DK1251125T3 - New Camptothecin Analogs, Methods of Preparation thereof, Their Use as Drugs and Pharmaceutical Preparations Containing These - Google Patents
New Camptothecin Analogs, Methods of Preparation thereof, Their Use as Drugs and Pharmaceutical Preparations Containing TheseInfo
- Publication number
- DK1251125T3 DK1251125T3 DK02077736T DK02077736T DK1251125T3 DK 1251125 T3 DK1251125 T3 DK 1251125T3 DK 02077736 T DK02077736 T DK 02077736T DK 02077736 T DK02077736 T DK 02077736T DK 1251125 T3 DK1251125 T3 DK 1251125T3
- Authority
- DK
- Denmark
- Prior art keywords
- drugs
- preparation
- hydroxy
- methods
- lower alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Medicinal Preparation (AREA)
- Cephalosporin Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Camptothecin analogues where the camptothecin hydroxy lactone is: (i) a beta -hydroxy lactone; or (ii) the corresp. beta -hydroxy acid resulting from ring-opening of the aforementioned lactone; or a (iii) deriv. of the beta -hydroxy acid in (ii) or its one of its salts. Also claimed are new industrial prods. of formula (M) and (A). R1 = lower alkyl, lower alkenyl, lower alkynyl, halo(lower alkyl), lower alkoxy(lower alkyl) or lower alkylthio(lower alkyl); R20 = H or halo; R22 = F, Cl, or lower alkoxy; R23 = prim. hydroxy-protecting gp.; and R18, R19 = H, halo, lower alkyl, lower alkoxy or OH.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9512670.2A GB9512670D0 (en) | 1995-06-21 | 1995-06-21 | Camptothecin analogues |
US61047696A | 1996-03-04 | 1996-03-04 | |
EP96924010A EP0835258B1 (en) | 1995-06-21 | 1996-06-21 | Novel camptothecin analogues, preparation methods therefor, use thereof as drugs, and pharmaceutical compositions containing said analogues |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1251125T3 true DK1251125T3 (en) | 2006-04-18 |
Family
ID=26307258
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK96924010T DK0835258T3 (en) | 1995-06-21 | 1996-06-21 | New Camptothecin Analogs, Methods of Preparation thereof, Their Use as Medicines and Pharmaceutical Preparations Containing These |
DK02077736T DK1251125T3 (en) | 1995-06-21 | 1996-06-21 | New Camptothecin Analogs, Methods of Preparation thereof, Their Use as Drugs and Pharmaceutical Preparations Containing These |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK96924010T DK0835258T3 (en) | 1995-06-21 | 1996-06-21 | New Camptothecin Analogs, Methods of Preparation thereof, Their Use as Medicines and Pharmaceutical Preparations Containing These |
Country Status (24)
Country | Link |
---|---|
EP (2) | EP1251125B1 (en) |
JP (2) | JP3576171B2 (en) |
KR (1) | KR100440838B1 (en) |
CN (1) | CN1114608C (en) |
AT (2) | ATE312105T1 (en) |
AU (1) | AU716377B2 (en) |
BR (1) | BR9608639A (en) |
CA (1) | CA2225528C (en) |
CL (1) | CL2004001168A1 (en) |
CZ (1) | CZ296156B6 (en) |
DE (2) | DE69623961T2 (en) |
DK (2) | DK0835258T3 (en) |
ES (2) | ES2184882T3 (en) |
HK (3) | HK1015783A1 (en) |
IL (2) | IL122635A (en) |
MX (1) | MX9710228A (en) |
NO (1) | NO316749B1 (en) |
NZ (1) | NZ312715A (en) |
PL (1) | PL185354B1 (en) |
PT (1) | PT835258E (en) |
