DK135895B - Analogous process for the preparation of derivatives of 4'-fluoro-4- (4- (alpha-hydroxybenzyl) piperidino) butyrophenones. - Google Patents

Analogous process for the preparation of derivatives of 4'-fluoro-4- (4- (alpha-hydroxybenzyl) piperidino) butyrophenones.

Info

Publication number
DK135895B
DK135895B DK582171AA DK582171A DK135895B DK 135895 B DK135895 B DK 135895B DK 582171A A DK582171A A DK 582171AA DK 582171 A DK582171 A DK 582171A DK 135895 B DK135895 B DK 135895B
Authority
DK
Denmark
Prior art keywords
butyrophenones
hydroxybenzyl
piperidino
fluoro
alpha
Prior art date
Application number
DK582171AA
Other languages
Danish (da)
Other versions
DK135895C (en
Inventor
Albert Anthony Carr
Original Assignee
Richardson Merrell Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richardson Merrell Inc filed Critical Richardson Merrell Inc
Publication of DK135895B publication Critical patent/DK135895B/en
Application granted granted Critical
Publication of DK135895C publication Critical patent/DK135895C/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK582171AA 1970-11-27 1971-11-26 Analogous process for the preparation of derivatives of 4'-fluoro-4- (4- (alpha-hydroxybenzyl) piperidino) butyrophenones. DK135895B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US9349570A 1970-11-27 1970-11-27

Publications (2)

Publication Number Publication Date
DK135895B true DK135895B (en) 1977-07-11
DK135895C DK135895C (en) 1977-12-12

Family

ID=22239276

Family Applications (1)

Application Number Title Priority Date Filing Date
DK582171AA DK135895B (en) 1970-11-27 1971-11-26 Analogous process for the preparation of derivatives of 4'-fluoro-4- (4- (alpha-hydroxybenzyl) piperidino) butyrophenones.

Country Status (16)

Country Link
JP (1) JPS5623985B2 (en)
BE (1) BE775593A (en)
CA (1) CA957376A (en)
CH (1) CH562215A5 (en)
DE (1) DE2158136C2 (en)
DK (1) DK135895B (en)
ES (1) ES397370A1 (en)
FR (1) FR2115451B1 (en)
GB (1) GB1314955A (en)
IE (1) IE35778B1 (en)
IL (1) IL38079A (en)
NL (1) NL175411C (en)
NO (1) NO135248C (en)
PH (1) PH9306A (en)
SE (1) SE369900B (en)
ZA (1) ZA717147B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK152669B (en) * 1979-02-09 1988-04-11 Richardson Merrell Inc METHOD OF ANALOGUE FOR THE PREPARATION OF 4- (NAPHTHYL-METHYL) -PIPERIDINE DERIVATIVES OR PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS THEREOF, AND COMPOUNDS FOR USING SOURCE MATERIALS

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7409245L (en) * 1973-07-19 1975-01-20 Robins Co Inc A H
IE49998B1 (en) * 1979-08-06 1986-01-22 Merrell Dow Pharma 4-(naphthalenyloxy)piperidine derivatives
US4283404A (en) * 1979-09-04 1981-08-11 Richardson-Merrell Inc. Aroylethenylpiperidinobutyrophenone antipsychotic agents
US4284636A (en) * 1979-09-04 1981-08-18 Richardson-Merrell Inc. Cinnamoylpiperidinobutyrophenone antipsychotic agents
ZA806501B (en) * 1979-10-27 1981-10-28 Richardson Merrell Inc 4-(4-alkyl-aroyl-1-piperidino)butyrophenone antipsychotic agents
ZA864772B (en) * 1985-07-02 1987-02-25 Merrell Dow Pharma Novel chemical compounds
US4783471A (en) * 1985-07-02 1988-11-08 Merrell Dow Pharmaceuticals Inc. N-aralkyl piperidine methanol derivatives and the uses thereof
IL117149A0 (en) * 1995-02-23 1996-06-18 Schering Corp Muscarinic antagonists
TW200621747A (en) * 2004-09-13 2006-07-01 Fmc Corp Processes for preparing n-(substituted arylmethyl)-4-(disubstituted methyl)piperidines and intermediates

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK152669B (en) * 1979-02-09 1988-04-11 Richardson Merrell Inc METHOD OF ANALOGUE FOR THE PREPARATION OF 4- (NAPHTHYL-METHYL) -PIPERIDINE DERIVATIVES OR PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS THEREOF, AND COMPOUNDS FOR USING SOURCE MATERIALS

Also Published As

Publication number Publication date
IE35778L (en) 1972-05-27
PH9306A (en) 1975-08-18
IL38079A0 (en) 1972-01-27
ZA717147B (en) 1972-07-26
CH562215A5 (en) 1975-05-30
NO135248B (en) 1976-11-29
FR2115451B1 (en) 1975-02-07
NL175411C (en) 1984-11-01
CA957376A (en) 1974-11-05
IE35778B1 (en) 1976-05-26
GB1314955A (en) 1973-04-26
IL38079A (en) 1974-10-22
BE775593A (en) 1972-03-16
ES397370A1 (en) 1974-05-16
DK135895C (en) 1977-12-12
NO135248C (en) 1977-03-09
NL7116194A (en) 1972-05-30
SE369900B (en) 1974-09-23
DE2158136C2 (en) 1982-11-18
FR2115451A1 (en) 1972-07-07
DE2158136A1 (en) 1972-05-31
NL175411B (en) 1984-06-01
JPS5623985B2 (en) 1981-06-03

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Legal Events

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PUP Patent expired