DK0615444T3 - Oral administration form for peptide drugs, especially insulin - Google Patents
Oral administration form for peptide drugs, especially insulinInfo
- Publication number
- DK0615444T3 DK0615444T3 DK92924546.2T DK92924546T DK0615444T3 DK 0615444 T3 DK0615444 T3 DK 0615444T3 DK 92924546 T DK92924546 T DK 92924546T DK 0615444 T3 DK0615444 T3 DK 0615444T3
- Authority
- DK
- Denmark
- Prior art keywords
- administration form
- oral administration
- gelatine
- peptide drugs
- especially insulin
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5169—Proteins, e.g. albumin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1658—Proteins, e.g. albumin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2063—Proteins, e.g. gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4891—Coated capsules; Multilayered drug free capsule shells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
-
- G—PHYSICS
- G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
- G03C—PHOTOSENSITIVE MATERIALS FOR PHOTOGRAPHIC PURPOSES; PHOTOGRAPHIC PROCESSES, e.g. CINE, X-RAY, COLOUR, STEREO-PHOTOGRAPHIC PROCESSES; AUXILIARY PROCESSES IN PHOTOGRAPHY
- G03C1/00—Photosensitive materials
- G03C1/005—Silver halide emulsions; Preparation thereof; Physical treatment thereof; Incorporation of additives therein
- G03C1/04—Silver halide emulsions; Preparation thereof; Physical treatment thereof; Incorporation of additives therein with macromolecular additives; with layer-forming substances
- G03C1/047—Proteins, e.g. gelatine derivatives; Hydrolysis or extraction products of proteins
- G03C2001/0471—Isoelectric point of gelatine
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Nanotechnology (AREA)
- Optics & Photonics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Abstract
A peroral administration form for peptidic medicaments contains the peptidic medicament, in particular insulin, distributed in a gelatine or gelatine derivate matrix, besides usual pharmaceutical excipients and additives. By selecting an appropriate gelatine, the medicament is released in the small or large intestine, so that it is no longer enzymatically decomposed by peptidases.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19914140178 DE4140178C2 (en) | 1991-12-05 | 1991-12-05 | Acute form for a medicament containing indolylacetic acid derivative and its preparation |
DE19914140177 DE4140177C2 (en) | 1991-12-05 | 1991-12-05 | Nanosol acute form for glibenclamide |
DE19914140195 DE4140195C2 (en) | 1991-12-05 | 1991-12-05 | Pharmaceutical nanosol and process for its manufacture |
DE19914140186 DE4140186C2 (en) | 1991-12-05 | 1991-12-05 | Peroral application form for peptide drugs, especially insulin |
US87686792A | 1992-04-30 | 1992-04-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0615444T3 true DK0615444T3 (en) | 1996-07-08 |
Family
ID=27511568
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK92924546.2T DK0615444T3 (en) | 1991-12-05 | 1992-12-04 | Oral administration form for peptide drugs, especially insulin |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0615444B1 (en) |
AT (1) | ATE134875T1 (en) |
AU (1) | AU671964B2 (en) |
CA (1) | CA2125284C (en) |
DE (1) | DE59205625D1 (en) |
DK (1) | DK0615444T3 (en) |
ES (1) | ES2085656T3 (en) |
GR (1) | GR3019608T3 (en) |
WO (1) | WO1993010767A1 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000018374A1 (en) * | 1998-10-01 | 2000-04-06 | Elan Pharma International, Ltd. | Controlled release nanoparticulate compositions |
DK1165119T3 (en) | 1999-04-08 | 2003-12-15 | Genentech Inc | Composition based on oppositely charged polypeptides |
DE19951617A1 (en) * | 1999-10-26 | 2001-05-03 | Basf Ag | Preparations of active pharmaceutical ingredients |
HUP0900482A2 (en) | 2009-08-03 | 2011-03-28 | Cera Med Kft | Pharmaceutical formulation for oral administration |
CN108309955B (en) * | 2018-04-27 | 2020-06-02 | 武昌理工学院 | Preparation method of polygeline-conjugated paclitaxel nanoparticles |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3312594A (en) * | 1963-06-21 | 1967-04-04 | Squibb & Sons Inc | Longlasting troche |
JPS5911563B2 (en) * | 1980-02-27 | 1984-03-16 | 日本原子力研究所 | Method for manufacturing multilayer sustained release composites |
EP0138216B1 (en) * | 1983-10-14 | 1993-01-07 | Sumitomo Pharmaceuticals Company, Limited | Sustained-release ifn preparation for parenteral administration |
EP0179904A1 (en) * | 1984-05-09 | 1986-05-07 | Medaphore Inc. | Oral insulin and a method of making the same |
DE3684446D1 (en) * | 1985-12-28 | 1992-04-23 | Sumitomo Pharma | MEDICINAL PRODUCTS WITH DELAYED RELEASED RELEASE. |
GB8723846D0 (en) * | 1987-10-10 | 1987-11-11 | Danbiosyst Ltd | Bioadhesive microsphere drug delivery system |
-
1992
- 1992-12-04 CA CA002125284A patent/CA2125284C/en not_active Expired - Fee Related
- 1992-12-04 AU AU30801/92A patent/AU671964B2/en not_active Ceased
- 1992-12-04 WO PCT/DE1992/001009 patent/WO1993010767A1/en active IP Right Grant
- 1992-12-04 EP EP92924546A patent/EP0615444B1/en not_active Expired - Lifetime
- 1992-12-04 DE DE59205625T patent/DE59205625D1/en not_active Expired - Fee Related
- 1992-12-04 ES ES92924546T patent/ES2085656T3/en not_active Expired - Lifetime
- 1992-12-04 AT AT92924546T patent/ATE134875T1/en not_active IP Right Cessation
- 1992-12-04 DK DK92924546.2T patent/DK0615444T3/en active
-
1996
- 1996-04-09 GR GR960401003T patent/GR3019608T3/en unknown
Also Published As
Publication number | Publication date |
---|---|
AU3080192A (en) | 1993-06-28 |
EP0615444B1 (en) | 1996-03-06 |
ES2085656T3 (en) | 1996-06-01 |
GR3019608T3 (en) | 1996-07-31 |
ATE134875T1 (en) | 1996-03-15 |
EP0615444A1 (en) | 1994-09-21 |
DE59205625D1 (en) | 1996-04-11 |
AU671964B2 (en) | 1996-09-19 |
WO1993010767A1 (en) | 1993-06-10 |
CA2125284C (en) | 2000-06-20 |
CA2125284A1 (en) | 1993-06-10 |
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