DK0732338T3 - 2,2-difluor-3-carbamoylribosesulfonatforbindelser og fremgangsmåde til fremstilling af beta-nucleosider - Google Patents

2,2-difluor-3-carbamoylribosesulfonatforbindelser og fremgangsmåde til fremstilling af beta-nucleosider

Info

Publication number
DK0732338T3
DK0732338T3 DK96300158T DK96300158T DK0732338T3 DK 0732338 T3 DK0732338 T3 DK 0732338T3 DK 96300158 T DK96300158 T DK 96300158T DK 96300158 T DK96300158 T DK 96300158T DK 0732338 T3 DK0732338 T3 DK 0732338T3
Authority
DK
Denmark
Prior art keywords
carbamoylribose
nucleosides
difluoro
beta
preparation
Prior art date
Application number
DK96300158T
Other languages
Danish (da)
English (en)
Inventor
Marvin Emanuel Wildfeuer
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of DK0732338T3 publication Critical patent/DK0732338T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/12—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Furan Compounds (AREA)
DK96300158T 1995-01-18 1996-01-09 2,2-difluor-3-carbamoylribosesulfonatforbindelser og fremgangsmåde til fremstilling af beta-nucleosider DK0732338T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/373,998 US5521294A (en) 1995-01-18 1995-01-18 2,2-difluoro-3-carbamoyl ribose sulfonate compounds and process for the preparation of beta nucleosides

Publications (1)

Publication Number Publication Date
DK0732338T3 true DK0732338T3 (da) 2002-06-17

Family

ID=23474799

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96300158T DK0732338T3 (da) 1995-01-18 1996-01-09 2,2-difluor-3-carbamoylribosesulfonatforbindelser og fremgangsmåde til fremstilling af beta-nucleosider

Country Status (9)

