DK13888A - CRYSTALLINIC CEFADROXIL, PROCEDURE FOR ITS PREPARATION, AND PHARMACEUTICAL PREPARATION CONTAINING SUCH IT - Google Patents

CRYSTALLINIC CEFADROXIL, PROCEDURE FOR ITS PREPARATION, AND PHARMACEUTICAL PREPARATION CONTAINING SUCH IT

Info

Publication number
DK13888A
DK13888A DK013888A DK13888A DK13888A DK 13888 A DK13888 A DK 13888A DK 013888 A DK013888 A DK 013888A DK 13888 A DK13888 A DK 13888A DK 13888 A DK13888 A DK 13888A
Authority
DK
Denmark
Prior art keywords
cefadroxil
preparation
crystallinic
procedure
cefadroxyl
Prior art date
Application number
DK013888A
Other languages
Danish (da)
Other versions
DK13888D0 (en
Inventor
Leonardo Marsili
Original Assignee
Rifar Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB878709804A external-priority patent/GB8709804D0/en
Priority claimed from GB878718394A external-priority patent/GB8718394D0/en
Application filed by Rifar Srl filed Critical Rifar Srl
Publication of DK13888D0 publication Critical patent/DK13888D0/en
Publication of DK13888A publication Critical patent/DK13888A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to a novel crystalline cefadroxyl hemihydrate having a K.F. between about 3.5 and 2.0% : such compound is more stable than other cefadroxyl molecules. The novel cefadroxyl is obtained preparing and isolating a novel cefadroxil solvate of dimethylacetamide, or of N-methyl-2--pyrrolidone or of monomethylformamide, slurrying said solvate with a mixture methanol/isopropyl alcohol 30:70 to 70:30 by volume in the presence of from 5% to 12% of water a temperature of about +45 DEG C to + 55 DEG C and then filtering the so obtained compound.
DK013888A 1987-04-24 1988-01-13 CRYSTALLINIC CEFADROXIL, PROCEDURE FOR ITS PREPARATION, AND PHARMACEUTICAL PREPARATION CONTAINING SUCH IT DK13888A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB878709804A GB8709804D0 (en) 1987-04-24 1987-04-24 Crystalline cefadroxil
GB878718394A GB8718394D0 (en) 1987-08-04 1987-08-04 Crystalline cefadroxil hemihydrate
US07/089,168 US4904776A (en) 1987-04-24 1987-08-25 Method for producing crystalline cefadroxil hemihydrate

Publications (2)

Publication Number Publication Date
DK13888D0 DK13888D0 (en) 1988-01-13
DK13888A true DK13888A (en) 1988-10-25

Family

ID=27263404

Family Applications (1)

Application Number Title Priority Date Filing Date
DK013888A DK13888A (en) 1987-04-24 1988-01-13 CRYSTALLINIC CEFADROXIL, PROCEDURE FOR ITS PREPARATION, AND PHARMACEUTICAL PREPARATION CONTAINING SUCH IT

Country Status (13)

Country Link
US (1) US4904776A (en)
EP (1) EP0287751B1 (en)
JP (1) JP2620582B2 (en)
CN (1) CN1019804B (en)
AT (1) ATE116322T1 (en)
AU (1) AU595415B2 (en)
DE (1) DE3852560T2 (en)
DK (1) DK13888A (en)
ES (1) ES2068812T3 (en)
FI (1) FI87569C (en)
PH (1) PH26292A (en)
PT (1) PT86653B (en)
SU (1) SU1630613A3 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8714180D0 (en) * 1987-06-17 1987-07-22 Rifar Srl Anhydrous crystalline cefadroxil
ATE112780T1 (en) * 1989-07-10 1994-10-15 Biochemie Sa STABLE FORM OF CEPHRADINE, PROCESS FOR ITS PRODUCTION AND INTERMEDIATE PRODUCTS USED THEREIN.
IN190389B (en) 1999-07-14 2003-07-26 Ranbaxy Lab Ltd
WO2001004126A1 (en) * 1999-07-14 2001-01-18 Ranbaxy Laboratories Limited Process for preparing crystalline cefadroxil hemihydrate from cefadroxil dimethylformamide solvate
CN1311830C (en) * 2004-02-27 2007-04-25 石药集团中奇制药技术（石家庄）有限公司 Cefadroxil oral disintegrant tablet, and its prepn. method
CN101448842A (en) * 2006-05-19 2009-06-03 帝斯曼知识产权资产管理有限公司 Process for the crystallisation of cefadroxil
CN102134250B (en) * 2011-01-19 2013-03-13 天津大学 Crystallization method of cefadroxil monohydrate and crystals
CN104447795B (en) * 2014-11-28 2016-08-17 珠海金鸿药业股份有限公司 A kind of cefadroxil benzyl compound and pharmaceutical composition thereof
CN105534937B (en) * 2015-12-30 2019-12-03 石药集团欧意药业有限公司 A kind of cefadroxil tablet and preparation method thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1532682A (en) * 1976-04-27 1978-11-22 Bristol Myers Co Process for the preparation of cephadroxil
US4504697A (en) * 1982-04-28 1985-03-12 Littelfuse, Inc. Sealed electrical devices

Also Published As

Publication number Publication date
ES2068812T3 (en) 1995-05-01
FI881038A0 (en) 1988-03-07
DK13888D0 (en) 1988-01-13
ATE116322T1 (en) 1995-01-15
CN1019804B (en) 1992-12-30
AU1028588A (en) 1988-10-27
PT86653A (en) 1988-02-01
DE3852560T2 (en) 1995-05-04
AU595415B2 (en) 1990-03-29
FI881038A (en) 1988-10-25
JP2620582B2 (en) 1997-06-18
DE3852560D1 (en) 1995-02-09
SU1630613A3 (en) 1991-02-23
EP0287751A3 (en) 1990-05-02
CN88101895A (en) 1988-11-30
US4904776A (en) 1990-02-27
PT86653B (en) 1992-07-31
EP0287751B1 (en) 1994-12-28
PH26292A (en) 1992-04-10
EP0287751A2 (en) 1988-10-26
FI87569C (en) 1993-01-25
FI87569B (en) 1992-10-15
JPS63267789A (en) 1988-11-04

Similar Documents

Publication Publication Date Title
DK513385D0 (en) POLYPEPTIDE, PROCEDURE FOR ITS PREPARATION AND PHARMACEUTICAL PREPARATION CONTAINING SUCH POLYPEPTIDE
DK13888A (en) CRYSTALLINIC CEFADROXIL, PROCEDURE FOR ITS PREPARATION, AND PHARMACEUTICAL PREPARATION CONTAINING SUCH IT
ES8705411A1 (en) 1-Piperazine carboxamide derivatives, their preparation and their use in pharmaceutical compositions.
NO168425C (en) PROCEDURE FOR THE PREPARATION OF CRYSTALLINIC CEFADROXYL MONOHYDRATE
DK680487A (en) IN THE Essential Anhydrous, Crystalline CEFADROXIL AND PROCEDURES FOR PRODUCING THEREOF
JPS567799A (en) Novel pseudotrisaccharide* its manufacture and use as medicine
ATE75479T1 (en) N-ACETYL-3-FLUORONEURAMIC ACID DERIVATIVES AND THEIR PRODUCTION.
JPS5663953A (en) Novel preparation of n- 1-ethyl-2-pyrrolidinylmethyl -2- methoxy-5-sulfamoylbenzamide
JPS5673086A (en) Preparation of cephalosporin compound

Legal Events

Date Code Title Description
AHB Application shelved due to non-payment