DK1105104T3 - Buccal bioadhesive tablet with long-term release - Google Patents

Buccal bioadhesive tablet with long-term release

Info

Publication number
DK1105104T3
DK1105104T3 DK99942454T DK99942454T DK1105104T3 DK 1105104 T3 DK1105104 T3 DK 1105104T3 DK 99942454 T DK99942454 T DK 99942454T DK 99942454 T DK99942454 T DK 99942454T DK 1105104 T3 DK1105104 T3 DK 1105104T3
Authority
DK
Denmark
Prior art keywords
long
term release
bioadhesive tablet
buccal bioadhesive
buccal
Prior art date
Application number
DK99942454T
Other languages
Danish (da)
Inventor
William J Bologna
Howard L Levine
Ziegler Dominique De
Philippe Cartier
Original Assignee
Columbia Lab Bermuda Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22265404&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1105104(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Columbia Lab Bermuda Ltd filed Critical Columbia Lab Bermuda Ltd
Application granted granted Critical
Publication of DK1105104T3 publication Critical patent/DK1105104T3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
DK99942454T 1998-08-25 1999-08-24 Buccal bioadhesive tablet with long-term release DK1105104T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9784398P 1998-08-25 1998-08-25
US09/379,310 US6248358B1 (en) 1998-08-25 1999-08-23 Bioadhesive progressive hydration tablets and methods of making and using the same

Publications (1)

Publication Number Publication Date
DK1105104T3 true DK1105104T3 (en) 2006-02-06

Family

ID=22265404

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99942454T DK1105104T3 (en) 1998-08-25 1999-08-24 Buccal bioadhesive tablet with long-term release

Country Status (26)

