DK121691D0 - Hindrede bindingsmidler og fremgangsmaade til dannelse af disulfidbindinger - Google Patents

Hindrede bindingsmidler og fremgangsmaade til dannelse af disulfidbindinger

Info

Publication number
DK121691D0
DK121691D0 DK911216A DK121691A DK121691D0 DK 121691 D0 DK121691 D0 DK 121691D0 DK 911216 A DK911216 A DK 911216A DK 121691 A DK121691 A DK 121691A DK 121691 D0 DK121691 D0 DK 121691D0
Authority
DK
Denmark
Prior art keywords
bindings
disulphide
creation
procedures
binding agents
Prior art date
Application number
DK911216A
Other languages
English (en)
Other versions
DK121691A (da
Inventor
Stephen Fitzhugh Carroll
Dane A Goff
Original Assignee
Xoma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xoma Corp filed Critical Xoma Corp
Publication of DK121691D0 publication Critical patent/DK121691D0/da
Publication of DK121691A publication Critical patent/DK121691A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/36—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/66—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Dental Preparations (AREA)
  • Hydrogenated Pyridines (AREA)
DK121691A 1988-12-22 1991-06-21 Hindrede bindingsmidler og fremgangsmaade til dannelse af disulfidbindinger DK121691A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28858688A 1988-12-22 1988-12-22
PCT/US1989/005789 WO1990006774A1 (en) 1988-12-22 1989-12-21 Hindered linking agents and methods

Publications (2)

Publication Number Publication Date
DK121691D0 true DK121691D0 (da) 1991-06-21
DK121691A DK121691A (da) 1991-06-21

Family

ID=23107753

Family Applications (1)

Application Number Title Priority Date Filing Date
DK121691A DK121691A (da) 1988-12-22 1991-06-21 Hindrede bindingsmidler og fremgangsmaade til dannelse af disulfidbindinger

Country Status (10)

Country Link
US (1) US5093475A (da)
EP (1) EP0454726A4 (da)
JP (1) JPH04502469A (da)
KR (1) KR910700242A (da)
AU (1) AU645745B2 (da)
CA (1) CA2006629A1 (da)
DK (1) DK121691A (da)
FI (1) FI913049A0 (da)
NZ (2) NZ231988A (da)
WO (1) WO1990006774A1 (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5563250A (en) * 1987-12-02 1996-10-08 Neorx Corporation Cleavable conjugates for the delivery and release of agents in native form
US6552170B1 (en) 1990-04-06 2003-04-22 Amgen Inc. PEGylation reagents and compounds formed therewith
US5169754A (en) * 1990-10-31 1992-12-08 Coulter Corporation Biodegradable particle coatings having a protein covalently immobilized by means of a crosslinking agent and processes for making same
DE4101394A1 (de) * 1991-01-18 1992-07-23 Medor Lab Fuer Biochemie Und K Verfahren zum koppeln von kohlenhydraten an traeger, insbesondere proteine
US5837491A (en) * 1991-11-04 1998-11-17 Xoma Corporation Polynucleotides encoding gelonin sequences
US6146850A (en) * 1991-11-04 2000-11-14 Xoma Corporation Proteins encoding gelonin sequences
US5621083A (en) * 1991-11-04 1997-04-15 Xoma Corporation Immunotoxins comprising ribosome-inactivating proteins
EP0683822B1 (en) * 1993-02-12 2002-05-02 Sealite Sciences, Inc. Preparation of photoprotein conjugates and methods of use thereof
US5648218A (en) * 1993-02-12 1997-07-15 Sealite Sciences, Inc. Preparation of photoprotein conjugates and methods of use thereof
US5565200A (en) * 1995-04-14 1996-10-15 University Of Southern California Pharmaceutical preparations derived from korean mistletoe
US6379714B1 (en) 1995-04-14 2002-04-30 Pharmaprint, Inc. Pharmaceutical grade botanical drugs
US5547674A (en) * 1995-04-14 1996-08-20 University Of Southern California Pharmaceutical preparations derived from European mistletoe
TW555765B (en) 1996-07-09 2003-10-01 Amgen Inc Low molecular weight soluble tumor necrosis factor type-I and type-II proteins
US6660843B1 (en) * 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
AU3847000A (en) * 1999-04-07 2000-10-23 Horticulture And Food Research Institute Of New Zealand Limited, The Modification of sexual behaviour in animals and pest control
US7723118B2 (en) * 2002-10-18 2010-05-25 Alt Bioscience, Llc. Compositions and methods for simultaneous detection of volatile sulfur compounds and polyamines
GB2446088B (en) * 2005-12-12 2010-10-20 Innova Biosciences Ltd Production of conjugates
CA2727668A1 (en) * 2008-06-13 2009-12-17 Alt Bioscience, Llc. Device for rapid determination of disease-associated thiol compounds
FR2947269B1 (fr) 2009-06-29 2013-01-18 Sanofi Aventis Nouveaux composes anticancereux
FR2963007B1 (fr) 2010-07-26 2013-04-05 Sanofi Aventis Derives anticancereux, leur preparation et leur application therapeutique

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3348940A (en) * 1963-12-05 1967-10-24 American Cyanamid Co Herbicidal and insecticidal composition
US3318910A (en) * 1963-12-05 1967-05-09 American Cyanamid Co 2-iminothiolanes and related compounds
US3317562A (en) * 1965-02-23 1967-05-02 American Cyanamid Co 2-oximinothiolanes and related compounds
US3755364A (en) * 1972-02-02 1973-08-28 Diamond Shamrock Corp 3-(n-carbamyloximino)-saturated thioheterocyclic compounds
US4590071A (en) * 1984-09-25 1986-05-20 Xoma Corporation Human melanoma specific immunotoxins
US4888415A (en) * 1985-03-04 1989-12-19 Dana-Farber Cancer Institute, Inc. Gelonin immunotoxin
EP0214995B1 (en) * 1985-03-04 1990-12-27 Dana Farber Cancer Institute Immunotoxin and method of making
US4880935A (en) * 1986-07-11 1989-11-14 Icrf (Patents) Limited Heterobifunctional linking agents derived from N-succinimido-dithio-alpha methyl-methylene-benzoates
ATE124269T1 (de) * 1988-02-09 1995-07-15 Mallinckrodt Inc Verfahren zur herstellung eines mit metall- radionuklid-markierten proteins.

Also Published As

Publication number Publication date
EP0454726A4 (en) 1991-11-27
FI913049A0 (fi) 1991-06-20
AU645745B2 (en) 1994-01-27
NZ231988A (en) 1992-04-28
US5093475A (en) 1992-03-03
DK121691A (da) 1991-06-21
NZ241869A (en) 1992-07-28
EP0454726A1 (en) 1991-11-06
AU4849190A (en) 1990-07-10
WO1990006774A1 (en) 1990-06-28
JPH04502469A (ja) 1992-05-07
KR910700242A (ko) 1991-03-14
CA2006629A1 (en) 1990-06-22

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Legal Events

Date Code Title Description
AHB Application shelved due to non-payment