DK1129096T3 - CRF receptor antagonists and related methods - Google Patents

CRF receptor antagonists and related methods

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Publication number
DK1129096T3
DK1129096T3 DK99961675T DK99961675T DK1129096T3 DK 1129096 T3 DK1129096 T3 DK 1129096T3 DK 99961675 T DK99961675 T DK 99961675T DK 99961675 T DK99961675 T DK 99961675T DK 1129096 T3 DK1129096 T3 DK 1129096T3
Authority
DK
Denmark
Prior art keywords
receptor antagonists
related methods
crf receptor
compounds
treatment
Prior art date
Application number
DK99961675T
Other languages
Danish (da)
Inventor
Mustapha Haddach
Zhiqiang Guo
James R Mccarthy
Original Assignee
Neurocrine Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurocrine Biosciences Inc filed Critical Neurocrine Biosciences Inc
Application granted granted Critical
Publication of DK1129096T3 publication Critical patent/DK1129096T3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/16—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/16—Peri-condensed systems

Abstract

Compounds are disclosed which have utility in the treatment of a variety of disorders, including the treatment of disorders manifesting hypersecretion of CRF in a warm-blooded animals, including stroke. The compounds of this invention have the following structures: wherein n, m, R, R1, R2, X and Ar are as defined herein, including stereoisomes and pharmaceutically acceptable salts thereof.
DK99961675T 1998-11-12 1999-11-12 CRF receptor antagonists and related methods DK1129096T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19095898A 1998-11-12 1998-11-12
US40074499A 1999-09-21 1999-09-21
PCT/US1999/026984 WO2000027850A2 (en) 1998-11-12 1999-11-12 Crf receptor antagonists and methods relating thereto

Publications (1)

Publication Number Publication Date
DK1129096T3 true DK1129096T3 (en) 2003-09-15

Family

ID=26886600

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99961675T DK1129096T3 (en) 1998-11-12 1999-11-12 CRF receptor antagonists and related methods

Country Status (19)

Country Link
US (3) US6348466B1 (en)
EP (1) EP1129096B1 (en)
JP (1) JP2002529469A (en)
KR (1) KR20010080402A (en)
CN (1) CN1178941C (en)
AT (1) ATE240958T1 (en)
AU (1) AU755997B2 (en)
BR (1) BR9915129A (en)
CA (1) CA2349904A1 (en)
DE (1) DE69908173T2 (en)
DK (1) DK1129096T3 (en)
ES (1) ES2196898T3 (en)
HK (1) HK1038925B (en)
IL (1) IL143105A0 (en)
NO (1) NO20012228D0 (en)
NZ (1) NZ511267A (en)
PT (1) PT1129096E (en)
TR (1) TR200102178T2 (en)
WO (1) WO2000027850A2 (en)

