DK145715C - Fremgangsmaade til fremstilling af peptider ved kobling ved hjaelp af en aktiv ester og under tilsaetning af en n-heterocyclisk katalysator - Google Patents

Fremgangsmaade til fremstilling af peptider ved kobling ved hjaelp af en aktiv ester og under tilsaetning af en n-heterocyclisk katalysator

Info

Publication number
DK145715C
DK145715C DK328672A DK328672A DK145715C DK 145715 C DK145715 C DK 145715C DK 328672 A DK328672 A DK 328672A DK 328672 A DK328672 A DK 328672A DK 145715 C DK145715 C DK 145715C
Authority
DK
Denmark
Prior art keywords
procedure
coupling
addition
active ester
preparing peptides
Prior art date
Application number
DK328672A
Other languages
English (en)
Other versions
DK145715B (da
Inventor
Wolfgang Koenig
Rolf Geiger
Hans Wissmann
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19712132767 external-priority patent/DE2132767A1/de
Priority claimed from DE2202613A external-priority patent/DE2202613C3/de
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of DK145715B publication Critical patent/DK145715B/da
Application granted granted Critical
Publication of DK145715C publication Critical patent/DK145715C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/695—Corticotropin [ACTH]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C329/00—Thiocarbonic acids; Halides, esters or anhydrides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/94—Oxygen atom, e.g. piperidine N-oxide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/36—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/10—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using coupling agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
    • C07K1/124—Hydrazinolysis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C07K14/625—Extraction from natural sources
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06043—Leu-amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK328672A 1971-07-01 1972-06-30 Fremgangsmaade til fremstilling af peptider ved kobling ved hjaelp af en aktiv ester og under tilsaetning af en n-heterocyclisk katalysator DK145715C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19712132767 DE2132767A1 (de) 1971-07-01 1971-07-01 Verfahren zur herstellung von peptiden
DE2132767 1971-07-01
DE2202613A DE2202613C3 (de) 1972-01-20 1972-01-20 Verfahren zur Herstellung von Peptiden
DE2202613 1972-01-20

Publications (2)

Publication Number Publication Date
DK145715B DK145715B (da) 1983-02-07
DK145715C true DK145715C (da) 1983-08-08

Family

ID=25761356

Family Applications (1)

Application Number Title Priority Date Filing Date
DK328672A DK145715C (da) 1971-07-01 1972-06-30 Fremgangsmaade til fremstilling af peptider ved kobling ved hjaelp af en aktiv ester og under tilsaetning af en n-heterocyclisk katalysator

Country Status (12)

Country Link
JP (1) JPS5110201B1 (da)
AT (1) AT340067B (da)
BE (1) BE785790A (da)
CA (1) CA988079A (da)
DD (1) DD99570A5 (da)
DK (1) DK145715C (da)
FR (1) FR2144416A5 (da)
GB (1) GB1396801A (da)
HU (1) HU169326B (da)
IL (1) IL39788A (da)
NL (1) NL176255C (da)
SU (1) SU511852A3 (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6262230B1 (en) * 1994-01-28 2001-07-17 Sciclone Pharmaceuticals Inc. Analogs of thymosin α1
KR102571783B1 (ko) * 2022-12-16 2023-08-29 스트라토 주식회사 대용량 검색 처리를 수행하는 검색 처리 시스템 및 그 제어방법

Also Published As

Publication number Publication date
DK145715B (da) 1983-02-07
HU169326B (en) 1976-11-27
BE785790A (fr) 1973-01-03
JPS5110201B1 (da) 1976-04-02
ATA565672A (de) 1977-03-15
IL39788A0 (en) 1972-08-30
CA988079A (en) 1976-04-27
FR2144416A5 (da) 1973-02-09
AT340067B (de) 1977-11-25
NL176255B (nl) 1984-10-16
DD99570A5 (da) 1973-08-12
NL7208757A (da) 1973-01-03
GB1396801A (en) 1975-06-04
SU511852A3 (ru) 1976-04-25
IL39788A (en) 1976-07-30
NL176255C (nl) 1985-03-18

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