DK1146044T3 - CNS-aktive cyclobutaindolcarboxamidderivater, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende disse - Google Patents

CNS-aktive cyclobutaindolcarboxamidderivater, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende disse

Info

Publication number
DK1146044T3
DK1146044T3 DK01400939T DK01400939T DK1146044T3 DK 1146044 T3 DK1146044 T3 DK 1146044T3 DK 01400939 T DK01400939 T DK 01400939T DK 01400939 T DK01400939 T DK 01400939T DK 1146044 T3 DK1146044 T3 DK 1146044T3
Authority
DK
Denmark
Prior art keywords
cyclobutaindole
cns
processes
active
preparation
Prior art date
Application number
DK01400939T
Other languages
Danish (da)
English (en)
Inventor
Jean-Louis Peglion
Mark Millan
Bertrand Goument
Francoise Lejeune
Didier Cussac
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Application granted granted Critical
Publication of DK1146044T3 publication Critical patent/DK1146044T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK01400939T 2000-04-13 2001-04-12 CNS-aktive cyclobutaindolcarboxamidderivater, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende disse DK1146044T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0004743A FR2807754A1 (fr) 2000-04-13 2000-04-13 Nouveaux derives de cyclobuta-indole carboxamide, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
DK1146044T3 true DK1146044T3 (da) 2004-12-27

Family

ID=8849213

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01400939T DK1146044T3 (da) 2000-04-13 2001-04-12 CNS-aktive cyclobutaindolcarboxamidderivater, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende disse

Country Status (24)

Country Link
US (2) US6452015B2 (no)
EP (1) EP1146044B1 (no)
JP (1) JP3396675B2 (no)
KR (1) KR100470691B1 (no)
CN (1) CN1323796A (no)
AR (1) AR042379A1 (no)
AT (1) ATE275140T1 (no)
AU (1) AU779366B2 (no)
BR (1) BR0101466A (no)
CA (1) CA2344108C (no)
DE (1) DE60105219T2 (no)
DK (1) DK1146044T3 (no)
EA (1) EA004738B1 (no)
ES (1) ES2227082T3 (no)
FR (1) FR2807754A1 (no)
HK (1) HK1040247A1 (no)
HU (1) HUP0101504A3 (no)
NO (1) NO318206B1 (no)
NZ (1) NZ511091A (no)
PL (1) PL347046A1 (no)
PT (1) PT1146044E (no)
SI (1) SI1146044T1 (no)
TR (1) TR200402685T4 (no)
ZA (1) ZA200103064B (no)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2837823B1 (fr) * 2002-03-27 2005-04-08 Servier Lab Nouveaux derives d'indoline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2933975B1 (fr) * 2008-07-17 2011-02-18 Servier Lab Nouveau procede de preparation de benzocyclobutenes fonctionnalises,et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable.
KR20220029900A (ko) * 2020-09-02 2022-03-10 에스케이하이닉스 주식회사 버퍼 회로

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994004533A1 (en) * 1992-08-20 1994-03-03 Smithkline Beecham Plc Condensed indole derivatives as 5ht2c and 5ht2b antagonists
GB9306460D0 (en) * 1993-03-29 1993-05-19 Smithkline Beecham Plc Novel compounds
JPH09512025A (ja) * 1994-04-23 1997-12-02 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー ５ｈｔ▲下２ｃ▼および５ｈｔ▲下２ｂ▼アンタゴニストとしての三環式誘導体
ATE197300T1 (de) * 1995-02-02 2000-11-15 Smithkline Beecham Plc Indolderivate als 5-ht rezeptorantagoniste
CA2195346C (en) * 1995-12-21 2007-04-10 Zhi Yuan Wang Benzocyclobutenones and polymers derived therefrom
WO1999043319A1 (en) * 1998-02-27 1999-09-02 The Board Of Trustees Of The University Of Illinois Agents with serotonin-related activity for the treatment for sleep apnea

Also Published As

Publication number Publication date
NZ511091A (en) 2001-09-28
SI1146044T1 (en) 2004-12-31
HUP0101504A3 (en) 2002-11-28
HUP0101504A2 (hu) 2002-02-28
ATE275140T1 (de) 2004-09-15
CA2344108A1 (fr) 2001-10-13
ES2227082T3 (es) 2005-04-01
PL347046A1 (en) 2001-10-22
DE60105219T2 (de) 2005-09-15
KR100470691B1 (ko) 2005-03-07
AU779366B2 (en) 2005-01-20
NO20011863D0 (no) 2001-04-11
AR042379A1 (es) 2005-06-22
HU0101504D0 (en) 2001-06-28
EP1146044B1 (fr) 2004-09-01
DE60105219D1 (de) 2004-10-07
EA004738B1 (ru) 2004-08-26
US20010044426A1 (en) 2001-11-22
PT1146044E (pt) 2004-11-30
NO318206B1 (no) 2005-02-14
ZA200103064B (en) 2001-10-18
CA2344108C (fr) 2005-11-29
EA200100344A3 (ru) 2002-02-28
BR0101466A (pt) 2001-12-11
US6452015B2 (en) 2002-09-17
JP3396675B2 (ja) 2003-04-14
EA200100344A2 (ru) 2001-10-22
HK1040247A1 (zh) 2002-05-31
EP1146044A1 (fr) 2001-10-17
FR2807754A1 (fr) 2001-10-19
TR200402685T4 (tr) 2004-11-22
CN1323796A (zh) 2001-11-28
JP2001302661A (ja) 2001-10-31
US6743818B2 (en) 2004-06-01
AU3518601A (en) 2001-10-18
KR20010098581A (ko) 2001-11-08
US20030032812A1 (en) 2003-02-13
NO20011863L (no) 2001-10-15

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