DK0639275T3 - Hidtil ukendte GABAa-receptorundertyper og fremgangsmåder til screening af lægemiddelforbindelser under anvendelse af imidazoquinoxaliner og pyrrolopyimidiner til binding til GABAa-receptorundertyper - Google Patents
Hidtil ukendte GABAa-receptorundertyper og fremgangsmåder til screening af lægemiddelforbindelser under anvendelse af imidazoquinoxaliner og pyrrolopyimidiner til binding til GABAa-receptorundertyperInfo
- Publication number
- DK0639275T3 DK0639275T3 DK93910819.7T DK93910819T DK0639275T3 DK 0639275 T3 DK0639275 T3 DK 0639275T3 DK 93910819 T DK93910819 T DK 93910819T DK 0639275 T3 DK0639275 T3 DK 0639275T3
- Authority
- DK
- Denmark
- Prior art keywords
- receptor subtypes
- methods
- gabaα
- gabaα receptor
- binding
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 238000012216 screening Methods 0.000 title abstract 2
- YELMWJNXDALKFE-UHFFFAOYSA-N 3h-imidazo[4,5-f]quinoxaline Chemical class N1=CC=NC2=C(NC=N3)C3=CC=C21 YELMWJNXDALKFE-UHFFFAOYSA-N 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 102000027484 GABAA receptors Human genes 0.000 abstract 1
- 108091008681 GABAA receptors Proteins 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
- G01N33/9406—Neurotransmitters
- G01N33/9426—GABA, i.e. gamma-amino-butyrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
- G01N33/948—Sedatives, e.g. cannabinoids, barbiturates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/20—Screening for compounds of potential therapeutic value cell-free systems
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Food Science & Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Anesthesiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/876,050 US5597920A (en) | 1992-04-30 | 1992-04-30 | Gabaa receptor subtypes and methods for screening drug compounds using imidazoquinoxalines and pyrrolopyrimidines to bind to gabaa receptor subtypes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0639275T3 true DK0639275T3 (da) | 1998-04-14 |
Family
ID=25366890
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK93910819.7T DK0639275T3 (da) | 1992-04-30 | 1993-04-30 | Hidtil ukendte GABAa-receptorundertyper og fremgangsmåder til screening af lægemiddelforbindelser under anvendelse af imidazoquinoxaliner og pyrrolopyimidiner til binding til GABAa-receptorundertyper |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US5597920A (de) |
| EP (1) | EP0639275B1 (de) |
| JP (1) | JPH08500333A (de) |
| KR (1) | KR950702032A (de) |
| AT (1) | ATE158414T1 (de) |
| AU (1) | AU691470B2 (de) |
| CA (1) | CA2134227A1 (de) |
| DE (1) | DE69314024T2 (de) |
| DK (1) | DK0639275T3 (de) |
| ES (1) | ES2110090T3 (de) |
| GR (1) | GR3025698T3 (de) |
| WO (1) | WO1993022681A1 (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6010861A (en) * | 1994-08-03 | 2000-01-04 | Dgi Biotechnologies, Llc | Target specific screens and their use for discovering small organic molecular pharmacophores |
| JP3868502B2 (ja) * | 1996-10-25 | 2007-01-17 | ニューロサーチ・アクティーゼルスカブ | 抗不安作用を有する化合物の同定方法 |
| JP2002544487A (ja) * | 1999-05-07 | 2002-12-24 | ニューロゲン コーポレイション | 特定の薬理活性を有するｇａｂａ−修飾化合物のスクリーニング方法 |
| US6737242B1 (en) | 1999-05-07 | 2004-05-18 | Neurogen Corporation | Methods for screening GABA-modulatory compounds for specified pharmacological activities |
