the form of a spring which preloads the rod upwards. The distal end of the lower end portion 74 of the rod 72 is secured to a support member 76 mounted on the support plate 42. The rod 72 passes through an opening 78 in the support plate 42 and the support member 76, 30 and the upper end of the rod not shown extends into a not shown. tapping area similar to the one shown in FIG. 1. The air inlet conduit 48 is squeezed or closed between a bent intermediate piece 79 of the rod 72 and a recess 80 in the carrier 76, 35 formed by downwardly extending ears 82 guiding the rod and conduit. When the rod 72 slidingly mounted in the generator housing not shown and in the opening 78 of the carrier 76 is pressed downward against its own spring load by means of a shielded elution bottle not shown in the same manner as described above, the clamping or closing of the conduit 48 is interrupted. so that the generator and elution bottle are exposed to sterile air which is sucked through a sterilization filter not shown and the air inflow line 48.
I sine foretrukne udførelsesformer angiver nærværende opfindelse således midler til afbrydelse af elutionsprocessen på ethvert givet tidspunkt ved nedtrykning af en elutionsflaske mod en fjederfor-15 spænding, hvorved der indføres steril luft i elu-tionsflasken. Endvidere er muligheden for hermetisk lukning af den komplette generator ikke hindret ved tilføjelsen af afbrydelsesmidlerne.Thus, in its preferred embodiments, the present invention provides means for interrupting the elution process at any given time by depressing an elution bottle against a spring tension, thereby introducing sterile air into the elution bottle. Furthermore, the possibility of hermetically closing the complete generator is not hindered by the addition of the interrupting means.
Claims (8)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL7902342 | 1979-03-26 | ||
| NL7902342A NL7902342A (en) | 1979-03-26 | 1979-03-26 | ISOTOPE GENERATOR. |
| PCT/NL1980/000009 WO1980002082A1 (en) | 1979-03-26 | 1980-03-25 | Radioisotope generator |
| NL8000009 | 1980-03-25 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK501680A DK501680A (en) | 1980-11-25 |
| DK151422B true DK151422B (en) | 1987-11-30 |
| DK151422C DK151422C (en) | 1988-07-04 |
Family
ID=19832865
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK501680A DK151422C (en) | 1979-03-26 | 1980-11-25 | Radioisotope GENERATOR |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4387303A (en) |
| JP (1) | JPS6361640B2 (en) |
| AT (1) | AT379252B (en) |
| AU (1) | AU533194B2 (en) |
| BE (1) | BE882456A (en) |
| CA (1) | CA1143872A (en) |
| CH (1) | CH650355A5 (en) |
| DE (1) | DE3038753T1 (en) |
| DK (1) | DK151422C (en) |
| FR (1) | FR2452767B1 (en) |
| GB (1) | GB2070319B (en) |
| IL (1) | IL59617A (en) |
| IT (1) | IT1128075B (en) |
| NL (2) | NL7902342A (en) |
| SE (1) | SE447521B (en) |
| WO (1) | WO1980002082A1 (en) |
| ZA (1) | ZA801749B (en) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4472299A (en) * | 1981-04-24 | 1984-09-18 | Amersham International Plc | Generator for radionuclide and process of use thereof |
| GB8303558D0 (en) * | 1983-02-09 | 1983-03-16 | Amersham Int Plc | Generator for radionuclide |
| CS255601B1 (en) * | 1984-05-18 | 1988-03-15 | Kristian Svoboda | 99 mtc elution unit-built generator and method of its production |
| US4833329A (en) * | 1987-11-20 | 1989-05-23 | Mallinckrodt, Inc. | System for generating and containerizing radioisotopes |
| CA2104386A1 (en) * | 1991-03-14 | 1992-10-01 | Harm M. Benjamins | Method of improving the elution yield of a radioisotope generator |
