DK1228203T3 - Peptide (VIRIP) which inhibits a circulating virus in humans as well as its use - Google Patents

Peptide (VIRIP) which inhibits a circulating virus in humans as well as its use

Info

Publication number
DK1228203T3
DK1228203T3 DK00987221T DK00987221T DK1228203T3 DK 1228203 T3 DK1228203 T3 DK 1228203T3 DK 00987221 T DK00987221 T DK 00987221T DK 00987221 T DK00987221 T DK 00987221T DK 1228203 T3 DK1228203 T3 DK 1228203T3
Authority
DK
Denmark
Prior art keywords
virip
virus
peptide
activity
antagonist
Prior art date
Application number
DK00987221T
Other languages
Danish (da)
Inventor
Frank Kirchhoff
Jan Muench
Ludger Staendker
Wolf-Georg Forssmann
Knut Adermann
Original Assignee
Ipf Pharmaceuticals Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1999153732 external-priority patent/DE19953732A1/en
Priority claimed from DE2000123665 external-priority patent/DE10023665A1/en
Application filed by Ipf Pharmaceuticals Gmbh filed Critical Ipf Pharmaceuticals Gmbh
Application granted granted Critical
Publication of DK1228203T3 publication Critical patent/DK1228203T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • AIDS & HIV (AREA)
  • Vascular Medicine (AREA)
  • Biotechnology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)

Abstract

The peptide VIRIP (human virus-inhibiting peptide) and its biologically active fragments and/or variants and/or derivatives, especially amidated, acetylated, sulfated, poly(ethylene glycol)-modified, phosphorylated and/or glycosylated derivatives, also synthetic peptides with the same biological activity (collectively (I)). VIRIP has the formula (1) Z1-LEAIPMSIPPEVKFNKPF-Z2 (1) Z1 and Z2 : 0-10 amino acids, or Z1 = hydrogen and Z2 = carboxy Independent claims are also included for the following: (a) nucleic acid (II) encoding (I); (b) vector containing (II); (c) genetically modified host cell containing the vector; (d) nucleic acid (IIa) that hybridizes with (II); (e) antibody (Ab), antagonist or inhibitor of (I); (f) combination of (I) and an adapter protein that ensures uptake into virus-infected cells; (g) galenical formulation containing (I) and a carrier; (h) method for preparing (I); (i) diagnostic agent containing Ab or (II); and (j) pharmaceutical composition containing (I), (II), Ab or an antagonist/inhibitor of (I). ACTIVITY : Antiviral; antibacterial; antifungal; anti-inflammatory; anticancer; growth regulating; neurological; cardiovascular; hematological; immunomodulatory; vulnerary. In peripheral blood mononuclear cells, incubation with 1000 Microg/ml VIRIP caused almost complete inhibition of replication (assessed from reverse transcriptase activity) of many different strains of human immune deficiency virus, regardless of the tropism of the virus. MECHANISM OF ACTION : Viral receptor blocker.
DK00987221T 1999-11-08 2000-11-08 Peptide (VIRIP) which inhibits a circulating virus in humans as well as its use DK1228203T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE1999153732 DE19953732A1 (en) 1999-11-08 1999-11-08 New human virus-inhibiting peptide, useful e.g. for treating viral or other infections or cancer, comprises fragment of alpha1-antitrypsin
DE2000123665 DE10023665A1 (en) 2000-05-16 2000-05-16 New human virus-inhibiting peptide, useful e.g. for treating viral or other infections or cancer, comprises fragment of alpha1-antitrypsin
PCT/EP2000/011020 WO2001034640A2 (en) 1999-11-08 2000-11-08 Peptide (virip) which inhibits a circulating virus in humans and the use thereof

Publications (1)

Publication Number Publication Date
DK1228203T3 true DK1228203T3 (en) 2008-10-20

Family

ID=26005679

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00987221T DK1228203T3 (en) 1999-11-08 2000-11-08 Peptide (VIRIP) which inhibits a circulating virus in humans as well as its use

Country Status (13)

Country Link
US (1) US7037896B1 (en)
EP (2) EP1959013B1 (en)
JP (1) JP4813720B2 (en)
AT (1) ATE398674T1 (en)
AU (1) AU2354801A (en)
CA (1) CA2390652C (en)
CY (1) CY1108330T1 (en)
DE (1) DE50015216D1 (en)
DK (1) DK1228203T3 (en)
ES (1) ES2307549T3 (en)
HK (1) HK1124083A1 (en)
PT (1) PT1228203E (en)
WO (1) WO2001034640A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100144630A1 (en) * 1999-03-05 2010-06-10 Leland Shapiro Compositions, methods and uses for inhibition and/or treatment of influenza infection
US20100210528A1 (en) * 1999-03-05 2010-08-19 Leland Shapiro Compositions, methods and uses for inhibition and/or treatment of influenza infection
EP1572743B1 (en) * 2002-12-19 2011-08-10 IPF Pharmaceuticals GmbH Peptides and their use for the treatment of hiv infections
CA2569807A1 (en) * 2004-06-18 2005-12-29 Ipf Pharmaceuticals Gmbh Oligomeric peptides and their use for the treatment of hiv infections
CA2658227A1 (en) 2006-01-17 2007-07-26 Health Research, Inc. Heteroduplex tracking assay
CN102507824B (en) * 2011-11-01 2013-10-09 北京三元基因工程有限公司 Analysis method for modification sites of polyethylene glycol modified protein
EP3473650A1 (en) * 2017-10-18 2019-04-24 Universitätsklinikum Jena Antibody for the specific detection of caap47/48 fragments
AU2021208650A1 (en) * 2020-01-16 2022-08-11 Case Western Reserve University Neutrophil elastase binding peptides and compositions thereof
WO2022083729A1 (en) * 2020-10-22 2022-04-28 The University Of Hong Kong Compositions of anti-viral peptides and/or compounds and methods of use thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0114777B1 (en) 1983-01-21 1990-08-01 Transgene S.A. Expression vehicles and their use in the preparation of a protein having human alpha-antitrypsin activity
US5827662A (en) 1989-06-23 1998-10-27 The Trustees Of The University Of Pennsylvania Methods for detecting genetic mutations resulting in protease inhibitor insufficiencies
EP0616614A1 (en) * 1991-04-18 1994-09-28 The Uab Research Foundation Compositions and methods for inhibiting elastase
US5175253A (en) 1991-04-24 1992-12-29 Washington University Binding peptides
US5972901A (en) * 1994-03-23 1999-10-26 Case Western Reserve University Serpin enzyme complex receptor--mediated gene transfer
AU782051B2 (en) 1996-06-03 2005-06-30 Case Western Reserve University Enhanced delivery via serpin enzyme complex receptor

Also Published As

Publication number Publication date
AU2354801A (en) 2001-06-06
EP1959013B1 (en) 2014-04-23
CY1108330T1 (en) 2014-02-12
EP1228203A2 (en) 2002-08-07
JP2003516729A (en) 2003-05-20
HK1124083A1 (en) 2009-07-03
PT1228203E (en) 2008-09-03
ATE398674T1 (en) 2008-07-15
JP4813720B2 (en) 2011-11-09
WO2001034640A3 (en) 2001-11-01
CA2390652A1 (en) 2001-05-17
DE50015216D1 (en) 2008-07-31
EP1959013A1 (en) 2008-08-20
EP1228203B1 (en) 2008-06-18
US7037896B1 (en) 2006-05-02
ES2307549T3 (en) 2008-12-01
WO2001034640A2 (en) 2001-05-17
CA2390652C (en) 2011-03-29

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