DK0593605T3 - Process for the preparation of starch esters for clinical, especially parenteral use - Google Patents
Process for the preparation of starch esters for clinical, especially parenteral useInfo
- Publication number
- DK0593605T3 DK0593605T3 DK92914886T DK92914886T DK0593605T3 DK 0593605 T3 DK0593605 T3 DK 0593605T3 DK 92914886 T DK92914886 T DK 92914886T DK 92914886 T DK92914886 T DK 92914886T DK 0593605 T3 DK0593605 T3 DK 0593605T3
- Authority
- DK
- Denmark
- Prior art keywords
- starch esters
- mole
- carbon atoms
- range
- clinical
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B31/00—Preparation of derivatives of starch
- C08B31/02—Esters
- C08B31/04—Esters of organic acids, e.g. alkenyl-succinated starch
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B35/00—Preparation of derivatives of amylopectin
- C08B35/02—Esters
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
In order to prepare physiologically tolerated water-soluble starch esters, the invention proposes that starch is converted by acid hydrolysis or enzymatic hydrolysis to a partially hydrolysed form with a mean molecular weight in the range from 10,000 to 500,000 Daltons. This partial hydrolysate is then acylated, in aqueous solution, with the anhydride or halide of an aliphatic monocarboxylic acid with 2 to 4 carbon atoms or an aliphatic dicarboxylic acid with 3 to 6 carbon atoms, or mixtures thereof, and an alkalinization agent, to give a product with a substitution ratio in the range from 0.1 to 1.0 mole/mole. Salts are removed from the resulting reaction mixture. The starch esters thus obtained are highly suited for clinical use, in particular parenteral administration and administration in the diet.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4123000A DE4123000A1 (en) | 1991-07-11 | 1991-07-11 | METHOD FOR PRODUCING STARCHESTERS FOR CLINICAL, IN PARTICULAR PARENTERAL APPLICATION |
| PCT/EP1992/001553 WO1993001217A1 (en) | 1991-07-11 | 1992-07-09 | Method of preparing starch esters for clinical, in particular parenteral, applications |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0593605T3 true DK0593605T3 (en) | 1998-08-10 |
Family
ID=6435928
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK92914886T DK0593605T3 (en) | 1991-07-11 | 1992-07-09 | Process for the preparation of starch esters for clinical, especially parenteral use |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0593605B1 (en) |
| JP (1) | JPH06511506A (en) |
| AT (1) | ATE160576T1 (en) |
| AU (1) | AU656014B2 (en) |
| CA (1) | CA2113162A1 (en) |
| CZ (1) | CZ5994A3 (en) |
| DE (2) | DE4123000A1 (en) |
| DK (1) | DK0593605T3 (en) |
| ES (1) | ES2112323T3 (en) |
| FI (1) | FI940097A (en) |
| GR (1) | GR3025927T3 (en) |
| HU (1) | HUT72587A (en) |
| PL (1) | PL170733B1 (en) |
| PT (1) | PT100679B (en) |
| RU (1) | RU2093522C1 (en) |
| SK (1) | SK279878B6 (en) |
| WO (1) | WO1993001217A1 (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4123001A1 (en) * | 1991-07-11 | 1993-01-14 | Laevosan Gmbh & Co Kg | PHARMACEUTICAL COMPOSITION FOR PERITONEAL DIALYSIS |
| DE4122999A1 (en) * | 1991-07-11 | 1993-01-14 | Laevosan Gmbh & Co Kg | METABOLIZABLE PLASMA REPLACEMENT |
| DE4242926C2 (en) | 1992-12-18 | 1994-12-15 | Fresenius Ag | Dialysis solution for peritoneal dialysis |
