DK1140135T3 - Cyclosporin solution - Google Patents

Cyclosporin solution

Info

Publication number
DK1140135T3
DK1140135T3 DK99964670T DK99964670T DK1140135T3 DK 1140135 T3 DK1140135 T3 DK 1140135T3 DK 99964670 T DK99964670 T DK 99964670T DK 99964670 T DK99964670 T DK 99964670T DK 1140135 T3 DK1140135 T3 DK 1140135T3
Authority
DK
Denmark
Prior art keywords
cyclosporin
cyclosporin solution
solution
water
precipitation
Prior art date
Application number
DK99964670T
Other languages
Danish (da)
Inventor
Wilfried Fischer
Original Assignee
Ratiopharm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ratiopharm Gmbh filed Critical Ratiopharm Gmbh
Application granted granted Critical
Publication of DK1140135T3 publication Critical patent/DK1140135T3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds

Abstract

The invention relates to a cyclosporin solution which contains dexpanthenol as solubilizing agent and in water forms stable colloidal solutions which can be diluted with water to any volume without precipitation of the cyclosporin.
DK99964670T 1998-12-23 1999-12-23 Cyclosporin solution DK1140135T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19859910A DE19859910C2 (en) 1998-12-23 1998-12-23 Oral medicine
PCT/EP1999/010358 WO2000038702A1 (en) 1998-12-23 1999-12-23 Cyclosporin solution

Publications (1)

Publication Number Publication Date
DK1140135T3 true DK1140135T3 (en) 2003-12-08

Family

ID=7892567

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99964670T DK1140135T3 (en) 1998-12-23 1999-12-23 Cyclosporin solution

Country Status (18)

Country Link
EP (1) EP1140135B1 (en)
JP (1) JP2002533401A (en)
AT (1) ATE249834T1 (en)
AU (1) AU762963B2 (en)
CA (1) CA2355271A1 (en)
CZ (1) CZ20012143A3 (en)
DE (2) DE19859910C2 (en)
DK (1) DK1140135T3 (en)
ES (1) ES2203235T3 (en)
HK (1) HK1037140A1 (en)
HU (1) HUP0104623A3 (en)
NO (1) NO20012932L (en)
PL (1) PL348180A1 (en)
PT (1) PT1140135E (en)
RU (1) RU2216342C2 (en)
SK (1) SK8702001A3 (en)
WO (1) WO2000038702A1 (en)
ZA (1) ZA200104828B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102008060549A1 (en) 2008-12-04 2010-06-10 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Drug-peptide construct for extracellular accumulation
DE102009037551A1 (en) 2009-08-17 2011-02-24 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Cyclosporin
DE102011111991A1 (en) 2011-08-30 2013-02-28 Lead Discovery Center Gmbh New cyclosporin derivatives
US8957048B2 (en) 2011-10-06 2015-02-17 Allergan, Inc. Compositions for the treatment of dry eye
US9907826B2 (en) 2011-12-07 2018-03-06 Allergan, Inc. Efficient lipid delivery to human tear film using a salt-sensitive emulsion system

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8903804D0 (en) * 1989-02-20 1989-04-05 Sandoz Ltd Improvements in or relating to organic compounds
US4996193A (en) * 1989-03-03 1991-02-26 The Regents Of The University Of California Combined topical and systemic method of administration of cyclosporine
DK0813865T3 (en) * 1993-04-20 2001-11-19 Hexal Ag Plastics with active substance
US5603951A (en) * 1994-11-09 1997-02-18 Hanmi Pharm. Ind. Co., Ltd. Cyclosporin-containing soft capsule compositions
US5798333A (en) * 1996-09-17 1998-08-25 Sherman; Bernard C. Water-soluble concentrates containing cyclosporins
CZ301382B6 (en) * 1997-03-12 2010-02-10 Abbott Laboratories Chad377/Ap6D-2 Hydrophilic binary systems for administering cyclosporin

Also Published As

Publication number Publication date
NO20012932D0 (en) 2001-06-13
HUP0104623A2 (en) 2002-04-29
CA2355271A1 (en) 2000-07-06
HK1037140A1 (en) 2002-02-01
PT1140135E (en) 2003-12-31
RU2216342C2 (en) 2003-11-20
DE59907058D1 (en) 2003-10-23
ATE249834T1 (en) 2003-10-15
AU762963B2 (en) 2003-07-10
JP2002533401A (en) 2002-10-08
HUP0104623A3 (en) 2002-08-28
DE19859910C2 (en) 2001-03-22
EP1140135A1 (en) 2001-10-10
NO20012932L (en) 2001-06-13
ZA200104828B (en) 2002-09-13
CZ20012143A3 (en) 2002-01-16
DE19859910A1 (en) 2000-06-29
SK8702001A3 (en) 2002-01-07
EP1140135B1 (en) 2003-09-17
ES2203235T3 (en) 2004-04-01
WO2000038702A1 (en) 2000-07-06
AU3043400A (en) 2000-07-31
PL348180A1 (en) 2002-05-06

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