DK0633473T3 - Measurement of the activated partial thromboplastin time (APTT) in a single-step reaction - Google Patents

Measurement of the activated partial thromboplastin time (APTT) in a single-step reaction

Info

Publication number
DK0633473T3
DK0633473T3 DK93110471T DK93110471T DK0633473T3 DK 0633473 T3 DK0633473 T3 DK 0633473T3 DK 93110471 T DK93110471 T DK 93110471T DK 93110471 T DK93110471 T DK 93110471T DK 0633473 T3 DK0633473 T3 DK 0633473T3
Authority
DK
Denmark
Prior art keywords
aptt
step reaction
partial thromboplastin
thromboplastin time
activated partial
Prior art date
Application number
DK93110471T
Other languages
Danish (da)
Inventor
Dieter Josef
Original Assignee
Stiftung F R Diagnostische For
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stiftung F R Diagnostische For filed Critical Stiftung F R Diagnostische For
Application granted granted Critical
Publication of DK0633473T3 publication Critical patent/DK0633473T3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2405/00—Assays, e.g. immunoassays or enzyme assays, involving lipids
    • G01N2405/04—Phospholipids, i.e. phosphoglycerides

Abstract

The invention relates to a method for determining the activated partial thromboplastin time (APTT) in a single-step reaction, characterised in that the determination of APTT is started by contacting a reagent which contains the substances required for the APTT determination in a premixed state with a sample liquid. The invention furthermore relates to a reagent for carrying out the method.
DK93110471T 1993-06-30 1993-06-30 Measurement of the activated partial thromboplastin time (APTT) in a single-step reaction DK0633473T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP93110471A EP0633473B1 (en) 1993-06-30 1993-06-30 Measurement of the activated partial thromboplastin time (APTT) in a single-step reaction

Publications (1)

Publication Number Publication Date
DK0633473T3 true DK0633473T3 (en) 1999-08-09

Family

ID=8213025

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93110471T DK0633473T3 (en) 1993-06-30 1993-06-30 Measurement of the activated partial thromboplastin time (APTT) in a single-step reaction

Country Status (8)

Country Link
US (1) US5506146A (en)
EP (1) EP0633473B1 (en)
JP (1) JPH07151763A (en)
AT (1) ATE177536T1 (en)
DE (1) DE59309435D1 (en)
DK (1) DK0633473T3 (en)
ES (1) ES2131543T3 (en)
GR (1) GR3029654T3 (en)

Families Citing this family (18)

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US6429017B1 (en) * 1999-02-04 2002-08-06 Biomerieux Method for predicting the presence of haemostatic dysfunction in a patient sample
US6898532B1 (en) * 1995-06-07 2005-05-24 Biomerieux, Inc. Method and apparatus for predicting the presence of haemostatic dysfunction in a patient sample
US5780255A (en) * 1995-06-09 1998-07-14 Instrumentation Laboratory, S.P.A. Protein C pathway screening test
AT405692B (en) * 1997-03-27 1999-10-25 Immuno Ag REAGENT FOR DETERMINING THE APTT
WO2000046603A1 (en) * 1999-02-04 2000-08-10 Akzo Nobel N.V. A method and apparatus for predicting the presence of haemostatic dysfunction in a patient sample
US6451610B1 (en) * 1999-04-14 2002-09-17 International Technidyne Corporation Method and apparatus for coagulation based assays
US7179612B2 (en) 2000-06-09 2007-02-20 Biomerieux, Inc. Method for detecting a lipoprotein-acute phase protein complex and predicting an increased risk of system failure or mortality
US6632678B2 (en) 2001-01-03 2003-10-14 Sienco, Inc. Method for performing activated clotting time test with reduced sensitivity to the presence of aprotinin and for assessing aprotinin sensitivity
JPWO2006129703A1 (en) * 2005-05-31 2009-01-08 学校法人 久留米大学 Test method for activated partial thromboplastin time
CN101221189B (en) * 2007-01-12 2012-08-15 上海太阳生物技术有限公司 External diagnostic reagent kit used for measuring activated partial thromboplastin time
GB0701821D0 (en) * 2007-02-01 2007-03-14 Pentapharm Ag Diagnostic composition and its use in the determination of coagulation characteristics of a test liquid
CN101226201B (en) * 2008-02-05 2011-05-11 长安大学 Agent for activation sector cruor activating-enzyme time (APTT)
JP2011133396A (en) * 2009-12-25 2011-07-07 Sysmex Corp Activated partial thromboplastin time measuring reagent, activated partial thromboplastin time measuring method, and determination method for determining presence or absence of blood coagulation inhibitor
JP5911345B2 (en) * 2012-03-27 2016-04-27 シスメックス株式会社 Coagulation time measurement reagent, coagulation time measurement reagent kit, and coagulation time measurement method
EP3970738A1 (en) 2012-07-25 2022-03-23 Bioverativ Therapeutics Inc. Blood factor monitoring assay and uses thereof
CN105445478B (en) * 2015-11-12 2017-08-29 武汉中太生物技术有限公司 APTT kit and preparation method thereof
CN107748267B (en) * 2017-10-13 2019-02-26 山东艾科达生物科技有限公司 A kind of kit measuring activated partial thromboplastin time (APTT)
CN108226540B (en) * 2018-02-08 2020-07-03 武汉市长立生物技术有限责任公司 Ellagic acid reagent, preparation method thereof, activated partial thromboplastin time determination reagent and APTT kit

