DK1056769T3 - 15-methyl-cyclopropanosteroids and process for their preparation - Google Patents
15-methyl-cyclopropanosteroids and process for their preparationInfo
- Publication number
- DK1056769T3 DK1056769T3 DK98965592T DK98965592T DK1056769T3 DK 1056769 T3 DK1056769 T3 DK 1056769T3 DK 98965592 T DK98965592 T DK 98965592T DK 98965592 T DK98965592 T DK 98965592T DK 1056769 T3 DK1056769 T3 DK 1056769T3
- Authority
- DK
- Denmark
- Prior art keywords
- methyl
- group
- cyclopropanosteroids
- hydrogen atom
- relates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C07J53/002—Carbocyclic rings fused
- C07J53/004—3 membered carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to novel 15-methyl-cyclopropanosteroids of general formula (I), wherein R1 represents a hydrogen atom, an alkyl group, an acyl group, or a sulfamoyl group, R2 and R3 represent independently from each other a hydrogen atom or a halogen atom, R4 represents an oxo group or a hydrogen atom and a hydroxy group, and the 14,15-methylene group has either an alpha or beta configuration, wherein the 15-methyl group is in beta position when the 14,15-methylene group is arranged in alpha position and vice-versa. The invention also relates to 15 methyl-pentasteroids which are suitable as parent compounds in the production of the inventive 15-methyl-cyclopropanosteroids. The invention further relates to a method for the production of the inventive 15-methyl-cyclopropanosteroids and 15-methylpentaensteroids.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19753363A DE19753363A1 (en) | 1997-12-02 | 1997-12-02 | 15-methyl-cyclopropanosteroids and process for their preparation |
PCT/DE1998/003516 WO1999028337A1 (en) | 1997-12-02 | 1998-11-30 | 15-methyl-cyclopropanosteroids and method for the production thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1056769T3 true DK1056769T3 (en) | 2002-10-14 |
Family
ID=7850458
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK98965592T DK1056769T3 (en) | 1997-12-02 | 1998-11-30 | 15-methyl-cyclopropanosteroids and process for their preparation |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP1056769B1 (en) |
JP (1) | JP2001525334A (en) |
AT (1) | ATE219497T1 (en) |
AU (1) | AU2148899A (en) |
DE (2) | DE19753363A1 (en) |
DK (1) | DK1056769T3 (en) |
ES (1) | ES2179550T3 (en) |
PT (1) | PT1056769E (en) |
WO (1) | WO1999028337A1 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7335650B2 (en) | 2000-01-14 | 2008-02-26 | Sterix Limited | Composition |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3766224A (en) * | 1971-06-03 | 1973-10-16 | Sandoz Ag | 15-methyl-substituted steroids |
DE4239946C2 (en) * | 1992-11-27 | 2001-09-13 | Jenapharm Gmbh | Estrane derivatives with a 14alpha, 15alpha-methylene group and process for their preparation |
DE4239945C2 (en) * | 1992-11-27 | 2002-11-28 | Jenapharm Gmbh | 14 alpha, 15 alpha-methylene steroids and process for their preparation |
DE4447714C2 (en) * | 1994-08-09 | 1998-02-05 | Jenapharm Gmbh | Oestrogen compsn contg. 3-sulphamoyl:oxy-oestratriene cpd. |
DE4429397C2 (en) * | 1994-08-09 | 2003-11-20 | Jenapharm Gmbh | Estra-1,3,5 (10) -triene derivatives, processes for their preparation and pharmaceutical compositions containing these compounds |
-
1997
- 1997-12-02 DE DE19753363A patent/DE19753363A1/en not_active Withdrawn
-
1998