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WO2001083486A1 (en) * 2000-05-01 2001-11-08 Bristol-Myers Squibb Pharma Company Tricyclic fused pyridine and pyrimidine derivatives as crf receptor antagonists
DE60102231T2 (en) 2000-05-18 2005-04-14 Neurocrine Biosciences, Inc., San Diego CRF RECEPTOR ANTAGONISTS AND METHODS RELATED TO THEM
ES2207614T3 (en) 2000-05-18 2004-06-01 Neurocrine Biosciences, Inc. ANTAGONISTS OF THE RECEIVER OF CRF AND METHODS RELATED TO THESE.
EP1341793B1 (en) 2000-11-03 2007-01-17 Neurocrine Biosciences, Inc. Crf receptor antagonists and methods relating thereto
ES2369837T3 (en) 2000-12-28 2011-12-07 Ono Pharmaceutical Co., Ltd. TRIHETEROCYCLIC COMPOUNDS AS RECRUITOR ANTIGONISTS CFR.
US6583143B2 (en) 2000-12-28 2003-06-24 Neurocrine Biosciences, Inc. CRF receptor antagonists and methods relating thereto
PL366854A1 (en) * 2001-04-30 2005-02-07 Glaxo Group Limited Crf receptor antagonists
US7273871B2 (en) 2001-07-17 2007-09-25 Sb Pharmco Puerto Rico Inc. Phenyl-5,6,6A,7,8,9-hexahydro-4H-1,4,9-triaza-phenalene derivatives as CRF antagonists
GB0117395D0 (en) * 2001-07-17 2001-09-05 Glaxo Group Ltd Chemical compounds
CA2529561C (en) 2003-06-25 2012-05-29 Ono Pharmaceutical Co., Ltd. Methanesulfonic acid salt of pyrazolopyrimidine compound, crystal thereof, and process for producing the same
US20060024661A1 (en) * 2003-07-30 2006-02-02 The Regents Of The University Of California Modulation of CRF potentiation of NMDA receptor currents via CRF receptor 2
ES2303130T3 (en) * 2003-12-22 2008-08-01 Sb Pharmco Puerto Rico Inc. ANTAGONISTS OF THE RECEIVER OF CRF AND METHODS RELATED TO THEM.
CN101133157A (en) 2004-06-03 2008-02-27 阿什洛米克斯控股有限公司 Agents and methods for diagnosing stress
US7869958B2 (en) * 2004-08-09 2011-01-11 Research Development Foundation Structure-based modulators of B1 G-protein coupled receptors
JP4952943B2 (en) 2004-08-25 2012-06-13 アーディア・バイオサイエンシーズ・インコーポレイテッド S-triazolyl α-mercaptoacetanilide as an inhibitor of HIV reverse transcriptase
WO2007050087A1 (en) 2004-08-25 2007-05-03 Ardea Biosciences, Inc. N[S(4-aryl-triazol-3-yl)α -mercaptoacetyl]-p-amino benozoic acids AS HIV REVERSE TRANSCRIPTASE INHIBITORS
BRPI0611455A2 (en) 2005-05-05 2010-09-08 Ardea Biosciences Inc diaryl purines, azapurines and deazapurines as non-nucleoside reverse transcriptase inhibitors for HIV treatment
MX2009005009A (en) 2006-11-09 2009-09-22 Ardea Biosciences Inc 4-cyanophenylamino-substituted bicyclic heterocyclic compounds as hiv inhibitors.
ME01294B (en) 2007-11-27 2013-06-20 Ardea Biosciences Inc Novel compounds and compositions and methods of use
US8207178B2 (en) 2007-12-14 2012-06-26 Ardea Biosciences, Inc. Fused pyrimidines as reverse transcriptase inhibitors

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Also Published As

Publication number Publication date
DE69908173D1 (en) 2003-06-26
CN1326458A (en) 2001-12-12
ES2196898T3 (en) 2003-12-16
HK1038925A1 (en) 2002-04-04
US20040229879A1 (en) 2004-11-18
WO2000027850A2 (en) 2000-05-18
ATE240958T1 (en) 2003-06-15
US6348466B1 (en) 2002-02-19
KR20010080402A (en) 2001-08-22
WO2000027850A3 (en) 2000-08-03
US6723721B2 (en) 2004-04-20
AU755997B2 (en) 2003-01-02
NO20012228L (en) 2001-05-04
IL143105A0 (en) 2002-04-21
EP1129096B1 (en) 2003-05-21
NO20012228D0 (en) 2001-05-04
DE69908173T2 (en) 2004-08-19
US20020143008A1 (en) 2002-10-03
NZ511267A (en) 2002-12-20
CA2349904A1 (en) 2000-05-18
AU1819900A (en) 2000-05-29
EP1129096A2 (en) 2001-09-05
JP2002529469A (en) 2002-09-10
PT1129096E (en) 2003-09-30
CN1178941C (en) 2004-12-08
BR9915129A (en) 2001-08-07
TR200102178T2 (en) 2002-01-21
HK1038925B (en) 2003-12-05

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