DK0621777T3 - Pellets containing active substance and with a matrix of hydrophilic macromolecules, and process for their preparation - Google Patents
Pellets containing active substance and with a matrix of hydrophilic macromolecules, and process for their preparationInfo
- Publication number
- DK0621777T3 DK0621777T3 DK93902034.3T DK93902034T DK0621777T3 DK 0621777 T3 DK0621777 T3 DK 0621777T3 DK 93902034 T DK93902034 T DK 93902034T DK 0621777 T3 DK0621777 T3 DK 0621777T3
- Authority
- DK
- Denmark
- Prior art keywords
- matrix
- preparation
- gelatin
- active substance
- containing active
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0216—Solid or semisolid forms
- A61K8/022—Powders; Compacted Powders
- A61K8/0225—Granulated powders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1658—Proteins, e.g. albumin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Abstract
Solid body consists of at least one active agent (A) dispersed in a matrix consisting mainly of at least one hydrophilic macromolecular structure-forming agent (I) selected from collagen, gelatin, fractionated gelatin, collagen hydrolysate, gelatin derivs., vegetable proteins, vegetable protein hydrolysates and elastin hydrolysates. (I) is pref. a thermoreversible sol-gel former. Also claimed are mixts. of (A) and (I), where (I) may additionally be one or more of albumin, agar, gum arabic, pectin, etc.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4201179A DE4201179A1 (en) | 1992-01-17 | 1992-01-17 | Granulates or pellets comprising dispersion of active agent in hydrophilic macromolecules - are e.g. for treatment of depression, hypertension, rheumatism, etc. |
DE4201173A DE4201173C2 (en) | 1992-01-17 | 1992-01-17 | Acute drugs in the form of pellets containing dihydropyridine derivatives and their preparation |
US07/876,864 US5405616A (en) | 1992-01-17 | 1992-04-30 | Means for containing active substances, having a shell of hydrophilic macromolecules, active substances and process for preparation thereof |
US07/876,877 US5384129A (en) | 1992-01-17 | 1992-04-30 | Pellets containing dihydropyridine derivatives process for the production thereof and use as rapid action dosage in heart and circulatory diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0621777T3 true DK0621777T3 (en) | 1996-10-21 |
Family
ID=27435369
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK95113398T DK0701815T3 (en) | 1992-01-17 | 1993-01-18 | Process for the preparation of active ingredient powders, granules or pellets with a basic structure of hydrophilic macar |
DK93902034.3T DK0621777T3 (en) | 1992-01-17 | 1993-01-18 | Pellets containing active substance and with a matrix of hydrophilic macromolecules, and process for their preparation |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK95113398T DK0701815T3 (en) | 1992-01-17 | 1993-01-18 | Process for the preparation of active ingredient powders, granules or pellets with a basic structure of hydrophilic macar |
Country Status (10)
Country | Link |
---|---|
EP (2) | EP0621777B1 (en) |
JP (1) | JPH07502736A (en) |
AT (2) | ATE181666T1 (en) |
AU (1) | AU679906B2 (en) |
CA (1) | CA2128244C (en) |
DE (2) | DE59309678D1 (en) |
DK (2) | DK0701815T3 (en) |
ES (2) | ES2092808T3 (en) |
GR (2) | GR3021223T3 (en) |
