DK0615458T3 - Fremgangsmåde til reduktion af infektioner relateret til medicinske anordninger - Google Patents
Fremgangsmåde til reduktion af infektioner relateret til medicinske anordningerInfo
- Publication number
- DK0615458T3 DK0615458T3 DK93900811.6T DK93900811T DK0615458T3 DK 0615458 T3 DK0615458 T3 DK 0615458T3 DK 93900811 T DK93900811 T DK 93900811T DK 0615458 T3 DK0615458 T3 DK 0615458T3
- Authority
- DK
- Denmark
- Prior art keywords
- medical devices
- infections related
- reducing infections
- reducing
- slime
- Prior art date
Links
- 208000015181 infectious disease Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 abstract 2
- 244000005700 microbiome Species 0.000 abstract 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 abstract 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 abstract 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 abstract 1
- 229960004889 salicylic acid Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
- A61L29/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/41—Anti-inflammatory agents, e.g. NSAIDs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0017—Catheters; Hollow probes specially adapted for long-term hygiene care, e.g. urethral or indwelling catheters to prevent infections
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
- Electrotherapy Devices (AREA)
- External Artificial Organs (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US80289191A | 1991-12-06 | 1991-12-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0615458T3 true DK0615458T3 (da) | 1997-09-15 |
Family
ID=25185005
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK93900811.6T DK0615458T3 (da) | 1991-12-06 | 1992-12-03 | Fremgangsmåde til reduktion af infektioner relateret til medicinske anordninger |
Country Status (10)
Country | Link |
---|---|
US (2) | US5366505A (de) |
EP (1) | EP0615458B1 (de) |
JP (1) | JPH07505131A (de) |
AT (1) | ATE156368T1 (de) |
AU (1) | AU667069B2 (de) |
CA (1) | CA2125167A1 (de) |
DE (1) | DE69221501T2 (de) |
DK (1) | DK0615458T3 (de) |
ES (1) | ES2106318T3 (de) |
WO (1) | WO1993010847A1 (de) |
Families Citing this family (81)
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US5055455A (en) * | 1988-09-28 | 1991-10-08 | Brigham And Women's Hospital | Capsular polysaccharide adhesin antigen, preparation, purification and use |
US5718694A (en) * | 1993-11-09 | 1998-02-17 | The Board Of Regents Of The University Of Nebraska | Inhibition of adherence of microorganisms to biomaterial surfaces by treatment with carbohydrates |
US6468649B1 (en) * | 1995-02-22 | 2002-10-22 | Scimed Life Systems, Inc. | Antimicrobial adhesion surface |
US6558798B2 (en) | 1995-02-22 | 2003-05-06 | Scimed Life Systems, Inc. | Hydrophilic coating and substrates coated therewith having enhanced durability and lubricity |
US6395292B2 (en) * | 1996-02-02 | 2002-05-28 | Alza Corporation | Sustained delivery of an active agent using an implantable system |
US5942499A (en) * | 1996-03-05 | 1999-08-24 | Orquest, Inc. | Method of promoting bone growth with hyaluronic acid and growth factors |
US6645945B1 (en) | 1996-03-05 | 2003-11-11 | Depuy Acromed, Inc. | Method of treating diseased, injured or abnormal cartilage with hyaluronic acid and growth factors |
US6221854B1 (en) | 1996-03-05 | 2001-04-24 | Orquest, Inc. | Method of promoting bone growth with hyaluronic acid and growth factors |
US20110207666A1 (en) * | 1996-03-05 | 2011-08-25 | Depuy Spine, Inc. | Method of promoting bone growth with hyaluronic acid and growth factors |
WO1997041901A1 (en) * | 1996-05-03 | 1997-11-13 | Uros Corporation | Pentosanpolysulfate coating for medical devices |
US6186985B1 (en) | 1997-10-03 | 2001-02-13 | Boston Scientific Corporation | Gastro-intestinal tube with dissolvable support bolster |
IT1298539B1 (it) * | 1998-02-03 | 2000-01-12 | Bracco Spa | Metodo per la determinazione di infezioni da protesi |
US6046020A (en) * | 1998-05-05 | 2000-04-04 | Biolog, Inc. | Use of anti-capsule agents in microbiological testing |
