DK1261603T5 - Flavone derivatives, processes for their preparation and their use as a drug - Google Patents

Flavone derivatives, processes for their preparation and their use as a drug

Info

Publication number
DK1261603T5
DK1261603T5 DK01909906T DK01909906T DK1261603T5 DK 1261603 T5 DK1261603 T5 DK 1261603T5 DK 01909906 T DK01909906 T DK 01909906T DK 01909906 T DK01909906 T DK 01909906T DK 1261603 T5 DK1261603 T5 DK 1261603T5
Authority
DK
Denmark
Prior art keywords
drug
processes
preparation
flavone derivatives
flavone
Prior art date
Application number
DK01909906T
Other languages
Danish (da)
Other versions
DK1261603T3 (en
Inventor
Jean-Luc Haesslein
Jidong Zhang
Dominique Lefrancois
Eric Uridat
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of DK1261603T3 publication Critical patent/DK1261603T3/en
Application granted granted Critical
Publication of DK1261603T5 publication Critical patent/DK1261603T5/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Hospice & Palliative Care (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK01909906T 2000-02-29 2001-02-27 Flavone derivatives, processes for their preparation and their use as a drug DK1261603T5 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0002528A FR2805538B1 (en) 2000-02-29 2000-02-29 NOVEL FLAVON DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF, THEIR USE AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND NOVEL USE
PCT/FR2001/000561 WO2001064673A1 (en) 2000-02-29 2001-02-27 Flavone derivatives, preparation method and use as medicines

Publications (2)

Publication Number Publication Date
DK1261603T3 DK1261603T3 (en) 2006-12-27
DK1261603T5 true DK1261603T5 (en) 2007-07-09

Family

ID=8847520

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01909906T DK1261603T5 (en) 2000-02-29 2001-02-27 Flavone derivatives, processes for their preparation and their use as a drug

Country Status (16)

Country Link
US (1) US20030119816A1 (en)
EP (1) EP1261603B1 (en)
JP (1) JP5118282B2 (en)
AR (1) AR029479A1 (en)
AT (1) ATE336490T1 (en)
AU (1) AU783663B2 (en)
CA (1) CA2403424C (en)
CY (1) CY1105786T1 (en)
DE (1) DE60122295T2 (en)
DK (1) DK1261603T5 (en)
ES (1) ES2270984T3 (en)
FR (1) FR2805538B1 (en)
MY (1) MY159418A (en)
PT (1) PT1261603E (en)
TW (1) TWI282338B (en)
WO (1) WO2001064673A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2522827T3 (en) * 2009-10-30 2014-11-18 Domain Therapeutics New oxime derivatives and their use as allosteric modulators of metabotropic glutamate receptors
CN103896895A (en) * 2013-12-31 2014-07-02 浙江工业大学 Method for preparing coumarin derivative
WO2018094275A1 (en) * 2016-11-18 2018-05-24 Tolero Pharmaceuticals, Inc. Alvocidib prodrugs and their use as protein kinase inhibitors
US11497756B2 (en) 2017-09-12 2022-11-15 Sumitomo Pharma Oncology, Inc. Treatment regimen for cancers that are insensitive to BCL-2 inhibitors using the MCL-1 inhibitor alvocidib
KR20210099066A (en) 2018-12-04 2021-08-11 스미토모 다이니폰 파마 온콜로지, 인크. CDK9 inhibitors and polymorphs thereof for use as agents for the treatment of cancer
JP2022525149A (en) 2019-03-20 2022-05-11 スミトモ ダイニッポン ファーマ オンコロジー， インコーポレイテッド Treatment of Acute Myeloid Leukemia (AML) with Venetoclax Failure
CN111057035B (en) * 2019-11-05 2021-10-26 中国人民解放军第二军医大学 Baicalein derivative and preparation method and application thereof
GB202104122D0 (en) * 2021-03-24 2021-05-05 Floratek Pharma Ag Compounds and their use

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN164232B (en) * 1986-04-11 1989-02-04 Hoechst India
DE3836676A1 (en) * 1988-10-28 1990-05-03 Hoechst Ag THE USE OF 4H-1-BENZOPYRAN-4-ON DERIVATIVES, NEW 4H-1-BENZOPYRAN-4-ON DERIVATIVES AND MEDICINAL PRODUCTS CONTAINING THEM
US5733920A (en) * 1995-10-31 1998-03-31 Mitotix, Inc. Inhibitors of cyclin dependent kinases
US5908934A (en) * 1996-09-26 1999-06-01 Bristol-Myers Squibb Company Process for the preparation of chiral ketone intermediates useful for the preparation of flavopiridol and analogs

Also Published As

Publication number Publication date
DK1261603T3 (en) 2006-12-27
CY1105786T1 (en) 2011-02-02
CA2403424A1 (en) 2001-09-07
AU783663B2 (en) 2005-11-24
AR029479A1 (en) 2003-07-02
EP1261603B1 (en) 2006-08-16
TWI282338B (en) 2007-06-11
PT1261603E (en) 2007-01-31
ATE336490T1 (en) 2006-09-15
FR2805538A1 (en) 2001-08-31
MY159418A (en) 2017-01-13
US20030119816A1 (en) 2003-06-26
AU3750101A (en) 2001-09-12
DE60122295T2 (en) 2007-11-15
DE60122295D1 (en) 2006-09-28
WO2001064673A1 (en) 2001-09-07
JP5118282B2 (en) 2013-01-16
FR2805538B1 (en) 2006-08-04
ES2270984T3 (en) 2007-04-16
JP2003525290A (en) 2003-08-26
EP1261603A1 (en) 2002-12-04
CA2403424C (en) 2011-02-01

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