Country Link
US (1) US6248358B1 (en)
EP (1) EP1105104B1 (en)
JP (2) JP5411398B2 (en)
KR (1) KR100716702B1 (en)
CN (2) CN1879608A (en)
AR (1) AR036972A1 (en)
AT (1) ATE306253T1 (en)
AU (1) AU754880B2 (en)
BR (1) BR9913239B1 (en)
CA (1) CA2341375C (en)
DE (1) DE69927694T2 (en)
DK (1) DK1105104T3 (en)
ES (1) ES2251220T3 (en)
HK (1) HK1034895A1 (en)
HU (1) HU226591B1 (en)
IL (1) IL141445A (en)
MA (1) MA24964A1 (en)
MX (1) MXPA01002007A (en)
MY (2) MY125919A (en)
NO (1) NO331255B1 (en)
NZ (1) NZ509963A (en)
PE (1) PE20001036A1 (en)
RU (1) RU2227022C2 (en)
UA (1) UA78967C2 (en)
WO (1) WO2000010536A1 (en)
ZA (1) ZA995445B (en)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6624200B2 (en) * 1998-08-25 2003-09-23 Columbia Laboratories, Inc. Bioadhesive progressive hydration tablets
AU2005203703B2 (en) * 1998-08-25 2007-05-24 Columbia Laboratories (Bermuda) Limited Bioadhesive progressive hydration tablets
US7803392B2 (en) * 2000-12-27 2010-09-28 University Of Kentucky Research Foundation pH-Sensitive mucoadhesive film-forming gels and wax-film composites suitable for topical and mucosal delivery of molecules
WO2002087552A2 (en) * 2001-05-01 2002-11-07 Mcgill University Androgen-mediated neuroprotection and uses thereof
US8425892B2 (en) * 2001-10-29 2013-04-23 Columbia Laboratories, Inc. Extended, controlled-release pharmaceutical compositions using charged polymers
US20030114394A1 (en) * 2001-10-29 2003-06-19 Levine Howard L. Vaginally administered anti-dysrhythmic agents for treating pelvic pain
US7709026B2 (en) 2001-10-29 2010-05-04 Columbia Laboratories, Inc. Low concentration of peroxide for treating or preventing vaginal infections
CN101327326A (en) * 2001-10-29 2008-12-24 哥伦比亚实验室(百慕大群岛)有限公司 Vaginally administered anti-dysrhythmic agents for treating pelvic pain and infertility
US7005138B2 (en) * 2001-12-21 2006-02-28 Duramed Pharmaceuticals, Inc. Method of systematically delivering SSRIs
GB0210397D0 (en) * 2002-05-07 2002-06-12 Ferring Bv Pharmaceutical formulations
PA8578501A1 (en) * 2002-07-25 2005-02-04 Pharmacia Corp DOSAGE FORM ONCE A DAY OF PRAMIPEXOL
US20050226926A1 (en) 2002-07-25 2005-10-13 Pfizer Inc Sustained-release tablet composition of pramipexole
RU2005105945A (en) * 2002-08-02 2005-07-10 Рэнбакси Лабораториз Лимитед (In) SODIUM FOSINOPRIL TABLETS STORAGE STABLE
US20040127476A1 (en) * 2002-11-14 2004-07-01 Alvin Kershman Oral testosterone delivery system with improved sustained release
CA2514325C (en) * 2003-01-24 2013-11-12 Magle Holding Ab A composition material for transmucosal delivery
SE0302947D0 (en) 2003-01-24 2003-11-07 Magle Ab A composition material for transmucosal delivery
ATE493973T1 (en) 2004-06-04 2011-01-15 Teva Pharma PHARMACEUTICAL COMPOSITION CONTAINING IRBESARTAN
CN101843597A (en) * 2004-08-13 2010-09-29 贝林格尔·英格海姆国际有限公司 The prolongation that comprises pramipexole or its officinal salt discharges pellet formulation, Its Preparation Method And Use
UA89052C2 (en) * 2004-08-13 2009-12-25 Бёрингер Ингельхайм Интернациональ Гмбх Extended release tablet formulation containing pramipexole or a pharmaceutically acceptable salt thereof, method for manufacturing the same and use thereof
CA2610465A1 (en) * 2005-06-03 2006-12-14 Duramed Pharmaceuticals, Inc. Pharmaceutical compositions comprising prostanoid-receptor agonists and methods of making and using the same
US20070048369A1 (en) * 2005-08-26 2007-03-01 National Starch And Chemical Investment Holding Corporation Mucosal delivery tablet
WO2007070632A2 (en) 2005-12-13 2007-06-21 Biodelivery Sciences International, Inc. Abuse resistant transmucosal drug delivery device
JP2009526021A (en) * 2006-02-10 2009-07-16 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Formulation with controlled release
WO2007090883A1 (en) * 2006-02-10 2007-08-16 Boehringer Ingelheim International Gmbh Extended release formulation
WO2007096906A2 (en) * 2006-02-27 2007-08-30 Panacea Biotec Ltd. Novel buccoadhesive compositions and process of preparation thereof
EP1837020A1 (en) 2006-03-24 2007-09-26 Bioalliance Pharma Mucosal bioadhesive slow release carrier for delivering active principles
US20070248655A1 (en) * 2006-04-21 2007-10-25 Haley Jeffrey T Lenticular shaped protective mouth sore discs
EP1872775A1 (en) 2006-06-29 2008-01-02 Polichem S.A. Use of a hydrophilic matrix comprising a polyacrylic acid derivative, a cellulose ether and a disintegrant for the manufacture of a medicament for treating female genital disorders
SI2054031T1 (en) 2006-07-21 2016-09-30 Biodelivery Sciences International, Inc. Transmucosal delivery devices with enhanced uptake
EP2112923A1 (en) 2007-01-22 2009-11-04 Targacept Inc. Intranasal, buccal, and sublingual administration of metanicotine analogs
CA2939778C (en) 2007-01-31 2019-01-29 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
US8828981B2 (en) 2007-02-06 2014-09-09 George Creasy Progesterone for the treatment or prevention of spontaneous preterm birth
EP2142562B1 (en) 2007-03-28 2013-07-03 President and Fellows of Harvard College Stitched polypeptides
EP1987820A1 (en) * 2007-05-04 2008-11-05 Christian Fiala, Ph. D. Slow release misoprostol for obstetric and/or gynaecological applications
CA2725578A1 (en) * 2008-04-24 2009-10-29 Evestra, Inc. Oral contraceptive dosage forms comprising a progestogen dispersed in an enteric polymer and further comprising an estrogen
EP2163240A1 (en) * 2008-09-12 2010-03-17 Universita' Degli Studi Di Genova A method for the production of bioadhesive compact matrices
BRPI1015046A2 (en) 2009-06-18 2016-04-12 Allergan Inc safe administration of desmopressin
EP2603600B1 (en) 2010-08-13 2018-11-21 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
EA201991223A1 (en) 2011-08-18 2019-10-31 NON-CALLING DEPENDENCE MUKOADHESIVE DEVICES FOR DELIVERY OF BUPRENORPHINE
KR20140100937A (en) 2011-10-18 2014-08-18 에일러론 테라퓨틱스 인코포레이티드 Peptidomimetic macrocycles
US9901539B2 (en) 2011-12-21 2018-02-27 Biodelivery Sciences International, Inc. Transmucosal drug delivery devices for use in chronic pain relief
JP6450192B2 (en) 2012-02-15 2019-01-09 エイルロン セラピューティクス，インコーポレイテッド Triazole-bridged and thioether-bridged peptidomimetic macrocycles
WO2013123266A1 (en) 2012-02-15 2013-08-22 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