WO (1) | WO1993013757A1 (en) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2714575B1 (en) * | 1994-01-03 | 1996-02-02 | Rhone Poulenc Nutrition Animal | New granules containing living organisms for animal feed. |
SE9704401D0 (en) * | 1997-11-28 | 1997-11-28 | Astra Ab | Matrix pellets for greasy, oily or sticky drug substances |
DE50105469D1 (en) * | 2001-03-22 | 2005-04-07 | Cognis Iberia Sl | Microcapsules (VII) |
US6828305B2 (en) | 2001-06-04 | 2004-12-07 | Nobex Corporation | Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
US6828297B2 (en) | 2001-06-04 | 2004-12-07 | Nobex Corporation | Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
US7713932B2 (en) | 2001-06-04 | 2010-05-11 | Biocon Limited | Calcitonin drug-oligomer conjugates, and uses thereof |
US6835802B2 (en) | 2001-06-04 | 2004-12-28 | Nobex Corporation | Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties |
US6713452B2 (en) | 2001-06-04 | 2004-03-30 | Nobex Corporation | Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
FR2843301B1 (en) * | 2002-08-09 | 2004-10-22 | Centre Nat Rech Scient | GALENIC FORM FOR THE COLIC DELIVERY OF ACTIVE INGREDIENTS |
FR2843302B1 (en) | 2002-08-09 | 2004-10-22 | Centre Nat Rech Scient | GALENIC FORM FOR COLLECTIVE DELIVERY OF ACTIVE PRINCIPLES |
AU2003276011A1 (en) * | 2002-10-16 | 2004-05-04 | Dr. Suwelack Skin And Health Care Ag | Use of molded bodies for external application |
US9107804B2 (en) | 2002-12-10 | 2015-08-18 | Nortec Development Associates, Inc. | Method of preparing biologically active formulations |
WO2006014673A2 (en) | 2004-07-19 | 2006-02-09 | Nobex Corporation | Insulin-oligomer conjugates, formulations and uses thereof |
FR2887455B1 (en) * | 2005-06-28 | 2007-08-10 | Sanofi Aventis Sa | FORMULATION WITH PROLONGED RELEASE OF ACTIVE MEDICINAL PRINCIPLES |
PL2061427T3 (en) * | 2006-09-15 | 2011-12-30 | Echo Pharmaceuticals Bv | Granulate containing a pharmaceutically active substance and an emulsifier and method for its manufacture |
EP2063861B1 (en) | 2006-09-15 | 2015-02-25 | Echo Pharmaceuticals B.V. | Dosage unit for sublingual, buccal or oral administration of water-insoluble pharmaceutically active substances |
US8273376B2 (en) | 2006-11-17 | 2012-09-25 | Da Volterra | Colonic delivery of metallo-dependent enzymes |
CN101904813A (en) | 2009-04-22 | 2010-12-08 | 苏维拉克皮肤及健康护理公司 | Freeze-dried coated mechanograph |
ES2786506T3 (en) * | 2012-08-01 | 2020-10-13 | Zahra Tavakoli | Flowable frozen compositions comprising a therapeutic agent |
ITMI20122145A1 (en) * | 2012-12-14 | 2014-06-15 | Velleja Res Srl | COMPOSITIONS FOR ORAL USE HYDRO-LAYERED CONTAINERS OF COLLAGEN, ELASTIN AND VITAMIN C FAVOR THE EXTRA-CELLULAR MATRIX DEPOSITION |
LU102656B1 (en) | 2021-03-11 | 2022-09-12 | Prosecur Gmbh | Liquid food supplement for immune stimulation, process for its production and use |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1248863B (en) * | 1959-01-30 | |||
GB887901A (en) * | 1960-04-13 | 1900-01-01 | ||
IE53696B1 (en) * | 1981-12-02 | 1989-01-18 | Wyeth John & Brother Ltd | Solid shaped articles |
EP0138216B1 (en) * | 1983-10-14 | 1993-01-07 | Sumitomo Pharmaceuticals Company, Limited | Sustained-release ifn preparation for parenteral administration |
US4837285A (en) * | 1984-03-27 | 1989-06-06 | Medimatrix | Collagen matrix beads for soft tissue repair |
US4642903A (en) * | 1985-03-26 | 1987-02-17 | R. P. Scherer Corporation | Freeze-dried foam dosage form |