RO (1) | RO117918B1 (en) |
RU (1) | RU2164515C2 (en) |
TW (1) | TW457234B (en) |
WO (1) | WO1997000876A1 (en) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2768431B1 (en) * | 1997-08-29 | 2000-03-24 | Sod Conseils Rech Applic | NOVEL OPTICALLY PURE CAMPTOTHECIN ANALOGS, A NEW OPTICALLY PURE SYNTHESIS INTERMEDIATE AND PROCESS FOR PREPARING THE SAME |
FR2757514B1 (en) * | 1996-12-20 | 1999-02-12 | Sod Conseils Rech Applic | NOVEL CAMPTOTHECIN ANALOGS, PREPARATION METHODS, USE THEREOF AS MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
FR2757515B1 (en) * | 1996-12-20 | 2000-05-05 | Sod Conseils Rech Applic | PRODROUGAL FORMS AND NEW CAMPTOTHECIN ANALOGS, PROCESSES FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
FR2790261B1 (en) * | 1999-02-26 | 2004-09-10 | Sod Conseils Rech Applic | NOVEL OPTICALLY PURE CAMPTOTHECIN ANALOGS AND PROCESSES FOR THEIR PREPARATION |
US6559309B2 (en) * | 1996-11-01 | 2003-05-06 | Osi Pharmaceuticals, Inc. | Preparation of a camptothecin derivative by intramolecular cyclisation |
UA57757C2 (en) * | 1996-12-20 | 2003-07-15 | Сос'Єте Де Консей Де Решерш Е Даплікасьон С'Єнтіфік (С.К.Р.А.С.) | FORMS OF PRODRUGS AND NEW ANALOGUES OF camptothecin, THEIR APPLICATION AS MEDICINES |
FR2772763B1 (en) * | 1997-12-24 | 2004-01-23 | Sod Conseils Rech Applic | NOVEL TETRACYCLIC CAMPTOTHECIN ANALOGS, PROCESSES FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
DE19826499A1 (en) * | 1998-06-13 | 1999-12-16 | Beiersdorf Ag | Use of lactone, thiolactone and/or dithiolactone derivatives |
US6207832B1 (en) | 1999-04-09 | 2001-03-27 | University Of Pittsburgh | Camptothecin analogs and methods of preparation thereof |
AU6941200A (en) | 1999-08-27 | 2001-03-26 | Ligand Pharmaceuticals Incorporated | 8-substituted-6-trifluoromethyl-9-pyrido(3,2-g)quinoline compounds as androgen receptor modulators |
US6566372B1 (en) | 1999-08-27 | 2003-05-20 | Ligand Pharmaceuticals Incorporated | Bicyclic androgen and progesterone receptor modulator compounds and methods |
CZ2002711A3 (en) * | 1999-08-27 | 2003-11-12 | Ligand Pharmaceuticals Incorporated | Androgenic receptor modulators, process of their preparation and their use |
CA2383565A1 (en) | 1999-09-14 | 2001-03-22 | Ligand Pharmaceuticals Incorporated | Rxr modulators with improved pharmacologic profile |
FR2801309B1 (en) * | 1999-11-18 | 2002-01-04 | Adir | NOVEL CAMPTOTHECIN-LIKE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
CZ298259B6 (en) | 2000-02-28 | 2007-08-08 | Aventis Pharma S. A. | Pharmaceutical combinations containing CPT-11 and capecitabine for treating cancer |
US6486320B2 (en) | 2000-09-15 | 2002-11-26 | Aventis Pharma S.A. | Preparation of camptothecin and of its derivatives |
JP2004517821A (en) | 2000-10-27 | 2004-06-17 | アベンティス・ファーマ・ソシエテ・アノニム | Combinations of camptothecin and stilbene derivatives for cancer treatment |
US6372906B1 (en) | 2001-04-12 | 2002-04-16 | University Of Pittsburgh | Synthesis of silyl camptothecins and silyl homocamptothecins |
FR2825278A1 (en) * | 2001-05-30 | 2002-12-06 | Sod Conseils Rech Applic | PRODUCT COMPRISING MIKANOLIDE, DIHYDROMIKANOLIDE OR AN ANALOGUE THEREOF IN ASSOCIATION WITH ANOTHER ANTI-CANCER AGENT FOR THERAPEUTIC USE IN THE TREATMENT OF CANCER |
