DK0748626T3 - Isosorbide dinitrate-containing patch and method for making it using an adhesive composition - Google Patents

Isosorbide dinitrate-containing patch and method for making it using an adhesive composition

Info

Publication number
DK0748626T3
DK0748626T3 DK95910006T DK95910006T DK0748626T3 DK 0748626 T3 DK0748626 T3 DK 0748626T3 DK 95910006 T DK95910006 T DK 95910006T DK 95910006 T DK95910006 T DK 95910006T DK 0748626 T3 DK0748626 T3 DK 0748626T3
Authority
DK
Denmark
Prior art keywords
adhesive
isosorbide dinitrate
containing patch
adhesive composition
making
Prior art date
Application number
DK95910006T
Other languages
Danish (da)
Inventor
Makoto Iwata
Takao Fujii
Minoru Furuya
Michisuke Ohe
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Application granted granted Critical
Publication of DK0748626T3 publication Critical patent/DK0748626T3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention provides an ISDN-containing patch that causes minimal occurrence of skin rash and has excellent percutaneous absorption and adhesive strength. The present invention discloses an isosorbide dinitrate-containing patch comprising: an adhesive layer formed on a flexible support, wherein said layer comprises an adhesive composition containing adhesive and isosorbide dinitrate, the adhesive being composed of silicone-based adhesive (A) and polyvinyl acetate-based adhesive (B), their weight ratio being A:B = 85:15 to 15:85, and the weight ratio of isosorbide dinitrate (C) to the adhesives (A+B) being (A+B):C = 90:10 to 60:40.
DK95910006T 1994-02-28 1995-02-28 Isosorbide dinitrate-containing patch and method for making it using an adhesive composition DK0748626T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2969994 1994-02-28
PCT/JP1995/000318 WO1995022970A1 (en) 1994-02-28 1995-02-28 Patch containing isosorbide dinitrate and prepared by using adhesive mixture

Publications (1)

Publication Number Publication Date
DK0748626T3 true DK0748626T3 (en) 2001-10-08

Family

ID=12283367

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95910006T DK0748626T3 (en) 1994-02-28 1995-02-28 Isosorbide dinitrate-containing patch and method for making it using an adhesive composition

Country Status (15)

Country Link
US (1) US5762954A (en)
EP (1) EP0748626B1 (en)
JP (1) JP3162079B2 (en)
KR (1) KR100354499B1 (en)
CN (1) CN1144481A (en)
AT (1) ATE204166T1 (en)
AU (1) AU689225B2 (en)
CA (1) CA2184389A1 (en)
DE (1) DE69522212T2 (en)
DK (1) DK0748626T3 (en)
ES (1) ES2158937T3 (en)
GR (1) GR3037058T3 (en)
NZ (1) NZ281334A (en)
PT (1) PT748626E (en)
WO (1) WO1995022970A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1102384C (en) * 1997-01-07 2003-03-05 帝人株式会社 Patch containing isosorbide dinitrate
ATE302598T1 (en) * 1999-04-01 2005-09-15 Alza Corp TRANSDERMAL DRUG ADMINISTRATION DEVICE HAVING A POLYURETHANE DRUG RESERVOIR
KR100439658B1 (en) * 2001-06-23 2004-07-12 제일약품주식회사 Transdermal Therapeutic System containing Isosorbide dinitrate
EA017580B1 (en) * 2008-02-15 2013-01-30 Тоо "Казнаномед" Method for increasing period of isosorbide dinitrate partial ejection in coronary insufficiency

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4849226A (en) * 1981-06-29 1989-07-18 Alza Corporation Method for increasing oxygen supply by administering vasodilator
JPS61100520A (en) * 1984-10-22 1986-05-19 Sekisui Chem Co Ltd Tape drug of percutaneous administration type
US4956181A (en) * 1987-05-08 1990-09-11 Eastman Kodak Nitrate therapy for angina pectoris
US5300291A (en) * 1988-03-04 1994-04-05 Noven Pharmaceuticals, Inc. Method and device for the release of drugs to the skin
US5474783A (en) * 1988-03-04 1995-12-12 Noven Pharmaceuticals, Inc. Solubility parameter based drug delivery system and method for altering drug saturation concentration
JP3064402B2 (en) * 1990-11-19 2000-07-12 森本 雍憲 Patch containing isosorbide dinitrate
JP3197039B2 (en) * 1991-08-08 2001-08-13 積水化学工業株式会社 Tape preparation
JPH05156328A (en) * 1991-12-09 1993-06-22 Nkk Corp Device for analyzing abnormal furnace condition in blast furnace
JP3081413B2 (en) * 1993-06-03 2000-08-28 帝三製薬株式会社 Method for producing patch containing isosorbide dinitrate using mixed adhesive

Also Published As

Publication number Publication date
WO1995022970A1 (en) 1995-08-31
AU689225B2 (en) 1998-03-26
ES2158937T3 (en) 2001-09-16
KR970701042A (en) 1997-03-17
CN1144481A (en) 1997-03-05
ATE204166T1 (en) 2001-09-15
DE69522212T2 (en) 2002-05-23
EP0748626A4 (en) 1997-11-12
AU1824795A (en) 1995-09-11
US5762954A (en) 1998-06-09
JP3162079B2 (en) 2001-04-25
DE69522212D1 (en) 2001-09-20
EP0748626A1 (en) 1996-12-18
NZ281334A (en) 1997-08-22
CA2184389A1 (en) 1995-08-31
EP0748626B1 (en) 2001-08-16
KR100354499B1 (en) 2003-01-06
PT748626E (en) 2002-02-28
GR3037058T3 (en) 2002-01-31

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