| US7473691B2 (en) | 2000-09-15 | 2009-01-06 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| SI1318997T1 (sl) * | 2000-09-15 | 2006-12-31 | Vertex Pharma | Pirazolne spojine, uporabne kot inhibitorji protein-kinaze |
| US6660731B2 (en) | 2000-09-15 | 2003-12-09 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| CN1926132B (zh) * | 2000-09-15 | 2010-12-29 | 沃泰克斯药物股份有限公司 | 可用作蛋白激酶抑制剂的吡唑化合物 |
| WO2002022605A1 (en) | 2000-09-15 | 2002-03-21 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| US6989385B2 (en) | 2000-12-21 | 2006-01-24 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| US20040009981A1 (en) | 2002-03-15 | 2004-01-15 | David Bebbington | Compositions useful as inhibitors of protein kinases |
| MY141867A (en) | 2002-06-20 | 2010-07-16 | Vertex Pharma | Substituted pyrimidines useful as protein kinase inhibitors |
| EA200500299A1 (ru) | 2002-08-02 | 2005-08-25 | Вертекс Фармасьютикалз Инкорпорейтед | Пиразольные композиции, используемые в качестве ингибиторов gsk-3 |
| NZ594383A (en) | 2005-11-03 | 2013-05-31 | Vertex Pharma | Aminopyrimidines useful as kinase inhibitors |
| JP5389785B2 (ja) | 2007-05-02 | 2014-01-15 | バーテックス ファーマシューティカルズ インコーポレイテッド | キナーゼ阻害剤として有用なチアゾールおよびピラゾール |
| NZ582879A (en) | 2007-07-31 | 2012-03-30 | Vertex Pharma | Process for preparing 5-fluoro-1h-pyrazolo [3, 4-b] pyridin-3-amine and derivatives thereof |
| KR20110050549A (ko) | 2008-09-03 | 2011-05-13 | 버텍스 파마슈티칼스 인코포레이티드 | 공-결정 및 이를 포함하는 제약 제제 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4280993A (en) * | 1978-01-19 | 1981-07-28 | Claus Braestrup | Process for determining the concentration of benzodiazepines in a body fluid |
| IL90315A0 (en) * | 1988-06-01 | 1989-12-15 | Ferrosan As | Imidazoquinoxaline compounds,their preparation and pharmaceutical compositions containing them |
| US5185446A (en) * | 1990-09-04 | 1993-02-09 | Neurogen Corporation | Certain cycloalkyl imidazopyrimidines; a new class of gaba brainreceptor ligands |
| JPH06502147A (ja) * | 1990-10-09 | 1994-03-10 | ニューロゲン コーポレイション | 或る種のシクロアルキルおよびアザシクロアルキルピロロピリミジン；新規な種類のｇａｂａ脳リセプタリガンド |
| US5130430A (en) * | 1990-10-31 | 1992-07-14 | Neurogen Corporation | 2-substituted imidazoquinoxaline diones, a new class of gaba brain receptor ligands |
| AU4117493A (en) * | 1992-04-08 | 1994-11-21 | Neurogen Corporation | Certain aryl fused pyrrolopyrimidines; a new class of gaba brain receptor ligands |
-
1992
- 1992-04-30 US US07/876,050 patent/US5597920A/en not_active Expired - Fee Related
-
1993
- 1993-04-30 KR KR1019940703877A patent/KR950702032A/ko not_active Application Discontinuation
- 1993-04-30 CA CA002134227A patent/CA2134227A1/en not_active Abandoned
- 1993-04-30 JP JP5519445A patent/JPH08500333A/ja active Pending
- 1993-04-30 AT AT93910819T patent/ATE158414T1/de not_active IP Right Cessation
- 1993-04-30 EP EP93910819A patent/EP0639275B1/de not_active Expired - Lifetime
- 1993-04-30 ES ES93910819T patent/ES2110090T3/es not_active Expired - Lifetime
- 1993-04-30 AU AU41177/93A patent/AU691470B2/en not_active Ceased
- 1993-04-30 DE DE69314024T patent/DE69314024T2/de not_active Expired - Fee Related
- 1993-04-30 US US08/331,501 patent/US5688654A/en not_active Expired - Fee Related
- 1993-04-30 WO PCT/US1993/003920 patent/WO1993022681A1/en active IP Right Grant
- 1993-04-30 DK DK93910819.7T patent/DK0639275T3/da active
