DK0575930T3 - Process for the preparation of solid pharmaceutical retard forms - Google Patents

Process for the preparation of solid pharmaceutical retard forms

Info

Publication number
DK0575930T3
DK0575930T3 DK93109860.2T DK93109860T DK0575930T3 DK 0575930 T3 DK0575930 T3 DK 0575930T3 DK 93109860 T DK93109860 T DK 93109860T DK 0575930 T3 DK0575930 T3 DK 0575930T3
Authority
DK
Denmark
Prior art keywords
binder
pharmaceutically acceptable
active substance
preparation
solid pharmaceutical
Prior art date
Application number
DK93109860.2T
Other languages
Danish (da)
Inventor
Axel Dr Sanner
Kurt Dr Wendel
Sven Dr Grabowski
Astrid Dr Kah-Helbig
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Application granted granted Critical
Publication of DK0575930T3 publication Critical patent/DK0575930T3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

The process entails applying a reconstituted aqueous dispersion of a pharmaceutically acceptable binder to a core containing active substance, or wet granulation of the pharmaceutical active substance with a dispersion of such a binder, or direct tabletting of an active substance with the redispersible binder powder, where the binder has been obtained by emulsion polymerisation and subsequent spray drying of the resulting aqueous dispersion with a water-soluble pharmaceutically acceptable spray aid with a glass transition temperature of at least 60 DEG C and, where appropriate, with a pharmaceutically acceptable antiblocking agent.
DK93109860.2T 1992-06-25 1993-06-21 Process for the preparation of solid pharmaceutical retard forms DK0575930T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4220782A DE4220782A1 (en) 1992-06-25 1992-06-25 Process for the preparation of solid pharmaceutical sustained release forms

Publications (1)

Publication Number Publication Date
DK0575930T3 true DK0575930T3 (en) 1997-04-01

Family

ID=6461767

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93109860.2T DK0575930T3 (en) 1992-06-25 1993-06-21 Process for the preparation of solid pharmaceutical retard forms

Country Status (10)

Country Link
US (1) US5490990A (en)
EP (1) EP0575930B1 (en)
JP (1) JP3619531B2 (en)
AT (1) ATE149826T1 (en)
CA (1) CA2098667C (en)
DE (2) DE4220782A1 (en)
DK (1) DK0575930T3 (en)
ES (1) ES2099318T3 (en)
GR (1) GR3023242T3 (en)
MX (1) MX9303604A (en)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4341156C2 (en) * 1993-12-02 1997-11-13 Wacker Chemie Gmbh Use of water-redispersible plastic dispersion powders as drug carriers
WO1997006787A2 (en) * 1995-08-17 1997-02-27 Dyer, Alison, Margaret Controlled release products
JPH1050306A (en) * 1996-07-31 1998-02-20 Toyota Autom Loom Works Ltd Manufacture of hydrogen storage alloy electrode
AT403914B (en) * 1996-09-24 1998-06-25 Krems Chemie Ag SPRAY-DRIED DISPERSIONS, METHOD FOR THEIR PRODUCTION AND THEIR USE
DE19709663A1 (en) * 1997-03-10 1998-09-17 Basf Ag Use of redispersible polymer powders or polymer granules as binders for the production of solid pharmaceutical dosage forms
DE19709532A1 (en) * 1997-03-10 1998-09-17 Basf Ag Use of redispersible polymer powders or polymer granules for coating pharmaceutical or agrochemical dosage forms
ATE526950T1 (en) * 1999-10-29 2011-10-15 Euro Celtique Sa CONTROLLED RELEASE HYDROCODONE FORMULATIONS
US10179130B2 (en) 1999-10-29 2019-01-15 Purdue Pharma L.P. Controlled release hydrocodone formulations
US7364752B1 (en) 1999-11-12 2008-04-29 Abbott Laboratories Solid dispersion pharamaceutical formulations
JP5767429B2 (en) * 1999-11-12 2015-08-19 アッヴィ・インコーポレイテッド Crystallization inhibitors in solid dispersants
GT200100039A (en) * 2000-03-16 2001-12-31 Pfizer INHIBITOR OF THE GLUCOGENO FOSFORILASA.
DE10014588A1 (en) * 2000-03-27 2001-10-04 Basf Ag Sustained-release oral dosage form that floats in gastric fluid includes a blend of polyvinyl acetate and polyvinylpyrrolidone
DE10015479A1 (en) * 2000-03-29 2001-10-11 Basf Ag Solid oral dosage forms with delayed release of active ingredient and high mechanical stability
US6399101B1 (en) 2000-03-30 2002-06-04 Mova Pharmaceutical Corp. Stable thyroid hormone preparations and method of making same
DE10026698A1 (en) * 2000-05-30 2001-12-06 Basf Ag Self-emulsifying active ingredient formulation and use of this formulation
US8257744B2 (en) * 2000-07-07 2012-09-04 Laboratorios Farmacéuticos Rovi, S.A. Pharmaceutical forms for the release of active compounds
FR2811227A1 (en) * 2000-07-07 2002-01-11 Philippe Maincent PARTICULATE VECTORS FOR IMPROVING ORAL ABSORPTION OF ACTIVE PRINCIPLES
EP2263658A1 (en) 2000-10-30 2010-12-22 Euro-Celtique S.A. Controlled release hydrocodone formulations
US20030099699A1 (en) 2001-11-13 2003-05-29 Hanshew Dwight D. Storage stable thyroxine active drug formulations and methods for their production
US6645526B2 (en) * 2001-11-13 2003-11-11 Mylan Pharmaceuticals, Inc. Storage stable thyroxine active drug formulations and methods for their production
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
US8377952B2 (en) * 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
EP1711535A4 (en) * 2004-02-05 2008-10-15 Lg Chemical Ltd Method of emulsion polymerization using liquid miniemulsion as seed particle
AU2005240137B2 (en) * 2004-05-04 2010-04-15 Innophos, Inc. Directly compressible tricalcium phosphate
US8168219B2 (en) * 2005-11-30 2012-05-01 Isp Investments Inc. Synergistic binder composition, method for making same, and tablets of an active and said binder having advantageous hardness and friability
WO2008067164A2 (en) * 2006-11-15 2008-06-05 Abbott Laboratories Solid pharmaceutical dosage formulations
US8802156B2 (en) 2007-11-14 2014-08-12 Laboratorios Farmacéuticos Rovi, S.A. Pharmaceutical forms for the release of active compounds