US6723853B2 (en) | 2001-08-27 | 2004-04-20 | University Of Pittsburgh | Intermediates and methods of preparation of intermediates in the enantiomeric synthesis of (20R)homocamptothecins and the enantiomeric synthesis of (20R)homocamptothecins |
AU2003225642A1 (en) * | 2002-03-01 | 2003-09-16 | Fluorous Techonologies Inc | Mappicine analogs, intermediates in the synthesis of mappicine analogs and methods of synthesis of mappicine analogs |
ITRM20020305A1 (en) * | 2002-05-31 | 2003-12-01 | Sigma Tau Ind Farmaceuti | CAMPTOTECINE WITH MODIFIED LATTON RING. |
ITRM20030344A1 (en) | 2003-07-14 | 2005-01-15 | Ist Naz Stud Cura Dei Tumori | 7-N-POLIAMMINOALCHIL (BONES) IMMINOMETILCAMPTOTECINE BETWEEN PROTECTIVE GROUPS. |
CN100408582C (en) * | 2004-02-12 | 2008-08-06 | 中国人民解放军第二军医大学 | Homocamptoth-ecine compounds, their preparation process and use |
ITRM20040288A1 (en) * | 2004-06-11 | 2004-09-11 | Sigma Tau Ind Farmaceuti | USE OF 7-T-BUTOXYIMINOMETHYL CAMPTOTECIN FOR THE PREPARATION OF A MEDICATION FOR THE TREATMENT OF UTERUS NEOPLASIES. |
WO2012050591A1 (en) | 2010-10-15 | 2012-04-19 | Rutgers, The State University Of New Jersey | Hydrogel formulation for dermal and ocular delivery |
US20090104254A1 (en) | 2004-12-22 | 2009-04-23 | Rutgers, The State University Of New Jersey | Controlled Release Hydrogels |
CN100339377C (en) * | 2005-09-05 | 2007-09-26 | 合肥中科大生物技术有限公司 | Camptothecine derivative and its preparation |
CN1319971C (en) * | 2005-09-09 | 2007-06-06 | 合肥中科大生物技术有限公司 | Camptothecine derivatives and their use |
CN100465175C (en) * | 2005-11-29 | 2009-03-04 | 中国人民解放军第二军医大学 | 7-bit substituted comptothecine kind compound and pharmaceutical use thereof |
CN1319970C (en) * | 2005-12-30 | 2007-06-06 | 合肥中科大生物技术有限公司 | Camptothecin derivative used as anti-tumor agent and preparation method thereof |
AU2007232206B2 (en) | 2006-03-30 | 2013-04-04 | Drais Pharmaceuticals, Inc. | Camptothecin-cell penetrating peptide conjugates and pharmaceutical compositions containing the same |
WO2007123995A2 (en) * | 2006-04-19 | 2007-11-01 | Bionumerik Pharmaceuticals, Inc. | Camptothecin-analog with a novel, “flipped” lactone-stable, e-ring and methods for making and using same |
CN101220037B (en) * | 2008-01-31 | 2011-02-16 | 中国人民解放军第二军医大学 | 10-substitution homocamptothecin compounds and uses |
CN100592871C (en) * | 2008-03-14 | 2010-03-03 | 浙江林学院 | Insecticide composition and its processing method |
CN101979392A (en) * | 2010-09-26 | 2011-02-23 | 中国人民解放军第二军医大学 | 7-arylethylene substituted high camptothecin compound and application thereof as medicament |
CN102746314B (en) * | 2011-04-18 | 2016-07-06 | 华东师范大学 | Containing stablizing the camptothecine compounds of 7 yuan of lactonic rings, preparation method and purposes |
CN105601641B (en) * | 2015-12-22 | 2018-01-16 | 兰州大学 | 7 piperazine sulfonamide camptothecine compounds, Preparation method and uses |
CN106478648B (en) * | 2016-09-21 | 2018-11-06 | 桑迪亚医药技术(上海)有限责任公司 | A kind of hCPT compound and its synthetic method |
