DK0610744T3 - Sulfonamidaminomethylenderivater som immunosuppressive stoffer - Google Patents

Sulfonamidaminomethylenderivater som immunosuppressive stoffer

Info

Publication number
DK0610744T3
DK0610744T3 DK94101263T DK94101263T DK0610744T3 DK 0610744 T3 DK0610744 T3 DK 0610744T3 DK 94101263 T DK94101263 T DK 94101263T DK 94101263 T DK94101263 T DK 94101263T DK 0610744 T3 DK0610744 T3 DK 0610744T3
Authority
DK
Denmark
Prior art keywords
sulfonamidaminomethylene
immunosuppressants
derivatives
compounds
chem
Prior art date
Application number
DK94101263T
Other languages
Danish (da)
English (en)
Inventor
Richard D Connell
David G Osterman
Michael E Katz
Robert D Dally
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Application granted granted Critical
Publication of DK0610744T3 publication Critical patent/DK0610744T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/66—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having a hetero atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
DK94101263T 1993-02-09 1994-01-28 Sulfonamidaminomethylenderivater som immunosuppressive stoffer DK0610744T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1550293A 1993-02-09 1993-02-09

Publications (1)

Publication Number Publication Date
DK0610744T3 true DK0610744T3 (da) 1999-07-19

Family

ID=21771780

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94101263T DK0610744T3 (da) 1993-02-09 1994-01-28 Sulfonamidaminomethylenderivater som immunosuppressive stoffer

Country Status (8)

Country Link
US (1) US5633277A (de)
EP (1) EP0610744B1 (de)
JP (1) JPH06234735A (de)
AT (1) ATE172985T1 (de)
CA (1) CA2115222A1 (de)
DE (1) DE69414279T2 (de)
DK (1) DK0610744T3 (de)
ES (1) ES2124327T3 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7026116B1 (en) 1996-04-04 2006-04-11 Bio-Rad Laboratories, Inc. Polymorphisms in the region of the human hemochromatosis gene
US6140305A (en) 1996-04-04 2000-10-31 Bio-Rad Laboratories, Inc. Hereditary hemochromatosis gene products
US6849399B1 (en) 1996-05-23 2005-02-01 Bio-Rad Laboratories, Inc. Methods and compositions for diagnosis and treatment of iron misregulation diseases
EP0923581B1 (de) * 1996-08-09 2003-05-21 Boehringer Ingelheim Pharmaceuticals Inc. 4-substituierte beta-carboline als immunomodulatoren
EP1757614B1 (de) 1997-06-13 2010-03-31 Bio-Rad Laboratories, Inc. Verfahren und Zusammensetzungen für die Diagnose und die Behandlung von Krankheiten, die mit Eisenüberschuss oder Eisenmangel assoziiert sind
AU1708099A (en) 1998-06-03 1999-12-20 Amgen, Inc. N-linked sulfonamides of n-heterocyclic carboxylic acids or carboxylic acid isosteres
US6331537B1 (en) 1998-06-03 2001-12-18 Gpi Nil Holdings, Inc. Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds
US6307049B1 (en) 1998-09-30 2001-10-23 The Procter & Gamble Co. Heterocyclic 2-substituted ketoamides
US6300341B1 (en) 1998-09-30 2001-10-09 The Procter & Gamble Co. 2-substituted heterocyclic sulfonamides
EP2147679B1 (de) 2001-07-25 2014-06-25 Raptor Pharmaceutical, Inc. Zusammensetzungen für den Blut-Hirn-Schrankentransport
WO2006116718A2 (en) 2005-04-28 2006-11-02 Proteus Biomedical, Inc. Pharma-informatics system
US8128460B2 (en) * 2006-09-14 2012-03-06 The Material Works, Ltd. Method of producing rust inhibitive sheet metal through scale removal with a slurry blasting descaling cell
US8795627B2 (en) 2007-03-21 2014-08-05 Raptor Pharmaceuticals Inc. Treatment of liver disorders by administration of RAP conjugates
CN102458374A (zh) 2009-05-06 2012-05-16 实验室护肤股份有限公司 包含活性剂-磷酸钙颗粒复合物的皮肤递送组合物及其使用方法
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
AU2012210489B2 (en) * 2011-01-28 2017-01-12 Immunic Ag IL17 and IFN-gamma inhibition for the treatment of autoimmune inflammation