| US5633900A (en) * | 1993-10-04 | 1997-05-27 | Hassal; Scott B. | Method and apparatus for production of radioactive iodine |
| WO1997045841A1 (en) * | 1996-05-29 | 1997-12-04 | Gosudarstvenny Nauchny Tsentr Fiziko-Energetichesky Institut | Device for producing sterile radionuclides |
| US6157036A (en) * | 1998-12-02 | 2000-12-05 | Cedars-Sinai Medical Center | System and method for automatically eluting and concentrating a radioisotope |
| EP1022049A1 (en) * | 1999-01-22 | 2000-07-26 | Mallinckrodt Medical, Inc. | Process for the purification and concentration of radioiodide isotopes |
| GB2386742B (en) * | 2002-03-20 | 2004-02-11 | Amersham Plc | Radioisotope generator component support |
| GB2386743B (en) * | 2002-04-11 | 2004-02-11 | Amersham Plc | Radioisotope generator |
| GB2382453B (en) * | 2002-04-11 | 2004-05-19 | Amersham Plc | Radioisotope generator and method of construction thereof |
| US6998052B2 (en) * | 2002-04-12 | 2006-02-14 | Pg Research Foundation | Multicolumn selectivity inversion generator for production of ultrapure radionuclides |
| CA2616832A1 (en) * | 2005-07-27 | 2007-02-08 | Mallinckrodt Inc. | Alignment adapter for use with a radioisotope generator and methods of using the same |
| EP1920443A2 (en) * | 2005-08-09 | 2008-05-14 | Mallinckrodt, Inc. | Radioisotope generation system having partial elution capability |
| US20070158271A1 (en) * | 2006-01-12 | 2007-07-12 | Draxis Health Inc. | Systems and Methods for Radioisotope Generation |
| US7700926B2 (en) * | 2006-01-12 | 2010-04-20 | Draximage General Partnership | Systems and methods for radioisotope generation |
| PL3270383T3 (en) | 2006-10-06 | 2020-04-30 | Mallinckrodt Nuclear Medicine Llc | Self-aligning radioisotope elution system |
| WO2009039074A1 (en) * | 2007-09-19 | 2009-03-26 | Mallinckrodt Inc. | Radioisotope-generator valve |
| US9240253B2 (en) | 2010-04-07 | 2016-01-19 | Ge-Hitachi Nuclear Energy Americas Llc | Column geometry to maximize elution efficiencies for molybdenum-99 |
| ITPD20100186A1 (en) * | 2010-06-11 | 2011-12-12 | Attilio Cecchin | APPARATUS FOR ELECTION AND ELECTION PROCEDURE |
| US8809804B2 (en) * | 2011-01-19 | 2014-08-19 | Mallinckrodt Llc | Holder and tool for radioisotope elution system |
| US8866104B2 (en) | 2011-01-19 | 2014-10-21 | Mallinckrodt Llc | Radioisotope elution system |
| US9153350B2 (en) | 2011-01-19 | 2015-10-06 | Mallinckrodt Llc | Protective shroud for nuclear pharmacy generators |
| NL2007925C2 (en) * | 2011-12-06 | 2013-06-10 | Univ Delft Tech | Radionuclide generator. |
| US11027030B2 (en) | 2014-08-29 | 2021-06-08 | Anmi S.A. | Kit for radiolabelling |
| BE1021191B1 (en) | 2014-08-29 | 2015-10-27 | Anmi S.A. | KIT FOR RADIOMARKING. |
| US11618529B2 (en) | 2020-06-03 | 2023-04-04 | Dextera Brakes, Llc | Grip assembly for vehicle |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3774035A (en) * | 1971-07-12 | 1973-11-20 | New England Nuclear Corp | Method and system for generating and collecting a radionuclide eluate |
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| FR1432721A (en) * | 1965-02-10 | 1966-03-25 | Saint Gobain Techn Nouvelles | Device for the production of radio-elements |
| US3369121A (en) * | 1966-04-06 | 1968-02-13 | Squibb & Sons Inc | Radioactive package and container therefor |
| NL6607699A (en) * | 1966-06-03 | 1967-12-04 | ||
| US3576998A (en) * | 1966-11-16 | 1971-05-04 | Nen Picker Radiopharmaceutical | Self-contained, closed system and method for generating and collecting a short-lived daughter radionuclide from a long-lived parent radionuclide |
