DK1287017T3 - 2-substituted pregna-1,3,5 (10) -triene and chola-1,3,5 (10) triene derivatives and their biological activity - Google Patents
2-substituted pregna-1,3,5 (10) -triene and chola-1,3,5 (10) triene derivatives and their biological activityInfo
- Publication number
- DK1287017T3 DK1287017T3 DK01928120T DK01928120T DK1287017T3 DK 1287017 T3 DK1287017 T3 DK 1287017T3 DK 01928120 T DK01928120 T DK 01928120T DK 01928120 T DK01928120 T DK 01928120T DK 1287017 T3 DK1287017 T3 DK 1287017T3
- Authority
- DK
- Denmark
- Prior art keywords
- group
- triene
- chola
- carboxaldehyde
- hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
- C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Reproductive Health (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Compounds of formula (I) in which: R<1> represents a hydrogen atom or an O-protecting group; R<2> represents a hydroxyl, lower alkoxy, carboxaldehyde, lower alk-1-enyl or hydroxy- or lower alkoxy-substituted lower alkyl group; R<3> represents a methyl group having alpha - or beta - configuration; X represents a C1-3 alkylene group or a valence bond; Y represents a carboxaldehyde group or a group of formula -C(R<4>) (R<5>)OR<1> where R<1> is as defined above and R<4> and R<5>, which may be the same or different, are each selected from hydrogen atoms, alkyl, alkenyl and alkynyl groups such that the total carbon content of R<4> and R<5> does not exceed three atoms, with the proviso that X is a valence bond when both R<4> and R<5> are other than hydrogen; and the dotted line signifies that a double bond may optionally be present at the 16(17) -position exhibit potent cell modulating activity, including antiproliferative and antiangiogenic effects.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20346200P | 2000-05-11 | 2000-05-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1287017T3 true DK1287017T3 (en) | 2005-12-05 |
Family
ID=22754111
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK01928120T DK1287017T3 (en) | 2000-05-11 | 2001-05-11 | 2-substituted pregna-1,3,5 (10) -triene and chola-1,3,5 (10) triene derivatives and their biological activity |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP1287017B1 (en) |
| JP (1) | JP2003532737A (en) |
| KR (1) | KR100740354B1 (en) |
| CN (1) | CN100338088C (en) |
| AT (1) | ATE301130T1 (en) |
| AU (1) | AU784563B2 (en) |
| CA (1) | CA2408751A1 (en) |
| CZ (1) | CZ298835B6 (en) |
| DE (1) | DE60112438T2 (en) |
| DK (1) | DK1287017T3 (en) |
| ES (1) | ES2247102T3 (en) |
| HK (1) | HK1053843A1 (en) |
| IL (2) | IL152728A0 (en) |
| NO (1) | NO323857B1 (en) |
| NZ (1) | NZ523042A (en) |
| WO (1) | WO2001085755A1 (en) |
| ZA (1) | ZA200209060B (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6908910B2 (en) | 1993-08-06 | 2005-06-21 | The Children's Medical Center Corporation | Estrogenic compounds as anti-mitotic agents |
| US7135581B2 (en) | 2000-08-18 | 2006-11-14 | Entremed, Inc. | Antiangiogenic agents |
| US6995278B2 (en) | 2000-08-18 | 2006-02-07 | Entre Med, Inc. | Antiangiogenic agents |
| AU8838601A (en) * | 2000-11-27 | 2002-06-03 | Entremed Inc | Antiangiogenic agents |
| WO2002092100A1 (en) * | 2001-05-11 | 2002-11-21 | Marsden, John, Christopher | 17-(c(ch3) (ch2) o-3c (r4, r5) n (r6, r7))-substituted 19-nor-pregna-1, 3, 5(10)-triene derivatives and their medical use |
| EA011123B1 (en) | 2003-03-24 | 2008-12-30 | Стерикс Лимитед | Oestrogen derivatives as inhibitors of steroid sulphatase |