- 1998-11-30 JP JP2000523228A patent/JP2001525334A/en active Pending
- 1998-11-30 ES ES98965592T patent/ES2179550T3/en not_active Expired - Lifetime
- 1998-11-30 AU AU21488/99A patent/AU2148899A/en not_active Abandoned
- 1998-11-30 AT AT98965592T patent/ATE219497T1/en not_active IP Right Cessation
- 1998-11-30 WO PCT/DE1998/003516 patent/WO1999028337A1/en active IP Right Grant
- 1998-11-30 DK DK98965592T patent/DK1056769T3/en active
- 1998-11-30 EP EP98965592A patent/EP1056769B1/en not_active Expired - Lifetime
- 1998-11-30 PT PT98965592T patent/PT1056769E/en unknown
- 1998-11-30 DE DE59804539T patent/DE59804539D1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP1056769B1 (en) | 2002-06-19 |
EP1056769A1 (en) | 2000-12-06 |
WO1999028337A1 (en) | 1999-06-10 |
PT1056769E (en) | 2002-11-29 |
DE19753363A1 (en) | 1999-06-10 |
DE59804539D1 (en) | 2002-07-25 |
ES2179550T3 (en) | 2003-01-16 |
AU2148899A (en) | 1999-06-16 |
ATE219497T1 (en) | 2002-07-15 |
JP2001525334A (en) | 2001-12-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO178764C (en) | Process for the preparation of oxetanones | |
TW341573B (en) | New erythromycin derivatives, their preparation process and their use as medicaments | |
ATE50774T1 (en) | NEW FRUCTOSYLTSANSFERASE AND PROCESS FOR THE PRODUCTION OF FRUCTOSYL DISACCHARIDS, AND A NEW HALOSACCHAROSE. | |
HU9203761D0 (en) | Method for producing substituted pyridine derivatives | |
DK0862577T3 (en) | Sulfamate derivatives of 1,3,5 (10) -estratrien derivatives, process for their preparation and pharmaceutical preparations which | |
DE69907656D1 (en) | POLYETHOXYLATED RETINAMIDE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF | |
JPS57106695A (en) | Anthracycline g lycoside compound | |
ATE61577T1 (en) | FLUORINATED VITAMIN D3 DERIVATIVES AND PROCESS FOR THEIR PRODUCTION. | |
DK1056769T3 (en) | 15-methyl-cyclopropanosteroids and process for their preparation | |
ATE148128T1 (en) | ANTHRACYCLINGLYCOSIDE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF | |
DE69427541D1 (en) | Process for the preparation of sulfonylurea derivatives | |
ES475587A1 (en) | 1,2,3,4,4a,10b-hexahydro-benz(f)isouqinolines | |
DE3777464D1 (en) | VITAMIN-D3 DERIVATIVES CONTAINING FLUORINE AND METHOD FOR THE PRODUCTION THEREOF. | |
ATE195115T1 (en) | METHOD FOR PRODUCING 5,6-DIHYDROXY-2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALINE DERIVATIVES | |
DE3578866D1 (en) | 2,3-DIAMINO-2,3-DIDESOXYHEXOSE DERIVATIVES, METHOD FOR THEIR PRODUCTION AND THEIR USE. | |
ATE135693T1 (en) | HALOGENO-4-METHYLPYRAZOLES AND METHOD FOR THE PRODUCTION THEREOF | |
JPS6483032A (en) | Manufacture of diene-1-ol, 9-hydroxydodecene- (10)-yl-1 tertiary butyl ether and use | |
YU59895A (en) | NEW SUBSTITUTED 3-CARBOXY-2-PYRIDONES AND NEW PROCEDURES FOR OBTAINING THEM | |
ATE39688T1 (en) | PROCESS FOR THE PREPARATION OF AMINOTRIAZINONE DERIVATIVES. | |
DE69816095D1 (en) | PRODUCTION OF BETA MEHTYLCARBAPENEM INTERMEDIATE PRODUCTS | |
DK590683A (en) | PROCEDURE FOR THE MANUFACTURING OF OXANOSIN AND AN INTERMEDIATE PRODUCT USED BY THIS PROCEDURE | |
YU55491A (en) | NEW SUBSTITUTED 3-CYANO-2-PYRIDONES AND PROCEDURE FOR THEIR OBTAINING | |
YU49004B (en) | LANOST-7,9- DIEN-3ß, 32-DIOL AND THE PROCESS FOR IT'S PRODUCTION | |
ES2022032A6 (en) | Procedure for the preparation of 3,4-dialcoxipiridinas. (Machine-translation by Google Translate, not legally binding) |