US9604919B2 (en) 2012-11-01 2017-03-28 Aileron Therapeutics, Inc. Disubstituted amino acids and methods of preparation and use thereof
BR112017005598A2 (en) 2014-09-24 2017-12-12 Aileron Therapeutics Inc peptidomimetic macrocycles and their uses
EP3294318A4 (en) 2015-03-20 2019-04-03 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3133862A (en) 1960-07-22 1964-05-19 Miles Lab Buccal tablet containing vitamin a and sodium proteinate
GB2042888B (en) 1979-03-05 1983-09-28 Teijin Ltd Preparation for administration to the mucosa of the oral or nasal cavity
US4389393A (en) 1982-03-26 1983-06-21 Forest Laboratories, Inc. Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose
CA1208558A (en) 1982-10-07 1986-07-29 Kazuo Kigasawa Soft buccal
US5225196A (en) * 1983-11-14 1993-07-06 Columbia Laboratories, Inc. Bioadhesive compositions and methods of treatment therewith
WO1985002092A1 (en) 1983-11-14 1985-05-23 Bio-Mimetics Inc. Bioadhesive compositions and methods of treatment therewith
US4540566A (en) 1984-04-02 1985-09-10 Forest Laboratories, Inc. Prolonged release drug dosage forms based on modified low viscosity grade hydroxypropylmethylcellulose
DE3580384D1 (en) 1984-04-09 1990-12-13 Toyo Boseki PREPARATION WITH DELAYED RELEASE FOR APPLICATION ON THE ORIGINAL SLIME.
JPS60215622A (en) * 1984-04-09 1985-10-29 Toyobo Co Ltd Sustained release preparation for mucosa in oral cavity
US4596795A (en) 1984-04-25 1986-06-24 The United States Of America As Represented By The Secretary, Dept. Of Health & Human Services Administration of sex hormones in the form of hydrophilic cyclodextrin derivatives
US4764378A (en) 1986-02-10 1988-08-16 Zetachron, Inc. Buccal drug dosage form
EP0273209B1 (en) 1986-12-30 1992-01-15 American Cyanamid Company Composition of matter containing polycarbophil
US4915948A (en) 1987-08-31 1990-04-10 Warner-Lambert Company Tablets having improved bioadhesion to mucous membranes
US4900552A (en) 1988-03-30 1990-02-13 Watson Laboratories, Inc. Mucoadhesive buccal dosage forms
US5252334A (en) 1989-09-08 1993-10-12 Cygnus Therapeutic Systems Solid matrix system for transdermal drug delivery
EP0452334A4 (en) * 1989-10-31 1991-12-11 Watson Laboratoires, Inc. Mucoadhesive carrier for delivery of therapeutical agent
US6017521A (en) * 1989-10-31 2000-01-25 Columbia Laboratories, Inc. Use of polycarboxylic acid polymers to treat vaginal infections
US5750136A (en) 1989-11-03 1998-05-12 Riker Laboratories, Inc. Bioadhesive composition and patch
US5750134A (en) 1989-11-03 1998-05-12 Riker Laboratories, Inc. Bioadhesive composition and patch
CA2043384A1 (en) * 1990-05-31 1991-12-01 Chin C. Hsu Bioadhesive carboxylic polymer composition and method relating thereto
FR2665357B1 (en) 1990-07-31 1995-03-31 Aiache Jean Marc PROCESS FOR THE PREPARATION OF A BIO-ADHESIVE GALENIC FORM AND GALENIC FORM THUS PREPARED.
US5686094A (en) 1991-04-01 1997-11-11 Theratech, Inc. Controlled release formulations for the treatment of xerostomia
US5110605A (en) 1990-08-21 1992-05-05 Oramed, Inc. Calcium polycarbophil-alginate controlled release composition and method
US5102666A (en) 1990-09-11 1992-04-07 Oramed, Inc. Calcium polycarbophil controlled release composition and method
JP2609022B2 (en) 1990-11-29 1997-05-14 北陸製薬株式会社 Polycarbophil calcium-containing preparation
JPH06100466A (en) 1992-02-14 1994-04-12 Tsumura & Co Controlling agent for cerebroneurocytic organ lesion with stress nature
DE69312487T2 (en) 1992-05-18 1997-11-27 Minnesota Mining & Mfg DEVICE FOR TRANSMUCOSAL DELIVERY OF ACTIVE SUBSTANCES
GR1002418B (en) * 1992-07-29 1996-08-21 Johnson & Johnson Consumer Products Inc. Bioactive treatment compositions and methods of use.
FI933979A0 (en) 1992-09-10 1993-09-10 Mcneil Ppc Inc BIOERODERBAR ANORDNING FOER DOSERING AV AKTIVA INGREDIENSER
US5458884A (en) 1992-09-10 1995-10-17 Britton; Peter Bioerodible device for administering active ingredients
US5298017A (en) 1992-12-29 1994-03-29 Alza Corporation Layered electrotransport drug delivery system
US5460820B1 (en) 1993-08-03 1999-08-03 Theratech Inc Method for providing testosterone and optionally estrogen replacement therapy to women
US5543150A (en) * 1993-09-15 1996-08-06 Columbia Laboratories, Inc. Method of progesterone delivery and affect thereof
FR2712807B1 (en) 1993-11-24 1996-02-23 Vetoquinol Sa Solid mucoadhesive, therapeutic or hygienic composition, for administration by application to the oral or nasal mucosa.
US5578315A (en) * 1993-12-01 1996-11-26 Rutgers, The State University Of New Jersey Mucosal adhesive device for long-acting delivery of pharmaceutical combinations in oral cavity
US5567439A (en) 1994-06-14 1996-10-22 Fuisz Technologies Ltd. Delivery of controlled-release systems(s)
US5958458A (en) * 1994-06-15 1999-09-28 Dumex-Alpharma A/S Pharmaceutical multiple unit particulate formulation in the form of coated cores
EP0714411B1 (en) 1994-06-16 1999-07-21 PHARMACIA & UPJOHN S.p.A. Process for obtaining mucoadhesive starch
US5554380A (en) 1994-08-04 1996-09-10 Kv Pharmaceutical Company Bioadhesive pharmaceutical delivery system
US5656284A (en) 1995-04-24 1997-08-12 Balkin; Michael S. Oral transmucosal delivery tablet and method of making it
US5624677A (en) 1995-06-13 1997-04-29 Pentech Pharmaceuticals, Inc. Controlled release of drugs delivered by sublingual or buccal administration
US5766620A (en) 1995-10-23 1998-06-16 Theratech, Inc. Buccal delivery of glucagon-like insulinotropic peptides
US5783212A (en) 1996-02-02 1998-07-21 Temple University--of the Commonwealth System of Higher Education Controlled release drug delivery system
DE19619045C1 (en) 1996-05-02 1997-11-13 Jenapharm Gmbh Use of combination products for the treatment of hypogonadal men and men with pituitary disorders
US5783208A (en) 1996-07-19 1998-07-21 Theratech, Inc. Transdermal drug delivery matrix for coadministering estradiol and another steroid
US5800832A (en) 1996-10-18 1998-09-01 Virotex Corporation Bioerodable film for delivery of pharmaceutical compounds to mucosal surfaces
US5807575A (en) 1997-02-14 1998-09-15 Rougier Inc. Manufacture of cross-linked amylose useful as a excipient for control release of active compounds