| AU2005222934B2 (en) | 2004-03-12 | 2010-06-17 | Entremed, Inc. | Antiangiogenic agents |
| AU2007227256B2 (en) | 2006-03-20 | 2012-10-04 | Entremed, Inc. | Disease modifying anti-arthritic activity of 2-methoxyestradiol |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3562260A (en) * | 1965-08-23 | 1971-02-09 | Ormonoterapia Richter Spa | 2-carbonyl-estratrienes and method of their preparation |
| JPS54112849A (en) * | 1978-02-23 | 1979-09-04 | Mitsubishi Chem Ind Ltd | Preparation of steroid derivative |
| JPS54112580A (en) * | 1978-02-23 | 1979-09-03 | Nec Corp | Electroless discharge lamp |
| JPS54112850A (en) * | 1978-02-23 | 1979-09-04 | Mitsubishi Chem Ind Ltd | Steroid derivative and its preparation |
| JPS54117454A (en) * | 1978-03-02 | 1979-09-12 | Mitsubishi Chem Ind Ltd | Acylsteroid derivative |
| JPS54117455A (en) * | 1978-03-02 | 1979-09-12 | Mitsubishi Chem Ind Ltd | Novel 19-norsteroid derivative |
| JPS54117456A (en) * | 1978-03-02 | 1979-09-12 | Mitsubishi Chem Ind Ltd | Alkoxysteroid derivative |
| GB9804861D0 (en) * | 1998-03-06 | 1998-04-29 | Res Inst Medicine Chem | Chemical compounds |
| GB9910934D0 (en) * | 1999-05-11 | 1999-07-14 | Res Inst Medicine Chem | Chemical compounds |
-
2001
- 2001-05-11 IL IL15272801A patent/IL152728A0/en active IP Right Grant
- 2001-05-11 ES ES01928120T patent/ES2247102T3/en not_active Expired - Lifetime
- 2001-05-11 CN CNB018124445A patent/CN100338088C/en not_active Expired - Fee Related
- 2001-05-11 EP EP01928120A patent/EP1287017B1/en not_active Expired - Lifetime
- 2001-05-11 KR KR1020027015057A patent/KR100740354B1/en not_active IP Right Cessation
- 2001-05-11 CZ CZ20023719A patent/CZ298835B6/en not_active IP Right Cessation
- 2001-05-11 JP JP2001582354A patent/JP2003532737A/en active Pending
- 2001-05-11 WO PCT/GB2001/002103 patent/WO2001085755A1/en active IP Right Grant
- 2001-05-11 DE DE60112438T patent/DE60112438T2/en not_active Expired - Fee Related
- 2001-05-11 AU AU54984/01A patent/AU784563B2/en not_active Ceased
- 2001-05-11 NZ NZ523042A patent/NZ523042A/en unknown
- 2001-05-11 CA CA002408751A patent/CA2408751A1/en not_active Abandoned
- 2001-05-11 DK DK01928120T patent/DK1287017T3/en active
- 2001-05-11 AT AT01928120T patent/ATE301130T1/en not_active IP Right Cessation
-
2002
- 2002-11-07 ZA ZA200209060A patent/ZA200209060B/en unknown
- 2002-11-10 IL IL152728A patent/IL152728A/en not_active IP Right Cessation
- 2002-11-11 NO NO20025392A patent/NO323857B1/en unknown
-
2003
- 2003-08-27 HK HK03106140A patent/HK1053843A1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IL152728A0 (en) | 2003-06-24 |
| IL152728A (en) | 2007-02-11 |
| AU784563B2 (en) | 2006-05-04 |
| NO20025392D0 (en) | 2002-11-11 |
| KR20030031899A (en) | 2003-04-23 |
| NO20025392L (en) | 2003-01-09 |
| ZA200209060B (en) | 2004-02-09 |
| CN100338088C (en) | 2007-09-19 |
| CZ298835B6 (en) | 2008-02-20 |
| ATE301130T1 (en) | 2005-08-15 |
| DE60112438D1 (en) | 2005-09-08 |
| KR100740354B1 (en) | 2007-07-26 |
| EP1287017A1 (en) | 2003-03-05 |
| NZ523042A (en) | 2004-05-28 |
| CZ20023719A3 (en) | 2003-04-16 |
| CA2408751A1 (en) | 2001-11-15 |
| HK1053843A1 (en) | 2003-11-07 |
| CN1444597A (en) | 2003-09-24 |
| DE60112438T2 (en) | 2006-06-08 |
| JP2003532737A (en) | 2003-11-05 |
| EP1287017B1 (en) | 2005-08-03 |
| WO2001085755A1 (en) | 2001-11-15 |
| ES2247102T3 (en) | 2006-03-01 |
| AU5498401A (en) | 2001-11-20 |
| NO323857B1 (en) | 2007-07-16 |
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