DK1339398T3 - Behandling af motoriske fluktuationer med 5-hydroxytryptamin 1A receptoraktivitetsforstærkende forbindelser - Google Patents
Behandling af motoriske fluktuationer med 5-hydroxytryptamin 1A receptoraktivitetsforstærkende forbindelserInfo
- Publication number
- DK1339398T3 DK1339398T3 DK01976536T DK01976536T DK1339398T3 DK 1339398 T3 DK1339398 T3 DK 1339398T3 DK 01976536 T DK01976536 T DK 01976536T DK 01976536 T DK01976536 T DK 01976536T DK 1339398 T3 DK1339398 T3 DK 1339398T3
- Authority
- DK
- Denmark
- Prior art keywords
- hydroxytryptamine
- receptor activity
- treatment
- motor fluctuations
- enhancing compounds
- Prior art date
Links
- 102000012306 5-Hydroxytryptamine 1A receptors Human genes 0.000 title abstract 3
- 108050002825 5-Hydroxytryptamine 1A receptors Proteins 0.000 title abstract 3
- 206010030312 On and off phenomenon Diseases 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 abstract 2
- 230000004913 activation Effects 0.000 abstract 1
- 229960003638 dopamine Drugs 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000000018 receptor agonist Substances 0.000 abstract 1
- 229940044601 receptor agonist Drugs 0.000 abstract 1
- 238000009256 replacement therapy Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Paper (AREA)
- Threshing Machine Elements (AREA)
- Processing Of Meat And Fish (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0027020.7A GB0027020D0 (en) | 2000-11-03 | 2000-11-03 | Treatment of movement disorders |
| PCT/GB2001/004774 WO2002036107A2 (en) | 2000-11-03 | 2001-10-29 | Treatment of motor fluctuations with 5-hydroxytryptamine 1a receptor activity enhancing coumpounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1339398T3 true DK1339398T3 (da) | 2009-01-26 |
Family
ID=9902589
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK01976536T DK1339398T3 (da) | 2000-11-03 | 2001-10-29 | Behandling af motoriske fluktuationer med 5-hydroxytryptamin 1A receptoraktivitetsforstærkende forbindelser |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20040067956A1 (da) |
| EP (1) | EP1339398B1 (da) |
| JP (2) | JP5189240B2 (da) |
| AT (1) | ATE406880T1 (da) |
| AU (2) | AU9580401A (da) |
| CA (1) | CA2431641A1 (da) |
| CY (1) | CY1108628T1 (da) |
| DE (1) | DE60135675D1 (da) |
| DK (1) | DK1339398T3 (da) |
| ES (1) | ES2311549T3 (da) |
| GB (1) | GB0027020D0 (da) |
| PT (1) | PT1339398E (da) |
| WO (1) | WO2002036107A2 (da) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9924941D0 (en) * | 1999-10-22 | 1999-12-22 | Univ Manchester | Treatment of dyskinesia |
| GB0027020D0 (en) | 2000-11-03 | 2000-12-20 | Univ Manchester | Treatment of movement disorders |
| US9066903B2 (en) | 2006-02-28 | 2015-06-30 | The United States Of America As Represented By The Department Of Veterans Affairs | Pharmacological treatment of Parkinson's disease |
| EP2908805B1 (en) * | 2012-10-22 | 2021-06-09 | Civitas Therapeutics, Inc. | Levodopa formulations for rapid relief of parkinson's disease |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU3241093A (en) * | 1992-01-07 | 1993-08-03 | Merrell Dow Pharmaceuticals Inc. | Treatment of involuntary movements with 5HT-1A receptor agonists |