CN111777608B (en) * | 2020-07-08 | 2021-08-03 | 湖北精瑜材料有限公司 | Novel plant modified quinoline quaternary ammonium salt compound, preparation method and application |
WO2023232145A1 (en) * | 2022-06-02 | 2023-12-07 | 华东师范大学 | Small molecule of homocamptothecins and use thereof |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5162532A (en) * | 1990-12-20 | 1992-11-10 | North Carolina State University | Intermediates and method of making camptothecin and camptothecin analogs |
US5391745A (en) * | 1992-07-23 | 1995-02-21 | Sloan-Kettering Institute For Cancer Research | Methods of preparation of camptothecin analogs |
-
1996
- 1996-06-21 PT PT96924010T patent/PT835258E/en unknown
- 1996-06-21 AU AU64608/96A patent/AU716377B2/en not_active Ceased
- 1996-06-21 DK DK96924010T patent/DK0835258T3/en active
- 1996-06-21 MX MX9710228A patent/MX9710228A/en unknown
- 1996-06-21 RU RU98101135/04A patent/RU2164515C2/en not_active IP Right Cessation
- 1996-06-21 ES ES96924010T patent/ES2184882T3/en not_active Expired - Lifetime
- 1996-06-21 EP EP02077736A patent/EP1251125B1/en not_active Expired - Lifetime
- 1996-06-21 RO RO97-02400A patent/RO117918B1/en unknown
- 1996-06-21 KR KR1019970709577A patent/KR100440838B1/en not_active IP Right Cessation
- 1996-06-21 CZ CZ0415397A patent/CZ296156B6/en not_active IP Right Cessation
- 1996-06-21 DE DE69623961T patent/DE69623961T2/en not_active Expired - Lifetime
- 1996-06-21 DE DE69635560T patent/DE69635560T2/en not_active Expired - Lifetime
- 1996-06-21 JP JP50364497A patent/JP3576171B2/en not_active Expired - Fee Related
- 1996-06-21 CN CN96196127A patent/CN1114608C/en not_active Expired - Fee Related
- 1996-06-21 EP EP96924010A patent/EP0835258B1/en not_active Expired - Lifetime
- 1996-06-21 NZ NZ312715A patent/NZ312715A/en not_active IP Right Cessation
- 1996-06-21 PL PL96324339A patent/PL185354B1/en not_active IP Right Cessation
- 1996-06-21 CA CA002225528A patent/CA2225528C/en not_active Expired - Fee Related
- 1996-06-21 AT AT02077736T patent/ATE312105T1/en not_active IP Right Cessation
- 1996-06-21 BR BR9608639A patent/BR9608639A/en not_active IP Right Cessation
- 1996-06-21 DK DK02077736T patent/DK1251125T3/en active
- 1996-06-21 AT AT96924010T patent/ATE224900T1/en not_active IP Right Cessation
- 1996-06-21 IL IL12263596A patent/IL122635A/en not_active IP Right Cessation
- 1996-06-21 ES ES02077736T patent/ES2254600T3/en not_active Expired - Lifetime
- 1996-06-21 WO PCT/FR1996/000980 patent/WO1997000876A1/en active IP Right Grant
- 1996-08-08 TW TW085109645A patent/TW457234B/en not_active IP Right Cessation
-
1997
- 1997-12-19 NO NO19975988A patent/NO316749B1/en not_active IP Right Cessation
-
1999
- 1999-01-14 IL IL12804499A patent/IL128044A0/en unknown
- 1999-03-09 HK HK99100955A patent/HK1015783A1/en not_active IP Right Cessation
-
2003
- 2003-04-23 HK HK03102868A patent/HK1050686A1/en not_active IP Right Cessation
- 2003-11-26 JP JP2003395824A patent/JP2004123756A/en active Pending
- 2003-12-12 HK HK03109070A patent/HK1056726A1/en not_active IP Right Cessation
-
2004
- 2004-05-20 CL CL200401168A patent/CL2004001168A1/en unknown
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