DK1102770T3 - Parmamagnetic 3-, 8-substituted deuteroporphyrin derivatives, pharmaceuticals containing them, methods for their preparation and their use in necrosis and infarct MRI imaging - Google Patents
Parmamagnetic 3-, 8-substituted deuteroporphyrin derivatives, pharmaceuticals containing them, methods for their preparation and their use in necrosis and infarct MRI imagingInfo
- Publication number
- DK1102770T3 DK1102770T3 DK99936616T DK99936616T DK1102770T3 DK 1102770 T3 DK1102770 T3 DK 1102770T3 DK 99936616 T DK99936616 T DK 99936616T DK 99936616 T DK99936616 T DK 99936616T DK 1102770 T3 DK1102770 T3 DK 1102770T3
- Authority
- DK
- Denmark
- Prior art keywords
- necrosis
- methods
- parmamagnetic
- infarct
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
Abstract
The invention relates to paramagnetic 3-,8-substituted deuteroporphyrin derivatives having different substituents in positions 13 and 17 of the porphyrin skeleton, diagnostic substances containing said compounds, their use in magnetic resonance imaging of necrosis and infarction and methods for producing said compounds and substances.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19835082A DE19835082A1 (en) | 1998-07-24 | 1998-07-24 | Paramagnetic 3-, 8-substituted deuteroporphyrin derivatives, pharmaceutical compositions containing them, processes for their preparation and their use for necrosis and infarct MR imaging |
PCT/EP1999/005522 WO2000005235A1 (en) | 1998-07-24 | 1999-07-15 | Paramagnetic 3-,8-substituted deuteroporphyrin derivatives, pharmaceutical preparations containing same, method for producing same and their use in magnetic resonance imaging of necrosis and infarction |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1102770T3 true DK1102770T3 (en) | 2003-12-01 |
Family
ID=7876347
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK99936616T DK1102770T3 (en) | 1998-07-24 | 1999-07-15 | Parmamagnetic 3-, 8-substituted deuteroporphyrin derivatives, pharmaceuticals containing them, methods for their preparation and their use in necrosis and infarct MRI imaging |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP1102770B1 (en) |
JP (1) | JP2002521384A (en) |
AT (1) | ATE247659T1 (en) |
AU (1) | AU5164699A (en) |
DE (2) | DE19835082A1 (en) |
DK (1) | DK1102770T3 (en) |
ES (1) | ES2205863T3 (en) |
NO (1) | NO317788B1 (en) |
PT (1) | PT1102770E (en) |
TW (1) | TW553941B (en) |
WO (1) | WO2000005235A1 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6482943B1 (en) | 1999-04-30 | 2002-11-19 | Slil Biomedical Corporation | Quinones as disease therapies |
CA2448570A1 (en) | 2001-05-31 | 2002-12-05 | Miravant Pharmaceuticals, Inc. | Substituted porphyrin and azaporphyrin derivatives and their use in photodynamic therapy, radioimaging and mri diagnosis |
AU2003248763A1 (en) * | 2002-06-28 | 2004-01-19 | Pharmacia Corporation | Methods and contrast agents useful in quantifying nitric oxide |
DE10240343A1 (en) * | 2002-08-27 | 2004-03-11 | Schering Ag | Peroxynitrite rearrangement catalysts |
WO2012105483A1 (en) * | 2011-01-31 | 2012-08-09 | 国立大学法人宇都宮大学 | Method for producing metal complex of compound that has porphyrin skeleton |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5284647A (en) * | 1988-03-18 | 1994-02-08 | Schering Aktiengesellschaft | Mesotetraphenylporphyrin complex compounds, process for their production and pharmaceutical agents containing them |
US5612016A (en) * | 1988-04-01 | 1997-03-18 | Immunomedics, Inc. | Conjugates of antibodies and bifunctional ligands |
DE3827940A1 (en) * | 1988-08-13 | 1990-03-01 | Schering Ag | 13,17-PROPIONIC ACID AND PROPIONIC ACID DERIVATIVE SUBSTITUTED PORPHYRINE COMPLEX COMPOUNDS, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL AGENTS CONTAINING THEM |
DE4232925A1 (en) * | 1992-09-28 | 1994-03-31 | Diagnostikforschung Inst | 3-, 8-substituted deuteroporphyrin derivatives, pharmaceutical compositions containing them and process for their preparation |