US7252828B2 (en) | 1998-07-15 | 2007-08-07 | The Brigham And Women's Hospital, Inc. | Polysaccharide vaccine for staphylococcal infections |
WO2000018392A1 (en) * | 1998-09-25 | 2000-04-06 | Glycox Corporation Limited | Fructosamine oxidase: antagonists and inhibitors |
US6596401B1 (en) | 1998-11-10 | 2003-07-22 | C. R. Bard Inc. | Silane copolymer compositions containing active agents |
IL131623A0 (en) * | 1999-08-27 | 2001-01-28 | Dan Weiss | Apparatus to couple ultrasonic energy to catheters and other transdermal medical devices |
US6602287B1 (en) * | 1999-12-08 | 2003-08-05 | Advanced Cardiovascular Systems, Inc. | Stent with anti-thrombogenic coating |
US6579539B2 (en) | 1999-12-22 | 2003-06-17 | C. R. Bard, Inc. | Dual mode antimicrobial compositions |
US20030216635A1 (en) * | 2000-01-06 | 2003-11-20 | Cohen Irun R | Method and system for monitoring pancreatic pathologies |
US6805695B2 (en) * | 2000-04-04 | 2004-10-19 | Spinalabs, Llc | Devices and methods for annular repair of intervertebral discs |
EP1303256B1 (de) * | 2000-06-09 | 2009-01-07 | Baylor College of Medicine | Kombination von antimikrobiellen wirkstoffen und bakterieller interferenz zum überziehen medizinischer vorrichtungen |
US7201940B1 (en) * | 2001-06-12 | 2007-04-10 | Advanced Cardiovascular Systems, Inc. | Method and apparatus for thermal spray processing of medical devices |
US6905613B2 (en) * | 2001-07-10 | 2005-06-14 | Honeywell International Inc. | Use of an organic dielectric as a sacrificial layer |
US20030216758A1 (en) * | 2001-12-28 | 2003-11-20 | Angiotech Pharmaceuticals, Inc. | Coated surgical patches |
US6887270B2 (en) | 2002-02-08 | 2005-05-03 | Boston Scientific Scimed, Inc. | Implantable or insertable medical device resistant to microbial growth and biofilm formation |
US8133501B2 (en) | 2002-02-08 | 2012-03-13 | Boston Scientific Scimed, Inc. | Implantable or insertable medical devices for controlled drug delivery |
US7993390B2 (en) | 2002-02-08 | 2011-08-09 | Boston Scientific Scimed, Inc. | Implantable or insertable medical device resistant to microbial growth and biofilm formation |
US8685427B2 (en) | 2002-07-31 | 2014-04-01 | Boston Scientific Scimed, Inc. | Controlled drug delivery |
ES2386782T3 (es) | 2002-03-08 | 2012-08-30 | Philera New Zealand Limited | Prevención y/o tratamiento de la enfermedad cardiovascular y/o la insuficiencia cardíaca asociada |
ES2330326T3 (es) | 2002-05-24 | 2009-12-09 | Angiotech International Ag | Composiciones y metodos para recubrir implantes medicos. |
US8313760B2 (en) | 2002-05-24 | 2012-11-20 | Angiotech International Ag | Compositions and methods for coating medical implants |
US8920826B2 (en) | 2002-07-31 | 2014-12-30 | Boston Scientific Scimed, Inc. | Medical imaging reference devices |
MXPA05002883A (es) | 2002-08-20 | 2005-10-05 | Protemix Corp Ltd | Formas de dosis y terapias relacionadas. |
US20050008763A1 (en) * | 2002-09-24 | 2005-01-13 | Schachter Steven C. | Antimicrobial coatings for medical applications |
DK1565478T3 (da) | 2002-11-12 | 2017-11-13 | Brigham & Womens Hospital Inc | Polysaccharidvaccine mod stafylokokinfektioner |
AU2003290867A1 (en) * | 2002-11-12 | 2004-06-03 | The Brigham And Women's Hospital, Inc. | Methods and products for treating staphylococcal infections |
ATE354380T1 (de) * | 2003-02-03 | 2007-03-15 | Polaschegg Hans-Dietrich Dr Te | Zusammensetzung zur prävention von infektionen durch subkutane prothesen |
US7488757B2 (en) | 2003-03-24 | 2009-02-10 | Becton, Dickinson And Company | Invisible antimicrobial glove and hand antiseptic |
WO2005051871A2 (en) * | 2003-11-20 | 2005-06-09 | Angiotech International Ag | Implantable sensors and implantable pumps and anti-scarring agents |
US7786255B2 (en) | 2004-04-21 | 2010-08-31 | The Bringham and Women's Hospital, Inc. | Poly-N-acetyl glucosamine (PNAG/dPNAG)-binding peptides and methods of use thereof |
EP1778618B1 (de) | 2004-07-19 | 2013-12-25 | PhilERA New Zealand Limited | Synthese von triethylenetetraminen |
