DK0758336T3 - Process for Preparation of 1- (3-Trialkylsilylphenyl) -2,2,2-Trifluoroethanone Derivatives - Google Patents

Process for Preparation of 1- (3-Trialkylsilylphenyl) -2,2,2-Trifluoroethanone Derivatives

Info

Publication number
DK0758336T3
DK0758336T3 DK95917074T DK95917074T DK0758336T3 DK 0758336 T3 DK0758336 T3 DK 0758336T3 DK 95917074 T DK95917074 T DK 95917074T DK 95917074 T DK95917074 T DK 95917074T DK 0758336 T3 DK0758336 T3 DK 0758336T3
Authority
DK
Denmark
Prior art keywords
trialkylsilylphenyl
preparation
trifluoroethanone
derivatives
trifluoroethanone derivatives
Prior art date
Application number
DK95917074T
Other languages
Danish (da)
Inventor
Richard A Wolf
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Application granted granted Critical
Publication of DK0758336T3 publication Critical patent/DK0758336T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/0825—Preparations of compounds not comprising Si-Si or Si-cyano linkages
    • C07F7/083—Syntheses without formation of a Si-C bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The present invention relates to a novel process for preparing 1-(3-trialkylsilylphenyl)-2,2,2-trifluoromethyl ethanones which are useful for the treatment of Alzheimer's disease and senile dementia as disclosed by Schirlin, et al. in European Patent Application Publication No. 0 409 676, published Jan. 23, 1991.
DK95917074T 1994-05-05 1995-04-18 Process for Preparation of 1- (3-Trialkylsilylphenyl) -2,2,2-Trifluoroethanone Derivatives DK0758336T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23876894A 1994-05-05 1994-05-05
US08/382,949 US5554780A (en) 1994-05-05 1995-02-01 Process for the preparation of 1-(3-trialkylsilylphenyl)-2,2,2-trifluoromethyl ethanone derivatives
PCT/US1995/004837 WO1995030678A1 (en) 1994-05-05 1995-04-18 Process for the preparation of 1-(3-trialkylsilylphenyl)-2,2,2-trifluoromethyl ethanone derivatives

Publications (1)

Publication Number Publication Date
DK0758336T3 true DK0758336T3 (en) 1999-11-29

Family

ID=26931932

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95917074T DK0758336T3 (en) 1994-05-05 1995-04-18 Process for Preparation of 1- (3-Trialkylsilylphenyl) -2,2,2-Trifluoroethanone Derivatives

Country Status (18)

Country Link
US (1) US5554780A (en)
EP (1) EP0758336B1 (en)
JP (1) JPH09512819A (en)
CN (1) CN1047176C (en)
AT (1) ATE182151T1 (en)
AU (1) AU681965B2 (en)
CA (1) CA2188761C (en)
DE (1) DE69510787T2 (en)
DK (1) DK0758336T3 (en)
ES (1) ES2138734T3 (en)
FI (1) FI964429A0 (en)
GR (1) GR3031283T3 (en)
HU (1) HU215133B (en)
IL (1) IL113605A (en)
NO (1) NO964652L (en)
NZ (1) NZ284696A (en)
TW (1) TW314521B (en)
WO (1) WO1995030678A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0749972A1 (en) * 1995-06-21 1996-12-27 Merrell Pharmaceuticals Inc. A process for preparing 1-(3-trialkylsilylphenyl)-2,2,2-trifluoromethyl ethanone derivatives
US20100210590A1 (en) * 1995-09-27 2010-08-19 Northwestern University Compositions and treatments for seizure-related disorders
US20050222123A1 (en) 2004-01-27 2005-10-06 North Shore-Long Island Jewish Research Institute Cholinesterase inhibitors for treating inflammation
WO2006050359A2 (en) * 2004-11-02 2006-05-11 Northwestern University Pyridazine compounds and methods
CA2650711A1 (en) * 2006-04-28 2007-11-08 Northwestern University Compositions and treatments using pyridazine compounds and cholinesterase inhibitors
CN106045836B (en) * 2016-06-30 2018-04-13 福州大学 A kind of method of copper catalysis synthesis aromatic hydrocarbons or heterocycle trifluoromethyl ketone

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4536265A (en) * 1984-04-19 1985-08-20 Loctite Corporation Siloxane polyphotoinitiators of the substituted acetophenone type
SU1576526A1 (en) * 1988-09-01 1990-07-07 Дальневосточный политехнический институт им.В.В.Куйбышева Method of obtaining n,n-dimethyl anilino-p-trifluormethylketone
EP0403713A1 (en) * 1989-06-22 1990-12-27 Merrell Dow Pharmaceuticals Inc. Novel acetylcholinesterase inhibitors

Also Published As

Publication number Publication date
ATE182151T1 (en) 1999-07-15
IL113605A (en) 1999-08-17
JPH09512819A (en) 1997-12-22
HU9603050D0 (en) 1997-01-28
EP0758336B1 (en) 1999-07-14
HUT75866A (en) 1997-05-28
FI964429A (en) 1996-11-04
WO1995030678A1 (en) 1995-11-16
ES2138734T3 (en) 2000-01-16
CN1147256A (en) 1997-04-09
NO964652D0 (en) 1996-11-04
EP0758336A1 (en) 1997-02-19
AU2390595A (en) 1995-11-29
TW314521B (en) 1997-09-01
HU215133B (en) 1998-09-28
NO964652L (en) 1996-11-04
CA2188761A1 (en) 1995-11-16
CN1047176C (en) 1999-12-08
US5554780A (en) 1996-09-10
GR3031283T3 (en) 1999-12-31
DE69510787D1 (en) 1999-08-19
CA2188761C (en) 1999-11-16
IL113605A0 (en) 1995-08-31
FI964429A0 (en) 1996-11-04
DE69510787T2 (en) 1999-11-11
NZ284696A (en) 1997-12-19
AU681965B2 (en) 1997-09-11

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