DK108786A - HETEROCYCLIC DISULFIDES AND THEIR USE AS IMMUNE MODULATORS - Google Patents

HETEROCYCLIC DISULFIDES AND THEIR USE AS IMMUNE MODULATORS Download PDF

Info

Publication number
DK108786A
DK108786A DK108786A DK108786A DK108786A DK 108786 A DK108786 A DK 108786A DK 108786 A DK108786 A DK 108786A DK 108786 A DK108786 A DK 108786A DK 108786 A DK108786 A DK 108786A
Authority
DK
Denmark
Prior art keywords
immune modulators
heterocyclic disulfides
disulfides
heterocyclic
modulators
Prior art date
Application number
DK108786A
Other languages
Danish (da)
Other versions
DK165181C (en
DK108786D0 (en
DK165181B (en
Inventor
Klaus Fleischmann
Walter Duerckheimer
Juergen Blumbach
Michael Limbert
Hans-Ulrich Schorlemmer
Gerhard Dichneite
Hans-Harald Sedlacek
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of DK108786D0 publication Critical patent/DK108786D0/en
Publication of DK108786A publication Critical patent/DK108786A/en
Publication of DK165181B publication Critical patent/DK165181B/en
Application granted granted Critical
Publication of DK165181C publication Critical patent/DK165181C/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79Acids; Esters
    • C07D213/80Acids; Esters in position 3
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28Sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/56One oxygen atom and one sulfur atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/101,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12Oxygen or sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D253/00Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/061,2,4-Triazines
    • C07D253/0651,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/071,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/36Sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38Nitrogen atoms
    • C07D277/44Acylated amino or imino radicals
    • C07D277/46Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D285/00Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01Five-membered rings
    • C07D285/02Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/121,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/1251,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK108786A 1985-03-12 1986-03-10 HETEROCYCLIC DISULFIDES PROCEDURE FOR THEIR PREPARATION AND PHARMACEUTICAL AGENTS CONTAINING THESE RELATIONSHIPS DK165181C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3508666 1985-03-12
DE19853508666 DE3508666A1 (en) 1985-03-12 1985-03-12 HETEROCYCLIC DISULFIDES AND THEIR USE AS IMMUNO MODULATORS

Publications (4)

Publication Number Publication Date
DK108786D0 DK108786D0 (en) 1986-03-10
DK108786A true DK108786A (en) 1986-09-13
DK165181B DK165181B (en) 1992-10-19
DK165181C DK165181C (en) 1993-03-01

Family

ID=6264871

Family Applications (1)

Application Number Title Priority Date Filing Date
DK108786A DK165181C (en) 1985-03-12 1986-03-10 HETEROCYCLIC DISULFIDES PROCEDURE FOR THEIR PREPARATION AND PHARMACEUTICAL AGENTS CONTAINING THESE RELATIONSHIPS

Country Status (19)

Country Link
EP (1) EP0194571B1 (en)
JP (1) JPH0751572B2 (en)
KR (1) KR940001773B1 (en)
AR (1) AR245113A1 (en)
AT (1) ATE58293T1 (en)
AU (1) AU594943B2 (en)
DE (2) DE3508666A1 (en)
DK (1) DK165181C (en)
ES (3) ES8801506A1 (en)
FI (1) FI860980A (en)
GR (1) GR860649B (en)
HU (1) HU201742B (en)
IE (1) IE58729B1 (en)
IL (1) IL78091A (en)
NO (1) NO168357C (en)
NZ (1) NZ215424A (en)
PH (1) PH22275A (en)
PT (1) PT82166B (en)
ZA (1) ZA861780B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3915094A1 (en) 1989-05-09 1991-01-10 Hoechst Ag PROCESS FOR THE PREPARATION OF 2-MERCAPTO-4-METHYL-1,3-THIAZOL-5-YL-ACETIC ACID AND THEIR ESTERS
TW252112B (en) * 1993-08-19 1995-07-21 Pfizer
DE10055219A1 (en) * 2000-11-08 2002-05-29 Bayer Ag Process for the preparation of dithiazolyl disulfides
AU2002239879A1 (en) * 2001-01-10 2002-07-24 Davide R. Grassetti Method of immunomodulation using thione-forming disulfides
DE102005004472A1 (en) * 2005-01-31 2006-08-10 Rhein Chemie Rheinau Gmbh Process for the preparation of bis-DMTD