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3219113A1 (de) * 1982-05-21 1983-11-24 Bayer Ag, 5090 Leverkusen Verwendung von n-substituierten 2,3-diaminocarbonsaeuren in arzneimitteln und ihre herstellung
HUT58764A (en) * 1988-07-08 1992-03-30 Smithkline Beckman Corp Process for producing peptides, pharmaceutical compositions containing them and amino-acid intermediates
IL90872A0 (en) * 1988-07-08 1990-02-09 Smithkline Beckman Corp Retroviral protease binding peptides
EP0361341A3 (de) * 1988-09-28 1991-07-03 Miles Inc. Therapeutika für AIDS auf der Basis von HIV-Protease-Inhibitoren
ZA897514B (en) * 1988-10-07 1990-06-27 Merrell Dow Pharma Novel peptidase inhibitors
EP0374097A3 (de) * 1988-12-15 1991-06-12 Ciba-Geigy Ag Verwendung von Peptidisosteren als retrovirale Proteasehemmer
DE3935371A1 (de) * 1988-12-23 1990-07-05 Merck Patent Gmbh Stickstoffhaltige ringverbindungen
US5342922A (en) * 1989-03-08 1994-08-30 Washington University Inhibitors of retroviral protease

Also Published As

Publication number Publication date
EP0610744B1 (de) 1998-11-04
ATE172985T1 (de) 1998-11-15
ES2124327T3 (es) 1999-02-01
EP0610744A1 (de) 1994-08-17
DE69414279T2 (de) 1999-04-08
US5633277A (en) 1997-05-27
DE69414279D1 (de) 1998-12-10
JPH06234735A (ja) 1994-08-23
CA2115222A1 (en) 1994-08-10

Similar Documents

Publication Publication Date Title
ES2119912T3 (es) Nuevos aminometilenpeptidos como inmunosupresores.
DK0610744T3 (da) Sulfonamidaminomethylenderivater som immunosuppressive stoffer
DK0564924T3 (da) 2-Oxoethylderivater som immunosuppressiva
DK0753506T3 (da) 6-Dimethylaminomethyl-1-phenyl-cyclohexanforbindelser som farmaceutisk aktive stoffer
DK0780369T3 (da) 1-phenyl-2-dimethylaminomethyl-cyclohexan-1-ol-forbindelser som farmaceutisk virksomme stoffer
DK0823889T3 (da) 1,3-propandiolderivater som bioaktive forbindelser
NO973167L (no) Bestemte 1,4,5-trisubstituerte imidazol-forbindelser anvendelige som cytokin
EP0857718A4 (de) Endothelin-antagonisten
DK0629616T3 (da) Optisk aktive 2-imidazolin-5-on-derivater som fungicider
DK0869949T3 (da) Benzoxaziner som antimikrobielle midler
MY114393A (en) 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1, 3-propanediol derivatives
EP0671911A4 (de) Carboxypeptidyl-derivate als antidegenerative wirkstoffe.
NO20022557D0 (no) 2,4-diaminopyrimidinforbindelser nyttige som immunosuppreserende midler
AU642753B2 (en) Halogen-containing compounds, herbicidal composition containing the same as an active ingredient, and intermediary compounds therefor
FI945164A0 (fi) Biologisesti aktiivisesti ureidojohdannaiset, jotka ovat käyttökelpoisia antimetastaattisina aineina
EP1008345A4 (de) Antiallergische mittel
NO961547D0 (no) Flavinderivater som anti-virusmidler
FI962010A (fi) Immuunivastetta heikentävinä aineina käytettäviä 6-okso-nukleosideja
ATE197953T1 (de) Pyrrolo(4,3,2-de)chinolin-derivat
FI950101A0 (fi) 4-oksa-1-atsabisyklo 3,2,0 -7heptanoni-johdannaiset kasvainten vastaisina aineina
FI931345A0 (fi) Tjuvalarm, som aktiveras av foeremaolets, som skall skyddas, roerelse
IT1273460B (it) Formulazioni farmaceutiche ad azione antivirale per uso topico
FI83U1 (fi) Limtraebalk eller -fackverk, som monteras pao byggnadsplatsen
ITCN920001A0 (it) Cabina per macchine operatrici da cantiere, parzialmente sopraelevabi-le
FIU950254U0 (fi) Regel som staengs automatiskt