Country Link
US (1) US5521294A (es)
EP (1) EP0732338B1 (es)
JP (1) JP3830999B2 (es)
AT (1) ATE217634T1 (es)
CA (1) CA2167361C (es)
DE (1) DE69621180T2 (es)
DK (1) DK0732338T3 (es)
ES (1) ES2176402T3 (es)
PT (1) PT732338E (es)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6326507B1 (en) * 1998-06-19 2001-12-04 Trustees Of Dartmouth College Therapeutic compounds and methods of use
US7435755B2 (en) * 2000-11-28 2008-10-14 The Trustees Of Dartmouth College CDDO-compounds and combination therapies thereof
EP1270008B1 (en) * 2001-05-31 2006-07-12 Yung Shin Pharmaceutical Ind. Co., Ltd. Fused tricyclic analogues of guanosine for treating tumors
CA2472581C (en) * 2002-01-15 2012-06-26 Trustees Of Dartmouth College Tricyclic-bis-enone derivatives and methods of use thereof
WO2004041203A2 (en) * 2002-11-04 2004-05-21 Xenoport, Inc. Gemcitabine prodrugs, pharmaceutical compositions and uses thereof
US7214791B2 (en) * 2004-07-01 2007-05-08 Shenzhen Hande Technology Co., Ltd. Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material
EP1812457A1 (en) * 2004-07-30 2007-08-01 Pharmaessentia Corp. STEREOSELECTIVE SYNTHESIS OF ß-NUCLEOSIDES
KR20070112774A (ko) * 2005-03-04 2007-11-27 다브르 파마 리미티드 베타―아노머가 많은２１데옥시，２１，２１－디플루오로－ｄ－리보푸라노실뉴클레오시드의 제조를 위한 중간체 및 제조 방법
US7485716B2 (en) * 2005-05-02 2009-02-03 Pharmaessentia Corp. Stereoselective synthesis of β-nucleosides
CN101356165A (zh) * 2005-12-13 2009-01-28 谢麦吉斯有限公司 吉西他滨的制备方法和相关的中间体
KR20080099263A (ko) * 2006-02-07 2008-11-12 케마지스 리미티드 젬시타빈 및 관련된 중간체의 제조 방법
US20070249823A1 (en) * 2006-04-20 2007-10-25 Chemagis Ltd. Process for preparing gemcitabine and associated intermediates
US8921340B2 (en) 2006-11-17 2014-12-30 Trustees Of Dartmouth College Methods for using synthetic triterpenoids in the treatment of bone or cartilage diseases or conditions
CA2670099A1 (en) * 2006-11-17 2008-05-29 Trustees Of Dartmouth College Synthesis and biological activities of new tricyclic-bis-enones (tbes)
WO2008064132A2 (en) * 2006-11-17 2008-05-29 Trustees Of Dartmouth College Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth
US20080262215A1 (en) * 2007-04-23 2008-10-23 Chemagis Ltd. Gemcitabine production process
CN100475832C (zh) * 2007-05-31 2009-04-08 南京卡文迪许生物工程技术有限公司 一种新颖的高立体选择性合成吉西他滨工艺及中间体
US20090048205A1 (en) * 2007-08-15 2009-02-19 Colin Meyer Combination therapy with synthetic triterpenoids and gemcitabine
JO2778B1 (en) 2007-10-16 2014-03-15 ايساي انك Certain vehicles, installations and methods
CN101883570B (zh) * 2007-11-06 2013-06-19 药华医药股份有限公司 β-核苷的新颖合成
TW200942231A (en) 2008-01-11 2009-10-16 Reata Pharmaceuticals Inc Synthetic triterpenoids and methods of use in the treatment of disease
TW201004627A (en) * 2008-04-18 2010-02-01 Reata Pharmaceuticals Inc Antioxidant inflammation modulators: novel derivatives of oleanolic acid
CN104250280A (zh) * 2008-04-18 2014-12-31 里亚塔医药公司 抗氧化剂炎症调节剂:c-17同系化齐墩果酸衍生物
WO2009129545A1 (en) 2008-04-18 2009-10-22 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: oleanolic acid derivatives with saturation in the c-ring
NZ588710A (en) 2008-04-18 2012-12-21 Reata Pharmaceuticals Inc Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at C-17
JP5564490B2 (ja) 2008-04-18 2014-07-30 リアタ ファーマシューティカルズ インコーポレイテッド 抗炎症性ファルマコアを含む化合物および使用法
JP5758801B2 (ja) 2008-07-22 2015-08-05 トラスティーズ・オブ・ダートマス・カレッジＴｒｕｓｔｅｅｓ ｏｆ Ｄａｒｔｍｏｕｔｈ Ｃｏｌｌｅｇｅ 単環式シアノエノンおよびその使用方法説明
US8609631B2 (en) 2009-04-06 2013-12-17 Eisai Inc. Compositions and methods for treating cancer
CA2757743C (en) * 2009-04-06 2017-10-10 Eisai Inc. (2'-deoxy-ribofuranosyl)-1,3,4,7-tetrahydro-(1,3) diazepin-2-0ne derivatives for treating cancer
US8329666B2 (en) * 2009-04-06 2012-12-11 Eisai Inc. Compositions and methods for treating cancer
CA2757745C (en) * 2009-04-06 2018-02-13 Eisai Inc. Combination of cytidine-based antineoplastic drugs with cytidine deaminase inhibitor and use thereof in the treatment of cancer
JP6042527B2 (ja) 2012-04-04 2016-12-14 ハロザイム インコーポレイテッド 抗ヒアルロナン剤と腫瘍標的タキサンの組み合わせ治療
US8921419B2 (en) 2012-05-08 2014-12-30 Trustees Of Dartmouth College Triterpenoids and compositions containing the same
MY176465A (en) 2013-10-29 2020-08-11 Otsuka Pharma Co Ltd Synthetic route to 2?-deoxy-2?,2?-difluorotetrahydrouridines
WO2019222435A1 (en) 2018-05-16 2019-11-21 Halozyme, Inc. Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2949449A (en) * 1959-01-14 1960-08-16 Hoffmann La Roche Synthesis of 3, 5-diaroyl-2-deoxy-d-ribofuranosyl ureas
US3575959A (en) * 1969-05-13 1971-04-20 Merck & Co Inc 5'-substituted ribofuranosyl nucleosides
US3658786A (en) * 1969-06-27 1972-04-25 Syntex Corp Branched chain ribofuranosyl nucleosides and intermediates
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
US4760137A (en) * 1984-08-06 1988-07-26 Brigham Young University Method for the production of 2'-deoxyadenosine compounds
US4656260A (en) * 1984-12-27 1987-04-07 Kanto Ishi Pharmaceutical Co., Ltd. Cyclic pyrazolo C-nucleoside compound and process for preparing the same
JPH0692392B2 (ja) * 1986-04-04 1994-11-16 信彦 勝沼 新規プソイドウリジン誘導体
US4965374A (en) * 1987-08-28 1990-10-23 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
DE3812681A1 (de) * 1988-04-16 1989-11-02 Bayer Ag Substituierte n-glycosylamide, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US4954623A (en) * 1989-03-20 1990-09-04 Eli Lilly And Company Recovery of difluoro sugar
US5216145A (en) * 1991-05-10 1993-06-01 American Cyanamid Company Asymmetric synthesis of 3-substituted furanoside compounds
US5371210A (en) * 1992-06-22 1994-12-06 Eli Lilly And Company Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5424416A (en) * 1993-08-25 1995-06-13 Eli Lilly And Company Process for preparation of 2-deoxy-2,2-difluoro-D-ribofuranosyl-3,5-hydroxy protected-1-alkyl and aryl sulfonates and their use in preparation of 2',2'-difluoro-2'-deoxy nucleosides