| FI942686A0 (en) * | 1994-06-07 | 1994-06-07 | Alko Ab Oy | Composition of the starch acetate with a variety of compounds, for the production and distribution |
| DE4442605A1 (en) * | 1994-11-30 | 1996-06-05 | Degussa | Swellable starch ester, process for its production and use |
| DE4442606C2 (en) * | 1994-11-30 | 1998-09-17 | Degussa | Swellable starch ester, process for its production and use |
| US7772391B2 (en) | 2005-06-16 | 2010-08-10 | The Procter & Gamble Company | Ethersuccinylated hydroxyl polymers |
| DE102010012183A1 (en) * | 2010-03-19 | 2011-09-22 | Fresenius Medical Care Deutschland Gmbh | Esterified polysaccharide osmotica |
| WO2016137751A1 (en) | 2015-02-24 | 2016-09-01 | The Procter & Gamble Company | Process for molecular weight reduction of ethersuccinylated polysaccharides |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2362282A (en) * | 1942-09-12 | 1944-11-07 | Wesley N Lindsay | Method of acetylating starch |
| US2363382A (en) * | 1943-08-27 | 1944-11-21 | Charles W Attwood | Scaffolding |
| US3639389A (en) * | 1968-05-15 | 1972-02-01 | Cpc International Inc | Low d.e. starch hydrolysate derivatives |
| GB1476057A (en) * | 1975-03-20 | 1977-06-10 | Unicliffe Ltd | Throat pastilles |
-
1991
- 1991-07-11 DE DE4123000A patent/DE4123000A1/en not_active Withdrawn
-
1992
- 1992-07-09 DK DK92914886T patent/DK0593605T3/en active
- 1992-07-09 AT AT92914886T patent/ATE160576T1/en not_active IP Right Cessation
- 1992-07-09 DE DE59209043T patent/DE59209043D1/en not_active Expired - Fee Related
- 1992-07-09 ES ES92914886T patent/ES2112323T3/en not_active Expired - Lifetime
- 1992-07-09 EP EP92914886A patent/EP0593605B1/en not_active Expired - Lifetime
- 1992-07-09 CZ CS9459A patent/CZ5994A3/en unknown
- 1992-07-09 CA CA002113162A patent/CA2113162A1/en not_active Abandoned
- 1992-07-09 WO PCT/EP1992/001553 patent/WO1993001217A1/en not_active Application Discontinuation
- 1992-07-09 RU RU9294016156A patent/RU2093522C1/en active
- 1992-07-09 AU AU22775/92A patent/AU656014B2/en not_active Ceased
- 1992-07-09 JP JP5501976A patent/JPH06511506A/en active Pending
- 1992-07-09 PL PL92301995A patent/PL170733B1/en unknown
- 1992-07-09 HU HU9400064A patent/HUT72587A/en unknown
- 1992-07-09 SK SK23-94A patent/SK279878B6/en unknown
- 1992-07-10 PT PT100679A patent/PT100679B/en not_active IP Right Cessation
-
1994
- 1994-01-10 FI FI940097A patent/FI940097A/en unknown
-
1998
- 1998-01-15 GR GR980400097T patent/GR3025927T3/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SK279878B6 (en) | 1999-05-07 |
| JPH06511506A (en) | 1994-12-22 |
| ATE160576T1 (en) | 1997-12-15 |
| DE4123000A1 (en) | 1993-01-14 |
| WO1993001217A1 (en) | 1993-01-21 |
| PT100679A (en) | 1993-09-30 |
| ES2112323T3 (en) | 1998-04-01 |
| PT100679B (en) | 1999-09-30 |
| CZ5994A3 (en) | 1994-07-13 |
| EP0593605B1 (en) | 1997-11-26 |
| FI940097A0 (en) | 1994-01-10 |
| EP0593605A1 (en) | 1994-04-27 |
| PL170733B1 (en) | 1997-01-31 |
| RU2093522C1 (en) | 1997-10-20 |
| SK2394A3 (en) | 1994-08-10 |
| HU9400064D0 (en) | 1994-05-30 |
| AU656014B2 (en) | 1995-01-19 |
| FI940097A (en) | 1994-01-10 |
| GR3025927T3 (en) | 1998-04-30 |
| HUT72587A (en) | 1996-05-28 |
| AU2277592A (en) | 1993-02-11 |
| CA2113162A1 (en) | 1993-01-21 |
| DE59209043D1 (en) | 1998-01-08 |
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