DK1343764T3 - Urea and urethane derivatives as integrin inhibitors - Google Patents

Urea and urethane derivatives as integrin inhibitors

Info

Publication number
DK1343764T3
DK1343764T3 DK01271360T DK01271360T DK1343764T3 DK 1343764 T3 DK1343764 T3 DK 1343764T3 DK 01271360 T DK01271360 T DK 01271360T DK 01271360 T DK01271360 T DK 01271360T DK 1343764 T3 DK1343764 T3 DK 1343764T3
Authority
DK
Denmark
Prior art keywords
urea
integrin inhibitors
urethane derivatives
urethane
derivatives
Prior art date
Application number
DK01271360T
Other languages
Danish (da)
Inventor
Wolfgang Staehle
Oliver Schadt
Alfred Jonczyk
Simon Goodman
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Application granted granted Critical
Publication of DK1343764T3 publication Critical patent/DK1343764T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurology (AREA)
  • Vascular Medicine (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Virology (AREA)
  • Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK01271360T 2000-12-18 2001-11-30 Urea and urethane derivatives as integrin inhibitors DK1343764T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10063173A DE10063173A1 (en) 2000-12-18 2000-12-18 Urea and urethane derivatives

Publications (1)

Publication Number Publication Date
DK1343764T3 true DK1343764T3 (en) 2004-12-06

Family

ID=7667710

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01271360T DK1343764T3 (en) 2000-12-18 2001-11-30 Urea and urethane derivatives as integrin inhibitors

Country Status (23)

Country Link
US (1) US7135587B2 (en)
EP (1) EP1343764B1 (en)
JP (1) JP4216071B2 (en)
KR (1) KR20030063432A (en)
CN (1) CN1481364A (en)
AR (1) AR035608A1 (en)
AT (1) ATE274497T1 (en)
AU (1) AU2002217078A1 (en)
BR (1) BR0116202A (en)
CA (1) CA2431974C (en)
CZ (1) CZ20031775A3 (en)
DE (2) DE10063173A1 (en)
DK (1) DK1343764T3 (en)
ES (1) ES2227063T3 (en)
HU (1) HUP0302753A3 (en)
MX (1) MXPA03005431A (en)
NO (1) NO20032754D0 (en)
PL (1) PL361745A1 (en)
PT (1) PT1343764E (en)
RU (1) RU2003121015A (en)
SK (1) SK8182003A3 (en)
WO (1) WO2002050039A1 (en)
ZA (1) ZA200305550B (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10204789A1 (en) * 2002-02-06 2003-08-14 Merck Patent Gmbh Inhibitors of the integrin alpha¶v¶beta6
EP2287199B1 (en) 2002-03-13 2017-08-02 Biogen MA Inc. Anti-alpha V beta 6 antibodies
KR101191068B1 (en) * 2003-10-01 2012-10-15 메르크 파텐트 게엠베하 Alfavbeta3 and alfavbeta6 integrin antagonists as antifibrotic agents
CN102875681A (en) 2005-07-08 2013-01-16 拜奥根Idec马萨诸塞公司 Anti-alpha v beta 6 antibodies and uses thereof
KR20090027241A (en) 2006-07-10 2009-03-16 바이오겐 아이덱 엠에이 인코포레이티드 Compositions and methods for inhibiting growth of smad4-deficient cancers
EP2087008A1 (en) * 2006-10-19 2009-08-12 The Regents of the University of California TREATMENT AND PREVENTION OF CHRONIC ASTHMA USING ANTAGONISTS OF INTEGRIN alphaVbeta6
AT509266B1 (en) * 2009-12-28 2014-07-15 Tech Universität Wien SUBSTITUTED PYRIDINES AND PYRIMIDINES
CN102353728B (en) * 2011-06-29 2013-03-27 中国食品发酵工业研究院 Rapid detection method for production process quality control of yellow wine
US10035860B2 (en) 2013-03-15 2018-07-31 Biogen Ma Inc. Anti-alpha V beta 6 antibodies and uses thereof
WO2014144466A1 (en) 2013-03-15 2014-09-18 Biogen Idec Ma Inc. Anti-alpha v beta 6 antibodies and uses thereof
WO2017068090A1 (en) * 2015-10-23 2017-04-27 Vifor (International) Ag Novel ferroportin inhibitors
JOP20180036A1 (en) 2017-04-18 2019-01-30 Vifor Int Ag Novel ferroportin-inhibitor salts