US20060095021A1 (en) * | 2004-11-02 | 2006-05-04 | Casas-Bejar Jesus W | Introduction of agent with medical device |
WO2006068516A1 (en) * | 2004-12-20 | 2006-06-29 | Protemix Corporation Limited | Implantable medical devices coated with or containing copper chelating compounds |
WO2006121887A2 (en) * | 2005-05-05 | 2006-11-16 | Cook Biotech Incorporated | Implantable materials and methods for inhibiting tissue adhesion formation |
WO2008048350A2 (en) * | 2006-02-24 | 2008-04-24 | Nanovibronix Inc. | System and method for surface acoustic wave treatment of skin |
US11229746B2 (en) | 2006-06-22 | 2022-01-25 | Excelsior Medical Corporation | Antiseptic cap |
US9259535B2 (en) | 2006-06-22 | 2016-02-16 | Excelsior Medical Corporation | Antiseptic cap equipped syringe |
US8512294B2 (en) * | 2006-07-28 | 2013-08-20 | Becton, Dickinson And Company | Vascular access device antimicrobial materials and solutions |
US20090041727A1 (en) * | 2007-08-08 | 2009-02-12 | Conjugon, Inc. | Compositions and Methods for Microbe Storage and Delivery |
CN105085349B (zh) | 2008-07-21 | 2018-02-09 | 布赖汉姆妇女医院 | 与合成的β‑1,6 葡糖胺寡糖相关的方法和组合物 |
US8622995B2 (en) | 2009-10-26 | 2014-01-07 | Pursuit Vascular, Inc. | Method for delivery of antimicrobial to proximal end of catheter |
US9022984B2 (en) | 2008-10-27 | 2015-05-05 | Pursuit Vascular, Inc. | Apparatus for delivery of device and antimicrobial agent into trans-dermal catheter |
US9078992B2 (en) | 2008-10-27 | 2015-07-14 | Pursuit Vascular, Inc. | Medical device for applying antimicrobial to proximal end of catheter |
US8622996B2 (en) | 2008-10-27 | 2014-01-07 | Pursuit Vascular, Inc. | Method for applying antimicrobial to proximal end of catheter |
US8821455B2 (en) * | 2009-07-09 | 2014-09-02 | Becton, Dickinson And Company | Antimicrobial coating for dermally invasive devices |
US20110065798A1 (en) * | 2009-09-17 | 2011-03-17 | Becton, Dickinson And Company | Anti-infective lubricant for medical devices and methods for preparing the same |
JP5055397B2 (ja) * | 2010-03-10 | 2012-10-24 | 株式会社ユニックスジャパン | 歯科用成形体、及び歯科用樹脂材料 |
US10166381B2 (en) | 2011-05-23 | 2019-01-01 | Excelsior Medical Corporation | Antiseptic cap |
CA2841832C (en) | 2011-07-12 | 2019-06-04 | Pursuit Vascular, Inc. | Device for delivery of antimicrobial agent into a trans-dermal catheter |
US9695323B2 (en) | 2013-02-13 | 2017-07-04 | Becton, Dickinson And Company | UV curable solventless antimicrobial compositions |
US9750928B2 (en) | 2013-02-13 | 2017-09-05 | Becton, Dickinson And Company | Blood control IV catheter with stationary septum activator |
US9750927B2 (en) | 2013-03-11 | 2017-09-05 | Becton, Dickinson And Company | Blood control catheter with antimicrobial needle lube |
US9327095B2 (en) | 2013-03-11 | 2016-05-03 | Becton, Dickinson And Company | Blood control catheter with antimicrobial needle lube |
US9789279B2 (en) | 2014-04-23 | 2017-10-17 | Becton, Dickinson And Company | Antimicrobial obturator for use with vascular access devices |
US10376686B2 (en) | 2014-04-23 | 2019-08-13 | Becton, Dickinson And Company | Antimicrobial caps for medical connectors |
US9675793B2 (en) | 2014-04-23 | 2017-06-13 | Becton, Dickinson And Company | Catheter tubing with extraluminal antimicrobial coating |
JP6546988B2 (ja) | 2014-05-02 | 2019-07-17 | エクセルシオール・メディカル・コーポレイションExcelsior Medical Corporation | 防腐キャップのためのストリップパッケージ |
US10232088B2 (en) | 2014-07-08 | 2019-03-19 | Becton, Dickinson And Company | Antimicrobial coating forming kink resistant feature on a vascular access device |
WO2016182822A1 (en) | 2015-05-08 | 2016-11-17 | Icu Medical, Inc. | Medical connectors configured to receive emitters of therapeutic agents |
US10493244B2 (en) | 2015-10-28 | 2019-12-03 | Becton, Dickinson And Company | Extension tubing strain relief |
AU2017341782B2 (en) | 2016-10-14 | 2023-03-16 | Icu Medical, Inc. | Sanitizing caps for medical connectors |
WO2018204206A2 (en) | 2017-05-01 | 2018-11-08 | Icu Medical, Inc. | Medical fluid connectors and methods for providing additives in medical fluid lines |