FR2634121B1 (en) * | 1988-07-13 | 1992-05-07 | Imedex | PROCESS FOR THE PREPARATION OF COLLAGEN MICROPARTICLES AND PRODUCTS OBTAINED |
JPH02135052A (en) * | 1988-11-17 | 1990-05-23 | Taiyo Kagaku Co Ltd | Preparation of granular food |
US5007790A (en) * | 1989-04-11 | 1991-04-16 | Depomed Systems, Inc. | Sustained-release oral drug dosage form |
FR2650502B1 (en) * | 1989-08-07 | 1994-05-27 | Delagrange Laboratoires | NEW ORAL GALENIC FORM IMPROVING BIOAVAILABILITY |
US5079018A (en) * | 1989-08-14 | 1992-01-07 | Neophore Technologies, Inc. | Freeze dry composition and method for oral administration of drugs, biologicals, nutrients and foodstuffs |
US5215756A (en) * | 1989-12-22 | 1993-06-01 | Gole Dilip J | Preparation of pharmaceutical and other matrix systems by solid-state dissolution |
ATE156350T1 (en) | 1992-01-17 | 1997-08-15 | Alfatec Pharma Gmbh | PELLETS CONTAINING PEPTIDE MEDICINAL SUBSTANCES AND THEIR PRODUCTION AND USE |
DE59301262D1 (en) | 1992-01-17 | 1996-02-08 | Alfatec Pharma Gmbh | METHOD FOR PRODUCING SOFT GEL CAPSULES BY A DROP METHOD |
ES2102637T3 (en) | 1992-01-17 | 1997-08-01 | Alfatec Pharma Gmbh | CRYOGRANULATED MOLDED BODIES CONTAINING AN EXTRACT OF ACTIVE VEGETABLE SUBSTANCES AND THEIR PHARMACEUTICAL OR COSMETIC USE. |
DE4221880A1 (en) * | 1992-07-03 | 1994-01-05 | Alfatec Pharma Gmbh | Solid and liquid solutions of poorly water-soluble drugs |
-
1993
- 1993-01-18 CA CA002128244A patent/CA2128244C/en not_active Expired - Fee Related
- 1993-01-18 EP EP93902034A patent/EP0621777B1/en not_active Expired - Lifetime
- 1993-01-18 DE DE59309678T patent/DE59309678D1/en not_active Expired - Fee Related
- 1993-01-18 EP EP95113398A patent/EP0701815B1/en not_active Expired - Lifetime
- 1993-01-18 AT AT95113398T patent/ATE181666T1/en not_active IP Right Cessation
- 1993-01-18 ES ES93902034T patent/ES2092808T3/en not_active Expired - Lifetime
- 1993-01-18 AT AT93902034T patent/ATE142484T1/en not_active IP Right Cessation
- 1993-01-18 DK DK95113398T patent/DK0701815T3/en active
- 1993-01-18 ES ES95113398T patent/ES2133633T3/en not_active Expired - Lifetime
- 1993-01-18 DK DK93902034.3T patent/DK0621777T3/en active
- 1993-01-18 WO PCT/DE1993/000038 patent/WO1993013757A1/en active IP Right Grant
- 1993-01-18 JP JP5512079A patent/JPH07502736A/en active Pending
- 1993-01-18 DE DE59303759T patent/DE59303759C5/en not_active Expired - Lifetime
- 1993-01-18 AU AU33432/93A patent/AU679906B2/en not_active Ceased
-
1996
- 1996-10-02 GR GR960402577T patent/GR3021223T3/en unknown
-
1999
- 1999-07-01 GR GR990401751T patent/GR3030675T3/en unknown
Also Published As
Publication number | Publication date |
---|---|
CA2128244C (en) | 1998-09-22 |
EP0621777B1 (en) | 1996-09-11 |
EP0701815B1 (en) | 1999-06-30 |
DE59303759C5 (en) | 2009-04-09 |
DK0701815T3 (en) | 2000-02-07 |
GR3021223T3 (en) | 1997-01-31 |
ATE181666T1 (en) | 1999-07-15 |
AU679906B2 (en) | 1997-07-17 |
CA2128244A1 (en) | 1993-07-22 |
EP0621777A1 (en) | 1994-11-02 |
WO1993013757A1 (en) | 1993-07-22 |
AU3343293A (en) | 1993-08-03 |
JPH07502736A (en) | 1995-03-23 |
DE59309678D1 (en) | 1999-08-05 |
GR3030675T3 (en) | 1999-11-30 |
DE59303759D1 (en) | 1996-10-17 |
ES2133633T3 (en) | 1999-09-16 |
ES2092808T3 (en) | 1996-12-01 |
EP0701815A1 (en) | 1996-03-20 |
ATE142484T1 (en) | 1996-09-15 |
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