DK1501859T3 - 17 alpha-fluoroalkyl-11 beta-benzaldoxime steroids, process for their preparation, pharmaceutical compositions containing these steroids and their use in the manufacture of drugs - Google Patents

17 alpha-fluoroalkyl-11 beta-benzaldoxime steroids, process for their preparation, pharmaceutical compositions containing these steroids and their use in the manufacture of drugs

Info

Publication number
DK1501859T3
DK1501859T3 DK03725149T DK03725149T DK1501859T3 DK 1501859 T3 DK1501859 T3 DK 1501859T3 DK 03725149 T DK03725149 T DK 03725149T DK 03725149 T DK03725149 T DK 03725149T DK 1501859 T3 DK1501859 T3 DK 1501859T3
Authority
DK
Denmark
Prior art keywords
steroids
fluoroalkyl
drugs
beta
alpha
Prior art date
Application number
DK03725149T
Other languages
Danish (da)
Inventor
Sven Ring
Gerd Schubert
Guenter Kaufmann
Walter Elger
Birgitt Schneider
Ingo Tornus
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10221034A external-priority patent/DE10221034A1/en
Application filed by Schering Ag filed Critical Schering Ag
Application granted granted Critical
Publication of DK1501859T3 publication Critical patent/DK1501859T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention relates to compounds of general formula I and the pharmaceutically compatible salts thereof, wherein R1 represents hydrogen, C1- to C6-alkyl, COR4, COOR4, COSR4 or CONHR5, wherein R4 represents C1- to C6-alkyl or unsubstituted or substituted aryl and R5 represents hydrogen, C1- to C6-alkyl or unsubstituted or substituted aryl, additionally R2 represents hydrogen, C1- to C6-alkyl or C1- to C6-acyl and R3 represents a CnF2n+1-group, wherein n = 1, 2 or 3, or represents a CH2O(CH2)mCnF2n+1-group, whereby m = 0 or 1 and n = 1, 2 or 3. The invention also relates to a method for producing said compounds of general formula I. Said compounds can be used in the production of medicaments.
DK03725149T 2002-05-03 2003-05-05 17 alpha-fluoroalkyl-11 beta-benzaldoxime steroids, process for their preparation, pharmaceutical compositions containing these steroids and their use in the manufacture of drugs DK1501859T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10221034A DE10221034A1 (en) 2002-05-03 2002-05-03 New 17-alpha-fluoroalkyl-11-beta-benzaldoxime-estradiene derivatives, useful as antigestagens in post-menopausal hormone replacement therapy or for treating e.g. gynecological disorders
US44940103P 2003-02-25 2003-02-25

Publications (1)

Publication Number Publication Date
DK1501859T3 true DK1501859T3 (en) 2006-03-06

Family

ID=29403591

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03725149T DK1501859T3 (en) 2002-05-03 2003-05-05 17 alpha-fluoroalkyl-11 beta-benzaldoxime steroids, process for their preparation, pharmaceutical compositions containing these steroids and their use in the manufacture of drugs

Country Status (8)

Country Link
EP (1) EP1501859B1 (en)
JP (1) JP2005536463A (en)
AT (1) ATE307823T1 (en)
AU (1) AU2003227717A1 (en)
DE (1) DE50301507D1 (en)
DK (1) DK1501859T3 (en)
ES (1) ES2252670T3 (en)
WO (1) WO2003093292A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006054535A1 (en) 2006-11-15 2008-05-21 Bayer Schering Pharma Aktiengesellschaft Progesterone receptor antagonist
DE102009034367A1 (en) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluoroethyl-estra-4,9 (10) -diene-11-benzylidene derivatives, process for their preparation and their use for the treatment of diseases
DE102009034362A1 (en) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluoroethyl-estra-4,9 (10) -diene-11-aryl derivatives, process for their preparation and their use for the treatment of diseases
DE102009034366A1 (en) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluoroethyl-estra-4,9 (10) -diene-11-methyleneoxyalkylene aryl derivatives, process for their preparation and their use for the treatment of diseases
DE102009034368A1 (en) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluoroethyl-estra-4,9 (10) -diene-11-acyloxyalkylenephenyl derivatives, process for their preparation and their use for the treatment of diseases
DE102009034525A1 (en) 2009-07-21 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluoroethyl-estra-4,9 (10) -diene-11-aryl derivatives, process for their preparation and their use for the treatment of diseases
DE102010007722A1 (en) 2010-02-10 2011-08-11 Bayer Schering Pharma Aktiengesellschaft, 13353 Progesterone receptor antagonist
DE102010007719A1 (en) 2010-02-10 2011-08-11 Bayer Schering Pharma Aktiengesellschaft, 13353 Progesterone receptor antagonist
US20130029953A1 (en) * 2011-07-28 2013-01-31 Klaus Nickisch Progesterone antagonists

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19706061A1 (en) * 1997-02-07 1998-08-13 Schering Ag Anti-gestagen effective steroids with fluorinated 17alpha alkyl chain
DE19745085A1 (en) * 1997-10-11 1999-04-15 Jenapharm Gmbh 11β-Benzaldoxim-9alpha, 10alpha-epoxy-estr-4-ene derivatives, processes for their preparation and pharmaceutical preparations containing these compounds

Also Published As

Publication number Publication date
DE50301507D1 (en) 2005-12-01
EP1501859B1 (en) 2005-10-26
ATE307823T1 (en) 2005-11-15
EP1501859A1 (en) 2005-02-02
ES2252670T3 (en) 2006-05-16
WO2003093292A1 (en) 2003-11-13
AU2003227717A1 (en) 2003-11-17
JP2005536463A (en) 2005-12-02

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