DK1080192T3 - Antisense oligonucleotides for the treatment of proliferating cells - Google Patents

Antisense oligonucleotides for the treatment of proliferating cells

Info

Publication number
DK1080192T3
DK1080192T3 DK99926337T DK99926337T DK1080192T3 DK 1080192 T3 DK1080192 T3 DK 1080192T3 DK 99926337 T DK99926337 T DK 99926337T DK 99926337 T DK99926337 T DK 99926337T DK 1080192 T3 DK1080192 T3 DK 1080192T3
Authority
DK
Denmark
Prior art keywords
treatment
antisense oligonucleotides
proliferating cells
oligodesoxyribonucleotides
oligoribo
Prior art date
Application number
DK99926337T
Other languages
Danish (da)
Inventor
Andreas Boehle
Hans-Dieter Flad
Johannes Gerdes
Irina Aehrchen-Deinert
Original Assignee
Faustus Forschungs Cie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Faustus Forschungs Cie filed Critical Faustus Forschungs Cie
Application granted granted Critical
Publication of DK1080192T3 publication Critical patent/DK1080192T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The invention relates to oligoribo- and oligodesoxyribonucleotides which are suitable for treating pathological conditions that are accompanied by increased cell proliferation. Said oligoribo- and oligodesoxyribonucleotides are characterised in that they are able to hybridise with the mRNA which codes the protein Ki-67, this protein being associated with the cell cycle.
DK99926337T 1998-05-22 1999-05-20 Antisense oligonucleotides for the treatment of proliferating cells DK1080192T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19822954A DE19822954A1 (en) 1998-05-22 1998-05-22 Ki-67 gene antisense oligonucleotide
EP99926337A EP1080192B1 (en) 1998-05-22 1999-05-20 Antisense oligonucleotides for treating proliferating cells

Publications (1)

Publication Number Publication Date
DK1080192T3 true DK1080192T3 (en) 2004-11-29

Family

ID=7868624

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99926337T DK1080192T3 (en) 1998-05-22 1999-05-20 Antisense oligonucleotides for the treatment of proliferating cells

Country Status (8)

Country Link
EP (1) EP1080192B1 (en)
AT (1) ATE272112T1 (en)
AU (1) AU4363699A (en)
DE (2) DE19822954A1 (en)
DK (1) DK1080192T3 (en)
ES (1) ES2226393T3 (en)
PT (1) PT1080192E (en)
WO (1) WO1999061607A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19955576B4 (en) 1999-11-18 2008-02-28 Faustus Forschungs Cie. Translational Cancer Research Gmbh Transfer compounds, their preparation and their use

Also Published As

Publication number Publication date
DE19822954A1 (en) 1999-11-25
PT1080192E (en) 2004-11-30
DE59910072D1 (en) 2004-09-02
ES2226393T3 (en) 2005-03-16
EP1080192A2 (en) 2001-03-07
AU4363699A (en) 1999-12-13
ATE272112T1 (en) 2004-08-15
EP1080192B1 (en) 2004-07-28
WO1999061607A3 (en) 2000-03-23
WO1999061607A2 (en) 1999-12-02

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