Also Published As

Publication number Publication date
AR036972A1 (en) 2004-10-20
CN1879608A (en) 2006-12-20
JP5411398B2 (en) 2014-02-12
HU226591B1 (en) 2009-04-28
WO2000010536A1 (en) 2000-03-02
HK1034895A1 (en) 2001-11-09
NO20010919D0 (en) 2001-02-23
DE69927694T2 (en) 2006-08-10
MY133365A (en) 2007-11-30
KR100716702B1 (en) 2007-05-14
MXPA01002007A (en) 2002-06-04
ATE306253T1 (en) 2005-10-15
BR9913239A (en) 2001-05-15
WO2000010536A9 (en) 2000-08-24
NO331255B1 (en) 2011-11-07
MA24964A1 (en) 2000-04-01
EP1105104A1 (en) 2001-06-13
IL141445A (en) 2005-12-18
MY125919A (en) 2006-08-30
IL141445A0 (en) 2002-03-10
CN1259903C (en) 2006-06-21
DE69927694D1 (en) 2005-11-17
BR9913239B1 (en) 2010-11-16
EP1105104B1 (en) 2005-10-12
HUP0103218A2 (en) 2001-12-28
PE20001036A1 (en) 2000-10-12
WO2000010536A8 (en) 2000-06-15
AU754880B2 (en) 2002-11-28
CA2341375A1 (en) 2000-03-02
AU5582699A (en) 2000-03-14
CA2341375C (en) 2006-07-11
RU2227022C2 (en) 2004-04-20
ES2251220T3 (en) 2006-04-16
UA78967C2 (en) 2007-05-10
US6248358B1 (en) 2001-06-19
KR20010072924A (en) 2001-07-31
CN1323201A (en) 2001-11-21
NO20010919L (en) 2001-03-22
NZ509963A (en) 2004-11-26
JP2010248231A (en) 2010-11-04
JP2004500317A (en) 2004-01-08
ZA995445B (en) 2000-11-27

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DE29906562U1 (en) ratchet
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UA2845S (en) TABLET
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