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6306840B1 (en) 1995-01-23 2001-10-23 Biogen, Inc. Cell adhesion inhibitors
DE69942610D1 (en) 1998-04-16 2010-09-02 Encysive Pharmaceuticals Inc THE BINDING OF INTEGRINES TO THEIR RECEPTORS PREVENTS CONNECTIONS
GB9909409D0 (en) * 1999-04-24 1999-06-23 Zeneca Ltd Chemical compounds
DE19939980A1 (en) * 1999-08-24 2001-03-01 Merck Patent Gmbh Inhibitors of the integrin alphavbeta¶3¶

Also Published As

Publication number Publication date
AR035608A1 (en) 2004-06-16
DE60105192T2 (en) 2005-09-08
NO20032754L (en) 2003-06-17
ES2227063T3 (en) 2005-04-01
CZ20031775A3 (en) 2003-09-17
HUP0302753A3 (en) 2005-03-29
EP1343764B1 (en) 2004-08-25
JP4216071B2 (en) 2009-01-28
HUP0302753A2 (en) 2003-12-29
US20040063644A1 (en) 2004-04-01
BR0116202A (en) 2003-12-23
AU2002217078A1 (en) 2002-07-01
CA2431974A1 (en) 2002-06-27
PL361745A1 (en) 2004-10-04
ZA200305550B (en) 2004-10-18
WO2002050039A1 (en) 2002-06-27
CA2431974C (en) 2010-08-17
US7135587B2 (en) 2006-11-14
EP1343764A1 (en) 2003-09-17
CN1481364A (en) 2004-03-10
DE10063173A1 (en) 2002-06-20
ATE274497T1 (en) 2004-09-15
PT1343764E (en) 2005-01-31
MXPA03005431A (en) 2003-09-10
JP2004516282A (en) 2004-06-03
DE60105192D1 (en) 2004-09-30
SK8182003A3 (en) 2003-10-07
KR20030063432A (en) 2003-07-28
NO20032754D0 (en) 2003-06-17
RU2003121015A (en) 2005-02-10

Similar Documents

Publication Publication Date Title
NO20026010L (en) Substituted quinazoline derivatives and their use as inhibitors
IS6934A (en) New spirotycyclic derivatives and their use as phosphodiesterase-7 inhibitors
DK2305250T3 (en) BENZIMIDAZOLD DERIVATIVES AND USE THEREOF AS PROTEINKINASE INHIBITORS
DK1282611T3 (en) Substituted phenylacetatamides and their use as glucokinase activators
DK1165516T3 (en) Heterocyclic urea and related compounds useful as anti-inflammatory agents
DE60024631T2 (en) Biaryl UREA DERIVATIVES
DE602004019294D1 (en) TETRAHYDRONAPHTHALIN AND UREA DERIVATIVES
NO20012688L (en) Benzamide derivatives and their use as APOB-100 secretion inhibitors
DK1268425T3 (en) Carbamate caspase inhibitors and their use
IS6385A (en) New uses and new N-azabicyclo-amide derivatives
NO20053356D0 (en) Aminindazole derivatives and their use as kinase inhibitors.
DK1097127T3 (en) Diacylhydrazine derivatives as integrin inhibitors
DK1299354T3 (en) Factor VIIA inhibitory (thio) urea derivatives, preparation and use thereof
PL356427A1 (en) Indol-3-yl derivatives and their use as integrin inhibitors
DK1667668T3 (en) Alphabeta3 and altabeta6 integrin antagonists as antifibrotic agents
DK1343764T3 (en) Urea and urethane derivatives as integrin inhibitors
NO20013853L (en) Heteroberlamidines, methylamidines and guanidines as protease inhibitors
NO20030294D0 (en) Egg-based powder and nutrient containing the same
IS5990A (en) New amidine benzylamine derivatives and their use as thrombin inhibitors
AU2002214166A1 (en) 1-sulfonyl substituted tryptophane derivatives and its use as integrin inhibitors
NO20025504L (en) New thiochromane derivatives and their use as thrombin inhibitors
NO20030998D0 (en) Arylpiperazine derivatives and their use as psychotropic agents
NO20023951D0 (en) Arylpiperazines and arylpiperidines and their use as metalloproteinase inhibitors
NO20030813D0 (en) Biphenyl derivatives and their use as integrin inhibitors
NO20013816D0 (en) Benzamide derivatives and drugs containing them