Also Published As

Publication number Publication date
EP0732338B1 (en) 2002-05-15
DE69621180D1 (de) 2002-06-20
ATE217634T1 (de) 2002-06-15
PT732338E (pt) 2002-09-30
US5521294A (en) 1996-05-28
JPH08239374A (ja) 1996-09-17
DE69621180T2 (de) 2002-10-31
EP0732338A1 (en) 1996-09-18
ES2176402T3 (es) 2002-12-01
CA2167361C (en) 2007-09-18
JP3830999B2 (ja) 2006-10-11
CA2167361A1 (en) 1996-07-19

Similar Documents

Publication Publication Date Title
DK0732338T3 (da) 2,2-difluor-3-carbamoylribosesulfonatforbindelser og fremgangsmåde til fremstilling af beta-nucleosider
AU9125191A (en) Retroviral protease inhibitors
NO950533D0 (no) Hydroksyetylaminosulfonamider som er nyttige som retrovirale proteasehemmere
MX9703564A (es) Inhibidores de proteasa multicatalitica.
ES2110421T3 (es) O-bencil-oximeteres y los agentes protectores de las plantas que contienen estos compuestos.
DK0572166T3 (da) Hidtil ukendte 7beta-substitueret-4-aza-5beta-androstan-3-oner som 5beta-reduktaseinhibitorer
DK0467331T3 (da) O-methylderivater af azithromycin A, fremgangsmåde og mellemprodukter til fremstilling deraf og anve ndelse deraf ved fremstilling af lægemidler
TR199901191T2 (xx) Benzamidoaldehitlerin sistein proteaz� inhibit�r� olarak kullan�m�.
DK0918776T3 (da) Totalsyntese af antitumor acylfulvener
DK0700380T3 (da) N-Alkylthiopolyaminderivater som radioprotektive midler
TW223630B (en) Retroviral protease inhibitors
NO981393D0 (no) Guanidinoproteasehemmere
YU49276B (sh) Postupak za dobijanje olanzapina
IT1293777B1 (it) Processo per la preparazione di tetraazamacrocicli
YU8597A (sh) Postupak za dobijanje nesimetričnih 4,6-bis(ariloksi) pirimidinskih jedinjenja
DK0552758T3 (da) N-5-Beskyttede 2,5-diamino-4,6-dichlorpyrimidiner og fremgangsmåde til deres fremstilling
BR9807785A (pt) Processo para a preparação do composto, e, composto
DK0736009T3 (da) N-oxider af 4-arylpiperaziner og 4-arylpiperidiner som antipsykotiske medikamenter
DK0975601T3 (da) Fremgangsmåde til fremstilling af butylthio-isoquinolin og mellemprodukter derfor
DK0640092T3 (da) Fremgangsmåde til fremstilling af ribonucleotid-reduktaseinhibitorer
TR200001122T2 (tr) Farmasötikler olarak bifenil türevleri.
BR9909756A (pt) Processo para a preparação de um composto
MX9603450A (es) Procedimiento para la obtencion de aminotriazolinas substituidas.
TW328903B (en) Substituted quinoline herbicide intermediates and process
DK0649426T3 (da) Inhibitorer af retrovirale proteaser