| US3535085A (en) * | 1967-08-07 | 1970-10-20 | Mallinckrodt Chemical Works | Closed system generation and containerization of radioisotopes |
| US3655981A (en) * | 1968-11-29 | 1972-04-11 | Mallinckrodt Chemical Works | Closed system generation and containerization of radioisotopes for eluting a daughter radioisotope from a parent radioisotope |
| US3710118A (en) * | 1970-05-25 | 1973-01-09 | Mallinckrodt Chemical Works | Radioisotope generator |
| US3774036A (en) * | 1972-02-23 | 1973-11-20 | Searle & Co | Generation of a supply of radionuclide |
| NO141829C (en) * | 1973-05-04 | 1980-05-21 | Squibb & Sons Inc | GENERATOR FOR STERILY, WASHABLE RADIOACTIVE MATERIAL |
| US3920995A (en) * | 1973-05-04 | 1975-11-18 | Squibb & Sons Inc | Radioactive material generator |
| US3986537A (en) * | 1975-11-11 | 1976-10-19 | Horix Manufacturing Company | Pneumatic system for controlling a container-filling machine filling valve |
| US4276256A (en) * | 1976-11-01 | 1981-06-30 | Karamian Narbik A | Method for preventing bacterial passage into sterile fluid systems |
-
1979
- 1979-03-26 NL NL7902342A patent/NL7902342A/en not_active Application Discontinuation
-
1980
- 1980-02-18 CA CA000346008A patent/CA1143872A/en not_active Expired
- 1980-03-14 IL IL59617A patent/IL59617A/en not_active IP Right Cessation
- 1980-03-25 FR FR8006600A patent/FR2452767B1/en not_active Expired
- 1980-03-25 GB GB8111220A patent/GB2070319B/en not_active Expired
- 1980-03-25 DE DE803038753T patent/DE3038753T1/en active Granted
- 1980-03-25 CH CH8818/80A patent/CH650355A5/en not_active IP Right Cessation
- 1980-03-25 NL NL8020105A patent/NL8020105A/nl unknown
- 1980-03-25 ZA ZA00801749A patent/ZA801749B/en unknown
- 1980-03-25 JP JP55501695A patent/JPS6361640B2/ja not_active Expired
- 1980-03-25 AT AT0908980A patent/AT379252B/en not_active IP Right Cessation
- 1980-03-25 IT IT67458/80A patent/IT1128075B/en active
- 1980-03-25 WO PCT/NL1980/000009 patent/WO1980002082A1/en active Application Filing
- 1980-03-25 AU AU56827/80A patent/AU533194B2/en not_active Ceased
- 1980-03-26 BE BE0/199969A patent/BE882456A/en not_active IP Right Cessation
- 1980-11-24 US US06/209,980 patent/US4387303A/en not_active Expired - Lifetime
- 1980-11-25 DK DK501680A patent/DK151422C/en not_active IP Right Cessation
-
1981
- 1981-04-24 SE SE8102620A patent/SE447521B/en not_active IP Right Cessation
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3774035A (en) * | 1971-07-12 | 1973-11-20 | New England Nuclear Corp | Method and system for generating and collecting a radionuclide eluate |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6361640B2 (en) | 1988-11-29 |
| CA1143872A (en) | 1983-03-29 |
| DK151422C (en) | 1988-07-04 |
| FR2452767B1 (en) | 1987-05-22 |
| CH650355A5 (en) | 1985-07-15 |
| AU5682780A (en) | 1980-10-02 |
| US4387303A (en) | 1983-06-07 |
| NL7902342A (en) | 1980-09-30 |
| DE3038753C2 (en) | 1991-01-10 |
| IL59617A (en) | 1983-07-31 |
| NL8020105A (en) | 1981-07-01 |
| IT1128075B (en) | 1986-05-28 |
| AT379252B (en) | 1985-12-10 |
| JPS56500312A (en) | 1981-03-12 |
| GB2070319B (en) | 1983-02-09 |
| FR2452767A1 (en) | 1980-10-24 |
| WO1980002082A1 (en) | 1980-10-02 |
| DK501680A (en) | 1980-11-25 |
| SE447521B (en) | 1986-11-17 |
| IT8067458A0 (en) | 1980-03-25 |
| SE8102620L (en) | 1981-04-24 |
| DE3038753T1 (en) | 1982-02-11 |
| ZA801749B (en) | 1981-03-25 |
| AU533194B2 (en) | 1983-11-10 |
| ATA908980A (en) | 1985-04-15 |
| BE882456A (en) | 1980-07-16 |
| GB2070319A (en) | 1981-09-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PBP | Patent lapsed |