DK0776363T3 - Ribozymbibliotek, fremstilling og anvendelse heraf - Google Patents

Ribozymbibliotek, fremstilling og anvendelse heraf

Info

Publication number
DK0776363T3
DK0776363T3 DK95918531T DK95918531T DK0776363T3 DK 0776363 T3 DK0776363 T3 DK 0776363T3 DK 95918531 T DK95918531 T DK 95918531T DK 95918531 T DK95918531 T DK 95918531T DK 0776363 T3 DK0776363 T3 DK 0776363T3
Authority
DK
Denmark
Prior art keywords
preparation
ribozyme library
ribozyme
library
Prior art date
Application number
DK95918531T
Other languages
English (en)
Inventor
Michael Strauss
Andre Lieber
Original Assignee
Max Planck Gesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Planck Gesellschaft filed Critical Max Planck Gesellschaft
Application granted granted Critical
Publication of DK0776363T3 publication Critical patent/DK0776363T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1093—General methods of preparing gene libraries, not provided for in other subgroups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/111—Antisense spanning the whole gene, or a large part of it
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • C12N2310/121—Hammerhead
DK95918531T 1994-07-04 1995-05-19 Ribozymbibliotek, fremstilling og anvendelse heraf DK0776363T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19944424762 DE4424762C1 (de) 1994-07-04 1994-07-04 Ribozym-Bibliothek, ihre Herstellung und ihre Verwendung
PCT/DE1995/000662 WO1996001314A2 (de) 1994-07-04 1995-05-19 Ribozym-bibliothek, ihre herstellung und ihre verwendung

Publications (1)

Publication Number Publication Date
DK0776363T3 true DK0776363T3 (da) 2000-06-13

Family

ID=6523076

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95918531T DK0776363T3 (da) 1994-07-04 1995-05-19 Ribozymbibliotek, fremstilling og anvendelse heraf

Country Status (4)

Country Link
EP (1) EP0776363B1 (da)
DE (1) DE4424762C1 (da)
DK (1) DK0776363T3 (da)
WO (1) WO1996001314A2 (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6107027A (en) * 1994-12-14 2000-08-22 University Of Washington Ribozymes for treating hepatitis C
GB9518864D0 (en) * 1995-09-14 1995-11-15 Cambridge Res & Innovation Oligonucleotides and their uses
JP2002514914A (ja) 1997-01-23 2002-05-21 イミュソール インコーポレイテッド ランダム化または標的特異的リボザイム遺伝子ベクターライブラリーを用いた遺伝子機能の分析および発見
CA2288640A1 (en) * 1997-05-09 1998-11-12 Ribozyme Pharmaceuticals, Inc. Enzymatic nucleic acids: synthesis, selection and use
US6548657B1 (en) 1997-06-09 2003-04-15 Ribozyme Pharmaceuticals, Inc. Method for screening nucleic acid catalysts
US6280936B1 (en) 1997-06-09 2001-08-28 Ribozyme Pharmaceuticals, Inc. Method for screening nucleic acid catalysts
US6183959B1 (en) 1997-07-03 2001-02-06 Ribozyme Pharmaceuticals, Inc. Method for target site selection and discovery
WO1999002192A1 (en) 1997-07-11 1999-01-21 Brandeis University Method of inducing apoptosis by reducing the level of thiamin
US6316612B1 (en) 1997-08-22 2001-11-13 Ribozyme Pharmaceuticals, Inc. Xylofuranosly-containing nucleoside phosphoramidites and polynucleotides
US6617438B1 (en) 1997-11-05 2003-09-09 Sirna Therapeutics, Inc. Oligoribonucleotides with enzymatic activity
US6127535A (en) * 1997-11-05 2000-10-03 Ribozyme Pharmaceuticals, Inc. Nucleoside triphosphates and their incorporation into oligonucleotides
EP1037972B1 (en) * 1997-12-19 2005-09-14 HK Pharmaceuticals, Inc. Non-bacterial cloning in delivery and expression of nucleic acids
DE69933856D1 (de) * 1998-02-13 2006-12-14 Koester Hubert Verwendung von ribozymen zur bestimmung der funktion von genen
AU3707099A (en) * 1998-04-08 1999-11-01 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Process for producing cell clone libraries
AU750598B2 (en) * 1998-07-22 2002-07-25 Immusol Incorporated Substantially complete ribozyme libraries
WO2000066780A2 (en) * 1999-04-30 2000-11-09 University Of Florida Adeno-associated virus-delivered ribozyme compositions and methods of use
GB9912965D0 (en) * 1999-06-03 1999-08-04 Oxford Biomedica Ltd In vivo selection method
IL130606A0 (en) * 1999-06-23 2000-06-01 Intelligene Ltd An array of nucleic acid sequence
US6808876B1 (en) 2000-05-02 2004-10-26 Immusol, Inc. Cellular regulators of infectious agents and methods of use
CA2436519A1 (en) * 2000-12-07 2002-06-13 The Penn State Research Foundation Selection of catalytic nucleic acids targeted to infectious agents

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2687411A1 (fr) * 1992-02-13 1993-08-20 Nice Sophia Antipolis Universi Vecteur comportant un gene viral transcrit par l'arn polymerase iii, et procede de production intracellulaire d'arn.

Also Published As

Publication number Publication date
EP0776363B1 (de) 1999-12-22
DE4424762C1 (de) 1995-07-27
WO1996001314A2 (de) 1996-01-18
EP0776363A1 (de) 1997-06-04
WO1996001314A3 (de) 1996-02-29

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