DK0759772T3 - Tri-, tetra-, penta- og polypeptider og deres terapeutiske anvendelse som antidepressiva - Google Patents

Tri-, tetra-, penta- og polypeptider og deres terapeutiske anvendelse som antidepressiva

Info

Publication number
DK0759772T3
DK0759772T3 DK95923659T DK95923659T DK0759772T3 DK 0759772 T3 DK0759772 T3 DK 0759772T3 DK 95923659 T DK95923659 T DK 95923659T DK 95923659 T DK95923659 T DK 95923659T DK 0759772 T3 DK0759772 T3 DK 0759772T3
Authority
DK
Denmark
Prior art keywords
residues
penta
polypeptides
tetra
tri
Prior art date
Application number
DK95923659T
Other languages
Danish (da)
English (en)
Inventor
Henry B Abajian
John F Noble
Joseph J Hlavka
Original Assignee
Innapharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innapharma Inc filed Critical Innapharma Inc
Application granted granted Critical
Publication of DK0759772T3 publication Critical patent/DK0759772T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C07K5/0823—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Pro-amino acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1027—Tetrapeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Psychiatry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK95923659T 1994-05-04 1995-05-02 Tri-, tetra-, penta- og polypeptider og deres terapeutiske anvendelse som antidepressiva DK0759772T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/238,089 US5589460A (en) 1994-05-04 1994-05-04 Tri-, tetra-, penta-, and polypeptides and their therapeutic use as an antidepressant agent
PCT/US1995/005560 WO1995030430A1 (en) 1994-05-04 1995-05-02 Tri-, tetra-, penta-, and polypeptides and their therapeutic use as an antidepressant agent

Publications (1)

Publication Number Publication Date
DK0759772T3 true DK0759772T3 (da) 2004-06-01

Family

ID=22896449

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95923659T DK0759772T3 (da) 1994-05-04 1995-05-02 Tri-, tetra-, penta- og polypeptider og deres terapeutiske anvendelse som antidepressiva

Country Status (16)

Country Link
US (1) US5589460A (fi)
EP (1) EP0759772B1 (fi)
JP (1) JP3878983B2 (fi)
CN (1) CN1150028C (fi)
AT (1) ATE258061T1 (fi)
AU (1) AU685292B2 (fi)
CA (1) CA2189145C (fi)
DE (1) DE69532470T2 (fi)
DK (1) DK0759772T3 (fi)
ES (1) ES2215175T3 (fi)
FI (1) FI964363A (fi)
MY (1) MY113407A (fi)
NO (1) NO317919B1 (fi)
PT (1) PT759772E (fi)
RU (1) RU2182910C2 (fi)
WO (1) WO1995030430A1 (fi)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6767897B2 (en) * 1994-05-04 2004-07-27 Innapharma, Inc. Therapeutic uses of tri-, tetra-, penta-, and polypeptides
US5767083A (en) * 1994-05-04 1998-06-16 Innapharma, Inc. Tri-, tetra-, penta-, and polypeptides and their therapeutic use as an antidepressant agent
US6093797A (en) * 1994-05-04 2000-07-25 Innapharma, Inc. Tri-, Tetra-, Penta-, and polypeptides and their therapeutic use as an antidepressant agent
US5792466A (en) * 1996-12-13 1998-08-11 The United States Of America, As Represented By The Secretary Of Agriculture Mimetic insect kinin analogs for insect control
AU8912698A (en) * 1997-08-19 1999-03-08 University Of Medicine And Dentistry Of New Jersey Inhibition of hiv-1 replication using d-amino acid peptides
US6150420A (en) * 1998-06-01 2000-11-21 Theramax, Inc. Method for enhanced brain delivery of bupropion
WO2005095441A1 (ja) * 2004-03-31 2005-10-13 National Institute Of Advanced Industrial Science And Technology 上皮系細胞増殖促進剤
CA2728140C (en) 2007-06-27 2019-09-03 The Board Of Trustees Of The Leland Stanford Junior University Peptide tyrosinase inhibitors and uses thereof
CN104083752B (zh) * 2007-06-27 2018-04-10 里兰斯坦福初级大学理事会 寡肽酪氨酸酶抑制剂及其应用
CN101284868A (zh) * 2008-05-26 2008-10-15 刘刚 一种肽水合盐类化合物及其立体异构体
CN108690121B (zh) * 2017-04-07 2020-05-15 深圳翰宇药业股份有限公司 一种奈米非肽液相制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3708593A (en) * 1971-08-24 1973-01-02 Abbott Lab Use of l-prolyl l-leucyl glycine amide as an anti-depressant
US3821188A (en) * 1972-06-14 1974-06-28 American Home Prod Proline and pyroglutamic acid containing tripeptides
US3795738A (en) * 1972-12-26 1974-03-05 Abbott Lab Use of l-propyl l-leucyl glycine amide to treat parkinson's disease
US3931184A (en) * 1974-10-31 1976-01-06 Abbott Laboratories Purification method for prolyl-leucylglycinamide
US4018912A (en) * 1975-07-28 1977-04-19 Ayerst Mckenna And Harrison Ltd. Tripeptide derivatives with central nervous system activity and preparation thereof
US4278595A (en) * 1979-12-10 1981-07-14 Vega Laboratories, Inc. Orally active MIF analogs with an effect on the central nervous system
JPS5830299B2 (ja) * 1981-10-30 1983-06-28 三菱化学株式会社 トリペプチドおよびその誘導体
DE3226241A1 (de) * 1982-07-14 1984-01-26 Basf Ag, 6700 Ludwigshafen N-acylderivate von peptiden, ihre herstellung und verwendung bei der bekaempfung von krankheiten und mittel dafuer
JP3349528B2 (ja) * 1992-08-14 2002-11-25 株式会社日清製粉グループ本社 ペプチド

Also Published As

Publication number Publication date
EP0759772B1 (en) 2004-01-21
MY113407A (en) 2002-02-28
EP0759772A1 (en) 1997-03-05
ATE258061T1 (de) 2004-02-15
EP0759772A4 (en) 1999-04-21
NO317919B1 (no) 2005-01-03
RU2182910C2 (ru) 2002-05-27
JP3878983B2 (ja) 2007-02-07
PT759772E (pt) 2004-06-30
FI964363A0 (fi) 1996-10-29
AU2813995A (en) 1995-11-29
DE69532470T2 (de) 2004-10-21
US5589460A (en) 1996-12-31
FI964363A (fi) 1996-12-23
CN1151700A (zh) 1997-06-11
CN1150028C (zh) 2004-05-19
DE69532470D1 (de) 2004-02-26
JPH10500407A (ja) 1998-01-13
NO964561L (no) 1996-12-27
CA2189145C (en) 2008-03-18
NO964561D0 (no) 1996-10-28
ES2215175T3 (es) 2004-10-01
WO1995030430A1 (en) 1995-11-16
AU685292B2 (en) 1998-01-15
CA2189145A1 (en) 1995-11-16

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