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR5680M (en) * 1966-08-19 1968-01-08
US4378364A (en) * 1970-05-05 1983-03-29 Grassetti Davide R Postoperative treatment of carcinoma patients
IL36587A (en) * 1970-05-05 1977-10-31 Grassetti D Compositions containing pyridine derivatives and their use in a method of modifying cellular surface reactions
GB1365943A (en) * 1970-09-16 1974-09-04 Gaf Corp Metalworking additive and composition and process for making the same
GB1327467A (en) * 1970-10-12 1973-08-22 Merck & Co Inc Pharmaceutical compositions for inhibiting indoleamine- n-methyl transferase
FR2403798A1 (en) * 1977-09-22 1979-04-20 Rorer Inc William H SYNERGIC COMPOSITIONS BASED ON BIS (2-PYRIDYL-1-OXIDE) DISULPHIDE AND THEIR USE FOR THEIR ANTI-INFLAMMATORY ACTIVITY
US4152439A (en) * 1978-01-12 1979-05-01 Davide R. Grassetti Stimulant and antidepressant agents
DE2944225A1 (en) * 1979-11-02 1981-05-07 Akzo Gmbh, 5600 Wuppertal METHOD FOR PRODUCING DITHIAZOL DISULFIDES
US4451471A (en) * 1981-03-18 1984-05-29 Ciba-Geigy Corporation Certain 2,4,5-tri-substituted thiazoles, pharmaceutical compositions containing same and methods of using same
DE3118128A1 (en) * 1981-05-07 1982-12-02 Bayer Ag, 5090 Leverkusen Use of disulphides as lipoxygenase inhibitors and pharmaceutical compositions containing these
ATE12730T1 (en) * 1981-10-21 1985-05-15 Beecham Group Plc TOPICAL BACTERICIDE COMPOSITIONS.
HU193951B (en) * 1985-03-11 1987-12-28 Richter Gedeon Vegyeszet Process for producing new sulfur-containing 5-substituted benzimidazol derivatives and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
NO860908L (en) 1986-09-15
PH22275A (en) 1988-07-14
DE3508666A1 (en) 1986-09-18
DK165181C (en) 1993-03-01
KR940001773B1 (en) 1994-03-05
ATE58293T1 (en) 1990-11-15
ES8801624A1 (en) 1988-02-16
IL78091A (en) 1990-04-29
KR860007246A (en) 1986-10-10
IL78091A0 (en) 1986-07-31
EP0194571B1 (en) 1990-11-14
PT82166A (en) 1986-04-01
AR245113A1 (en) 1993-12-30
NZ215424A (en) 1989-04-26
DE3675561D1 (en) 1990-12-20
EP0194571A1 (en) 1986-09-17
GR860649B (en) 1986-07-11
ZA861780B (en) 1986-10-29
IE58729B1 (en) 1993-11-03
AU5460586A (en) 1986-10-16
NO168357C (en) 1992-02-12
DK108786D0 (en) 1986-03-10
ES8801625A1 (en) 1988-02-16
ES557615A0 (en) 1988-02-16
PT82166B (en) 1988-07-29
IE860630L (en) 1986-09-12
ES557614A0 (en) 1988-02-16
ES8801506A1 (en) 1988-01-16
HU201742B (en) 1990-12-28
JPH0751572B2 (en) 1995-06-05
ES552840A0 (en) 1988-01-16
NO168357B (en) 1991-11-04
JPS61207331A (en) 1986-09-13
AU594943B2 (en) 1990-03-22
DK165181B (en) 1992-10-19
FI860980A (en) 1986-09-13
FI860980A0 (en) 1986-03-10

Similar Documents

Publication Publication Date Title
DK157867C (en) TERTIARY HYDROXYALKYLXANTHINES AND THEIR USE AS MEDICINES
DK289886A (en) SUBSTITUTED 3-PHENYL-4-CYANOPYRROL DERIVATIVES AND THEIR PREPARATION AND USE
DK543386A (en) THIENOOXAZINONES THEIR PREPARATION AND USE
AT386862B (en) HINGE
DK29686A (en) 13BETA-ALKYL-MILBEMYCINE DERIVATIVES AND THEIR PREPARATION AND USE
DK108686A (en) HETEROCYCLIC SULPHIDS AND THEIR USE AS IMMUNE MODULATORS
DK503986D0 (en) HINGE
DK408385D0 (en) SULPHONAMIDES AND THEIR USE AS HERBICIDES
DK108786D0 (en) HETEROCYCLIC DISULFIDES AND THEIR USE AS IMMUNE MODULATORS
DK223287D0 (en) HETEROCYCLIC SULPHONAMIDES AND THEIR USE AS HERBICIDES
DK116087D0 (en) 2-UREETEROCYCLYLMETHYLSULPHINYLATEHIENOIMIDAZOLE COMPOUNDS AND THEIR USE AS ANTIULCUS AGENTS
ATA356985A (en) HINGE
DK172486D0 (en) HETEROCYCLYL-PENEM COMPOUNDS AND THEIR PREPARATION AND USE
DK548586D0 (en) THIENYLSULPHONYLGUANIDINE DERIVATIVES, THEIR PREPARATION AND USE
DK77286A (en) 1-0-ACYLED HEXOSIDE DERIVATIVES AND THEIR PREPARATION AND USE
DK206686A (en) ACYLAMINOMETHYL-PENEM COMPOUNDS AND THEIR PREPARATION AND USE
ES2022107B3 (en) HINGE
DK395684A (en) FLUORED PYRROLIDONE DERIVATIVES AND THEIR USE AS HERBICIDES
DK437986A (en) 1-AMINO-3-PHENYL-PROPAN-2-OL-DERIVATIVES AND THEIR PREPARATION AND USE
ATA139385A (en) HINGE
DK490086D0 (en) AROYLTHIAZOLONES AND THEIR USE AS CARDIOTONIC AGENTS
KR860014928U (en) Hinges
DK480786D0 (en) SULFAMOYLURIN SUBSTANCES AND THEIR USE AS HERBICIDES
SE8502476D0 (en) BALANCED Pulse time modulator
NO883791D0 (en) OPTICALLY ACTIVE BENZOCSAZINE DERIVATIVES AND PROCEDURE FOR THEIR PREPARATION.