-
1997
- 1997-12-17 GR GR970403349T patent/GR3025698T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2134227A1 (en) | 1993-11-11 |
| DE69314024D1 (de) | 1997-10-23 |
| US5688654A (en) | 1997-11-18 |
| EP0639275A1 (de) | 1995-02-22 |
| US5597920A (en) | 1997-01-28 |
| AU691470B2 (en) | 1998-05-21 |
| AU4117793A (en) | 1993-11-29 |
| ATE158414T1 (de) | 1997-10-15 |
| GR3025698T3 (en) | 1998-03-31 |
| EP0639275B1 (de) | 1997-09-17 |
| WO1993022681A1 (en) | 1993-11-11 |
| KR950702032A (ko) | 1995-05-17 |
| DE69314024T2 (de) | 1998-04-16 |
| JPH08500333A (ja) | 1996-01-16 |
| ES2110090T3 (es) | 1998-02-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK0639275T3 (da) | Hidtil ukendte GABAa-receptorundertyper og fremgangsmåder til screening af lægemiddelforbindelser under anvendelse af imidazoquinoxaliner og pyrrolopyimidiner til binding til GABAa-receptorundertyper | |
| ES2164657T3 (es) | Derivados aza-biciclicos puenteados como antagonistas de la sustancia p. | |
| DK0800519T3 (da) | Steroidreceptormodulatorforbindelser og fremgangsmåder | |
| DK0831837T3 (da) | Anvendelse af squalamin i fremstilling af et medikament til inhibering af NHE | |
| DE69318854T2 (de) | Spiroazacyclischderivate als substanz p antagonisten | |
| NO20000521L (no) | 1-(N-fenylaminoalkyl)-piperazin derivater substituert i posisjon 2 põ fenylringen | |
| DK0873295T3 (da) | Dimer-selektive RXR-modulatorer og fremgangsmåder til deres anvendelse | |
| NO952494D0 (no) | Nytt protein fra urin med betegnelse komponent B | |
| DK0554247T3 (da) | Neurobeskyttende indolon og beslægtede derivater | |
| TR199901710T2 (xx) | IL-8 resept�r antagonistleri. | |
| DK0841928T3 (da) | Sustained release-formulering af d-threo-methylphenidat | |
| ATE318845T1 (de) | Therapeutische multispezifische verbindungen, die antikörper gegen den fcalpha-rezeptor enthalten | |
| DK0966447T3 (da) | Anvendelige små molekyler til behandling af betændelsessygdomme | |
| DK0726765T3 (da) | Apparat og fremgangsmåde til fremstilling af faste former med styret frigivelse af den aktive bestanddel | |
| TR199900318T2 (xx) | IL-8 resept�r antagonistleri. | |
| DK0652768T3 (da) | Præparat til aktivering af naturlige dræberceller (NK-celler), hvilket præparat indeholder interferon-alfa og histamin, ser | |
| TR199900501T2 (xx) | Benzamin t�revleri ve bunlar�n ila� olarak kullan�m�. | |
| NO991926L (no) | Oppl°selige lymfotoksin-<beta> reseptorer, anti-lymfotoksin-reseptor antistoff samt anti-lymfotoksin-ligand antistoff som terapeutiske midler til behandling av immunologiske sykdommer | |
| DK472887A (da) | Imidazolylguanidinderivater, fremgangsmaade til fremstilling deraf og laegemidler, der indeholder disse forbindelser | |
| DE3770875D1 (de) | Elektroskopische toner enthaltend rhodaminester-farbstoffe und loeschfarbstoffe dafuer und ihre verwendung. | |
| DE69412073D1 (de) | Xanthinderivate als adenosin-a1 rezeptor antagonisten | |
| DK0589949T3 (da) | Hidtil ukendte peptider, fremgangsmåder til fremstilling heraf og anvendelse af disse | |
| PT87244A (pt) | Rezeptor der kleinen rhinovirus rezeptor gruppe | |
| DK0462468T3 (da) | 9-amino-2-phenylbicyclo(3.3.1)nonaner og 9-amino-2-phenylbicyclo(3.3.1)non-2-ener og terapeutiske midler indeholdende disse | |
| IE782353L (en) | Ethyl 2-aryl allophanates, medicaments |