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE27107E (en) * 1968-05-01 1971-03-30 Drug composition
US3784648A (en) * 1971-10-01 1974-01-08 Wacker Chemie Gmbh Process for the preparation of free-flowing,lump-free,redispersible,synthetic resin powders
DE3013839A1 (en) * 1979-04-13 1980-10-30 Freunt Ind Co Ltd METHOD FOR PRODUCING AN ACTIVATED PHARMACEUTICAL COMPOSITION
DE3143071A1 (en) * 1981-10-30 1983-05-11 Basf Ag, 6700 Ludwigshafen Process for the preparation of blocking-resistant, water- redispersible polymer powders by spraying aqueous polymer dispersions
LU85058A1 (en) * 1983-10-24 1985-06-19 Pharlyse SUSTAINED-RELEASE PHARMACEUTICAL TABLETS, THEIR PREPARATION AND THEIR USE
DE3344242A1 (en) * 1983-12-07 1985-06-20 Wacker-Chemie GmbH, 8000 München METHOD FOR PRODUCING A REDISPERGABLE DISPERSION POWDER AND ITS APPLICATION
DE3438291A1 (en) * 1984-10-19 1986-04-24 Röhm GmbH, 6100 Darmstadt METHOD FOR PRODUCING AN AQUEOUS COATING DISPERSION AND THE USE THEREOF FOR COATING MEDICINAL PRODUCTS
DE3719241A1 (en) * 1987-06-06 1988-12-15 Roehm Gmbh SPRAY-DRYED EMULSION POLYMER, METHOD FOR THE PRODUCTION AND USE THEREOF AND MOLDING DIMENSIONED THEREOF
DE3723668A1 (en) * 1987-07-17 1989-01-26 Roehm Gmbh LOW-DUST SPRAY-DRIED EMULSION POLYMER AND PROCESS FOR ITS PRODUCTION AND APPLICATION
US5025004A (en) * 1988-06-13 1991-06-18 Eastman Kodak Company Water-dispersible polymeric compositions
DE3923229A1 (en) * 1989-07-14 1991-01-24 Basf Ag POLYMERISAT POWDER REDISPERGABLE IN WATER, PRODUCED BY SPRAYING OF AQUEOUS POLYMERISAT DISPERSIONS, AND THEIR USE AS ADDITIVES TO HYDRAULIC BINDERS
DE4133192A1 (en) * 1991-10-07 1993-04-08 Basf Ag METHOD FOR COVERING MEDICINAL FORMS

