DK1303313T3 - Methods for dispensing measured amounts of hyperpolarized noble gas and associated devices - Google Patents

Methods for dispensing measured amounts of hyperpolarized noble gas and associated devices

Info

Publication number
DK1303313T3
DK1303313T3 DK01920381T DK01920381T DK1303313T3 DK 1303313 T3 DK1303313 T3 DK 1303313T3 DK 01920381 T DK01920381 T DK 01920381T DK 01920381 T DK01920381 T DK 01920381T DK 1303313 T3 DK1303313 T3 DK 1303313T3
Authority
DK
Denmark
Prior art keywords
container
gas
hyperpolarized gas
hyperpolarized
fluid
Prior art date
Application number
DK01920381T
Other languages
Danish (da)
Inventor
Kenton C Hasson
Paul L Bogorad
David L Zollinger
Geri T K Zollinger
Original Assignee
Medi Physics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medi Physics Inc filed Critical Medi Physics Inc
Application granted granted Critical
Publication of DK1303313T3 publication Critical patent/DK1303313T3/en

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Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/20Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/282Means specially adapted for hyperpolarisation or for hyperpolarised contrast agents, e.g. for the generation of hyperpolarised gases using optical pumping cells, for storing hyperpolarised contrast agents or for the determination of the polarisation of a hyperpolarised contrast agent
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806Suspensions, emulsions, colloids, dispersions
    • A61K49/1815Suspensions, emulsions, colloids, dispersions compo-inhalant, e.g. breath tests

Landscapes

  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Chemical Vapour Deposition (AREA)

Abstract

Methods of extracting and removing hyperpolarized gas from a container include introducing an extraction fluid into the container to force the hyperpolarized gas out of an exit port. The hyperpolarized gas is forced out of the container separate and apart from the extraction fluid. Alternatively, if the fluid is a gas, a portion of the gas is mixed with the hyperpolarized gas to form a sterile mixed fluid product suitable for introduction to a patient. An additional method includes engaging a gas transfer source such as a syringe to a transport container and pulling a quantity of the hyperpolarized gas out of the container in a controlled manner. Alternatively, one or more gas syringes can be employed to mete out predictable quantities of hyperpolarized gas or gas mixtures including quantities of buffer gases. Another method includes introducing a quantity of liquid into a container and covering at least one predetermined internal surface or component with the liquid to mask the surfaces and keep the hyperpolarized gas away from the predetermined internal surface, thereby inhibiting any depolarizing affect from same. Examples of surfaces or components suitable for masking include valves, seals, and the like. Yet another extraction method includes expanding a resilient member inside the container to force the hyperpolarized gas to exit therefrom. Containers include a resilient member positioned in fluid communication with the hyperpolarized gas in the container. An additional container includes inlet and outlet ports in fluid communication with the chamber and positioned on opposing sides or end portions of the container. Another container includes a port configured to receive a portion of a syringe therein. An additional aspect of the disclosure relates to calibration methods and apparatus for identifying the hyperpolarization status of the gas.
DK01920381T 2000-03-20 2001-03-15 Methods for dispensing measured amounts of hyperpolarized noble gas and associated devices DK1303313T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/528,750 US6286319B1 (en) 1998-09-30 2000-03-20 Meted hyperpolarized noble gas dispensing methods and associated devices

Publications (1)

Publication Number Publication Date
DK1303313T3 true DK1303313T3 (en) 2005-11-14

Family

ID=24107017

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01920381T DK1303313T3 (en) 2000-03-20 2001-03-15 Methods for dispensing measured amounts of hyperpolarized noble gas and associated devices

Country Status (8)

Country Link
US (1) US6286319B1 (en)
EP (1) EP1303313B1 (en)
AT (1) ATE299379T1 (en)
AU (1) AU2001247439A1 (en)
DE (1) DE60111944T2 (en)
DK (1) DK1303313T3 (en)
ES (1) ES2245981T3 (en)
WO (1) WO2001070102A2 (en)

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US7287390B2 (en) * 2001-10-22 2007-10-30 Medi-Physics, Inc. Optical pumping modules, polarized gas blending and dispensing systems, and automated polarized gas distribution systems and related devices and methods
US7287391B2 (en) * 2001-10-22 2007-10-30 Medi-Physics, Inc. Automated modular hyperpolarizers and related devices and methods
US7277775B2 (en) * 2002-07-23 2007-10-02 Medi-Physics, Inc. Automated dynamic pressure-responsive dispensing systems, and associated methods and computer program products
DE10324365A1 (en) * 2003-05-27 2005-01-05 Forschungszentrum Jülich GmbH Device with a space for receiving hyperpolarized noble gas
WO2009143368A2 (en) * 2008-05-23 2009-11-26 University Of Utah Non-cryogenic storage cell for hyperpolarized 129xe
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US20110068793A1 (en) * 2009-09-21 2011-03-24 The Regents Of The University Of California SOLVATED HYPERPOLARIZED XeNMR AND MRI SIGNAL AMPLIFICATION BY GAS EXTRACTION
US8698493B2 (en) * 2011-08-05 2014-04-15 Wisconsin Alumni Research Foundation Noble gas magnetic resonator
WO2013166430A2 (en) * 2012-05-04 2013-11-07 Trustees Of The University Of Pennsylvania System for delivery of gaseous imaging contrast agents and methods for using same
CN102967834B (en) * 2012-11-23 2014-10-15 中国科学院武汉物理与数学研究所 Device and method for magnetic resonance engine
CN103815907B (en) * 2014-03-04 2016-04-06 合肥工业大学 Imaging gas and the caisson thereof of picture is detected as human respiratory

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Also Published As

Publication number Publication date
ATE299379T1 (en) 2005-07-15
DE60111944D1 (en) 2005-08-18
EP1303313B1 (en) 2005-07-13
EP1303313A2 (en) 2003-04-23
ES2245981T3 (en) 2006-02-01
US6286319B1 (en) 2001-09-11
DE60111944T2 (en) 2006-04-20
WO2001070102A2 (en) 2001-09-27
AU2001247439A1 (en) 2001-10-03
WO2001070102A3 (en) 2003-01-23

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