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4495278A (en) * 1981-04-27 1985-01-22 Baxter Travenol Laboratories, Inc. Process for making novel blood clotting enzyme compositions
US4480029A (en) * 1981-04-27 1984-10-30 Baxter Travenol Laboratories, Inc. Biological indicators and their use
US4470968A (en) * 1983-01-13 1984-09-11 Miles Laboratories, Inc. Pasteurized therapeutically active blood coagulation factor concentrates
DE3311287A1 (en) * 1983-03-28 1984-10-04 Behringwerke Ag, 3550 Marburg METHOD FOR PHOTOMETRICALLY DETERMINING THE ACTIVATED PARTIAL THROMBOPLASTIN TIME AND REAGENT TO IT
DE3516579A1 (en) * 1984-11-19 1986-05-22 Boehringer Mannheim Gmbh, 6800 Mannheim Coagulation test on test strips
US5086002A (en) * 1987-09-07 1992-02-04 Agen Biomedical, Ltd. Erythrocyte agglutination assay
US5055412A (en) * 1989-03-21 1991-10-08 Proksch Gary J Factor sensitive reagent for testing of blood coagulation containing ellagic acid and divalent metal ions and method of making the same
US5039617A (en) * 1989-04-20 1991-08-13 Biotrack, Inc. Capillary flow device and method for measuring activated partial thromboplastin time
IT1230744B (en) * 1989-07-07 1991-10-29 Instrumentation Lab Spa METHOD FOR DETERMINING THE FUNCTIONAL ACTIVITY OF PROTEIN S IN HUMAN PLASMA.
US5091304A (en) * 1989-08-21 1992-02-25 International Technidyne Corporation Whole blood activated partial thromboplastin time test and associated apparatus
US5169786A (en) * 1989-12-19 1992-12-08 Ortho Diagnostic Systems, Inc. Method of determining levels of extrinsic and intrinsic clotting factors and protein c
US5288612A (en) * 1991-07-03 1994-02-22 The Scripps Research Institute Assay methods for detecting serum proteases, particularly activated protein C
JP3180824B2 (en) * 1991-08-30 2001-06-25 シスメックス株式会社 Blood coagulation reagent

Also Published As

Publication number Publication date
EP0633473A1 (en) 1995-01-11
ATE177536T1 (en) 1999-03-15
DE59309435D1 (en) 1999-04-15
ES2131543T3 (en) 1999-08-01
US5506146A (en) 1996-04-09
JPH07151763A (en) 1995-06-16
EP0633473B1 (en) 1999-03-10
GR3029654T3 (en) 1999-06-30

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