JPH10500122A (en) * | 1994-05-11 | 1998-01-06 | シエーリング アクチェンゲゼルシャフト | Use of porphyrin complex or extended porphyrin complex compound as infarct localization diagnostic agent |
DE19824653A1 (en) * | 1998-02-25 | 1999-08-26 | Schering Ag | Use of compounds concentrating in necrotic tissue as drug depots, e.g. for radiation therapy, pharmacotherapy, restenosis prevention and diagnosis |
-
1998
- 1998-07-24 DE DE19835082A patent/DE19835082A1/en not_active Withdrawn
-
1999
- 1999-07-02 TW TW088111288A patent/TW553941B/en not_active IP Right Cessation
- 1999-07-15 AU AU51646/99A patent/AU5164699A/en not_active Abandoned
- 1999-07-15 WO PCT/EP1999/005522 patent/WO2000005235A1/en active IP Right Grant
- 1999-07-15 EP EP99936616A patent/EP1102770B1/en not_active Expired - Lifetime
- 1999-07-15 AT AT99936616T patent/ATE247659T1/en not_active IP Right Cessation
- 1999-07-15 DE DE59906695T patent/DE59906695D1/en not_active Expired - Fee Related
- 1999-07-15 ES ES99936616T patent/ES2205863T3/en not_active Expired - Lifetime
- 1999-07-15 JP JP2000561191A patent/JP2002521384A/en active Pending
- 1999-07-15 PT PT99936616T patent/PT1102770E/en unknown
- 1999-07-15 DK DK99936616T patent/DK1102770T3/en active
-
2001
- 2001-01-23 NO NO20010392A patent/NO317788B1/en unknown
Also Published As
Publication number | Publication date |
---|---|
DE59906695D1 (en) | 2003-09-25 |
DE19835082A1 (en) | 2000-02-03 |
NO317788B1 (en) | 2004-12-13 |
JP2002521384A (en) | 2002-07-16 |
ATE247659T1 (en) | 2003-09-15 |
ES2205863T3 (en) | 2004-05-01 |
NO20010392L (en) | 2001-03-23 |
EP1102770A1 (en) | 2001-05-30 |
NO20010392D0 (en) | 2001-01-23 |
PT1102770E (en) | 2004-01-30 |
AU5164699A (en) | 2000-02-14 |
TW553941B (en) | 2003-09-21 |
EP1102770B1 (en) | 2003-08-20 |
WO2000005235A1 (en) | 2000-02-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Albrand et al. | The use of transferred nuclear Overhauser effects in the study of the conformations of small molecules bound to proteins | |
WO2000030688A3 (en) | Amphipatic polycarboxylic chelates and complexes with paramagnetic metals as mri contrast agents | |
ES2087938T3 (en) | USE OF CHELATED COMPLEXES. | |
DK0874645T3 (en) | Perflouralkyl-containing metal complexes and their use in NMR diagnostics | |
Xia et al. | Clean STD‐NMR spectrum for improved detection of ligand‐protein interactions at low concentration of protein | |
DK1102770T3 (en) | Parmamagnetic 3-, 8-substituted deuteroporphyrin derivatives, pharmaceuticals containing them, methods for their preparation and their use in necrosis and infarct MRI imaging | |
Zech et al. | Probing the water coordination of protein‐targeted MRI contrast agents by pulsed ENDOR spectroscopy | |
BR9508435A (en) | Macrocyclic chelates and their chelates and their uses in the diagnostic field | |
DE69120826T2 (en) | CHELATE-MAKING AGENTS | |
Rizzi et al. | Structure and single crystal EPR study of Cu (II)(l-threonine) 2· H2O | |
Kövér et al. | 15N and 13C Group‐Selective Techniques Extend the Scope of STD NMR Detection of Weak Host–Guest Interactions and Ligand Screening | |
Yamamoto et al. | NMR investigation of the heme electronic structure in deoxymyoglobin possessing a fluorinated heme | |
Krishnamoorthi et al. | A 1H NMR comparison of the met-cyano complexes of elephant and sperm whale myoglobin. Assignment of labile proton resonances in the heme cavity and determination of the distal glutamine orientation from relaxation data. | |
Yamamoto et al. | 19 F NMR study of protein-induced rhombic perturbations on the electronic structure of the active site of myoglobin | |
de la Fuente et al. | EPR study of the 1: 1 complexes of chromium (III) and copper (II) with 5′-GMP and 5′-CMP | |
Pezeshk et al. | Drug-metal interactions: spectroscopic studies of copper hydantoin complexes | |
AU7353400A (en) | Macrocyclic chelants for metallopharmaceuticals |