US11541220B2 (en) | 2018-11-07 | 2023-01-03 | Icu Medical, Inc. | Needleless connector with antimicrobial properties |
US11400195B2 (en) | 2018-11-07 | 2022-08-02 | Icu Medical, Inc. | Peritoneal dialysis transfer set with antimicrobial properties |
US10525250B1 (en) | 2018-11-07 | 2020-01-07 | Pursuit Vascular, Inc. | Infusion device with antimicrobial properties |
US11534595B2 (en) | 2018-11-07 | 2022-12-27 | Icu Medical, Inc. | Device for delivering an antimicrobial composition into an infusion device |
US11517732B2 (en) | 2018-11-07 | 2022-12-06 | Icu Medical, Inc. | Syringe with antimicrobial properties |
US11541221B2 (en) | 2018-11-07 | 2023-01-03 | Icu Medical, Inc. | Tubing set with antimicrobial properties |
JP2022513096A (ja) | 2018-11-21 | 2022-02-07 | アイシーユー・メディカル・インコーポレーテッド | リング及びインサートを有するキャップを備える抗菌装置 |
CA3204371A1 (en) | 2020-12-07 | 2022-06-16 | Icu Medical, Inc. | Peritoneal dialysis caps, systems and methods |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3695921A (en) * | 1970-09-09 | 1972-10-03 | Nat Patent Dev Corp | Method of coating a catheter |
US4343788A (en) * | 1979-06-29 | 1982-08-10 | The Procter & Gamble Company | Antimicrobial polymer compositions |
US4479795A (en) * | 1979-06-29 | 1984-10-30 | The Procter & Gamble Company | Antimicrobial polymer compositions |
US4769013A (en) * | 1982-09-13 | 1988-09-06 | Hydromer, Inc. | Bio-effecting medical material and device |
US4581028A (en) * | 1984-04-30 | 1986-04-08 | The Trustees Of Columbia University In The City Of New York | Infection-resistant materials and method of making same through use of sulfonamides |
US4642267A (en) * | 1985-05-06 | 1987-02-10 | Hydromer, Inc. | Hydrophilic polymer blend |
US4886505A (en) * | 1985-06-07 | 1989-12-12 | Becton, Dickinson And Company | Antimicrobial surfaces and inhibition of microorganism growth thereby |
US4713402A (en) * | 1985-08-30 | 1987-12-15 | Becton, Dickinson And Company | Process for preparing antithrombogenic/antibiotic polymeric plastic materials |
DK530787D0 (da) * | 1987-10-09 | 1987-10-09 | Bukh Meditec | Indretning til indfoering i en legemshulhed |
US4865870A (en) * | 1988-07-07 | 1989-09-12 | Becton, Dickinson And Company | Method for rendering a substrate surface antithrombogenic |
US4925668A (en) * | 1989-01-18 | 1990-05-15 | Becton, Dickinson And Company | Anti-infective and lubricious medical articles and method for their preparation |
AU1579092A (en) * | 1991-02-27 | 1992-10-06 | Nova Pharmaceutical Corporation | Anti-infective and anti-inflammatory releasing systems for medical devices |
-
1992
- 1992-12-03 DE DE69221501T patent/DE69221501T2/de not_active Expired - Fee Related
- 1992-12-03 EP EP93900811A patent/EP0615458B1/de not_active Expired - Lifetime
- 1992-12-03 JP JP5510339A patent/JPH07505131A/ja active Pending
- 1992-12-03 AU AU32352/93A patent/AU667069B2/en not_active Ceased
- 1992-12-03 WO PCT/US1992/010413 patent/WO1993010847A1/en active IP Right Grant
- 1992-12-03 DK DK93900811.6T patent/DK0615458T3/da active
- 1992-12-03 CA CA002125167A patent/CA2125167A1/en not_active Abandoned
- 1992-12-03 ES ES93900811T patent/ES2106318T3/es not_active Expired - Lifetime
- 1992-12-03 AT AT93900811T patent/ATE156368T1/de not_active IP Right Cessation
-
1993
- 1993-03-23 US US08/035,553 patent/US5366505A/en not_active Expired - Lifetime
-
1994
- 1994-07-25 US US08/279,585 patent/US5716406A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO1993010847A1 (en) | 1993-06-10 |
AU667069B2 (en) | 1996-03-07 |
DE69221501T2 (de) | 1998-03-12 |
EP0615458A1 (de) | 1994-09-21 |
DE69221501D1 (de) | 1997-09-11 |
EP0615458B1 (de) | 1997-08-06 |
CA2125167A1 (en) | 1993-06-10 |
EP0615458A4 (de) | 1995-02-08 |
ES2106318T3 (es) | 1997-11-01 |
JPH07505131A (ja) | 1995-06-08 |
ATE156368T1 (de) | 1997-08-15 |
AU3235293A (en) | 1993-06-28 |
US5716406A (en) | 1998-02-10 |
US5366505A (en) | 1994-11-22 |
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