| WO1994022495A1 (en) * | 1993-03-31 | 1994-10-13 | The Trustees Of The University Of Pennsylvania | Dopamine d-3 and serotonin (5-ht1a) receptor ligands and imaging agents |
| GB9408084D0 (en) * | 1994-04-23 | 1994-06-15 | Boots Co Plc | Medical treatment |
| GB9815618D0 (en) * | 1998-07-18 | 1998-09-16 | Univ Manchester | Treatment of dyskinesia |
| HN1999000146A (es) * | 1998-09-21 | 2000-11-11 | Pfizer Prod Inc | Agentes farmaceuticos para el tratamiento de la enfermedad de parkinson, adhd y microadenomas. |
| US6136559A (en) | 1998-10-07 | 2000-10-24 | Ortho Pharmaceutical Corporation | DNA encoding as human histamine receptor of the H3 subtype |
| GB9924941D0 (en) * | 1999-10-22 | 1999-12-22 | Univ Manchester | Treatment of dyskinesia |
| GB0027020D0 (en) | 2000-11-03 | 2000-12-20 | Univ Manchester | Treatment of movement disorders |
| CA2499200A1 (en) * | 2002-09-17 | 2004-04-01 | Motac Neuroscience Limited | Use of compounds in the treatment of dyskinesia |
| MY148457A (en) | 2006-06-16 | 2013-04-30 | Solvay Pharm Bv | Combination preparations comprising slv308 and a dopamine agonist |
| US7786126B2 (en) * | 2006-06-16 | 2010-08-31 | Solvay Pharmaceuticals B.V. | Combination preparations comprising SLV308 and a dopamine agonist |
| CN101808646A (zh) | 2007-11-30 | 2010-08-18 | 阿斯比奥制药株式会社 | 用于改善帕金森氏病的运动并发症或精神症状的药剂 |
-
2000
- 2000-11-03 GB GBGB0027020.7A patent/GB0027020D0/en not_active Ceased
-
2001
- 2001-10-29 WO PCT/GB2001/004774 patent/WO2002036107A2/en active IP Right Grant
- 2001-10-29 AU AU9580401A patent/AU9580401A/xx active Pending
- 2001-10-29 CA CA002431641A patent/CA2431641A1/en not_active Abandoned
- 2001-10-29 AT AT01976536T patent/ATE406880T1/de active
- 2001-10-29 AU AU2001295804A patent/AU2001295804B2/en not_active Ceased
- 2001-10-29 US US10/415,817 patent/US20040067956A1/en not_active Abandoned
- 2001-10-29 JP JP2002538919A patent/JP5189240B2/ja not_active Expired - Fee Related
- 2001-10-29 DK DK01976536T patent/DK1339398T3/da active
- 2001-10-29 DE DE60135675T patent/DE60135675D1/de not_active Expired - Lifetime
- 2001-10-29 PT PT01976536T patent/PT1339398E/pt unknown
- 2001-10-29 ES ES01976536T patent/ES2311549T3/es not_active Expired - Lifetime
- 2001-10-29 EP EP01976536A patent/EP1339398B1/en not_active Expired - Lifetime
-
2008
- 2008-12-02 CY CY20081101390T patent/CY1108628T1/el unknown
-
2010
- 2010-07-16 JP JP2010161831A patent/JP2010241827A/ja active Pending
-
2011
- 2011-03-31 US US13/077,478 patent/US9668995B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| ES2311549T3 (es) | 2009-02-16 |
| US20110178178A1 (en) | 2011-07-21 |
| JP2004512360A (ja) | 2004-04-22 |
| AU2001295804B2 (en) | 2007-01-04 |
| JP5189240B2 (ja) | 2013-04-24 |
| WO2002036107A2 (en) | 2002-05-10 |
| ATE406880T1 (de) | 2008-09-15 |
| GB0027020D0 (en) | 2000-12-20 |
| EP1339398A2 (en) | 2003-09-03 |
| DE60135675D1 (de) | 2008-10-16 |
| US20040067956A1 (en) | 2004-04-08 |
| CA2431641A1 (en) | 2002-05-10 |
| WO2002036107A3 (en) | 2003-01-16 |
| JP2010241827A (ja) | 2010-10-28 |
| PT1339398E (pt) | 2008-11-03 |
| AU9580401A (en) | 2002-05-15 |
| EP1339398B1 (en) | 2008-09-03 |
| US9668995B2 (en) | 2017-06-06 |
| CY1108628T1 (el) | 2014-04-09 |
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