Also Published As

Publication number Publication date
GR3023242T3 (en) 1997-07-30
ES2099318T3 (en) 1997-05-16
US5490990A (en) 1996-02-13
JP3619531B2 (en) 2005-02-09
DE59305700D1 (en) 1997-04-17
DE4220782A1 (en) 1994-01-05
CA2098667A1 (en) 1993-12-26
CA2098667C (en) 2003-10-28
ATE149826T1 (en) 1997-03-15
EP0575930A1 (en) 1993-12-29
JPH0656651A (en) 1994-03-01
MX9303604A (en) 1994-06-30
EP0575930B1 (en) 1997-03-12

Similar Documents

Publication Publication Date Title
DK0575930T3 (en) Process for the preparation of solid pharmaceutical retard forms
PL338010A1 (en) Novel pharmaceutic preparations of controllable active substance release
AU582920B2 (en) Continuous release pharmaceutical compositions
ES8306322A1 (en) Improvements to methods for preparing galenical preparation with delayed action and programmed release and galenical preparations for drugs obtained thereby
CA2074309A1 (en) Stabilized controlled release formulations having acrylic polymer coating
DE69032445D1 (en) Delayed-release medicines
NO870558D0 (en) PROCEDURE FOR THE PREPARATION OF A SLOW RELEASE PHARMACEUTICAL PREPARATION.
IT7928301A0 (en) GALENIC FORMS OF ADMINISTRATION OF MEDICINES ORALLY, WITH PROGRAMMED RELEASE, AND THEIR PREPARATION PROCEDURES
EP0013000A3 (en) Polymeric agent for releasing 5-aminosalicylic acid or its derivatives into the gastrointestinal tract, pharmaceutical formulation comprising said agent,method of its preparation and method of preparing said formulation
GR3018970T3 (en) Freeze-dried polymer dispersions and the use thereof in preparing sustained-release pharmaceutical compositions.
YU48766B (en) Procedure for production of pharmaceutical preparation for oral dosage with reduced speed of realise of active substance without solution
ATE197808T1 (en) POLYMER POWDER REDISPRESSIBLE IN AQUEOUS SOLUTION
NO155239C (en) ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE, MIXED SALTS OF ESSENTIAL OR SEMI-ESSENTIAL AMINO ACIDS AND NITROGEN FREE ANALOGS THEREOF.
EP0171528A3 (en) Controlled release pharmaceutical preparations
TW223592B (en)
HUP0000843A2 (en) New formulation for inhalation having a poured bulk density of from 0,28 to 0,38 g/ml, comprising formoterol
NL7901596A (en) ACETIC ACID DERIVATIVES, METHOD OF PREPARATION THEREOF, AND PHARMACEUTICAL PREPARATIONS ON THE BASIS.
FI906372A0 (en) SPRAYTORKNINGSFOERFARANDE FOER FRAMSTAELLNING AV PHARMACEUTISKA PULVERKOMPOSITIONER, VILKA AER PRESSBARA DIREKT TILL TABLETTER.
NO155289C (en) ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVATED 4,5-Saturated PROSTANIC ACID DERIVATIVES.
NL190371C (en) CYCLOAL CANON OXIMETHERS WITH THERAPEUTIC PROPERTIES AND ACID ADDITION SALTS AND QUATERNARY AMMONIUM DERIVATIVES THEREOF, INCLUDING PHARMACEUTICAL COMPOSITIONS, CONTAINING THESE COMPOUNDS, AND PROCESS FOR THE PREPARATION OF THE COMPOUND.
NO167807C (en) ANALOGY PROCEDURE FOR THE PREPARATION OF 3 ', 4'-DINITROGEN SUBSTITUTED EPIPODOPHYLLOTOXING LUCOSIDE DERIVATIVES.
NO157421C (en) ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY ACTIVE 3,7-DIAZABICYCLO- (3.3.1) -NONANE DERIVATIVES.
HUT49873A (en) Herbicides and acaricides, as well as process for producing the active ingredient aryl- or heteroaryldione derivatives
PT72397B (en) Process for the preparation of n,n-dialkyl-o-(pyrazol-5-yl) carbanic acid derivatives and insecticide and nematicide compositions thereof
NL186699B (en) KANAMYCIN DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF, PROCESS FOR THE PREPARATION OF PHARMACEUTICAL PREPARATIONS AND FORMED PHARMACEUTICAL PREPARATIONS.